Syntaxin1B antibody 110 402 from Synaptic Systems GmbH

Product Specs
ItemSyntaxin1B antibody
CompanySynaptic Systems GmbH
Price $360.00Supplier Page View Company Product Page
Catalog Number110 402
Reactivityhuman, rat, mouse, hamster, cow, pig, chicken, zebrafish
Quantity200 µl
Conjugate/TagUnconjugated
Formatlyophilized
Hostrabbit
TargetSyntaxin1B
ApplicationsWB, IP, ICC, IHC, IHC-P
Clonalitypolyclonal
ValidationKO
ImmunogenSynthetic peptide corresponding to AA 171 to 187 from rat Syntaxin1B
NCBI Full Gene Namesyntaxin 1B
NCBI Gene AliasesStx1b2, Stx2
Antibody TypePrimary antibody

Questions and Answers

Can this Syntaxin 1B antibody be used in studies related to epilepsy?

Yes, the Syntaxin 1B antibody has been utilized in research examining the role of syntaxin 1B in epilepsy. For instance, a study demonstrated that syntabulin, which transports syntaxin 1B, plays a protective role in maintaining the excitation/inhibition balance in the hippocampus, thereby influencing seizure susceptibility and severity ().

Is this antibody effective for immunofluorescence applications?

The Syntaxin 1B antibody has been shown to work effectively in immunofluorescence applications. It was used in a study to visualize syntaxin 1B in neurons, confirming its localization and involvement in synaptic function ().

What relevance does this antibody have in the context of neurodegenerative diseases?

The Syntaxin 1B antibody has been implicated in neurodegenerative research, particularly in studies of amyotrophic lateral sclerosis (ALS). Research indicated that syntaxin 1B is deregulated at both mRNA and protein levels in ALS-affected tissues, suggesting its potential role in synaptic dysfunction associated with the disease ().

Can this antibody be used for Western blotting?

Yes, the Syntaxin 1B antibody is suitable for Western blotting applications. It has been cited in multiple studies for detecting syntaxin 1B in protein extracts, confirming its utility in this technique (, ).

Synaptic Systems GmbH

Rudolf-Wissell-Str. 28

Goettingen 37079

Germany

Phone: +49-551-50556-0
+49-551-50556-384

Company Profile

Website: http://www.sysy.com/

(1) Palmitoylation is required for Sept8-204 and Sept5 to form vesicle-like structure and colocalize with synaptophysinJournal of cellular biochemistryMarch 1, 2024Liu H, Tan R, Tong J, Wen S, Wu C, Rao M, Zhu J, Qi S, Kong E.

(2) Analysis of the neuromuscular deficits caused by STAM1 deficiencyCurr Res NeurobiolJanuary 1, 2024McLean JW, VanHart M, McWilliams MP, Farmer CB, Crossman DK, Cowell RM, Wilson JA, Wilson SM.from MilliporeSigma (Burlington, MA), SYT1 (cat. # 105 008), STX1A (cat. # 110 302) and STX1B (cat. # 110 402) from Synaptic Systems (Göttingen, Germany), and SV2A (cat. # SV2), ACTB (cat. # JLA20) and TUBB3 (cat.

(3) Syntabulin regulates neuronal excitation/inhibition balance and epileptic seizures by transporting syntaxin 1BCell death discoveryJune 22, 2023Ke P, Gu J, Liu J, Liu Y, Tian X, Ma Y, Meng Y, Xiao F.Cat. No.: 110 302, Goettingen, Germany), rabbit anti-syntaxin 1B (1: 1000, Synaptic Systems, Cat. No.: 110 402), rabbit anti-TFAP2A (1:500, Abcam, ab108311, Cambridge, UK), rabbit anti-GAPDH (1: 5000; Proteintech;

(4) Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene doseAlzheimer's & dementia : the journal of the Alzheimer's AssociationMay 1, 2023Chen XQ, Zuo X, Becker A, Head E, Mobley WC.anti-synaptobrevin 2 (1:5000; 104 211), rabbit anti-neurofilament L (171 002), and anti-syntaxin 1B (110 402) were purchased Synaptic Systems (Goettingen, Germany). Mouse antibody anti-synaptotagmin (1:2000; 610434)

(5) Dynamin controls neuropeptide secretion by organizing dense-core vesicle fusion sitesScience advancesMay 1, 2021Moro A, van Nifterick A, Toonen RF, Verhage M.

(6) Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic TerminalsCell systemsFebruary 17, 2021Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, et al.Cat# 105 003AF, RRID:AB_2744565); Anti-Syntaxin 1B, rabbit polyclonal at 1:500 (Synaptic Systems Cat# 110 402, RRID:AB_887901); Anti-Vamp1, rabbit polyclonal at 1:500 (Abcam Cat# ab41324, RRID:AB_1281203); Anti-Vesicular Glutamate Transporter 1

(7) SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarityThe Journal of cell biologyJanuary 4, 2021Kunii M, Noguchi Y, Yoshimura SI, Kanda S, Iwano T, Avriyanti E, Atik N, Sato T, Sato K, Ogawa M, et al.104302), anti-Syntaxin1A (mouse; Sigma-Aldrich, S0664), anti-Syntaxin1B (rabbit; Synaptic Systems, 110402), anti-Lamp2 (mouse; Developmental Studies Hybridoma Bank, H4B4), anti-GAPDH (mouse; Calbiochem, CB1001),

(8) Facilitation of glutamate, but not GABA , release in Familial Alzheimer's APP mutant Knock‐in rats with increased β‐cleavage of APP Aging CellDecember 1, 2019Marc D. Tambini, Wen Yao, Luciano D'AdamioN terminus, EMD‐Millipore Mab348), Synaptotagmin1B (Synaptotagmin1B a.a. 171‐187, Synaptic Systems 110402), Synaptophysin (Synaptophysin a.a. ~230, Cell Signaling 5461), Vamp2 (Vamp2 a.a. 2‐17, Synaptic Systems

(9) Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by β- or α-Secretase CleavageThe Journal of neuroscience : the official journal of the Society for NeuroscienceAugust 28, 2019Yao W, Tambini MD, Liu X, D'Adamio L.123002), Stx1bp1 rabbit polyclonal (Synaptic Systems, 116002), Stx1b rabbit polyclonal (Synaptic Systems, 110402), Snap25 rabbit polyclonal (Synaptic Systems, 111002), Vglut1 rabbit polyclonal (Synaptic Systems, 135303),

(10) Massive transcriptome sequencing of human spinal cord tissues provides new insights into motor neuron degeneration in ALSScientific reportsAugust 30, 2017D'Erchia AM, Gallo A, Manzari C, Raho S, Horner DS, Chiara M, Valletti A, Aiello I, Mastropasqua F, Ciaccia L, et al.USA), rabbit anti-Syntaxin-1A (110302, Synaptic System, Goettingen, Germany), rabbit anti-Syntaxin-1B (110402, Synaptic System, Goettingen, Germany), mouse anti-GAPDH (MAB 374, Millipore, Billerica, MA, USA) and

(11) Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in DiseaseThe Journal of biological chemistryApril 8, 2016Liu C, Song X, Nisbet R, Götz J.Dallas, TX, catalog no. sc-30089); anti-syntaxin 1B (Synaptic Systems, Göttingen, Germany, catalog no. 110402); anti-synapsin 1 (Abcam, catalog no. ab8); anti-synaptogyrin-3 (Santa Cruz Biotechnology, catalog no.

(12) Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctionsJournal of neurophysiologyOctober 1, 2015Wu YJ, Tejero R, Arancillo M, Vardar G, Korotkova T, Kintscher M, Schmitz D, Ponomarenko A, Tabares L, Rosenmund C.

(13) Quantitative Proteomic Analysis Reveals Molecular Adaptations in the Hippocampal Synaptic Active Zone of Chronic Mild Stress-Unsusceptible RatsThe international journal of neuropsychopharmacologySeptember 12, 2015Zhou J, Liu Z, Yu J, Han X, Fan S, Shao W, Chen J, Qiao R, Xie P.from Abcam); synaptotagmin 1 (Syt1, Millipore MAB5200, 1:1000); syntaxin-1B (Stx1b, Synaptic Systems 110402, 1:1000); and PSD95 (CST #3450, 1:1000). Horseradish peroxidase-conjugated anti-mouse and anti-rabbit

(14) Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviorsEBioMedicineFebruary 1, 2015Cartier E, Hamilton PJ, Belovich AN, Shekar A, Campbell NG, Saunders C, Andreassen TF, Gether U, Veenstra-Vanderweele J, Sutcliffe JS, et al.

(15) Novel cell types, neurosecretory cells, and body plan of the early-diverging metazoan Trichoplax adhaerensCurrent biology : CBJuly 21, 2014Smith CL, Varoqueaux F, Kittelmann M, Azzam RN, Cooper B, Winters CA, Eitel M, Fasshauer D, Reese TS.against syntaxins (BoNT/C fragment of rat syntaxin1; Aa 183–240 of rat syntaxin 1A; Synaptic Systems #110402, abbreviation “Sx” in illustrations, and #110022), synaptobrevin (Synaptic Systems #104002, “Sb”, and

(16) The neural cell adhesion molecule promotes maturation of the presynaptic endocytotic machinery by switching synaptic vesicle recycling from adaptor protein 3 (AP-3)- to AP-2-dependent mechanismsThe Journal of neuroscience : the official journal of the Society for NeuroscienceOctober 16, 2013Shetty A, Sytnyk V, Leshchyns'ka I, Puchkov D, Haucke V, Schachner M.antibodies against SNAP25 (clone 71.2), rabbit polyclonal antibodies against syntaxin 1B (catalog #110402), synaptotagmin 1 lumenal domain (catalog #105102), and proton ATPase (catalog #109002) were from Synaptic Systems

(17) Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cellsJournal of neurochemistryJuly 1, 2013Arsenault J, Ferrari E, Niranjan D, Cuijpers SA, Gu C, Vallis Y, O'Brien J, Davletov B.

(18) Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmissionThe European journal of neuroscienceOctober 1, 2012Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T.

(19) Syntaxin 1B suppresses macropinocytosis and semaphorin 3A-induced growth cone collapseThe Journal of neuroscience : the official journal of the Society for NeuroscienceMay 18, 2011Kabayama H, Takeuchi M, Taniguchi M, Tokushige N, Kozaki S, Mizutani A, Nakamura T, Mikoshiba K.

(20) How pig sperm prepares to fertilize: stable acrosome docking to the plasma membranePloS oneJune 18, 2010Tsai PS, Garcia-Gil N, van Haeften T, Gadella BM.

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Syntaxin1B antibody

Syntaxin1B antibody

Syntaxin1B antibody

Syntaxin1B antibody

Syntaxin1B antibody from Synaptic Systems GmbH

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Synaptic Systems GmbH

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Syntaxin1B antibody from Synaptic Systems GmbH

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