GSK-3beta (D5C5Z) XP ® Rabbit mAb 12456S from Cell Signaling Technology

Product Specs
ItemGSK-3beta (D5C5Z) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $371.00 Inquire
Catalog Number12456S
Quantity100 µl
ApplicationsW, W-S, IP, IHC-P, IF-IC, FC-FP
ReactivityH, M, R, Mk
TargetGSK3-beta
HostRabbit
NCBI Full Gene Nameglycogen synthase kinase 3 beta
ClonalityMonoclonal
Research AreaPI3K / Akt Signaling
CloneD5C5Z
Molecular Weight46

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Panx1 Deficiency Exacerbates GAN Diet-Induced Obesity by Destabilizing β-Catenin via GSK3βiScienceApril 17, 2026Hangfei Xu, Jinhan Zhao, Shan Lu, Qin Wang, Rui Sun, Yuxue Gao, Fang Xie, Yanjun Wang, Ryan Cao, Yingmei Feng, et al.,Cell Signaling Technology,Cat# 8480S; RRID: AB_11127855 GSK-3β (D5C5Z) XP Rabbit mAb,Cell Signaling Technology,Cat# 12456S; RRID: AB_2636978 CK1α polyclonal antibody,Proteintech,Cat# 55192-1-AP APC polyclonal antibody,Proteintech,Cat#

(2) Reticulocalbin-2 in the Hippocampus Improves Cognitive Function of Diabetic MiceBrain BehavApril 15, 2026Ting Zhang, Simiao Tang, Jiahui Cheng, Biao Hu, Ling-Qi Xie, Yalun Cheng, Xin Chen, Genqing Xieantibodies were used as follows: PHF (ab184951, 1:1000, Abcam), Syn (AB1543, 1:1000, Sigma‐Aldrich), GSK3β (12456T, 1:1,000; Cell Signaling Technology), RCN2 (10193‐2‐AP, 1:2000, Proteintech), and β‐actin (MABT825,

(3) Rapamycin Prevents Sulfate-Reducing Bacteria-Induced Effects on Snail and GSK-3 and Impaired Intestinal BarrierMicroorganismsMarch 30, 2026Sudha B. Singh, Cody A. Braun, Amanda Carroll-Portillo, Henry C. LinSnail (Cell Signaling Technology: #3879), phosphorylated GSK-3a/b Ser 21/9 (9331) and total GSK-3b (12456). Antibodies were diluted as recommended by the manufacturer. Blots were incubated with secondary antibodies

(4) ZCCHC4 Orchestrates Hepatocellular Carcinoma Metastasis by Regulating Lipid biosynthesis and TMEM97/LCN2/Twist1 PathwayInt J Biol SciMarch 25, 2026Juan Ye, Xinyi Wen, Ruiyang Liu, Caini Huang, Zhijie Xu, Yi Zhan, Fuyuan Xu, Hongbin Huang, Chunhui Qi, Yao Tang, et al.anti-FASN (10624-2-AP, Proteintech, China), anti-SQLE (12544-1-AP, Proteintech, China), anti-GSK-3β (12456T, CST, USA), anti-pGSK-3β (5558T, CST, USA), anti-active β-catenin (8814S, CST, USA), anti-E-Cadherin

(5) MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathwayCell Death DiscoveryMarch 25, 2026Stephanie Maher, Andrew Roe, Kieran Wynne, Vadim Zhernovkov, Melinda HalaszCREB (#9197), Phospho-CREB (Ser133) (#9191), GAP43 (#8945), Tyrosine hydroxylase (#2792), GSK-3β (#12456), and GAPDH (14C10) (#2118), from Cell Signalling Technology. V5-tag monoclonal antibody (#R960-25)

(6) PPARγ activation rescues oxidative stress-induced embryonic arrest by suppressing Wnt/β-catenin signaling via GSK3β upregulationiScienceMarch 20, 2026Lihong Liu, Siyao Ha, Hui Chen, MingQing Li, Zhiling Li,Cell Signaling Technology,Cat# 8480S; RRID: AB_11127855 "GSK3β (Rabbit monoclonal, clone 27C10)",Cell Signaling Technology,Cat# 12456S; RRID: AB_2636978 "OCT4 (Rabbit monoclonal, clone C30A3)",Cell Signaling Technology,Cat# 75463S; RRID:

(7) The Adiponectin‐ PP2A Pathway Confers Cognitive Benefits of Physical Exercise Against Chronic Stress‐Induced Tau Hyperphosphorylation in the HippocampusAging CellMarch 17, 2026Hui‐Hui Guo, Hai‐Ning Ou, Jia‐Sui Yu, Zi‐Rui Luo, Suk‐Yu Yau, Hector Wing‐Hong TsangPME‐1 (1:1000, Santa Cruz, #sc‐25278); LCMT1 (1:1000, Santa Cruz, #sc‐81609); GSK‐3β (1:1000, CST, #12456S); GAPDH (1:5000, Genetex, #GTX100118); and α‐tubulin (1:1000, Invitrogen, #62204). The membranes were

(8) Disrupting Akt-Wnt/β-catenin signaling suppresses glioblastoma stem cell growth and tumor progression in immunocompetent miceJ NeurooncolMarch 14, 2026Md Marzan Sarkar, Nathan Gonsalves, Amin Davarzani, Emma Mitchell, Amar M. Singh, Lohitash Karumbaiah, Steven L. Stice(p-AKT Ser473, Cat No.: 4060T; Akt pan, Cat No.: 4691T; p-GSK-3β Ser9, Cat No.: 5558T; GSK-3β, Cat No.: 12456T; and β-actin, Cat No.: 4970 S) in 5% BSA in TBST at 4 °C overnight, followed by incubation with secondary

(9) Danhong Injection Alleviates Blood-Brain Barrier Disruption Caused by Cerebral Ischemia-Reperfusion Injury in 5Hyperlipidemia Rats by Regulating the Wnt/β-Catenin PathwayPharmaceuticals (Basel)March 9, 2026Zhanhua Shi, Jingwei Wang, Kang Liu, Feiyang Ma, Haixia DuWaltham, MA, USA), Cyclin D1 (55506), β-catenin (8480), phospho-GSK3β (Ser9, 5558), and total GSK3β (12456) from Cell Signaling Technology (Danvers, MA, USA); MMP-9 (ab228402), Wnt3α (ab172612), LAMIN B1 (ab229025),

(10) Long noncoding RNA SRRM2-AS1 mediates coronary artery damage in Kawasaki disease by promoting endothelial-to-mesenchymal transitionClinical and Experimental MedicineFebruary 24, 2026Shiyang Song, Hui Zhang, Renchao Lin, Jingyi Zhang, Qianqian Zhang, Changhao Li, Yushan Xia, Jingjing Zeng, Kongchang Lu, Donghui Ge, et al.Cell Signaling Technology), anti-Akt (1:1000, Cat. No. 4691 S, Cell Signaling Technology), anti-GSK-3β (1:1000, Cat. No. 12456 S, Cell Signaling Technology), anti-β-catenin (1:1000, Cat. No. 8480 S, Cell Signaling Technology).

(11) Synovial inflammatory macrophage-derived extracellular vesicles exacerbate cartilage lesions with a FMRP-selectively sorted manner in osteoarthritisBone ResearchFebruary 17, 2026Shu Zhao, Jian Wang, Mengxin Xue, Baitong Wu, Lanyue Sheng, Yi Wen, Guangming Wang, Jianxing Song, Dajiang Du, Jun XuATG7-antibody (1:1 000, CST, 8558), LAMP1-antibody(1:1 000, Abcam, ab62562), GSK-3β-antibody (1: 1000, CST, 12456), p-GSK-3β-antibody (1:1 000, CST, 5558), p70S6-antibody (1:1000, CST, 9202), P-p70S6-antibody (1:1 000

(12) PLOD2 promotes proliferation, migration and invasion of colorectal cancer cells via PI3K-AKT-GSK3β signaling pathwayScientific ReportsFebruary 10, 2026Hua Fang, Jing Zheng, Shutong Ren, Danjing Chen, Yunli Wu, Xian-E PengCell Signaling Technology, Inc., USA), Phosoho-AKT antibody (13038, Cell Signaling Technology, Inc., USA). GSK3β antibody (12456, Cell Signaling Technology, Inc., USA), p-GSK3β antibody (5558, Cell Signaling Technology, USA), rabbit

(13) Danggui-Baishao herb pair protects against dextran sulfate sodium-induced colitis by modulating the Wnt/β-catenin pathwayWorld Journal of GastroenterologyFebruary 7, 2026Tian Xu, Wei-Xin Hou, Sun-Ting Yang, Yu-Pei Shao, Jing Wang, Tao-Tao Han, Jing-Nan Liab32572, ABCAM, United Kingdom), p-GSK-3β (1:1000, 5558S, CST, MA, Unites States), GSK-3β (1:1000, 12456S, CST, MA, Unites States), Cyclin D1 (1:1000, ab134175, ABCAM, United Kingdom), Lgr5 (1:1000, ab75850,

(14) Transglutaminase 2 exacerbates ovarian cancer survival by directly inactivating GSK3βCell Death DisFebruary 2, 2026Ho Lee, Joon Hee Kang, Hyun Jung Kim, Kyun Heo, Mi Kyung Park, Jeong Hwan Park, Byung Il Lee, Jong In Yook, Soo-Youl Kim(#sc-6260) and anti-HA-tag (#sc-7392) were from Santa Cruz Biotechnology (Dallas, TX, USA); anti-GSK3β (#12456), anti-p-GSK3β (Ser9) (#9323), anti-non-p (Active) β-catenin (Ser33/37/Thr41) (#8814) and anti-Snail

(15) Disruption of FGL2 induces TFEB-dependent lysosomal degradation of PD-L1 and enhances the efficacy of anti-PD1 therapy in hepatocellular carcinomaCell Communication and SignalingFebruary 2, 2026Meiwen Han, Qianting Guan, Fangfei Yan, Ming Wang, Dong Xi, Qin Ningphospho-4EBP1 (1:1000) (2855, CST), AKT (1:1000) (9272, CST), phospho-AKT (1:1000) (4060, CST), GSK3β(1:1000) (12456, CST), phospho-GSK3β (1:1000) (5558, CST), PKC (1:4000) (12919-1-AP, Proteintech), phospho-PKC (1:1000)

(16) Co-Exposure to Bisphenol A and a High-Fat Diet Induces Insulin Resistance via Suppression of Insulin Signaling Molecule Expression and GLUT4 TranslocationToxicsFebruary 1, 2026Zeqi Lu, Min Cao, Jiaoxiang Zhang, Congzheng Qi, Bing Huang, Wenxue Li, Juntao Li, Guangyu Yang, Yan Zhang, Jinyin Wu, et al.UK, ab181869, 1:5000), GLUT4 (Abcam, Cambridge, UK, ab33780, 1:1000), GSK3β (CST, Beverly, MA, USA, 12456, 1:1000), pGSK3βSer9 (CST, Beverly, MA, USA, 9322, 1:1000), and GAPDH (Abcam, Cambridge, UK, ab8245,

(17) Mitochondrial integrity modulates mTOR signaling and podocyte functioniScienceJanuary 16, 2026Cem Özel, Khawla Abualia, Duc Nguyen-Minh, Mahsa Matin, David Unnersjö-Jess, Martin Höhne, Wilhelm Bloch, Henning Hagmann, Richard J.M. Coward, Sebastian Brähler, et al.rabbit anti-phospho GSK3β (1:1000, Cell Signalling, #5558), rabbit anti-GSK3β (1:1000, Cell Signalling, #12456). nLC-MS/MS Proteomic and phosphoproteomic studies were conducted as previously described.60,66 Briefly,

(18) Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 InhibitionAdvanced ScienceJanuary 14, 2026Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung(Cell Signaling Technology, #12716), CaMKII (Abcam, #52476), pGSK3β (BD science #612313), GSK‐3β (Cell Signaling Technology, #12456), pERK1/2 (Cell Signaling Technology, #9101), ERK1/2 (Cell Signaling Technology, #9102), p35/25 (Cell Signaling Technology

(19) GLP-1 agonists reduce right ventricular mitochondrial dysfunction by inhibiting the GSK3β-Drp1 signalling in pulmonary hypertensionEuropean Journal of Medical ResearchJanuary 10, 2026Lin Zhao, Yanghong Liu, Ziwei Ou, Xiexiong Zhao, Wen Zhang, Tangzhiming Li, Zhe Sheng, Ye Chen, Hui LuoPhospho-Drp1 (Ser637) (Cell Signaling Technology, #6319), Total GSK3β (Cell Signaling Technology, #12456), Total Drp1 (Cell Signaling Technology, #8570), and GAPDH (Cell Signaling Technology, #2118). After

(20) Pan-cancer multi-omics reveals DCAF7 as an immune-modulating prognostic driver and Wnt/β-catenin activator in hepatocellular carcinomaClin Transl MedDecember 31, 2025Ruina Luan, Hanbin Lin, Xin Zhao, Jianpeng Li, Maohe Chen, Shiping Luo, Xinjian Lin(ABclonal; #AE070, 1:3000), YTHDC1 (CST; #77422, 1:1000), p‐GSK‐3β (CST; #5558, 1:1000), GSK‐3β (CST; #12456, 1:1000; CST; #9832, 1:1000), β‐catenin (CST; #8480, 1:1000), c‐Myc (Proteintech; #10828‐1‐AP, 1:1000)

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GSK-3beta (D5C5Z) XP ® Rabbit mAb

GSK-3beta (D5C5Z) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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GSK-3beta (D5C5Z) XP ® Rabbit mAb from Cell Signaling Technology

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