PKM1/2 (C103A3) Rabbit mAb 3190S from Cell Signaling Technology

Product Specs
ItemPKM1/2 (C103A3) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number3190S
Quantity100 µl
ApplicationsW, IF-IC
ReactivityH, M, R, Mk
TargetPKM1/2
HostRabbit
NCBI Gene AliasesCTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1, p58
ClonalityMonoclonal
NCBI Full Gene Namepyruvate kinase M1/2
Research AreaMetabolism
CloneC103A3
Molecular Weight60

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) ASO-based PKM splice-switching therapy increases anti-CTLA-4 antibody efficacy in pancreatic ductal adenocarcinomaCell DiscovApril 21, 2026Lijie Han, Lina Gan, Balázs Schäfer, Dillon M. Voss, Mathias Danielsen, Ondrej Kostov, Jia Liu, Ting Wang, Marvin H. Caruthers, Hao Chen, et al.Technology, rabbit monoclonal, 7067S), anti-PKM1/2 (1:1000; Cell Signaling Technology, rabbit monoclonal, 3190S), anti-β-actin (1:1000; Sigma‒Aldrich, mouse monoclonal, A1978) or anti-vinculin (1:1000; Santa Cruz

(2) TDP-43 impairs glycolysis by sequestering hexokinase 1 in amyotrophic lateral sclerosisActa NeuropatholMarch 16, 2026Cassandra Barone, Rihua Wang, Sarah Cooke, Hang Pong Ng, Rodolfo S. Ferreira, Helen C. Miranda, Xin Qifollowing antibodies against HK1 (C35C4) (#2024; IF-tissue 1:50, IF-cells 1:500) and PKM1/2 (C103A3) (#3190; IF-cells 1:500, WB 1:2000) were from Cell Signaling (Danvers, MA, USA). The antibodies against Actin

(3) Cooperative CCL2/CCR2 and HGF/MET signaling enhances breast cancer growth and invasion associated with metabolic reprogrammingCancer Biology & TherapyDecember 31, 2025Wei Fang, Yuuka Kozai, Diana S. Acevedo, Rebecca Brodine, Haasini S. Gorrepati, Nizhoni Arviso, Paige Cote, Alala Thompson, Zachary Gerdes, Ashley Espinoza, et al.sc -377,228), HK2 (Cell Signaling Technology, cat no.2867), PKM1/2 (Cell Signaling Technology, cat no.3190S), LDHA (Santa Cruz Biotechnology, cat no.sc -137,243), phospho-AMPKα Thr172 (Cell Signaling Technology

(4) Ailanthone induces apoptosis in U-2OS cells through the endoplasmic reticulum stressFront ImmunolOctober 2, 2025Yue Zhang, Taiding Wu, Chang Li, Nianfang Luo, Jun Wang, Jingxian Li, Min Tian, Lei Liu, Ruiting Li, Jingyi ZhangTween 20 (TBST) for 1 h at room temperature. Primary antibodies against PERK (1:1000 dilution, cat no. 3190, Cell Signaling Technology, Danvers, MA, USA), eIF2α (1:2000 dilution, cat no. 3398, Cell Signaling Technology

(5) HDAC inhibitor MS275 reprograms metabolism to induce differentiation and suppress proliferation in hepatocellular carcinomaFrontiers in ImmunologySeptember 16, 2025Jingjie Li, Cheng Hu, Yuyu Ye, Song Wei, Wenbo Zhu, Jiankai Liang, Jing Cai, Yuan Lin, Liang Peng, Guangmei Yan, et al.HNF3A (1:1000; CST, 58613), PKM1 (1:1000; CST, 7067), PKM2 (1:1000; CST, 4053), PKM1/2 (1:1000; CST, 3190), GAPDH (1:1000; CST, 2146),Hexokinase I (1:1000; CST, 2024), Hexokinase II (1:1000; CST, 2867), PD

(6) DPP-4 inhibitor linagliptin modulates myocardial metabolism in a model of coronary artery diseaseJTCVS OpenSeptember 12, 2025Kelsey C. Muir, Dwight D. Harris, Christopher Stone, Meghamsh Kanuparthy, Jad Hamze, Frank W. Sellke,Cell Signaling,11954 LDHA,Cell Signaling,3582 HK2,Cell Signaling,2867 PFKP,Cell Signaling,8164 PKM1/2,Cell Signaling,3190 SDHA,Cell Signaling,5839 Antibodies

(7) Immunoassay for pyruvate kinase M1/2 as an Alzheimer's biomarker in CSFOpen Life SciJuly 7, 2025Matthijs B. de Geus, Pia Kivisäkk, Bianca A. Trombetta, Betty M. Tijms, Pieter Jelle Visser, Steven E. Arnold, Becky C. Carlylespecifically quantify PKM in CSF. Two PKM rabbit monoclonal antibodies, C103A3 (Cell Signaling Technology, #3190) and C5E6 (Cell Signaling Technology, #3106), were obtained in carrier-free solution, and stored at

(8) Gut microbiota-derived indole-3-propionic acid alleviates diabetic kidney disease through its mitochondrial protective effect via reducing ubiquitination mediated-degradation of SIRT1Journal of Advanced ResearchJuly 1, 2025Yan Zeng, Man Guo, Qi Wu, Xiaozhen Tan, Chunxia Jiang, Fangyuan Teng, Jiao Chen, Fanjie Zhang, Xiumei Ma, Xinyue Li, et al.131368, Abcam, USA), Tubulin (cat. 3163, Bioworlde, USA), β-actin (cat. 3700, CST, USA), Histone H3 (cat. 3190, Bioworlde, USA), HRP-labeled goat anti-mouse/ rabbit IgG(H + L) (cat. 0216/cat. 0208, Beyotime, China),

(9) Defining Biological Variability, Analytical Precision and Quantitative Biophysiochemical Characterization of Human Urinary Extracellular VesiclesJournal of extracellular vesiclesMay 1, 2025Aksamitiene E, Park J, Marjanovic M, Boppart SA.C103A3), anti‐GAPDH (D16H11) XP (Cell Signaling Technology, Danvers, MA, #3501, #3205, #4866, #4850, #3190, and #5174, respectively) rabbit monoclonal antibodies, anti‐Flotillin 1 (Clone 18) (BD Biosciences,

(10) Fragile X messenger ribonucleoprotein 1 (FMRP) regulates glycolytic gene expression under chronic hypoxia in HCT116 cellsSci RepApril 17, 2025Yoko Ogura, Xiaoning Sun, Zaijun Zhang, Kentaro Kawata, Jinyu Wu, Ryuma Matsubara, Atsuko Nakanishi Ozeki, Kenzui Taniue, Rena Onoguchi-Mizutani, Shungo Adachi, et al.anti-PFKL,IgG,1:1000,"Abcam, Cat#ab181064" Mouse monoclonal anti-PKM1/2,IgG,1:5000,"Cell signaling technology, Cat#3190s" Mouse monoclonal anti-β-actin,IgG,1:2000,"MBL, Cat#M177-3" Polyclonal anti-rabbit IgG/HRP,IgG,1:5000,"Cell signaling technology

(11) ATF6β is not essential for the development of physiological cardiac hypertrophyPLoS OneApril 7, 2025Emery Davis, Mohammad-Reza Shokri, Mary B. Rowland, Thomas York, Caroline T. Cohen, Anna Grace Johnson, Patrick E. Moore, Saige Schweitzer, Jon Sin, Chuong Bui, et al.(Cell Signaling Technology); LDHA (C4B5) #3582, 1:1000 (Cell Signaling Technology); PKM1/2 (C103A3) #3190, 1:1000 (Cell Signaling Technology); and PFKP (D4B2) #8164, 1:1000 (Cell Signaling Technology). Secondary

(12) Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activationNature MetabolismFebruary 19, 2025Alva M. Casey, Dylan G. Ryan, Hiran A. Prag, Suvagata Roy Chowdhury, Eloïse Marques, Keira Turner, Anja V. Gruszczyk, Ming Yang, Dane M. Wolf, Jan Lj. Miljkovic, et al.IL-1β (12507), GAPDH (5174), gasdermin D (E9S1X) (39754), hexokinase I (2024T), NLRP3 (15101), PKM1/2 (3190), PKM2 (4053T), pyruvate dehydrogenase (3205) and VDAC (4661) antibodies were purchased from Cell Signaling.

(13) Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-α breast cancer riskCell Reports MedicineJanuary 21, 2025Alana A. Arnone, Yu-Ting Tsai, J. Mark Cline, Adam S. Wilson, Brian Westwood, Meghan E. Seger, Akiko Chiba, Marissa Howard-McNatt, Edward A. Levine, Alexandra Thomas, et al.Membranes were incubated overnight at 4°C with primary antibodies Pyruvate Kinase (PKM1/2; Cell Signaling, #3190) and α-tubulin (Cell Signaling, # 2144) at a 1:1000 dilution. The next day, membranes were washed and

(14) Local glycolysis supports injury-induced axonal regenerationJournal of Cell BiologyDecember 2, 2024Luca Masin, Steven Bergmans, Annelies Van Dyck, Karl Farrow, Lies De Groef, Lieve Moons12746, RRID:AB_2736917; Cell Signaling Technology), rabbit monoclonal anti-PKM1/2 (clone C103A3, Cat# 3190, RRID:AB_2163695; Cell Signaling Technology), rabbit monoclonal anti-LDHA (clone C4B5, Cat# 3582, RRID:AB_2066887,

(15) O-GlcNAcylation mediates Wnt-stimulated bone formation by rewiring aerobic glycolysisEMBO ReportsSeptember 10, 2024Chengjia You, Fangyuan Shen, Puying Yang, Jingyao Cui, Qiaoyue Ren, Moyu Liu, Yujie Hu, Boer Li, Ling Ye, Yu Shiab06699, 1:1000), anti-PFK1 (Novus Biologicals, JU53-31, 1:1000), anti-PKM1/2 (Cell Signaling Technology, #3190, 1:1000), anti-LDHA (Proteintech, 19987-1-AP, 1:2000), anti-PDK1 (Enzo, ADI-KAP-PK112-D, 1:1000), anti-β-catenin

(16) Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activationSignal Transduction and Targeted TherapyAugust 15, 2024Tao Zhang, Zilu Pan, Jing Gao, Qingqing Wu, Gang Bai, Yan Li, Linjiang Tong, Fang Feng, Mengzhen Lai, Yingqiang Liu, et al.(Cell Signaling Technology, #8164S), LDHA (Cell Signaling Technology, #3582S), PKM1/2 (Cell Signaling Technology, #3190S). The membranes were washed with TBS-T and then incubated with secondary antibodies. After another wash

(17) A tipping point in dihydroxyacetone exposure: mitochondrial stress and metabolic reprogramming alter survival in rat cardiomyocytes H9c2 cellsChemico-Biological InteractionsMay 1, 2024Arlet Hernandez, Luxene Belfleur, Marie Migaud, Natalie R. Gassman,Cell Signaling PARP-1 (556494),"BD Biosciences, Franklin Lakes, NJ, USA" PDH (3205),Cell Signaling PKM1/2 (3190),Cell Signaling SOD2 (13141),Cell Signaling TKFC (HPA039486),"Sigma Aldrich, St. Louis, MO, USA" Tom20

(18) Apoptin Inhibits Glycolysis and Regulates Autophagy by Targeting Pyruvate Kinase M2 (PKM2) in Lung Cancer A549 CellsCurrent Cancer Drug TargetsApril 1, 2024Gaojie Song, Chao Shang, Yilong Zhu, Zhiru Xiu, Yaru Li, Xia Yang, Chenchen Ge, Jicheng Han, Ningyi Jin, Yiquan Li, et al.PKM2 (cat. NO. 4053), HK1 (cat. NO. 2024), HK2 (cat. NO. 2867), LDHA (cat. NO. 3582), PKM1 (cat. NO. 3190), PARP (cat. NO. 9532), Beclin-1 (cat. NO. 3495), Phospho-ULK1 (cat. NO. 14202), ULK1 (cat. NO. 8054),

(19) Epigenetically active chromatin in neonatal iWAT reveals GABPα as a potential regulator of beige adipogenesisFrontiers in endocrinologyJanuary 1, 2024Mooli RGR, Zhu B, Khan SR, Nagati V, Michealraj KA, Jurczak MJ, Ramakrishnan SK.,Cell Signaling Technology 4,H3K9ac,#9649,Cell Signaling Technology 5,GABPα,Sc-28312,Santa Cruz Biotechnology 6,PKM1/2,#3190,Cell Signaling Technology 7,HK2,#2867,Cell Signaling Technology 8,LDHA,#3582,Cell Signaling Technology 9,PGC-1α,ab54481,Abcam 10,SDHA,#5839,Cell Signaling Technology

(20) Pyruvate kinase M in germ cells is essential for sperm motility and male fertility but not spermatogenesisAsian Journal of AndrologyJanuary 1, 2024Gao-Qing Qian, Xiao-Chen Wang, Xi Zhang, Bin Shen, Qiang LiuMillipore, Darmstadt, Germany), as well as a rabbit monoclonal antibody against PKM1/2 (1:1000; mAb #3190; Cell Signaling Technology, Danvers, MA, USA) at 4°C. Following three tris-buffered saline with 0.1%

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PKM1/2 (C103A3) Rabbit mAb

PKM1/2 (C103A3) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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PKM1/2 (C103A3) Rabbit mAb from Cell Signaling Technology

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