Bim (C34C5) Rabbit mAb (PE Conjugate) 12186S from Cell Signaling Technology

Product Specs
ItemBim (C34C5) Rabbit mAb (PE Conjugate)
CompanyCell Signaling Technology
Price $450.00 Inquire
Catalog Number12186S
Quantity100 µl
ApplicationsFC-FP
Conjugate/TagPE
ReactivityH, M, R
TargetBim
CloneC34C5
HostRabbit
NCBI Full Gene NameBCL2 like 11
NCBI Gene AliasesBAM, BIM, BOD
ClonalityMonoclonal
Research AreaApoptosis
IsotypeIgG

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cellsImmunityMarch 11, 2025Adriana M. Mujal, Mark Owyong, Endi K. Santosa, John C. Sauter, Simon Grassmann, Anna-Marie Pedde, Philippa Meiser, Claire K. Wingert, Marine Pujol, Veit R. Buchholz, et al.,Thermo Fisher,Cat# 58-0112-82; RRID: AB_2811905 anti-mouse BIM (Clone C34C5),Cell Signaling Technologies,Cat# 12186; RRID: AB_2797842 anti-mouse c-Myc/N-Myc (Clone D3N8F),Cell Signaling Technologies,Cat# 35876; RRID:

(2) IL-21 shapes the B cell response in a context-dependent mannerCell reportsJanuary 28, 2025Kim Y, Manara F, Grassmann S, Belcheva KT, Reyes K, Kim H, Downs-Canner S, Yewdell WT, Sun JC, Chaudhuri J.(K112-91),BD Biosciences,Cat#561525; RRID: AB_10898007 BIM - PE (C34C5),Cell Signaling Technology,Cat#12186; RRID: AB_2797842 CD138 - APC (281-2),BioLegend,Cat#142505; RRID: AB_10960141 CD138 - BV650 (281-2),BioLegend,Cat#142518;

(3) Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunityImmunityAugust 1, 2024Rebecca B. Delconte, Mark Owyong, Endi K. Santosa, Katja Srpan, Sam Sheppard, Tomi J. McGuire, Aamna Abbasi, Carlos Diaz-Salazar, Jerold Chun, Inez Rogatsky, et al.M1/70),Thermofisher,Cat#58-0112-82; RRID:AB_2811905 anti-mouse BIM (clone C34C5),Cell Signaling,Cat#12186; RRID:AB_2797842 anti-mouse Ly-6G (clone 1A8),BD Biosciences,Cat#612921; RRID:AB_2870206 anti-mouse

(4) Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activityCell Death & DiseaseJune 19, 2024Peiran Feng, Liang Luo, Quanli Yang, Wanqing Meng, Zerong Guan, Zhizhong Li, Guodong Sun, Zhongjun Dong, Meixiang Yangantibodies against mouse TCF1 (Cat#9066S), phospho-Mob1 (Thr35) (Cat#8699), Bim (C34C5) Rabbit mAb (Cat#12186), Phospho-Stat5 (Tyr694) (Cat#9359), phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cat#4370S) and polyclonal

(5) Interruption of the intratumor CD8+ T cell:Treg crosstalk improves the efficacy of PD-1 immunotherapyCancer CellJune 10, 2024Shannon N. Geels, Alexander Moshensky, Rachel S. Sousa, Claire Murat, Matias A. Bustos, Benjamin L. Walker, Rima Singh, Stacey N. Harbour, Giselle Gutierrez, Michael Hwang, et al.(clone: 54H6),Cell Signaling Technology,Cat# 2767S Bim PE (clone: C34C5),Cell Signaling Technology,Cat# 12186S CD107a (Lamp-1) Ax647 (clone: 1D4B),BioLegend,Cat# 121610 CD11c Ax700 (clone: HL3),BD Biosciences,Cat#

(6) Neoadjuvant cobimetinib and atezolizumab with or without vemurafenib for high-risk operable Stage III melanoma: the Phase II NeoACTIVATE trialNature CommunicationsFebruary 16, 2024Tina J. Hieken, Garth D. Nelson, Thomas J. Flotte, Eric P. Grewal, Jun Chen, Robert R. McWilliams, Lisa A. Kottschade, Lu Yang, Evidio Domingo-Musibay, Roxana S. Dronca, et al.32990, BioLegend), CX3CR1-APC/Cy7 (clone 2A9-1, catalog 341616, BioLegend), Bim-PE (clone C34C5, catalog 12186S, Cell Signaling Technology), NKG7 monoclonal antibody (AG1490 Rb mAb 8H3/8K3)-FITC conjugated (Fusion

(7) The lncRNA Malat1 inhibits miR-15/16 to enhance cytotoxic T cell activation and memory cell formationeLifeDecember 21, 2023Wheeler BD, Gagnon JD, Zhu WS, Muñoz-Sandoval P, Wong SK, Simeonov DS, Li Z, DeBarge R, Spitzer MH, Marson A, et al.monoclonal)",eBiosciences,11-0271-82,(1:200) Antibody,"anti-Bim PE (Clone-C34C5, rabbit monoclonal)",Cell Signaling,12186S,(1:100) Antibody,"anti-CD43 Percp-Cy5.5 (Clone-1B11, rat monoclonal)",BioLegend,121224,(1:200) Antibody,"anti-CD45.2

(8) Tumor-Derived Extracellular Vesicles Predict Clinical Outcomes in Oligometastatic Prostate Cancer and Suppress Antitumor ImmunityInternational journal of radiation oncology, biology, physicsNovember 15, 2022Lucien F, Kim Y, Qian J, Orme JJ, Zhang H, Arafa A, Abraha F, Thapa I, Tryggestad EJ, Harmsen WS, et al.(BioLegend, clone EH12.2H7, catalog 32990), Bim-PE (Cell Signaling Technology, clone CD34C5, catalog 12186S), Granzyme B-PerCP (Novus Biologicals, clone CLB0GB11, catalog NBP1–50071PCP), and CX3CR1-APC/Cy7 (BioLegend,

(9) Overcoming Immunotherapy Resistance With Radiation Therapy and Dual Immune Checkpoint BlockadeAdvances in radiation oncologyJuly 1, 2022Davidson T, Zhang H, Dong H, Grams MP, Park SS, Yan Y.catalog 341616; BioLegend), BCL-2-interacting mediator of cell death (Bim)-PE (clone C34C5, catalog 12186S; Cell Signaling Technology, Danvers, MA), Ki-67-BV421 (clone B56, catalog 562899; BD Biosciences), and

(10) The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8αα(+) intraepithelial lymphocyte precursorsNature immunologyApril 1, 2022Nie J, Carpenter AC, Chopp LB, Chen T, Balmaceno-Criss M, Ciucci T, Xiao Q, Kelly MC, McGavern DB, Belkaid Y, et al.eBioscience, 1:100), LRF (eFluor 660, clone 13E9, 50–3309-80, eBioscience, 1:200), Bim (PE, clone C34C5, 12186, Cell Signaling, 1:20), Cleaved Caspase-3 (Pacific Blue, clone D3-E9, 8788, Cell Signaling, 1:10), Bcl2

(11) Dl-3-n-Butylphthalide Alleviates Behavioral and Cognitive Symptoms Via Modulating Mitochondrial Dynamics in the A53T-α-Synuclein Mouse Model of Parkinson's DiseaseFrontiers in neuroscienceJanuary 1, 2021Li H, Wang H, Zhang L, Wang M, Li Y.following reagents were used: anti-DRP1 #8570 (Cell Signaling Technology, United States), anti-MFN1 #12186-AP (Proteintech Group, United States), anti-Parkin #2132s (Cell Signaling Technology, United States),

(12) An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell DevelopmentImmunityDecember 15, 2020Chopp LB, Gopalan V, Ciucci T, Ruchinskas A, Rae Z, Lagarde M, Gao Y, Li C, Bosticardo M, Pala F, et al.,Cell Signaling Technology,"Cat# 10408S, RRID:AB_2797721" Anti-Bim-PE (C34C5),Cell Signaling Technology,"Cat# 12186S, RRID:AB_2797842" Anti-Cleaved Caspase-3 (ASP175) (Clone D3-E9),Cell Signaling Technology,"Cat# 8788S,

(13) Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector T_reg CellsCell metabolismDecember 1, 2020Su W, Chapman NM, Wei J, Zeng H, Dhungana Y, Shi H, Saravia J, Zhou P, Long L, Rankin S, et al.,Thermo Fisher Scientific,"Cat# 12–0051-81, RRID:AB_465522" Anti-Bim (C34C5),Cell Signaling Technology,"Cat# 12186, RRID:AB_2797842" Anti-Rap1A (C-17),Santa Cruz Biotechnology,"Cat# sc-1482, RRID:AB_2177124" Anti-HDJ2

(14) Chemo-immunotherapy combination after PD-1 inhibitor failure improves clinical outcomes in metastatic melanoma patientsMelanoma researchAugust 1, 2020Vera Aguilera J, Paludo J, McWilliams RR, Zhang H, Li Y, Kumar AB, Failing J, Kottschade LA, Block MS, Markovic SN, et al.2A9-1, catalog 341616), Bim-PE (Cell Signaling Technology, Danvers, Massachusett, clone C34C5, catalog 12186S), Ki-67-BV421(BD Biosciences, clone B56, catalog 562899), Granzyme B-PerCP (Novus Biologicals, Danvers,

(15) Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseasesAgingJune 10, 2020Zhang X, Zhao D, Wu W, Ali Shah SZ, Lai M, Yang D, Li J, Guan Z, Li W, Gao H, et al.(8570, CST), OPA1 rabbit mAb (80471, CST), anti-FIS1 (D122377-0025, BBI life sciences), anti-MFN2 (12186, Proteintech), antibeta tubulin (10094, Proteintech), anti-PSD95 (20665, Proteintech), spinophilin rabbit

(16) Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription FactorCell reportsNovember 12, 2019Shen E, Rabe H, Luo L, Wang L, Wang Q, Yin J, Yang X, Liu W, Sido JM, Nakagawa H, et al.(3F11),BD Biosciences,Cat# 554221; RRID: AB_395312 Anti-mouse Bim (C34C5),Cell Signaling Technology,Cat# 12186; RRID: AB_2797842 Anti-mouse Helios (22F6),Biolegend,Cat# 137229; 137220; RRID: AB_2561639; RRID: AB_10690535 Anti-mouse

(17) Flow Cytometry-Based Detection and Analysis of BCL-2 Family Proteins and Mitochondrial Outer Membrane Permeabilization (MOMP)Methods in molecular biology (Clifton, N.J.)January 1, 2019Ludwig LM, Maxcy KL, LaBelle JL.Abcam ab197035 (detects human and murine isoforms). (d) BIM: •(C34C5) Rabbit mAb (PE conjugate) CST 12186S (detects human and murine isoforms). (e) BAX: •(6A7) mAb (requires a secondary antibody conjugated

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Bim (C34C5) Rabbit mAb (PE Conjugate)

Bim (C34C5) Rabbit mAb (PE Conjugate) from Cell Signaling Technology

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Cell Signaling Technology

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Bim (C34C5) Rabbit mAb (PE Conjugate) from Cell Signaling Technology

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