Histone H2B (D2H6) Rabbit mAb 12364S from Cell Signaling Technology

Product Specs
ItemHistone H2B (D2H6) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number12364S
Quantity100 µl
ApplicationsW, IHC-P, ChIP
ReactivityH, M, R, Mk
ClonalityMonoclonal
TargetH2B
HostRabbit
NCBI Full Gene NameH2B clustered histone 3
NCBI Gene AliasesH2B.1, H2B/f, H2BFF, HIST1H2BB
Research AreaChromatin Regulation / Nuclear Function
IsotypeIgG
CloneD2H6
Molecular Weight14

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Cell Signaling Technology

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Phone: 877-616-CELL
Phone: 978-867-2388
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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stabilityMolecular CellFebruary 19, 2026Carlos Origel Marmolejo, Celina Sanchez, Erin Helms, Melissa J. McEvoy, Juyoung Lee, Marcel Werner, Paige Roberts, Stephan Hamperl, Joshua C. Saldivar,Cell Signaling Technology,Cat#12349S; RRID:AB_2687875 Rabbit monoclonal anti-histone H2B (D2H6),Cell Signaling Technology,Cat#12364S; RRID:AB_2714167 Rabbit monoclonal anti-histone H3 (D1H2),Cell Signaling Technology,Cat#4499S; RRID:AB_10544537 Rabbit

(2) DNA damage induced by HIV-1 Vpr triggers epigenetic remodeling and transcriptional programs to enhance virus transcription and latency reactivationPLoS BiolFebruary 2, 2026Nicholas Saladino, Emily Leavitt, Hoi Tong Wong, Jae-Hoon Ji, Diako Ebrahimi, Daniel J. Salamango2576), acetyl-histone H2A.Z K4/K7 (1:1,000, Cell Signaling 75336), total H2B (1:1,000, Cell Signaling 12364), acetyl-histone H2BK5 (1:1,000, Cell Signaling 12799), acetyl-histone H2BK12 (1:1,000, Cell Signaling

(3) Short-Chain Fatty Acids Elicit Differential Expression of Growth Factors and Pro-Inflammatory Cytokines in Immortalized Rat Enteric Glial CellsNutrientsJanuary 29, 2026Michelle M. Beltran, Danielle M. Defries#24585). Membranes were blocked in 3% BSA-TBST before being probed with primary antibodies (histone H2B, catalog #12364; acetyl-histone H2B, catalog #12799; histone H3, catalog #4499; acetyl-histone H3, catalog #9649, Cell Signaling Technology

(4) SF3B1 Phosphorylation Prompts U2AF2 Dissociation for Widespread Control of pre-mRNA SplicingbioRxivJanuary 23, 2026Christopher L. Kirchhoff, Hannah R. Powell, Justin W. Galardi, Sarah Loerch, Mary J. Pulvino, Jermaine L. Jenkins, Paul L. Boutz, Clara L. KielkopfInvitrogen, Cat. No. 740001), HA (Sigma-Aldrich, Cat. No. H6908), H2B (Cell Signaling Technology, Cat. No. 12364), or GAPDH (Cell Signaling, Cat. No. 2118). Antibodies were diluted 1:1000 v/v with 5% w/v dry milk

(5) Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregationDevelopmental CellJanuary 14, 2026Catherine A. Tower, Gabriel Manske, Emily L. Ferrell, Dilara N. Anbarci, Kelsey Jorgensen, Binbin Ma, Mansour Aboelenain, Rajesh Ranjan, Saikat Chakraborty, Lindsay Moritz, et al.GTX13939), mouse α H2B at 1:500 (Abcam ab52484), or rabbit α H2B at 1:1000 (Cell Signaling Technologies 12364). Primary antibodies hosted in mouse were detected with HRP-conjugated goat α mouse IgG at 1:10,000

(6) Spt7 Deletion Reveals Vulnerabilities in Cryptococcus neoformans Stress Adaptation and VirulenceMicroorganismsJanuary 1, 2026Chendi Katherine Yu, Christina J. Stephenson, Benjamin L. Schulz, James A. Fraser(Cell Signaling Technology, Danvers, MA, USA) were used for detection of histone and histone modification marks: H2B (#12364), H3 (#4499); H2BK120ub (#5546), H3K9ac (#9649), H3K14ac (#7627), H3K18ac (#13998), H4K8ac (#2594),

(7) Distinct characteristics of VEXAS-causative UBA1 M41 and recurrent functional non-M41 mutationsLeukemiaDecember 1, 2025Maki Sakuma, Amy K. Wang, Samuel J. Magaziner, Sachiko P. Keane, Manja Meggendorfer, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach, David B. Beck, Wencke Walter8240), H2A (Cell Signaling, 12349), ubiquitylated-H2B (Cell Signaling, 5546S), H2B (Cell Signaling, 12364), and β-actin (Cell Signaling, 4970) were used at a concentration of 1:1000 and visualized using HRP-conjugated

(8) Overexpression of ATase1 and ATase2 disrupts the secretome and causes a progeria phenotypeLife science allianceDecember 1, 2025Cheng TL, Wu F, Haque ME, Thiel AR, Wang D, Helgager JJ, Li L, Puglielli L.Lys12 (#13944, 1:1,000; Cell Signaling), Histone H2A (#12349, 1:1,000; Cell Signaling), Histone H2B (#12364, 1:1,000; Cell Signaling), Histone H3 (#4499, 1:1,000; Cell Signaling), Histone H4 (#13919, 1:1,000;

(9) Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylationNature chemical biologyNovember 1, 2025Kolvenbach A, Palumbieri MD, Colby T, Nadarajan D, Bode R, Matić I.(Cell Signaling Technology, 9715; 1:1,000), rabbit anti-histone H2B (D2H6) (Cell Signaling Technology, 12364; 1:1,000), HRP-coupled anti-histone H3 (D1H2) (Cell Signaling Technology, 12648; 1:1,000), Anti-ubiquitin

(10) Nucleosome stability safeguards cell identity, stress resilience and healthy agingbioRxivSeptember 22, 2025Hiroshi Tanaka, Brenna S. McCauley, Clara Guida, Xue Lei, Sha Li, Tatiana M. Moreno, K’leigh Guillotte, Zong-Ming Chua, Adrianna Abele, Aashna Lamba, et al.antibodies were used: Flag M2 (Sigma, F3165, 1:5000; Cell Signaling, 14793, 1:5000), H2B (Cell signaling, 12364, 1:5000), GFP (Abcam, 6556, 1:1000) and GAPDH (Santa Cruz, sc-47724, 1:10000; Abcam, 9485, 1:10000).

(11) Regulation of the MDM2-p53 nexus by a nuclear phosphoinositide and small heat shock protein complexJournal of Biological ChemistrySeptember 1, 2025Jeong Hyo Lee, Mo Chen, Tianmu Wen, Richard A. Anderson, Vincent L. Cryns(clone 75D8, #2497, Cell Signaling), Histone H2A (#2578, Cell Signaling), Histone H2B (clone D2H6, #12364, Cell Signaling), Ubiquitin (P37, #58395, Cell Signaling) were utilized in this study. For conventional

(12) PFKM phosphorylates histone H3 and promotes mitotic progression by sensing the levels of citrateNat CommunJuly 22, 2025Pianpian Lin, Yijun Qi, Huiying Chu, Hongyu Wu, Yajuan Zhang, Xiaolan Huang, Chen Li, Xiaoyan Xu, Hong Gao, Rong Zeng, et al.anti-phospho-Histone H3 (Ser10) (9701), rabbit monoclonal anti-HA (3724) and rabbit monoclonal anti-Histone H2B (12364S) were purchased from Cell Signaling Technology. Rabbit monoclonal anti-Flag (20543-1-AP) and mouse monoclonal

(13) Chromatin heterogeneity modulates nuclear condensate dynamics and phase behaviorNat CommunJuly 11, 2025Jing Xia, Jessica Z. Zhao, Amy R. Strom, Clifford P. Brangwynnebuffer (Invitrogen #NP0007). For H2B detection, an anti-H2B primary antibody (Cell Signaling Technology #12364) was used at a dilution of 1:2000. For miRFP detection, a miRFP antibody (Thermo Fisher Scientific Inc,

(14) IFI16 Mediates Deacetylation of KSHV Chromatin via Interaction with NuRD and Sin3A Co-Repressor ComplexesVirusesJune 28, 2025Anandita Ghosh, Bala Chandran, Arunava Roy12349); Acetyl-Histone H2A anti-rabbit (Cell Signaling, 2576); Histone H2B anti-rabbit (Cell Signaling 12364); Acetyl-Histone H2B anti-rabbit (Cell Signaling, 12799); Histone H3 anti-rabbit (Cell Signaling, 4499);

(15) A nucleosome switch primes hepatitis B virus infectionCellApril 17, 2025Nicholas A. Prescott, Tracy Biaco, Andrés Mansisidor, Yaron Bram, Justin Rendleman, Sarah C. Faulkner, Abigail A. Lemmon, Christine Lim, Rachel Tiersky, Eralda Salataj, et al.,Cell Signaling Technology,Cat# 12349 "H2A, immunoblot",Abcam,Cat# 18255 H2B,Cell Signaling Technology,Cat# 12364 H3,Abcam,Cat# ab1791 H3K4me3,Epicypher,Cat# 13-004 H4,Abcam,Cat# ab7311 HBcAg,Santa Cruz Biotechnology,Cat#

(16) A CRISPR-edited isoform of the AMPK kinase LKB1 improves the response to cisplatin in A549 lung cancer cellsJournal of Biological ChemistryFebruary 13, 2025Matheus Brandemarte Severino, Ana Paula Morelli, Isadora Carolina Betim Pavan, Mariana Camargo Silva Mancini, Mariana Marcela Góis, Rafael Junqueira Borges, Renata Rosseto Braga, Luiz Guilherme Salvino da Silva, Nathalia Quintero-Ruiz, Maíra Maftoum Costa, et al.(Cell signaling #14793), lactate dehydrogenase A (Abcam #ab52488), HK2 (Abcam #ab209847), H2B (Cell signaling #12364), puromycin (Sigma-Aldrich 12D10). Secondary antibodies: HRP-conjugated goat anti-mouse IgG (Sigma-Aldrich

(17) HIV-1 Vpr drives epigenetic remodeling to enhance virus transcription and latency reactivationbioRxivJanuary 31, 2025Nicholas Saladino, Emily Leavitt, Hoi Tong Wong, Jae-Hoon Ji, Diako Ebrahimi, Daniel J Salamango2576), acetyl-histone H2A.Z K4/K7 (1:1000, Cell Signaling 75336), total H2B (1:1000, Cell Signaling 12364), acetyl-histone H2BK5 (1:1000, Cell Signaling 12799), acetyl-histone H2BK12 (1:1000, Cell Signaling

(18) The impact of circulating nucleosomes on inflammation in acute lung injuryThe FASEB JournalDecember 15, 2024Saugata Dutta, Yin Zhu, Sultan Almuntashiri, Payaningal R. Somanath, Shaheen Islam, Wenbo Zhi, Gustavo Ramírez, Nora Regino, María Jose Leyva‐Zilli, Victoria Muñoz‐Guido, et al.with primary antibodies against Histone H2A (Cat#12349, Lot# 3, Cell Signaling Technology), H2B (Cat#12364T, Lot# 3, Cell Signaling Technology), H3 (Cat#4499T, Lot# 9, Cell Signaling Technology), or H4 (Cat#13919T,

(19) Monoubiquitinated H2B, a Main Chromatin Target of Formaldehyde, Is Important for S‐Phase Checkpoint Signaling and Genome StabilityMolecular CarcinogenesisDecember 1, 2024Sasmita Mishra, Casey Krawic, Michal W. Luczak, Anatoly ZhitkovichHistone antibodies: H2Bub1 (Cell Signaling, 5546), H2Aub1 (Cell Signaling, 8240), H2B (Cell Signaling, 12364), H2A (Cell Signaling, 2578), H2AX (Cell Signaling, 7631), γH2AX (Cell Signaling, 9718), H2AZ (Cell Signaling

(20) Sensitive Detection of Histones and γ-H2AX by Immunoblotting: Problems and SolutionsChemical research in toxicologySeptember 16, 2024Krawic C, Luczak MW, Zhitkovich A.(Cell Signaling, 2718), H2Aub1 (Cell Signaling, 8240), H2AK5ac (Cell Signaling, 2576), H2B (Cell Signaling, 12364 and Millipore, 07–371), H2Bub1 (Cell Signaling, 5546), H2BK5ac (Cell Signaling, 12799), H3 (Cell Signaling,

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Histone H2B (D2H6) Rabbit mAb

Histone H2B (D2H6) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Histone H2B (D2H6) Rabbit mAb from Cell Signaling Technology

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