SMARCC2/BAF170 (D8O9V) Rabbit mAb 12760S from Cell Signaling Technology

Product Specs
ItemSMARCC2/BAF170 (D8O9V) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number12760S
Quantity100 µl
ApplicationsW, IP, ChIP, ChIP-seq, C&R
ReactivityH, M, R, Mk
TargetSMARCC2
HostRabbit
NCBI Full Gene NameSWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
NCBI Gene AliasesBAF170, CRACC2, CSS8, Rsc8
ClonalityMonoclonal
Research AreaChromatin Regulation / Nuclear Function
CloneD8O9V
Molecular Weight162, 170

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activityResearch SquareApril 8, 2025Garrett W Cooper, Benjamin P Cooper, Benjamin Lee, Yongdong Kim, Yongdong Chen, Victor Salas, Xiaoping Salas, Xiaoping Lintner, Frederica Piccioni, Federica Giacomelli, et al.(Santa Cruz – sc-166165), β-actin (CST - 8457S), DPF2 (Cell signaling - 71642S), SMARCC2 (Cell signaling - 12760S), SMARCA4 (Santa Cruz- sc-17796). Secondary antibodies: Alexa Fluor® IRDye 680RD goat anti-rabbit (ThermoFisher)

(2) Identification of selective SWI/SNF dependencies in enzalutamide-resistant prostate cancerCommun BiolFebruary 4, 2025Bengul Gokbayrak, Umut Berkay Altintas, Shreyas Lingadahalli, Tunc Morova, Chia-Chi Flora Huang, Betul Ersoy Fazlioglu, Ivan Pak Lok Yu, Batuhan M. Kalkan, Paloma Cejas, Sonia H. Y. Kung, et al.gene knockdowns were confirmed by RT-qPCR. GAPDH (Santa Cruz, sc-25778) and SMARCC2 (Cell Signaling, Cat.No.12760S) antibodies were used as primary antibodies. Goat anti-mouse IgG-HRP (Santa Cruz, sc-2055) and goat anti-rabbit IgG-HRP

(3) Mitochondrial complex I inhibition enhances astrocyte responsiveness to pro-inflammatory stimuliScientific ReportsNovember 8, 2024Lena Wischhof, Amal John Mathew, Lorenzo Bonaguro, Marc Beyer, Dan Ehninger, Pierluigi Nicotera, Daniele Banoanti‐BAF47 (8745, Cell Signaling), rabbit anti‐BAF60C (62265, Cell Signaling), rabbit anti‐BAF170 (12760, Cell Signaling), rabbit anti‐BRG1 (ab110641, Abcam), rabbit anti‐BRM (11966, Cell Signaling), rabbit

(4) mTORC2-driven chromatin cGAS mediates chemoresistance through epigenetic reprogramming in colorectal cancerNature cell biologySeptember 1, 2024Lv G, Wang Q, Lin L, Ye Q, Li X, Zhou Q, Kong X, Deng H, You F, Chen H, et al.D2A8U, 1:1,000 dilution), anti-MCM7 (CST, no. 3735, D10A11, 1:1,000 dilution), anti-SMARCC2 (CST, no. 12760, D8O9V, 1:1,000 dilution), anti-Akt (CST, no. 9272, 1:1,000 dilution), anti-pSer473-Akt (CST, no. 4060,

(5) Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancerCancer CellAugust 12, 2024Leslie Duplaquet, Kevin So, Alexander W. Ying, Shreoshi Pal Pal Choudhuri, Xinyue Li, Grace D. Xu, Yixiang Li, Xintao Qiu, Rong Li, Shilpa Singh, et al.(Cell Signaling #12354, 1:1000), Mouse Anti-ARID2 (ThermoFisher #MA5–27862), Rabbit Anti-SMARCC2 (Cell Signaling #12760, 1:1000), Goat Anti-SMARCC1 (Santa Cruz Bio #sc-9746, 1:500), Mouse Anti-SMARCD2 (Santa Cruz Bio #sc-101162,

(6) The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb budsDevelopmental BiologyDecember 1, 2023Janani Ramachandran, Wanlu Chen, Rachel K. Lex, Kathryn E. Windsor, Hyunji Lee, Tingchang Wang, Weiqiang Zhou, Hongkai Ji, Steven A. Vokes(Cell Signaling Technologies cat. #33360T), 1:1000 anti-SMARCC2 (Cell Signaling Technologies Cat. #12760T), 1:1000 anti-ARID1A (Cell Signaling Technologies cat. #12354T), 1:1000 anti-ARID1B (Cell Signaling Technologies

(7) Therapeutic targeting of CNBP phase separation inhibits ribosome biogenesis and neuroblastoma progression via modulating SWI/SNF complex activityClinical and translational medicineApril 1, 2023Hu A, Chen G, Bao B, Guo Y, Li D, Wang X, Wang J, Li Q, Zhou Y, Gao H, et al.and antibodies against CNBP (sc‐515387, Santa Cruz Biotechnology, Inc., Dallas, TX, USA), SMARCC2 (#12760), SMARCC1 (#11956) or SMARCA4 (#49360, Cell Signaling Technology). Two confluent 55 cm2 dishes of cells

(8) Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disordersCell GenomMarch 8, 2023Pintacuda G, Hsu YH, Tsafou K, Li KW, Martín JM, Riseman J, Biagini JC, Ching JKT, Mena D, Gonzalez-Lozano MA, et al.AB_2800172 SMARCC1,Cell Signaling Technology,Cat# 11956; RRID: AB_2797776 SMARCC2,Cell Signaling Technology,Cat# 12760S; RRID: AB_2798017 SPTBN1,Abcam,Cat# ab72239; RRID: AB_1270902 SYNGAP,Cell Signaling Technology,Cat#

(9) Long non-coding RNA lncMGC mediates the expression of TGF-β-induced genes in renal cells via nucleosome remodelersFrontiers in molecular biosciencesJanuary 1, 2023Kato M, Chen Z, Das S, Wu X, Wang J, Li A, Chen W, Tsark W, Tunduguru R, Lanting L, et al.(LSBio, LS-B12352), KAP1 (Abcam, ab10484), Nucleolin (Abcam, ab134164), and SMARCC2 (Cell Signaling, #12760) by gently rocking at 4°C and washed with lysis buffer three times. RNAs were extracted using phenol-isoamyl

(10) BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiationThe EMBO journalDecember 1, 2022Wischhof L, Lee HM, Tutas J, Overkott C, Tedt E, Stork M, Peitz M, Brüstle O, Ulas T, Händler K, et al.anti‐BAF60C (62265, Cell Signaling), rabbit anti‐BAF155 (11956, Cell Signaling), rabbit anti‐BAF170 (12760, Cell Signaling), rabbit anti‐BCL7A (HPA019762, Sigma), rabbit anti‐BCL7B (11751‐1‐AP, Proteintech),

(11) SMARCC2 mediates the regulation of DKK1 by the transcription factor EGR1 through chromatin remodeling to reduce the proliferative capacity of glioblastomaCell Death & DiseaseNovember 23, 2022Chiyang Li, Tong Wang, Junwei Gu, Songtao Qi, Junjie Li, Lei Chen, Hang Wu, Linyong Shi, Chong Song, Hong Li, et al.P9416), incubated with primary antibody at 4 °C overnight (Rat anti-SMARCC2 (Cell Signaling Technology, 12760, 1:1000), rat anti-SMARCC1 (Cell Signaling Technology, 11956, 1:1000), anti- SMARCA4 (Cell Signaling Technology

(12) Inositol polyphosphate multikinase physically binds to the SWI/SNF complex and modulates BRG1 occupancy in mouse embryonic stem cellseLifeMay 12, 2022Beon J, Han S, Yang H, Park SE, Hyun K, Lee SY, Rhee HW, Seo JK, Kim J, Kim S, et al.SMARCB1 (A301-087, Bethyl), BRG1 (ab110641, Abcam), BAF155 (11956, Cell Signaling Technology), BAF170 (12760, Cell Signaling Technology), BAF250A (12354, Cell Signaling Technology), BRM (11966, Cell Signaling Technology

(13) Radiation-Induced Phosphorylation of a Prion-Like Domain Regulates Transformation by FUS-CHOPCancer ResearchOctober 1, 2021Mark Chen, Joseph P. Foster, Ian C. Lock, Nathan H. Leisenring, Andrea R. Daniel, Warren Floyd, Eric Xu, Ian J. Davis, David G. Kirsch,Cell Signaling Technology,#11912 BRG1,Cell Signaling Technology,#49360 SNF2H,EMD Millipore,ABE1026 BAF170,Cell Signaling Technology,#12760 ACF1,Abcam,ab187670 HDAC1,Cell Signaling Technology,#5356 TBP,Cell Signaling Technology,#44059 H3K27me3,Cell Signaling Technology

(14) Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemiaCell reportsSeptember 21, 2021Simeoni F, Romero-Camarero I, Camera F, Amaral FMR, Sinclair OJ, Papachristou EK, Spencer GJ, Lie-A-Ling M, Lacaud G, Wiseman DH, et al.RRID:AB_10900735 Anti-FLAG,Sigma,Cat#F3165; RRID:AB_259529 anti-SP1,Abcam,Cat#ab13370; RRID:AB_300283 anti-SMARCC2,Cell Signaling,Cat#12760; RRID:AB_2798017 anti-SPI1,Cell Signaling,Cat#2258; RRID:AB_2186909 anti-Myc tag,Cell Signaling,Cat#2278;

(15) PD-L1 Overexpression, SWI/SNF Complex Deregulation, and Profound Transcriptomic Changes Characterize Cancer-Dependent Exhaustion of Persistently Activated CD4(+) T CellsCancersAugust 18, 2021Jancewicz I, Szarkowska J, Konopinski R, Stachowiak M, Swiatek M, Blachnio K, Kubala S, Oksinska P, Cwiek P, Rusetska N, et al.AMPK (p-AMPK) (#8208, Cell Signaling Technology), BAF155 (#11956, Cell Signaling Technology), BAF170 (#12760, Cell Signaling Technology), BRG1 (#3538, Cell Signaling Technology), BRM (#11966, Cell Signaling Technology),

(16) Global Chromatin Changes Resulting from Single-Gene Inactivation-The Role of SMARCB1 in Malignant Rhabdoid TumorCancersMay 23, 2021Kenny C, O'Meara E, Ulaş M, Hokamp K, O'Sullivan MJ.immunoprecipitated overnight at 4 ◦ C with antibodies: BAF170 (Cell SignalingTechnology, Danvers, MA, USA, Cat: 12760S), BAF155 (Cell Signalling, Cat: 11956S), BRG1 (Abcam, Cambridge, United Kingdom, Cat: ab110641), SS18

(17) MUC1-C Activates the BAF (mSWI/SNF) Complex in Prostate Cancer Stem CellsCancer ResearchFebruary 15, 2021Masayuki Hagiwara et al.(12354, 1:500; CST), anti-BAF60a (ab81621, 1:1000; abcam), anti-BAF155 (11956, 1:5000; CST), anti-BAF170 (12760, 1:5000; CST), anti-BRD9 (71232, 1:1000; CST), anti-NOTCH1 (3608, 1:1000; CST), anti-cleaved NOTCH1

(18) BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR DependencyCancer ResearchSeptember 15, 2020Manav Gupta et al.antibodies – ATR (2790S), CHK1 (2360S), pCHK1 (2341S), Histone H3 (4499S), BAF155 (11956S), BAF170 (12760S), ARID1A (12354S), CDC6 (3387T), ORC1 (4731T), RPA1 (2267S), RPA2 (52448S), BAF47 (91735S), LKB1 (3047S),

(19) Long non-coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complexEMBO reportsMarch 4, 2020Panatta E, Lena AM, Mancini M, Smirnov A, Marini A, Delli Ponti R, Botta-Orfila T, Tartaglia GG, Mauriello A, Zhang X, et al.antibodies used were as follows: anti‐ACTL6A (Cell Signaling, 76682S); anti‐SMARCC2 (Cell Signaling, D809V, 12760S); and anti‐H3K27ac (Diagenode, C15410174). RNA immunoprecipitation RIP was performed using Magna RIP RNA‐Binding Protein Immunoprecipitation Kit

(20) Modeling medulloblastoma in vivo and with human cerebellar organoidsNature communicationsJanuary 29, 2020Ballabio C, Anderle M, Gianesello M, Lago C, Miele E, Cardano M, Aiello G, Piazza S, Caron D, Gianno F, et al.,Cell Signaling Technology,91735 SMARCC1/BAF155,Rabbit,1:1000,Cell Signaling Technology,11956 SMARCC2/BAF170,Rabbit,1:1000,Cell Signaling Technology,12760 Vinculin,Mouse,1:1000,Santa Cruz Biotechnology,sc-73614 Secondary antibodies,Dilution,Company,Reference Peroxidase AffiniPure Goat Anti-Rabbit IgG (H + L

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SMARCC2/BAF170 (D8O9V) Rabbit mAb

SMARCC2/BAF170 (D8O9V) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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SMARCC2/BAF170 (D8O9V) Rabbit mAb from Cell Signaling Technology

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