SirT2 (D4O5O) Rabbit mAb 12650S from Cell Signaling Technology

Product Specs
ItemSirT2 (D4O5O) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number12650S
Quantity100 µl
ApplicationsW
ReactivityH, M, R, Mk
TargetSirT2
HostRabbit
NCBI Full Gene Namesirtuin 2
NCBI Gene AliasesSIR2, SIR2L, SIR2L2
ClonalityMonoclonal
Research AreaChromatin Regulation / Nuclear Function
CloneD4O5O
Molecular Weight39, 43

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) SirT2 Inhibition is Associated with Improvements in Depression-like Behavior and Memory Impairment in Olfactory Bulbectomized MiceMol NeurobiolApril 21, 2026Kohei Takahashi, Kazuhiro Kurokawa, Daiki Hiraga, Hiroshi Takeda, Minoru TsujiMillipore, Billerica, MA, USA; 07–131), SirT2 (1:2000; Cell Signaling Technology [CST], Danvers, MA, USA; #12650), SirT3 (1:1000; CST; #5490), SirT4 (1:2000; Proteintech, Rosemont, IL, USA; 66543–1-Ig), SirT5 (1:1000;

(2) SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signalingNature ImmunologyJanuary 29, 2026Imene Hamaidi, Pingyan Cheng, Soo Young Jun, Alak Manna, Min-Hsuan Wang, Anh Nguyen, Ismail Can, Min G. Zhang, Odesha O. Taylor, Luis Uriel Lopez Bailon, et al.membranes for immunoblotting analysis. Immunoblotting was performed using primary Abs against SIRT2 (12650, 1:1,000 dilution), LCK (2752, 1:1,000 dilution) and His-tag (2365, 1:1,000 dilution) from Cell Signaling. Pulldown

(3) Deacetylation of HSC70 by SIRT2 promotes chaperone mediated autophagyAutophagy ReportsDecember 31, 2025Byunghyun Ahn, Wenzhe Chen, Wenbiao Shi, Ruben Shrestha, Fenghua Hu, Hening LinRRID:Addgene_102365). Primary Antibodies from Invitrogen: HSC70 (MA1-26078); Cell Signaling Technologies: SIRT2 (#12650), Santa Cruz Biotechnology: HA-HRP (sc-7392); Flag-horse radish peroxidase (Sigma #A8592) was used to

(4) SIRT2-Mediated ACSS2 K271 Deacetylation Suppresses Lipogenesis Under Nutrient StressElifeMay 7, 2025Rezwana Karim, Wendi Teng, Cameron D Behram, Hening Linβ-actin (sc-47778, 1:1000) was purchased from Santa Cruz Biotechnology. Antibodies against SIRT2 (#12650, 1:1000), ACSS2 (D19C6, 1:1000), Ubiquitin (E4I2J, 1:1000), K48-linkage Specific Polyubiquitin (#4289,

(5) TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent mannerMolecular metabolismFebruary 1, 2025Chhetri A, Park C, Kim H, Manandhar L, Chuluunbaatar C, Hwang J, Wei X, Jang G, Chinbold B, Kwon HM, et al.Novus Biological (Minneapolis, MN, USA). Anti-PPAR-γ (#2443S), anti-SIRT1 (#9475 and #2028S), anti-SIRT2 (#12650), anti-SIRT3 (#5490), anti-SIRT4 (#69786), anti-SIRT5 (#8782), anti-SIRT6 (#12486), anti-SIRT7 (#5360)

(6) Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical StressInvest Ophthalmol Vis SciJanuary 17, 2025Chien-Chia Su, Vaibhav Desikan, Kevin Betsch, Myoung Sup Shim, Kate E. Keller, Paloma B. Liton(T5168, 1:5000; Sigma-Aldrich), anti-ACTB (SC-69879, 1:1000; Santa Cruz Biotechnology), anti-SIRT2 (12650S, 1:2000; Cell Signaling Technology, Danvers, MA, USA), and anti-HDAC6 (7558S, 1:2000; Cell Signaling Technology

(7) Suppression of Hepatocellular Carcinoma by Deletion of SIRT2 in Hepatocytes via Elevated C/EBPβ/GADD45γCellular and molecular gastroenterology and hepatologyJanuary 1, 2025Wang F, Keating CR, Xu Y, Hou W, Malnassy G, Boedeker K, Perera A, Ham E, Patel D, Ding X, et al.Protein,Species,Catalog number,Source,Application SIRT2,Rabbit,12650,Cell Signaling,Western blot SIRT2,Mouse,sc-28298,Santa Cruz,IHC C/EBPβ,Mouse,sc-7962,Santa Cruz,Western blot

(8) Amodiaquine ameliorates stress-induced premature cellular senescence via promoting SIRT1-mediated HR repairCell Death DiscoveryOctober 11, 2024Jie Du, Fuqiang Chen, Chenghong Du, Wenna Zhao, Zihan Chen, Zhenhua Ding, Meijuan ZhoupNBS1 (#3001), NBS1 (#14956), Rad54 (#15016), Rad51 (#8875), RPA2 (#35869), SIRT1 (#9475), SIRT2 (#12650), SIRT3 (#5490), SIRT6 (#12486), Histone Deacetylase (HDAC) Antibody Sampler Kit (#9928) and β-actin

(9) Loss of NAMPT and SIRT2 but not SIRT1 attenuate GLO1 expression and activity in human skeletal muscleRedox BiologySeptember 1, 2024Edwin R. Miranda, Pallavi Varshney, Corey E. Mazo, James Shadiow, Andrew T. Ludlow, Jacob M. HausAB-62352, ABCAM, Cambridge, UK), and KEAP1 (1:1000, A1820, ABclonal, Woburn, MA), or SIRT2 (1:1000, #12650S, Cell Signaling Technology) depending on the predicted molecular weight of the target. The next day,

(10) Sirt5 improves cardiomyocytes fatty acid metabolism and ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via CPT2 de-succinylationRedox BiologyJuly 1, 2024Maoxiong Wu, Jing Tan, Zhengyu Cao, Yangwei Cai, Zhaoqi Huang, Zhiteng Chen, Wanbing He, Xiao Liu, Yuan Jiang, Qingyuan Gao, et al.were probed with primary antibodies against Ksuc (PTM BIO, PTM-401), Sirt1 (CST, 2314), Sirt2 (CST, 12650), Sirt3 (CST, 5490), Sirt4 (CST, 24662), Sirt5 (CST, 8782), Sirt6 (CST, 12486), Sirt7 (CST, 5360), CPT2,

(11) Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxiaThe Journal of physiologyJune 1, 2024Welch N, Mishra S, Bellar A, Kannan P, Gopan A, Goudarzi M, King J, Luknis M, Musich R, Agrawal V, et al.https://antibodyregistry.org/AB_2617130,1:2000 Sirt2(D4050) rabbit mAb,"Cell Signaling Technology, Danvers, MA",12650s: https://antibodyregistry.org/AB_2716762,1:2000 Sirt3 rabbit pAb,"AbCam, Waltham, MA",Ab189860,1:2000 Sirt4

(12) Neutrophil Elastase Degrades Histone Deacetylases and Sirtuin 1 in Primary Human Monocyte Derived MacrophagesInternational Journal of Molecular SciencesApril 12, 2024Shuo Zheng, Gamze B. Bulut, Apparao B. Kummarapurugu, Jonathan Ma, Judith A. Voynow(1:1000),HDAC11,sc-390737 (1:500) HDAC3,CST #3949s (1:1000),Sirt 1,CST 9475T (1:1000) HDAC4,sc-46672 (1:500),Sirt 2,CST 12650 (1:1000) HDAC5,sc-133106 (1:500),Sirt 3,CST 5490 (1:1000) HDAC6,CST #7558s (1:2000),Sirt 5,CST 8782

(13) A homogeneous time-resolved fluorescence screen to identify SIRT2 deacetylase and defatty-acylase inhibitorsPloS oneJanuary 1, 2024Yang J, Cassel J, Boyle BC, Oppong D, Ahn YH, Weiser BP.c400 imager. Antibodies used were a rabbit SIRT2 primary antibody (Cell Signaling Technology catalog #12650), an HRP-conjugated goat anti-rabbit secondary antibody (Invitrogen catalog #65–6120), a mouse alpha-tubulin

(14) Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative StressCurrent issues in molecular biologyDecember 11, 2023Oh YC, Jeong YH, Yang HJ, Li W, Ma JY.,Cell Signaling,#15101,AB_2722591,1:1000 C-Caspase-1,Cell Signaling,#89332,AB_2923067,1:1000 IL-18,Cell Signaling,#57058,,1:1000 SIRT2,Cell Signaling,#12650,AB_2716762,1:1000 P2X7,Cell Signaling,#13809,AB_2798319,1:1000 BAX,Cell Signaling,#2772,AB_10695870,1:1000 Bcl-2,Cell Signaling

(15) Doxorubicin-Induced Cardiac Senescence Is Alleviated Following Treatment with Combined Polyphenols and Micronutrients through Enhancement in MitophagyCellsNovember 10, 2023Foglio E, D'Avorio E, Vitiello L, Masuelli L, Bei R, Pacifici F, Della-Morte D, Mirabilii S, Ricciardi MR, Tafuri A, et al.anti-SIRT1 (#9475; Cell Signaling Technology Inc., Danvers, MA, USA); rabbit monoclonal anti-SIRT2 (#12650; Cell Signaling Technology Inc., Danvers, MA, USA); rabbit monoclonal anti-SIRT3 (#5490; Cell Signaling Technology

(16) In-silico and in-vitro functional validation of imidazole derivatives as potential sirtuin inhibitorFrontiers in MedicineNovember 7, 2023Uma Maheswara Rao Dindi, Suhadha Parveen Sadiq, Sameer Al-Ghamdi, Naif Abdurhman Alrudian, Salman Bin Dayel, Abdulwahab Ali Abuderman, Mohammad Shahid, Thiyagarajan Ramesh, Ravikumar VilwanathanLaboratories Pvt. Ltd. (SRL, Maharashtra, India). The antibodies used in the study of Sirt 1 (9475), Sirt 2 (12650), Sirt 3 (5490), Sirt 5 (8782), Sirt 6 (12486), and Sirt 7 (5360) came from Cell Signaling Technology,

(17) Circulating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditureNature communicationsApril 8, 2023Park JW, Roh E, Kang GM, Gil SY, Kim HK, Lee CH, Jang WH, Park SE, Moon SY, Kim SJ, et al.Cell Signaling, 2880S), SIRT1 (1:1000, mouse, Santa Cruz, sc-74465), and SIRT2 (1:1000, rabbit, Cell Signaling, 12650). A 2-μl volume of plasma was diluted in 18 μl of lysis buffer and then subjected to immunoblotting

(18) The Carotenoid Diatoxanthin Modulates Inflammatory and Angiogenesis Pathways In Vitro in Prostate Cancer CellsAntioxidants (Basel)February 2, 2023Clementina Sansone, Luigi Pistelli, Luana Calabrone, Angelo Del Mondo, Angelo Fontana, Marco Festa, Douglas M. Noonan, Adriana Albini, Christophe Brunet126915, Cell Signaling Technology Inc., Danvers, MA, USA) and SIRT2 (antibody 1:1000 diluted, cat. 12650S, Cell Signaling Technology Inc., Danvers, MA, USA) proteins were investigated. Positive control was

(19) SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's diseaseRedox biologyDecember 1, 2022Chao CC, Huang CL, Cheng JJ, Chiou CT, Lee IJ, Yang YC, Hsu TH, Yei CE, Lin PY, Chen JJ, et al.from Adooq BioScience (Irvine, CA, USA). Anti-phosphorylated (p)-SIRT1(2314), -SIRT1 (9475), -SIRTT2 (12650), -SIRTT3 (5490), -SIRTT5 (8782), -SIRTT6 (12486), and -SIRTT7 (5360) antibodies were purchased from

(20) Golgi stress induces SIRT2 to counteract Shigella infection via defatty-acylationNature communicationsAugust 2, 2022Wang M, Zhang Y, Komaniecki GP, Lu X, Cao J, Zhang M, Yu T, Hou D, Spiegelman NA, Yang M, et al.described27. The following antibodies were purchased from Cell Signaling Technology (Danvers, MA): SIRT2 (D4050, #12650, used at 1:1000), PARP (#9542, used at 1:1000), LC3 (#3868, used at 1:1000), and anti-rabbit IgG HRP-linked

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SirT2 (D4O5O) Rabbit mAb

SirT2 (D4O5O) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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SirT2 (D4O5O) Rabbit mAb from Cell Signaling Technology

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