Phospho-MAPKAPK-2 (Thr222) (9A7) Rabbit mAb 3316S from Cell Signaling Technology

Product Specs
ItemPhospho-MAPKAPK-2 (Thr222) (9A7) Rabbit mAb
CompanyCell Signaling Technology
Price $397.00 Inquire
Catalog Number3316S
Quantity100 µl
ApplicationsW
ReactivityH, M, R, Mk
TargetMAPKAPK-2 (Thr222) phosphate
IsotypeIgG
Molecular Weight49
ModificationsMAPKAPK-2 (Thr222) phosphate
Clone9A7
HostRabbit
NCBI Full Gene NameMAPK activated protein kinase 2
NCBI Gene AliasesMAPKAP-K2, MK-2, MK2
ClonalityMonoclonal
Research AreaMAP Kinase Signaling

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Nucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growthNat CommunAugust 4, 2025Gaoxiang Zhao, Shudi Luo, Hong Zhao, Qingxia Ma, Hongfei Jiang, Lin Wang, Juanjuan Liu, Dong Guo, Runze Wang, Qianqian Xu, et al.(#2101), Acetyl-CoA Carboxylase (ACC) (#3676S), ACC pS79 (#11818S), MAPK/APK2 (#3042), MAPKAPK-2 pT222 (#3316S), HRP-conjugated goat anti-mouse (#7076) and anti-rabbit (#7074) secondary antibodies were purchased

(2) Ezrin defines TSC complex activation at endosomal compartments through EGFR–AKT signalingElifeFebruary 12, 2025Giuliana Giamundo, Daniela Intartaglia, Eugenio Del Prete, Elena Polishchuk, Fabrizio Andreone, Marzia Ognibene, Sara Buonocore, Bruno Hay Mele, Francesco Giuseppe Salierno, Jlenia Monfregola, et al.anti-MAPKAPK-2 (1:1000, Cell Signaling 3042), rabbit anti-phospho-MAPKAPK-2 (Thr222) (1:1000, Cell Signaling 3316), rabbit anti-p38 MAPK (1:1000, Cell Signaling 8690), rabbit anti-phospho-p38 MAPK (Thr180/Tyr182) (1:1000,

(3) Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signalingElifeFebruary 12, 2025Giuliana Giamundo, Daniela Intartaglia, Eugenio Del Del Prete, Elena Polishchuk, Fabrizio Andreone, Marzia Ognibene, Sara Buonocore, Bruno Hay Hay Mele, Francesco Giuseppe Salierno, Jlenia Monfregola, et al.anti-MAPKAPK-2 (1:1000, Cell Signaling 3042), rabbit anti-phospho-MAPKAPK-2 (Thr222) (1:1000, Cell Signaling 3316), rabbit anti-p38 MAPK (1:1000, Cell Signaling 8690), rabbit anti-phospho-p38 MAPK (Thr180/Tyr182) (1:1000,

(4) Noncanonical role of Golgi-associated macrophage TAZ in chronic inflammation and tumorigenesisSci AdvJanuary 24, 2025So Yeon Park, Sungeun Ju, Jaehoon Lee, Hwa-Ryeon Kim, Yujin Sub, Dong Jin Park, Seyeon Park, Doru Kwon, Hyeok Gu Kang, Ji Eun Shin, et al.9153), ERK1/2 (CST, no. 4377), p-ERK1/2 (CST, no. 4695), p-p38 MAPK (CST, no. 8690), p-MK2 (CST, no. 3316), p65 (CST, no. 8242), p-p65 (CST, no. 3033), p-STAT3 (CST, no. 9145), p-STAT5 (CST, no. 9351), p-STAT6

(5) Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s diseaseNeuronJanuary 22, 2025Pourya Naderi Naderi Yeganeh, Sang Su Kwak, Mehdi Jorfi, Katjuša Koler, Thejesh Kalatturu, Djuna von Maydell, Zhiqing Liu, Kevin Guo, Younjung Choi, Joseph Park, et al.,Cell Signaling Technologies,Cat. # 3489; RRID:AB_2285349 Anti-phospho-MAPKAPK-2 (T222),Cell Signaling Technologies,Cat. # 3316; RRID:AB_2141311 Anti-MAPKAPK-2,Cell Signaling Technologies,Cat. # 12155; RRID:AB_2797831 Anti-phospho-HSP27

(6) Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume controlCell Death & DiseaseJanuary 22, 2024Daric J. Wible, Zalak Parikh, Eun Jeong Cho, Miao-Der Chen, Collene R. Jeter, Somshuvra Mukhopadhyay, Kevin N. Dalby, Shankar Varadarajan, Shawn B. Bratton(#2339), phospho-p38α (pThr-180/pThr-182; #9216), phospho-hsp27 (pSer-82; #2406), phospho-MK2 (pThr-222; #3316), Rab7 (#95746), and Rab9 (#5118) were purchased from Cell Signaling Technology (Danvers, MA). Recombinant

(7) MKL1 fuels ROS-induced proliferation of vascular smooth muscle cells by modulating FOXM1 transcriptionRedox biologyFebruary 1, 2023Wu T, Li N, Zhang Q, Liu R, Zhao H, Fan Z, Zhuo L, Yang Y, Xu Y.(Cell Signaling Tech, 9631), anti-MK2 (Cell Signaling Tech, 3042), anti-phosphorylated MK2 (Cell Signaling Tech, 3316), and anti-β-actin (Sigma, A2228). 2.7 Histology Histological analyses were performed essentially

(8) N-benzyl-N-methyldecan-1-amine and its derivative mitigate 2,4- dinitrobenzenesulfonic acid-induced colitis and collagen-induced rheumatoid arthritisFrontiers in pharmacologyJanuary 1, 2023Kim JE, Kang C, Budluang P, Yawut N, Cho IR, Choi YJ, Kim J, Ju S, Lee B, Sohn DH, et al.(Cat. No; 3042s), NF-κB (Cat. No; 4764) and their phospho-specific antibodies (Cat. No; 9255s, 9216s, 3316s, and 3033s, respectively) were acquired from Cell Signaling Technology (Danvers, MA, United States).

(9) CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3pMolecular CancerDecember 1, 2022Yong Xi, Yaxing Shen, Donglei Wu, Jingtao Zhang, Chengbin Lin, Lijie Wang, Chaoqun Yu, Bentong Yu, Weiyu ShenMillipore) was used to develop the films. The primary antibodies against GPX4 (#52455, 1:2000) and GAPDH (#3316 s, 1:2000) were purchased from Cell Signaling Technology (Danvers, MA, USA). Luciferase reporter assay Dual-luciferase

(10) MYD88 signals induce tumour-initiating cell generation through the NF-κB-HIF-1α activation cascadeScientific reportsFebruary 17, 2021Tanimura A, Nakazato A, Tanaka N.Cell Signaling Technology, Inc.), p38 (#9212; Cell Signaling Technology, Inc.), phosphor-MAPKAP2 (#3316; Cell Signaling Technology, Inc.), and MAPKAP2 (#12155; Cell Signaling Technology, Inc.). Immunofluorescence

(11) MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate KinasesStructureOctober 1, 2020Péter Sok et al.Thr218/Tyr220; Cell Signaling #3371), phospho-MK2 antibody (Phospho-MAPKAPK-2 T222 Rabbit; Cell Signaling #3316S), and phospho-RSK1 antibody (phospho-p90RSK Thr573; Cell Signaling #9346). The phosphorylation state

(12) WIP1 promotes cancer stem cell properties by inhibiting p38 MAPK in NSCLCSignal transduction and targeted therapyApril 15, 2020Deng K, Liu L, Tan X, Zhang Z, Li J, Ou Y, Wang X, Yang S, Xiang R, Sun P.anti-MAPKAPK-2 (Cell Signaling Technology, #3042), anti-phospho-MAPKAPK-2 (Thr222) (Cell Signaling Technology, #3316), anti-phospho-MAPKAPK-2 (Thr334) (Cell Signaling Technology, #3041), anti-HSP27 (Cell Signaling Technology,

(13) MAPKAPK2 (MK2) inhibition mediates radiation-induced inflammatory cytokine production and tumor growth in head and neck squamous cell carcinomaOncogeneNovember 28, 2019Kiersten L. Berggren, Sebastian Restrepo Restrepo Cruz, Michael D. Hixon, Andrew T. Cowan, Stephen B. Keysar, Stephanie Craig, Jacqueline James, Marc Barry, Michelle A. Ozbun, Antonio Jimeno, et al.antibodies from Cell Signaling Technologies: MK2 (#12155; clone D1E11; 1:10,000 dilution), p-MK2 (#3316; Thr222, clone 9A7; 1:1,000 dilution), HSP27 (#2402; clone G31; 1:10,000 dilution), p-HSP27 (#9709;

(14) Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics dataMolecular Systems BiologyAugust 6, 2019Alexander Schäfer, Enio Gjerga, Richard WD Welford, Imke Renz, Francois Lehembre, Peter MA Groenen, Julio Saez‐Rodriguez, Ruedi Aebersold, Matthias Gstaiger(6967), PKA motif (9624), pS6 S235/6 (4858), pRB S807/11 (8516), CaMKII S286 (12716), pMAPKAPK2 T222 (3316), p‐cJun S73 (3270), p‐cRAF S338 (9427), pACC S79 (11818), pHSP27 S82 (9709), AKT (4691) and CREB (9197)].

(15) Protein imbalance in the development of skeletal muscle wasting in tumour-bearing miceJournal of Cachexia, Sarcopenia and MuscleOctober 16, 2018Jacob L. Brown et al.p‐p38 MAPK (Cell Signaling 9211, T 180/182), p38 MAPK (Cell Signaling 9212), p‐MAPK APK (Cell Signaling 3316S, T 222), and MAPK APK (Cell Signaling (3042S) isolated from rabbit and mouse. Antibodies were diluted

(16) ILâ€‘1Î² and TNFâ€‘Î± suppress TGFâ€‘Î²â€‘promoted NGF expression in periodontal ligamentâ€‘derived fibroblasts through inactivation of TGFâ€‘Î²â€‘induced Smad2/3â€‘ and p38 MAPKâ€‘mediated signalsInternational Journal of Molecular MedicineJune 4, 2018Maiko Ohta, Naoyuki Chosa, Seiko Kyakumoto, Seiji Yokota, Naoto Okubo, Akira Nemoto, Masaharu Kamo, Shigeharu Joh, Kenichi Satoh, Akira Ishisakianti‑phospho‑MAPKAPK‑2 (Thr222), anti‑JNK and anti‑phospho‑JNK rabbit antibodies (1:1,000; cat. nos. 8828, 9212, 9211, 12155, 3316, 9252S and 9251S, respectively; Cell Signaling Technology, Inc.). Next, the blots were incubated with

(17) IL-1Î² and TNF-Î± suppress TGF-Î²-promoted NGF expression in periodontal ligament-derived fibroblasts through inactivation of TGF-Î²-induced Smad2/3- and p38 MAPK-mediated signalsInt. J. Mol. MedJune 4, 2018Maiko Ohta, Naoyuki Chosa, Seiko Kyakumoto, Seiji Yokota, Naoto Okubo, Akira Nemoto, Masaharu Kamo, Shigeharu Joh, Kenichi Satoh, Akira Ishisakianti‑phospho‑MAPKAPK‑2 (Thr222), anti‑JNK and anti‑phospho‑JNK rabbit antibodies (1:1,000; cat. nos. 8828, 9212, 9211, 12155, 3316, 9252S and 9251S, respectively; Cell Signaling Technology, Inc.). Next, the blots were incubated with

(18) The regulator of calcineurin 1 increases adenine nucleotide translocator 1 and leads to mitochondrial dysfunctionsJournal of neurochemistryJanuary 1, 2017Jiang H, Zhang C, Tang Y, Zhao J, Wang T, Liu H, Sun X.

(19) p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and agingPloS oneJanuary 1, 2017Tormos AM, Rius-Pérez S, Jorques M, Rada P, Ramirez L, Valverde ÁM, Nebreda ÁR, Sastre J, Taléns-Visconti R.p-MKK3/6 (Ser189/ 207) (9231), p-MKK4 (Ser257/Thr261) (9156), p-MK2 (Thr334) (3007), p-MK2 (Thr222) (3316), p-p38 (Thr 180/Tyr188) (4511XP), p-MNK1(Thr197/202) (2111), p27 (2552), from Cell Signaling Technology.

(20) Vascular endothelial growth factor suppresses TNFSF15 production in endothelial cells by stimulating miR-31 and miR-20a expression via activation of Akt and Erk signalsFEBS open bioJanuary 1, 2017Deng HT, Liu HL, Zhai BB, Zhang K, Xu GC, Peng XM, Zhang QZ, Li LY.for Phospho‐akt (#12178s, 1 : 2000), Akt (#4691s, 1 : 2000), Phospho‐erk (#4370p, 1 : 2000), Erk (#3316s, 1 : 2000) were purchased from Cell Signaling Technology (Danvers, MA, USA). Statistical analysis At

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Phospho-MAPKAPK-2 (Thr222) (9A7) Rabbit mAb

Phospho-MAPKAPK-2 (Thr222) (9A7) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Phospho-MAPKAPK-2 (Thr222) (9A7) Rabbit mAb from Cell Signaling Technology

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