Human CCR2 Antibody MAB150-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemHuman CCR2 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberMAB150-100
Quantity100 ug (also 25 ug)
ApplicationsFlow Cytometry,Immunohistochemistry,Immunocytochemistry/Immunofluorescence,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry,CyTOF-ready,Cell Culture
Conjugate/TagUnconjugated
ReactivityHuman,Mouse,Primate - Chlorocebus pygerythrus (Vervet Monkey),Rat
TargetCCR2
IsotypeIgG2b
Clone48607
HostMouse
NCBI Full Gene NameC-C motif chemokine receptor 2
NCBI Gene AliasesCCR2B, CD192, CKR2, CCR-2, CKR2B, CKR2A, CMKBR2, CC-CKR-2, MCP-1-R, CCR2A
ClonalityMonoclonal
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ImmunogenNS0 mouse myeloma cell line transfected with human CCR2, Met1-Leu360, Accession # NP_001116868
ConcentrationLYOPH
PurityProtein A or G purified from ascites
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

Questions and Answers

Can this CCR2 antibody be used in studies involving microglial activation in neuroinflammation?

Yes, the CCR2 antibody has been utilized in research related to microglial activation. For instance, in a study investigating Parkinson's disease, the antibody was employed to assess the inflammatory responses of primary microglia to various stimuli, including patient-derived α-synuclein fibrils, which are known to activate microglial cells.

What species can this antibody detect, and is it effective for human samples?

The CCR2 antibody is reactive with multiple species, including human, mouse, rat, and non-human primates. It has been shown to effectively detect human CCR2 transfectants, making it suitable for studies involving human samples.

Is this antibody suitable for immunocytochemistry applications?

Yes, the CCR2 antibody has been shown to work in immunocytochemistry applications. This method can be particularly useful for visualizing CCR2 expression in cultured cells, such as microglia, in the context of neuroinflammatory research.

How does this antibody perform in terms of specificity?

The CCR2 antibody specifically detects human CCR2 transfectants and does not recognize the parental cell line or CCR5 transfectants. This specificity is crucial for ensuring accurate results in experiments focused on CCR2-related signaling pathways.

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Intracranial injection of genetically modified, mosquito non-transmissible Zika virus: Safety in primates and ramifications for brain tumor therapyCell Rep MedDecember 16, 2025Alec J. Hirsch, Amanda de Andrade Costa, Cody German, Christopher J. Parkins, Jessica L. Smith, Emilie Russler-Germain, Ashwani Kesarwani, Yuping Li, Verginia Cuzon Carlson, Timothy Carlson, et al.#A-11029, RRID:AB_2534088" CD3 [LN10],Biocare Medical,API3152AA Human CCR2 Antibody,R&D Systems,"cat #MAB150-100, RRID:AB_2247178" CD11c Antibody (BU15),Novus Biologicals,"cat #NBP1-45018, NBP1-45018" Anti-CD8 alpha antibody [EPR21769

(2) CCL2/CCR2 Expression in Locally Advanced Prostate Cancer and Patient Long-Term Outcome: 10-Year Results from the TROG 03.04 RADAR TrialCancersAugust 8, 2024Marsland M, Jiang CC, Faulkner S, Steigler A, McEwan K, Jobling P, Oldmeadow C, Delahunt B, Denham JW, Hondermarck H.

(3) Parkinson's disease-derived α-synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotypeJournal of neuroinflammationFebruary 21, 2024Yildirim-Balatan C, Fenyi A, Besnault P, Gomez L, Sepulveda-Diaz JE, Michel PP, Melki R, Hunot S.anti-mouse CD25 (Bio-Rad, MCA1260), anti-mouse CD11b (Bio-Rad, MCA74G), anti-human CCR2 (R&D Systems; MAB150-100), anti-human CX3CR1 (Bio-Rad, AHP566). Mouse TNFα ELISA Kit (Thermo Fisher Scientific, BMS607-3), Mouse

(4) Innate Immune Signaling in Hearts and Buccal Mucosa Cells of Patients with Arrhythmogenic CardiomyopathybioRxiv : the preprint server for biologyJuly 27, 2023Bueto-Beni C, Tafuni A, Chelko SP, Sheppard MN, Field E, Tollit J, Heenan IK, Barnes A, Taylor MR, Mestroni L, et al.

(5) Dynamic bioinspired coculture model for probing ER(+) breast cancer dormancy in the bone marrow nicheScience advancesMarch 10, 2023Pradhan L, Moore D, Ovadia EM, Swedzinski SL, Cossette T, Sikes RA, van Golen K, Kloxin AM.

(6) α(1B/D)-adrenoceptors regulate chemokine receptor-mediated leukocyte migration via formation of heteromeric receptor complexesProceedings of the National Academy of Sciences of the United States of AmericaMay 17, 2022Enten GA, Gao X, Strzelinski HR, Weche M, Liggett SB, Majetschak M.

(7) An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancerCell reports. MedicineFebruary 15, 2022Johnson BE, Creason AL, Stommel JM, Keck JM, Parmar S, Betts CB, Blucher A, Boniface C, Bucher E, Burlingame E, et al.

(8) A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell linesCommunications biologyNovember 25, 2021Song S, Manook M, Kwun J, Jackson AM, Knechtle SJ, Kelsoe G.

(9) Atlas of clinically distinct cell states and ecosystems across human solid tumorsCellOctober 14, 2021Luca BA, Steen CB, Matusiak M, Azizi A, Varma S, Zhu C, Przybyl J, Espín-Pérez A, Diehn M, Alizadeh AA, et al.

(10) Expression of CCL2/CCR2 signaling proteins in breast carcinoma cells is associated with invasive progressionScientific reportsApril 22, 2021Fang WB, Sofia Acevedo D, Smart C, Zinda B, Alissa N, Warren K, Fraga G, Huang LC, Shyr Y, Li W, et al.

(11) Development and application of a high-content virion display human GPCR arrayNature communicationsApril 30, 2019Syu GD, Wang SC, Ma G, Liu S, Pearce D, Prakash A, Henson B, Weng LC, Ghosh D, Ramos P, et al.

(12) Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic TargetsCancer cellApril 15, 2019Cassetta L, Fragkogianni S, Sims AH, Swierczak A, Forrester LM, Zhang H, Soong DYH, Cotechini T, Anur P, Lin EY, et al.

(13) Regulation of C-C chemokine receptor 5 (CCR5) stability by Lys¹⁹⁷ and by transmembrane protein aptamers that target it for lysosomal degradationThe Journal of biological chemistryJune 8, 2018Petti LM, Marlatt SA, Luo Y, Scheideman EH, Shelar A, DiMaio D.

(14) Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expressionScientific reportsJuly 31, 2017Sebastiani G, Ventriglia G, Stabilini A, Socci C, Morsiani C, Laurenzi A, Nigi L, Formichi C, Mfarrej B, Petrelli A, et al.

(15) Macrophage infiltration and genetic landscape of undifferentiated uterine sarcomasJCI insightJune 2, 2017Przybyl J, Kowalewska M, Quattrone A, Dewaele B, Vanspauwen V, Varma S, Vennam S, Newman AM, Swierniak M, Bakuła-Zalewska E, et al.

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(17) Evidence for chemokine synergy during neutrophil migration in ARDSThoraxJanuary 1, 2017Williams AE, José RJ, Mercer PF, Brealey D, Parekh D, Thickett DR, O'Kane C, McAuley DF, Chambers RC.

(18) Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and CytotoxicityFrontiers in immunologyJanuary 1, 2016Maghazachi AA, Sand KL, Al-Jaderi Z.

(19) JAM-A and ALCAM are therapeutic targets to inhibit diapedesis across the BBB of CD14+CD16+ monocytes in HIV-infected individualsJournal of leukocyte biologyFebruary 1, 2015Williams DW, Anastos K, Morgello S, Berman JW.

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CCR2 Antibody

CCR2 Antibody

CCR2 Antibody

CCR2 Antibody

CCR2 Antibody

Human CCR2 Antibody from R&D Systems, a Bio-Techne Brand

Description

Specifications/Features

Questions and Answers

R&D Systems, a Bio-Techne Brand

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Reviews

Human CCR2 Antibody from R&D Systems, a Bio-Techne Brand

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