Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb 2710S from Cell Signaling Technology

Product Specs
ItemPhospho-Syk (Tyr525/526) (C87C1) Rabbit mAb
CompanyCell Signaling Technology
Price $401.00 Inquire
Catalog Number2710S
Quantity100 µl
ApplicationsW, W-S, IP, IF-IC, FC-FP
ReactivityH
TargetSyk (Tyr525/Tyr526) phosphate
ModificationsSyk (Tyr525/Tyr526) phosphate
HostRabbit
NCBI Gene AliasesIMD82, p72-Syk
ClonalityMonoclonal
NCBI Full Gene Namespleen associated tyrosine kinase
Research AreaImmunology and Inflammation
IsotypeIgG
CloneC87C1
Molecular Weight72 kDa

Questions and Answers

What applications has the Phospho-Syk (Tyr525/526) antibody been shown to be effective in?

The Phospho-Syk (Tyr525/526) antibody has been shown to work effectively in applications such as Western blotting, flow cytometry, immunocytochemistry, immunofluorescence, and immunoprecipitation.

Can this antibody be used to study the role of Syk in immune responses, particularly in relation to fungal infections?

Yes, the antibody has been utilized in studies examining the role of Syk in immune responses, such as its activation in phagocytes during fungal infections like Candida albicans, where Syk signaling is critical for enhancing antifungal responses.

Is there evidence supporting the use of this antibody in research related to liver injury and inflammation?

Yes, the antibody has been referenced in studies investigating hepatic ischemia-reperfusion injury, where Syk activation was shown to exacerbate liver inflammation and injury, indicating its relevance in this area of research.

How does the Phospho-Syk (Tyr525/526) antibody contribute to understanding the mechanisms of viral infections?

The antibody has been used to elucidate the role of Syk in the STING-mediated immune response to viral infections, highlighting its importance in the phosphorylation of STING and subsequent interferon induction, which is crucial for antiviral defense.

Cell Signaling Technology

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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Codonopsis pilosula polysaccharide attenuates the inflammatory response in macrophages induced by Brucella abortus outer membrane protein 19 via regulating ATP2A1 to modulate cell adhesion and calcium signalingFront ImmunolJune 2, 2026Xuxu Wang, Zhiyong Zhou, Nan Zhang, Ziying Zhang, Xingyue Qi, Xingguang Zhang, Zhiguo Gong, Wuzhi Zhong, Kun Liu, Yuan ShenUSA), phospho-ERK (P-ERK) (Affinity, AF1015, USA), phospho-SYK (P-SYK) (Cell Signaling Technology, 2710T, USA), and phospho-FAK (P-FAK) (Affinity, AF3398, USA) were used. Primary antibodies were diluted as

(2) SYK Signalling in NLRP3 Inflammasome-Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgGEur J ImmunolMay 4, 2026Kristina Mašalaitė, Milda Norkienė, Aurelija Žvirblienė, Asta Lučiūnaitėantibodies used: anti‐NLRP3 (D4D8T) rabbit mAb (#15101), Phospho‐Syk (Tyr525/526) (C87C1) Rabbit mAb (#2710), and Phospho‐Zap‐70 (Tyr319)/Syk (Tyr352) rabbit pAb (#2701) from Cell Signaling Technology. Then,

(3) Non-receptor tyrosine kinase c-Abl downstream of C-type lectin receptors regulates innate antifungal immunity through c-Cbl/MAPK pathwayInfection and ImmunityMarch 10, 2026Shu-Jun Ma, Ke-Fang Xie, Jie-Lin Duan, Xian-Long Wang, Yi-Heng Yang, Ying Wang,Cell Signaling Technology phospho-c-Cbl,8869,Cell Signaling Technology c-Cbl,2747,Cell Signaling Technology phospho-Syk,2710,Cell Signaling Technology Syk,13198,Cell Signaling Technology β-Tubulin,2148,Cell Signaling Technology β-Actin,4970,Cell Signaling Technology

(4) Visomitin as a differentiation-inducing therapeutic agent through SYK inhibition in AMLFrontiers in PharmacologyFebruary 24, 2026Byeol-Eun Jeon, Chan-Seong Kwon, Ji-Eun Lee, Su-Ji Lee, Youngseuk Cho, Ho-Jin Shin, Sang-Woo Kim, Youngmi Jung(Cell Signaling Technology; 9718S), SYK (Santa Cruz Biotechnology; sc-1240), phospho-SYK (Cell Signaling Technology; 2710S), and β-actin (Santa Cruz Biotechnology; sc-4778). HRP-conjugated anti-rabbit and anti-mouse secondary

(5) Ring finger protein 213 regulates B-cell receptor signaling, metabolism, and development in B lymphocytesSignal Transduction and Targeted TherapyFebruary 18, 2026Ziyin Zhang, Nanshu Xiang, Qian Liu, Yanfeng Li, Linhua Wang, Xinpu Yang, Ju Liu, Lichen Zhang, Liaoxun Lu, Yinming Liang, et al.and immunoblotting was performed with the following antibodies: anti-pSYK (Cell Signaling Technology, CST, 2710S), anti-SYK (CST, 13198S), anti-pCD19 (CST, 3571S), anti-CD19 (CST, 90176S), anti-β-actin (Proteintech,

(6) Viscoelastic hydrogel primed CAR-macrophage for pulmonary fibrosis treatmentNature CommunicationsFebruary 13, 2026Yan Zhang, Zhiqiang Liu, Wenyu Kong, Yanxiao Ao, Rui Zhang, Yanan DuF(ab’)2, 115-065-072, Jackson; anti-FAP, ab53066, Abcam; anti-α-SMA, MA5-11547, Invitrogen; anti-p-SYK, 2710 T, Cell Signaling Technology; anti-p-ERK1/2, 4377S, Cell Signaling Technology; anti-p-JNK, 1255S, Cell

(7) Syk activation during FcγR-mediated phagocytosis involves Syk palmitoylation and desulfenylationLife Sci AllianceFebruary 4, 2026Maxime Jansen, Jean-Marc Strub, Laurent Chaloin, Peter Coopman, Bruno Beaumelleanti-rabbit light chain-peroxidase. Syk phosphorylation on mSyk-Tyr519/520 was followed using CST# 2710 and mouse anti-rabbit light chain-peroxidase. Sulfenylation assays After SRBC phagocytosis or NAC

(8) Paeoniflorin Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by SYK/SH3BP2 Signaling PathwayResearch (Wash D C)February 2, 2026Yuqing Liu, Jie Tao, Dongyu Tan, Feifan Zheng, Zhuoxuan Su, Jianfeng Yuan, Chunmei Zhu, Zhensen Zheng, Xiuteng Zhou, Duosheng Luo1:1,000), α-tubulin (66031, Proteintech, 1:20,000), GAPDH (60004-1-IG, Proteintech, 1:6,000), Phospho-Syk (2710T, CST, 1:1,000), Syk (2712T, CST, 1:1,000), SH3BP2 (PA5-87739, Invitrogen, 1:1,000), Goat anti-Mouse

(9) SYK Activation Enhances Dendritic Cell Functions in Spontaneous Rheumatoid ArthritisInflammationDecember 30, 2025Zhiyang Zeng, Xiya Cao, Haozhe Guo, Yuxuan Lai, Weihua Yang, Youyuan He, Jialiang Sun, Zhenliang Sun, Dali Li, Yamin Tanspecific for pSyk (Tyr525/526) (Cell Signaling Technology, 13198), Syk (Cell Signaling Technology, 2710), pErk1/2 (T202/Y204) (Cell Signaling Technology, 9201), Total Erk1/2 (Cell Signaling Technology, 4695),

(10) Characterization of Novel Variants in P2YRY12, GP6 and TBXAS1 in Patients with Lifelong History of BleedingBiomoleculesNovember 21, 2025Ana Zamora-Cánovas, Ana Marín-Quílez, Lorena Díaz-Ajenjo, Ana Sánchez-Fuentes, Pedro Luis Gómez-González, Marilena Crescente, Nuria Fernández-Mosteirín, José Padilla, José Ramón González-Porras, Rocío Benito, et al.primary antibodies anti-Phospho SYK (Tyr525/526) (Cell Signaling Technology, Danvers, MA, USA, rabbit, #2710, 1:1000), anti-Phospho-LAT (Tyr220) (Cell Signaling Technology, Rabbit #3584, 1:200), anti-Syk (4D10)

(11) Natural killer cell-specific chimeric antigen receptor enhances CAR NK cell functions and anti-tumor activityTheranosticsNovember 6, 2025Changqing Pan, You Zhai, Zhongliang Cui, Yiyun Yin, Menghui Xu, Di Wang, Yishuo Sun, Jiazheng Zhang, Chen Wang, Ziwei Li, et al.incubated overnight at 4 °C with primary antibodies: SYK (Tyr525/526; Cell Signaling Technology, Cat# 2710), SYK (Cell Signaling Technology, Cat# 2712), ZAP70 (Tyr319; Cell Signaling Technology, Cat# 2701),

(12) Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infectionsImmunitySeptember 9, 2025Marco Di Gioia, Valentina Poli, Piao J. Tan, Roberto Spreafico, Anne Chu, Alex G. Cuenca, Zhongyang Wu, Mehdi Benamar, Laura Pandolfi, Federica Meloni, et al.,Cell Signaling Technology,Cat# 4257; RRID: AB_659889 Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb,Cell Signaling Technology,Cat# 2710; RRID: AB_2197222 Syk (D3Z1E) XP® Rabbit Antibody,Cell Signaling Technology,Cat# 13198; RRID: AB_2687924 Phospho-mTOR (Ser2448) (D9C2) XP® Rabbit mAb

(13) Swiprosin-1 Negatively Regulates Osteoclast Differentiation and Bone Resorption via Akt/MAPK/NF-κB Pathway and αvβ3 Integrin-Dependent SignalingInternational Journal of Molecular SciencesSeptember 4, 2025Yoon-Hee Cheon, Sung Chul Kwak, Chong Hyuk Chung, Chang Hoon Lee, Myeung Su Lee, Ju-Young Kimp-PLCγ2 (#3874), cortactin (#3502), p-cortactin (#4569), Src (#2123, 32G6), p-Src (#6943, D49G4), p-Syk (#2710, C87C1), Cbl (#2747), and p-Cbl (#3555) were supplied by Cell Signaling Technology (Beverly, MA, USA).

(14) AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progressionNat CommunJuly 29, 2025Qiaohua Wang, Yongjian Wu, Yili Long, Rongna Li, Yu Shi, Yanfen Zheng, Xiaohui Chen, Xiang Li, Yihong Zhou, Xi Huang, et al.(Cell Signalling Technology, 2712, 1:1000), Phospho-Syk (Tyr525/526) (C87C1) mAb (Cell Signalling Technology, 2710, 1:1000), ROR gamma (t) mAb (AFKJS-9) (Thermo Fisher Scientific, 14-6988-80, 1:1000), Anti-beta-Actin

(15) Unique compound with anti-allergic action: inhibition of Lyn kinase activity by KIRA6Front PharmacolJuly 25, 2025Goshi Matsushima, Yuri Matsui, Hanano Okamoto, Nagisa Umeda, Mai Kakimoto, Megumi Mino, Tadashi Nakagawa, Kaori Ishii, Yoshimi Matsuo, Daiki Matsubara, et al.Immunoblotting was performed using anti-Syk (#2712; Cell Signaling) and anti-phospho Syk (Tyr525/526; #2710; Cell Signaling) antibodies at 4 °C overnight. Horseradish peroxidase-conjugated secondary antibodies

(16) Ganoderma lucidum spore oil alleviates psychological stress-evoked tumor progression by enhancing FcγR-mediated macrophage phagocytosisChin MedJuly 14, 2025Dong-Dong Li, Zi-Xuan Li, Yang-Fan Zhou, Ling Jin, Wan-Li Liang, Wen-Dong Xu, Xiang Luo, Guan-Di Xiao, Qi-Jun Chen, Ting Xie, et al.Cell Signaling Technology, USA) and anti-phosphorylated spleen tyrosine kinase antibody (p-SYK) (Cat#: 2710 s, Cell Signaling Technology, USA). CID16020046 (Cat#: C288401, Shanghai Aladdin Biochemical Technology

(17) Salvia miltiorrhiza Root Extract as a Potential Therapeutic Agent for IgE/Ag-Induced Allergic Reactions and Atopic Dermatitis via the Syk/MAPK PathwayBiomedicinesJune 25, 2025Min-ah Kim, Jin-Ho Lee, Keunjung Woo, Eunwoo Jeong, Tack-Joong KimBuckinghamshire, UK). The antibodies used in the study are as follows: β-actin (4967S), Syk (12358S), p-Syk (2710S), ERK (4695S), p-ERK (4377S), JNK (9252S), p-JNK (9251S), AKT (9272S), and p-AKT (9271S; Cell Signaling Technology

(18) EPHA5 regulates antifungal innate immunity by phosphorylating EPHB2 and Dectin-1PLoS PathogJune 9, 2025Ru Gao, Heping Wang, Zhihui Cui, Yanyun Du, Ruirui He, Lingyun Feng, Bo Zeng, Yangyang Li, Guoling Huang, Ting Pan, et al.anti-JNK1, anti-p-Syk, and anti-EPHB2, all of which were purchased from CST (cat. no. 5209S, 4668S, 3708S, 2710S, and 83029S). Anti-EPHA5, anti-Flag, and anti-HA antibodies were obtained from ABclonal (cat. no. A14238,

(19) Hancinone possesses potentials on increasing the ability of HMC3 cells to phagocytosis of Aβ1-42 via TREM2/Syk/PI3K/AKT/mTOR signaling pathwayPLoS OneMay 27, 2025Yushun Zhou, Guran Yu, Hao Li(FBS) was purchased from Yuanyi Biotechnology Co., Ltd. Phospho-Syk (Try525/526) antibody (Cat No: #2710), Syk antibody (Cat No: #13198) and phospho- AKT(Ser473) antibody (Cat No: #4060) were obtained from

(20) Drug screening targeting TREM2-TYROBP transmembrane bindingMol MedMay 5, 2025M. Cobas-Carreño, A. Esteban-Martos, L. Tomas-Gallardo, I. Iribarren, L. Gonzalez-Palma, A. Rivera-Ramos, J. Elena-Guerra, E. Alarcon-Martin, R. Ruiz, M. J. Bravo, et al.BCA in TBS. Membranes were then incubated with the different antibodies overnight at 4 °C (anti-hSYK #2710, anti-hPhospho-SYK #2712 from Cell Signaling were used according to manufacturer’s instructions), followed

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Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb

Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb from Cell Signaling Technology

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