PPARgamma (C26H12) Rabbit mAb 2435S from Cell Signaling Technology

Product Specs
ItemPPARgamma (C26H12) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2435S
Quantity100 µl
ApplicationsW, IHC-P, IF-IC, ChIP, ChIP-seq
ReactivityH, M
TargetPPAR-gamma
HostRabbit
NCBI Gene AliasesCIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARG5, PPARgamma
ClonalityMonoclonal
NCBI Full Gene Nameperoxisome proliferator activated receptor gamma
Research AreaNuclear Receptor Signaling
IsotypeIgG
CloneC26H12
Molecular Weight53, 57

Questions and Answers

Can this antibody be used to study PPARγ in adipogenesis research?

Yes, the PPARγ (C26H12) Rabbit mAb has been utilized in studies investigating adipogenesis. For instance, it was employed in a study that demonstrated the role of PPARγ in regulating macrophage polarization during sepsis-induced intestinal injury, highlighting its importance in adipogenic processes ().

Is this antibody effective for immunohistochemical applications?

The PPARγ antibody has been shown to work effectively in immunohistochemistry, as evidenced by its use in detecting PPARγ expression in various tissues, including aortas in studies examining diabetes-induced vascular injury ().

What species can this antibody detect?

The PPARγ antibody is reactive to both human (Homo sapiens) and mouse (Mus musculus) samples, making it suitable for a variety of experimental models in cell biology research.

Has this antibody been cited in studies related to cancer research?

Yes, the PPARγ antibody has been cited in cancer research, particularly in studies exploring its role in bladder cancer. For example, it was used in a genome-wide CRISPR screen to identify regulators of PPARγ gene expression in luminal bladder cancer cells ().

Cell Signaling Technology

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Phone: 978-867-2388
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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) SirT2 Inhibition is Associated with Improvements in Depression-like Behavior and Memory Impairment in Olfactory Bulbectomized MiceMol NeurobiolApril 21, 2026Kohei Takahashi, Kazuhiro Kurokawa, Daiki Hiraga, Hiroshi Takeda, Minoru TsujiPA5-104560), phospho-FoxO1 (Ser256; 1:500; CST; #9461), total FoxO1 (1:500; CST; #2880), PPARγ (1:500; CST; #2435), phospho-AKT (Thr308; 1:200; CST; #13038), phospho-AKT (Ser473; 1:1000; CST; #4060), total AKT (1:1000;

(2) Deletion of miR-130b/301b cluster promotes macrophage efferocytosis and resolution of adipose tissue inflammationiScienceApril 17, 2026Lei Yang, Tuerdiguli Abuduyimiti, Yibo Xi, Gianfilippo Coppola, Chen Liu, Shaoning Jiang(SDS-PAGE). The blots were incubated with antibodies specific for PPARγ (Cell Signaling Technology, #2435), PGC-1α (Cell Signaling Technology, #4259), β-actin (Cell Signaling Technology, #5125), CX3CR1 (Abcam,

(3) The DBC1-HIF-1α-PPAR-γ axis regulates Treg cell differentiation to promote myocardial fibrosis in experimental diabetic cardiomyopathy through the paracrine secretion of AregFront Endocrinol (Lausanne)April 13, 2026Linhe Lu, Yifei Xu, Changnuan Wen, Qiancong Zhao, Zhihang Li, Jiaqi Liu, Fujie Xu, Jincheng Liu, Jiayou TangAbcam, 1:8000), anti-HIF-1α (#3716, Cell Signaling Technology, Danvers, MA, USA, 1:1000), anti-PPAR-γ (#2435, Cell Signaling Technology, 1:1000), or anti-GAPDH (#ab9485, Abcam, 1:2500) antibody. Signal development

(4) 18F-FDG-PET/CT-negative gastric cancer employs glutamine-based gluconeogenesis and fatty acid oxidation to support tumor growthCell Death & DiseaseMarch 26, 2026Jia Liu, Mingjie Xia, Zhexuan Zhao, Tian Gao, Yanzhao Qu, Qian Wang, Xiangdan Liu, Jianlan Du, Shunxin Han, Shiying Yang, et al.anti-CREB1 (ABclonal, #A11989), anti-FOXO1 (ABclonal, #A2934), anti-PPARγ (Cell Signaling Technology, #2435S) and anti-β-Actin (Proteintech, #23660-1-AP). Secondary antibodies included: goat anti-mouse IgG secondary

(5) Etifoxine drives macrophage M2 polarization via Schwann cell-derived progesterone activation of PPARγ to accelerate peripheral nerve repairFrontiers in Cellular NeuroscienceMarch 23, 2026Chao Guo, Song LiuThe membranes were probed overnight at 4°C with the following primary antibodies: anti-PPARγ (CST, #2435), anti-CPT1A (CST, #12252), anti-PGC1α (CST, #2178), anti-BNIP3L (Selleck, F0469), anti-Parkin (Selleck,

(6) PPARγ activation rescues oxidative stress-induced embryonic arrest by suppressing Wnt/β-catenin signaling via GSK3β upregulationiScienceMarch 20, 2026Lihong Liu, Siyao Ha, Hui Chen, MingQing Li, Zhiling LiSDS-PAGE, transferred to PVDF membranes, and probed with primary antibodies (PPARγ antibody (1:1000; CST, 2435S), β-Catenin antibody (1:1000; CST, 8480S), GSK3β antibody (1:1000; CST, 12456) overnight at 4°C. After

(7) Aerobic glycolysis drives differentiation of unilocular adipocytesJournal of Lipid ResearchMarch 17, 2026Alice Maestri, Min Cai, Ruby Schipper, Julia Backman, Alana Vannay, Anneli Olsson, Ewa Ehrenborg, Roland Nilsson, Carolina E. HagbergFisher Scientific), CIDEC (1:10, PA1-46128, Invitrogen), UCP1 (1:50, MAB6158, R&D Systems), PPARγ (1:50, 2435S, Cell Signaling), FAS (1:50, 3180, BioTechne), ATGL (1:50, 2138, Cell Signaling), Total OXPHOS cocktail

(8) Effects of Progranulin Deficiency on Inflammation and Fibrosis in the Kidneys and Liver of Diabetic Mice Fed a High-Fat DietEndocrinology and MetabolismFebruary 28, 2026Hiroko Sakuma, Maki Murakoshi, Shinji Hagiwara, Terumi Shibata, Yusuke Suzuki, Tomohito Gohdaproliferator-activated receptor α (PPARα) (#SC-398394; Santa Cruz Biotechnology, Dallas, TX, USA), and PPARγ (#2435; Cell Signaling Technology). After incubation with secondary antibodies (1:10,000) for 1 hour at room

(9) CD146 + interstitial cells contribute to the dystrophic skeletal muscle phenotype in vitroScientific ReportsFebruary 24, 2026Bartosz Mierzejewski, Zuzanna Michalska, Dominika Kulma, Aleksandra Bos, Wladyslawa Streminska, Zbigniew Bartoszewicz, Edyta BrzoskaCell Signaling), rabbit monoclonal anti-phosphorylated c-Jun (#5348, Cell Signaling), anti-PPARγ (#2435, Cell Signaling) and mouse monoclonal anti-α-tubulin (T5168; Sigma-Aldrich). Secondary antibodies used:

(10) Capg enhances proliferation, adipogenesis, and inflammatory response in preadipocytes: insights from bioinformatics analysis and functional validationPeerJFebruary 10, 2026Luyao Zhang, Botao Sang, Sainan Li, Ying Li, Dachuan Guo, Qinan Ma, Xiangfei Liu, Xiaoshuo Li, Beidong Chen, Deping Liu(1:6000, 10094-1-AP, Proteintech, Rosemont, IL, USA), DDDDK-Tag (ABclonal, AE169PM, 47kD), PPARγ (1:1000, #2435T, CST), Adiponectin (1:1000, #2789, CST), CylinD1(1:2000, HY-P80098, MCE). Subsequently, HRP-conjugated

(11) PPAR-gamma regulates PFAS-mediated proinflammatory cytokines in lung epithelial cellsFrontiers in PharmacologyFebruary 3, 2026Sadiya Bi Shaikh, Md Imam Faizan, Khursheed Ul Islam, Virender K. Rehan, Irfan Rahmanprimary antibodies anti-PPARα (mouse; Proteintech, Cat# 66826-1-Ig) and anti-PPARγ (rabbit; CST, Cat# 2435S), each at 1:1000 with gentle agitation. After washing in 1× TBST, membranes were incubated with HRP-conjugated

(12) Ellagic Acid Alleviates Abnormal Fat Reduction by Activating the RXRβ–PPARγ Pathways in a CT26 Tumour‐Induced Cachexia Mouse ModelJournal of Cachexia, Sarcopenia and MuscleFebruary 1, 2026Woo Yong Park, Beomsu Kim, Gahee Song, Sang Hee Kim, Jin‐Hyung Kim, Ja Yeon Park, Se Jin Jung, Wenjun Jiao, Jisoo Han, Taekyoung Kong, et al.program (National Institute of Health, MD, USA). The following primary antibodies were used: PPARγ (Cat# 2435S, Cell Signaling Technology), RXRβ (sc‐741, Santa Cruz Biotechnology) and SREBP1 (sc‐366, Santa Cruz Biotechnology

(13) Unraveling the potential mechanisms of Xiaochaihu decoction alleviates metabolic associated fatty liver disease (MAFLD) by integrated transcriptomics, metabolomics, and network pharmacologyChinese MedicineJanuary 20, 2026Ying Zhong, Xiao-min Zhu, Jian-chao Li, Li-song Sheng, Jia-ying Qi, Xian-hui Shen, Hang Du, Na-na Huang, Rong Sunanalysis targeting PLIN2 (ab108323) were purchased from Abcam (Cambridge, MA, USA). Antibodies PPARγ (2435S) were purchased from Cell Signaling Technology Inc. (Danvers, MA, USA). Antibodies Plin3 (10694–1-AP),

(14) Andrographolide inhibits the upregulation of SLC19A3 to block the adipogenic differentiation of adipose-derived stem cellsiScienceJanuary 16, 2026Yili Yang, Xuan Wang, Guangfeng Zhou, Xiaodan Hou, Yang He, Yuan Feng, Yuxue Jiang, Yuexi Gu, Jun Ye,Cell Signaling Technology,Cat#2120S; RRID: AB_2102466 Rabbit monoclonal anti-PPARγ,Cell Signaling Technology,Cat#2435S; RRID:AB_2166051 Rabbit monoclonal anti-SLC19A3,Abcam,Cat# ab237630 Phospho-GSK3β (Ser9) (5B3),Cell Signaling Technology

(15) METTL3 abrogation promotes glioma progression through regulating the ISG15-FASN axis-mediated lipid metabolism in macrophagesNature CommunicationsJanuary 8, 2026Huilong Yin, Xiaoyi Yu, Chenglong Hu, Yuhang Yang, Mengke Wang, Yating Xing, Baile Zuo, Chenxing Zhang, Weilong Yang, Yitong Li, et al.Cell Signaling Technology), rabbit anti-Perilipin-1 (1:1000, 9349S, Cell Signaling Technology), rabbit anti-PPARγ (1:1000, 2435S, Cell Signaling Technology), rabbit anti-AceCS1 (1:1000, 3658S, Cell Signaling Technology), Mouse anti-ISG15

(16) Cirsiliol alleviates diabetic cardiomyopathy by inhibiting oxidative stress and improving energy metabolism through the PPAR-α/AMPK pathwayScientific ReportsDecember 11, 2025Jing Tao, Siqi Liu, Yunzhi Ling, Hanlin Bai, Lei Liu, Ru Yu, Guangling Li# 37385), SOD2 (Catalog # 13141), IL-6 (Catalog # 12153), MCP-1 (Catalog # 2029), PPAR-α (Catalog # 2435), AMPK (Catalog # 5831), LKB1 (Catalog # 3047), and ACADM (Catalog # 4321) were purchased from Cell Signaling Technology

(17) Integrated Transcriptomic, Proteomic, and Network Pharmacology Analyses Unravel Key Therapeutic Mechanisms of Xuebijing Injection for Severe Acute PancreatitisPharmaceuticals (Basel)December 7, 2025Linbo Yao, Xinmin Yang, Mei Yuan, Shiyu Liu, Qiqi Wang, Yongzi Wu, Wenjuan Luo, Xueying Wu, Wenhao Cai, Lan Li, et al.1:1000), TLR4 (Santa:sc-293072, 1:500), MMP-9 (CST:13667, 1:1000), HSP90 (CST:4877, 1:1000), PPARγ (CST:2435, 1:1000), NF-κB (CST:8242,1:1000) and β-actin(Proteintech:66009-1-lg, 1:10,000). 4.8. Necrotic Cell

(18) Intermittent fasting alleviates obesity-associated impairments in bone fracture healing: Exploring the role of gut microbiomeBone ReportsDecember 1, 2025Honey Hendesi, Dana A. Godfrey, Ana Ferreira Ruble, Aaron M. Tran, David A. Villani, Samantha H. Landgrave, Nur A. Hasan, Douglas J. Adams, Michael J. ZuscikBurlingame, CA, USA) was used to detect the primary mouse-anti-PPARγ rabbit monoclonal antibody (1∶100: Cat. #2435: Cell Signaling Technology, Inc., Danvers, MA). Reactions were then visualized with diaminobenzidine

(19) Effect of Mulberry Leaf and Its Active Component, 1-Deoxynojirimycin, on Palmitic Acid-Induced Lipid Accumulation in HepG2 CellsBiomedicinesNovember 28, 2025Dahae Lee, Jiyeon Kim, Min Ji Han, Seon Hwa Kim, Tae Hoon Kim, Dae-Woon Eom, Inhyeok Song, Daesik Jeong, Noriko Yamabe, Ki Hyun Kimprimary antibodies (1:1000 dilution; Cell Signaling Technology) against the FAS (#4233S), PPAR-γ (#2435S), glyceraldehyde 3-phosphate dehydrogenase (#2118S) overnight at 4 °C, followed by incubation with secondary

(20) Optimizing adipogenic cocktail composition to enhance beige adipogenesis and evaluate thermogenic potential in primary mouse subcutaneous fat cell culturesInternational Journal of ObesityNovember 24, 2025Yujie Ma, Zijie Zhang, Erika Thalia Ramos, Elias Martin, Rahul Gunukula, Kara Sprabary, Heejin JunTotal OXPHOS Rodent WB Antibody Cocktail (1:2000, Abcam, #ab110413, Cambridge, MA, USA), PPARG (1:2000, Cell Signaling, #2435S, Danvers, MA, USA), HSP90 (1:5000, Cell Signaling, #4874S, Danvers, MA, USA) or β-actin (1:5000, Cell Signaling

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PPARgamma (C26H12) Rabbit mAb

PPARgamma (C26H12) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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PPARgamma (C26H12) Rabbit mAb from Cell Signaling Technology

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