Aggrecan Neo Antibody PA1-1746 from Thermo Fisher Scientific

Product Specs
ItemAggrecan Neo Antibody
CompanyThermo Fisher Scientific
Price Supplier Page
Catalog NumberPA1-1746
Quantity100 µg
ApplicationsImmunohistochemistry, Western Blot
Conjugate/TagUnconjugated
FormatPBS with 1mg/mL BSA and 0.05% sodium azide
Concentration0.83 mg/mL
PurityAffinity chromatography
ReactivityBovine, Canine, Human, Mouse, Porcine, Rat
HostRabbit
TargetAggrecan Neo
IsotypeIgG
Storage Temperature-20° C, Avoid Freeze/Thaw Cycles
Antibody TypePrimary
NCBI Gene Aliasesb2b183Clo, Cspg1, SSOAOD, CSPGCP, cmd, Agc, AGCAN, Agc1, CSPG1, AGC1, MSK16, CSPCP, SEDK
ClonalityPolyclonal
ImmunogenSynthetic peptide corresponding to residues C G G N(387) I T E G E(392) of human aggrecan
NCBI Full Gene Nameaggrecan
Storage-20°C, Avoid Freeze/Thaw Cycles

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(1) Activity-dependent extracellular proteolytic cascade cleaves the ECM component brevican to promote structural plasticityEMBO reportsNovember 19, 2025Singh JB, Perelló-Amorós B, Schneeberg J, Mirzapourdelavar H, Seidenbecher CI, Fejtová A, Dityatev A, Frischknecht R.System,973-TM Tissue-Tek,Sakura,4583 "2,2,2-trichloroethanol",Merck,T54801 Antibodies,Antibodies,Antibodies Aggrecan (rb),Millipore,AB1031 Aggrecan Neo (rb),ThermoFisher,PA1-1746 Bassoon (ms),Synaptic Systems,141111 (mab7f) Brevican (ms),BD Transduction Laboratories,610894 Brevican

(2) Blockade of ZMIZ1‐GATA4 Axis Regulation Restores Youthfulness to Aged CartilageAdvanced ScienceMarch 5, 2025Jiho Nam, Hyunmin Woo, Jihye Yang, Seok Jung Kim, Kwang Pyo Lee, Ji Hoon Yu, Tae Joo Park, Seong‐il Eyun, Siyoung YangUK, ab52237), anti‐MMP3 (Abcam, ab52915), anti‐COL2A1 (Chemicon, MAB8887), anti‐aggrecan (Invitrogen, PA1‐1746), anti‐SOX9 (Santa Cruz, SC‐20095), and anti‐p16 (Proteintech, 10883‐1‐AP). ERK was detected as a loading

(3) Diacetoxy-6-gingerdiol protects the extracellular matrix of nucleus pulposus cells and ameliorates intervertebral disc degeneration by inhibiting the IL-1β-mediated NLRP3 pathwayHeliyonNovember 15, 2024Xi H, Weng Y, Zheng Y, Wu L, Han D.Collagen II (#K009364P, 1:500) was purchased from Solarbio (Beijing, China). the abtibody Aggrecan (#PA1-1746, 1:1000) was obtained from Invitrogen (Beverly, MA, USA). The Anti-rabbit IgG, HRP Antibody (#S0001,

(4) IGF1 drives Wnt-induced joint damage and is a potential therapeutic target for osteoarthritisNature communicationsOctober 24, 2024Escribano-Núñez A, Cornelis FMF, De Roover A, Sermon A, Cailotto F, Lories RJ, Monteagudo S.dilution 5 µg/ml), TCF1 (Abcam, ab96777; dilution 1:50), COLX (Abcam, ab58632; dilution 1:400), NITEGE (PA1-1746, Thermo Fisher Scientific; dilution 1:50), MMP13 (Abcam, ab39012, dilution 1:75) and ADAMTS5 (Abcam,

(5) A novel spherical GelMA-HAMA hydrogel encapsulating APET×2 polypeptide and CFIm25-targeting sgRNA for immune microenvironment modulation and nucleus pulposus regeneration in intervertebral discsJournal of nanobiotechnologySeptember 12, 2024Yu XJ, Zhao YT, Abudouaini H, Zou P, Li TQ, Bai XF, Wang SX, Guan JB, Li MW, Wang XD, et al.

(6) Advancing osteoarthritis therapy with GMOCS hydrogel-loaded BMSCs-exosJournal of nanobiotechnologyAugust 19, 2024Zhou R, Guo J, Jin Z.Subsequently, the slices were incubated overnight at 4 °C with primary antibodies against Aggrecan (PA1-1746, 1:50, Thermo Fisher Scientific Inc.) and MMP13 (ab219620, 1:2000, abcam), then for 60 min at room temperature

(7) Bisdemethoxycurcumin, a curcumin, protects chondrocytes, and reduces cartilage inflammation via the NRF2/HO-1/NLRP3 pathwayImmunity, inflammation and diseaseFebruary 1, 2024Jin G, Xu W, Tang H, Cui Y, Zhang H.collagen II (#K009364P, 1:500) was obtained from Solarbio, while the primary antibody against aggrecan (#PA1‐1746, 1:1000) and the primary antibody against IL‐1β (#A1112, 1:1000) were obtained from Thermo Fisher Scientific

(8) Tomatidine Alleviates Intervertebral Disc Degeneration by Activating the Nrf2/HO-1/GPX4 Signaling PathwayDrug design, development and therapyJanuary 1, 2024Li Z, Cheng P, Xi H, Jiang T, Zheng X, Qiu J, Gong Y, Wu X, Mi S, Hong Y, et al.ab305290). Aggrecan neo polyclonal antibody was purchased from Thermo Fisher Scientific (UK; cat. no. PA1-1746). The collagen II antibody, ADAMTS-4 antibody, SLC40A1 antibody, xCT antibody, Nrf2 antibody, GPX4 antibody,

(9) Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activationEMBO molecular medicineJanuary 1, 2024Ruiz-Rodríguez MJ, Oller J, Martínez-Martínez S, Alarcón-Ruiz I, Toral M, Sun Y, Colmenar Á, Méndez-Olivares MJ, López-Maderuelo D, Kern CB, et al.antibodies: rabbit polyclonal anti-neo-Acan (specific NITEGE sequence generated by Adamts1 cleavage of Acan, PA1-1746, Thermo Fisher, 1/500), anti-neo-Vcan (specific DPEAAE neoepitope generated by Adamts1 cleavage of Vcan,

(10) Synergetic enrichment of aggrecan in nucleus pulposus cells by scAAV6-shRNA-mediated knockdown of aggrecanase-1 and aggrecanase-2Experimental biology and medicine (Maywood, N.J.)July 1, 2023Mern DS, Thomé C.

(11) E7 Peptide Enables BMSC Adhesion and Promotes Chondrogenic Differentiation of BMSCs Via the LncRNA H19/miR675 AxisBioengineering (Basel, Switzerland)June 30, 2023Shi W, Wu J, Pi Y, Yan X, Hu X, Cheng J, Yu H, Shao Z.Anti-Col II (Abcam, ab188570, 1:2000), anti-sox 9 (Abcam, ab185866, 1:1000), anti-acan (Thermo Fisher, PA1-1746, 1:1000), anti-β-actin (ZSGB-BIO, TA-09, 1:1000), anti-mouse secondary antibody (ZSGB-BIO, ZB-2305,

(12) Maltol ameliorates intervertebral disc degeneration through inhibiting PI3K/AKT/NF-κB pathway and regulating NLRP3 inflammasome-mediated pyroptosisInflammopharmacologyFebruary 1, 2023Gong Y, Qiu J, Jiang T, Li Z, Zhang W, Zheng X, He Z, Chen W, Wang Z, Feng X, et al.TX, USA). iNOS (Cat# A3774) and IL-1β (Cat# A19635) were from Abclonal (Wuhan, China). Aggrecan (Cat# PA1-1746) was purchased from Invitrogen (Waltham, MA, USA). Collagen II (Cat# K009364P) was purchased from Solarbio

(13) Paroxetine Attenuates Chondrocyte Pyroptosis and Inhibits Osteoclast Formation by Inhibiting NF-κB Pathway Activation to Delay Osteoarthritis ProgressionDrug design, development and therapyJanuary 1, 2023Zheng X, Qiu J, Gao N, Jiang T, Li Z, Zhang W, Gong Y, Hong Z, Hong H.1:1000) and ADAMTS5 (ab185722, 1:1000) were purchased from Abcam (Cambridge, UK). The aggrecan antibody (PA1-1746, 1:1000) was procured from Thermo Fisher Scientific (Waltham, MA, USA), and MMP3 (ET1705-98, 1:1000)

(14) Calcium-binding protein 39 overexpression promotes macrophages from ‘M1’ into ‘M2’ phenotype and improves chondrocyte damage in osteoarthritis by activating the AMP-activated protein kinase/sirtuin 1 axisBioengineeredApril 12, 2022Qiuliang Liu, Kai Pian, Zhen Tian, Haitao Duan, Qi Wang, Hui Zhang, Longyan Shi, Dongjian SongAbcam, 1:5000), anti-MMP3 (ab52915, Abcam, 1:1000), anti-MMP13 (ab51072, Abcam, 1:1000), anti-Aggrecan (PA1-1746, Thermo Fisher, 1:1000), anti-p-AMPKα (PA5-17,831, Thermofisher, 1:1000), anti-Sirt-1 (ab189494, Abcam,

(15) Selumetinib - a potential small molecule inhibitor for osteoarthritis treatmentFrontiers in pharmacologyJanuary 1, 2022Zheng X, Qiu J, Pan W, Gong Y, Zhang W, Jiang T, Chen L, Chen W, Hong Z.(Beijing, China). Collagen II monoclonal antibody (MA5-12789) and aggrecan neo polyclonal antibody (PA1-1746) were purchased from Thermo Fisher Scientific (Waltham, MA, United States). Anti-MMP9 (ab76003), anti-Adamts4

(16) Role of Ciliary Protein Intraflagellar Transport Protein 88 in the Regulation of Cartilage Thickness and Osteoarthritis Development in MiceArthritis & rheumatology (Hoboken, N.J.)January 1, 2022Coveney CR, Zhu L, Miotla-Zarebska J, Stott B, Parisi I, Batchelor V, Duarte C, Chang E, McSorley E, Vincent TL, et al.

(17) Enhancement of DUSP14 (dual specificity phosphatase 14) limits osteoarthritis progression by alleviating chondrocyte injury, inflammation and metabolic homeostasisBioengineeredOctober 4, 2021Zandong Zhao, Jie Yang, Liang zhang, Yunping Zhouincubated with specific primary antibodies against rat DUSP14 (#PA5-75,585; Invitrogen), aggrecan (#PA1-1746; Invitrogen), ADAMTS5 (#ab41037), collagen II (#ab188570), p-p65 NF-κB (phospho S536; #ab239882) and

(18) Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hipAgingApril 4, 2021Xu R, Zhang F, Lu J, Wang K, Pan P, Sun Y, Zhang Y.described. Anti-SOX9 antibody (Abcam, Catalog No: ab185966), Anti-ACAN antibody (Invitrogen, Catalog No: PA1-1746), Anti-ITGA8 antibody (Abcam, Catalog No: ab243027), Anti-ITGAV antibody (Abcam, Catalog No: ab179475)

(19) Platelet-Derived Growth Factor-BB Inhibits Intervertebral Disc Degeneration via Suppressing Pyroptosis and Activating the MAPK Signaling PathwayFrontiers in pharmacologyJanuary 1, 2021Zhang W, Gong Y, Zheng X, Qiu J, Jiang T, Chen L, Lu F, Wu X, Cheng F, Hong Z.antibody were purchased from Thermo Fisher Scientific, United Kingdom (cat. nos. PA5-88272; MA5-12789; PA1-1746); MMP3 antibody, MMP9 antibody, Adamts4 antibody, Adamts5 antibody and Caspase1 antibody were purchased

(20) Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birtheLifeSeptember 10, 2020Nandadasa S, Szafron JM, Pathak V, Murtada SI, Kraft CM, O'Donnell A, Norvik C, Hughes C, Caterson B, Domowicz MS, et al.Millipore Sigma AB1031 RRID:AB_90460 IF (1:400) all species Antibody Rabbit polyclonal anti-aggrecan neo epitope NITEGE Invitrogen PA1-1746 RRID:AB_2242021 IF (1:200) all species Antibody Rat monoclonal anti-endomucin antibody (clone eBioV.7C7) Invitrogen 14-5851-85 RRID:AB_891531 IF

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Aggrecan Neo Antibody

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Aggrecan Neo Antibody from Thermo Fisher Scientific

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Aggrecan Neo Antibody from Thermo Fisher Scientific

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