NLRC4 (D5Y8E) Rabbit mAb 12421S from Cell Signaling Technology

Product Specs
ItemNLRC4 (D5Y8E) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number12421S
Quantity100 µl
ApplicationsW, IP
ReactivityH
ClonalityMonoclonal
TargetNLRC4
HostRabbit
NCBI Full Gene NameNLR family CARD domain containing 4
NCBI Gene AliasesAIFEC, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, FCAS4, IPAF
Research AreaImmunology and Inflammation
CloneD5Y8E
Molecular Weight110

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) SENP6 Restrains NLRP3 Inflammasome Activation via DeSUMOylation-Driven K48-Linked Ubiquitination of NLRP3 in Acute Lung InjuryResearch (Wash D C)January 12, 2026Angran Gu, Bailun Wang, Yi Zhang, Chang Sun, Yi Wei, Jie Yan, Yizheng Yang, Yichen Wang, Runmeng Liu, Ruirui Zhang, et al.(Shanghai, China). Anti-NLRP3 (15101S), anti-caspase-1/p20 (3866S), anti-IL-1β/p17 (63124S), anti-NLRC4 (12421S), and anti-AIM2 (12948S) were from Cell Signaling Technology (MA, USA). Anti-β-actin (66009-1-Ig), anti-hemagglutinin

(2) Dopamine-driven increase in IL-1β in myeloid cells is mediated by differential dopamine receptor expression and exacerbated by HIVJournal of neuroinflammationMarch 23, 2025Matt SM, Nolan R, Manikandan S, Agarwal Y, Channer B, Oteju O, Daniali M, Canagarajah JA, LuPone T, Mompho K, et al.4 °C in either anti-NLRP3 antibody (15101S, 1:1000 in 5% BSA, Cell Signaling), anti-NLRC4 antibody (12421, 1:1000 in 5% BSA, Cell Signaling) or anti-AIM2 antibody ( MA5-38442, 1:1000 in 5% BSA, Thermo Fisher Scientific

(3) Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effectsiScienceApril 19, 2024Huiting Hu, Yuqian Cai, Yuanfang Shi, Shengyu Zhang, Xiaoxuan Yu, Tonghui Ma, Shanting LiaoAB_2687540 anti-human-AIM2,Cell Signaling Technology,Cat#12948; RRID: AB_2798067 anti-NLRC4,Cell Signaling Technology,Cat#12421; RRID: AB_2797906 anti-human-pro-IL-1β,Cell Signaling Technology,Cat#12703; RRID: AB_2737350 anti-human-cleaved-IL-1β,Cell Signaling Technology

(4) A flagellin-conjugate protein induces dual NLRC4- and NLRP3-inflammasome activation which modulates inflammatory cytokine secretion from macrophagesFrontiers in immunologyJanuary 1, 2023Lin YJ, Jamin A, Wolfheimer S, Fiedler A, Junker AC, Goretzki A, Scheurer S, Schülke S.membranes were incubated with the following primary antibodies overnight at 4°C: anti-NLRC4 antibody (#12421, Cell Signaling Technologies), anti-Caspase-1 antibody (#3866, Cell Signaling Technologies), anti-β-Tubulin

(5) Abortive HIV-1 RNA induces pro-IL-1β maturation via protein kinase PKR and inflammasome activation in humansEuropean journal of immunologyOctober 1, 2021Stunnenberg M, van Hamme JL, Trimp M, Gringhuis SI, Geijtenbeek TBH.anti‐ASC (1:50, 4628S, Cell Signaling), anti‐NLRP3 (1:50, 13158S, Cell Signaling), anti‐NLRC4 (1:50, 12421S, Cell Signaling), anti‐DDX3 (1:50, 2635S, Cell Signaling), and anti‐PKR (1:50, ab32052, Abcam), followed

(6) Plasma extracellular vesicle delivery of miR-210-3p by targeting ATG7 to promote sepsis-induced acute lung injury by regulating autophagy and activating inflammationExperimental & Molecular MedicineJuly 28, 2021Guang Li, Bo Wang, Xiangchao Ding, Xinghua Zhang, Jian Tang, Huiqing Lindomain-containing 3 (NLRP3, 1:1000, #15101, CST), and NLR family CARD domain containing 4 (NLRC4, 1:1000, #12421, CST) overnight at 4 °C, followed by incubation with horseradish peroxidase-conjugated secondary antibodies

(7) Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon responseEMBO reportsSeptember 3, 2020Jena KK, Mehto S, Nath P, Chauhan NR, Sahu R, Dhar K, Das SK, Kolapalli SP, Murmu KC, Jain A, et al.1:1,000), OAS1 (CST #14498; 1:1,000), ISG15 (CST #2743; 1:1,000), AIM2 (CST #12948; 1:1,000), NLRC4 (CST #12421; 1:1,000); GAPDH (CST #2118; 1:1,000), Normal rabbit IgG (CST #2729), LC3B (Sigma #L7543; 1:1,000),

(8) The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective AutophagyMolecular cellFebruary 7, 2019Mehto S, Jena KK, Nath P, Chauhan S, Kolapalli SP, Das SK, Sahoo PK, Jain A, Taylor GA, Chauhan S.9542L; RRID:AB_2160739 Gasdermin D,Cell Signaling,Cat #: 96458 NLRC4 (D5Y8E),Cell Signaling,Cat #: 12421S AIM2 (D5X7K),Cell Signaling,Cat #: 12948S Anti- beta Actin,Abcam,Cat #: ab6276; RRID:AB_2223210 Rabbit

(9) Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASCFrontiers in microbiologyJanuary 1, 2018Wu Q, Zhu YH, Xu J, Liu X, Duan C, Wang MJ, Wang JF.were as follows: rabbit anti-NLRP3 (19771-1-AP, 1:200 dilution; Proteintech Group), rabbit anti-NLRC4 (12421, 1:1,000 dilution; Cell Signaling Technologies Inc., Danvers, MA, United States), mouse anti-caspase-1

(10) Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCαPLoS pathogensJanuary 1, 2017Koh HJ, Kim YR, Kim JS, Yun JS, Jang K, Yang CS.(3831), phospho-(Ser561)-PLD2 (3834), PLD1 (3832), PLD2 (13904), PKCα (2056), PKCγ (43806), and NLRP4 (12421) were purchased from Cell Signaling Technology. Antibodies specific for actin (I-19), ASC (N-15-R),

(11) NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22The Journal of clinical investigationMay 2, 2016Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, et al.anti–IL-1β (CST; 3A6, 12242); AIM2 (Santa Cruz Biotechnology Inc.; D14; sc-137967); NLRC4 (CST; D5Y8E, 12421); PTPN2 (Merck Millipore; CF-41D, PH03L). For immunoprecipitation, samples were precleared with Sepharose

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NLRC4 (D5Y8E) Rabbit mAb

NLRC4 (D5Y8E) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (11)

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NLRC4 (D5Y8E) Rabbit mAb from Cell Signaling Technology

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