Fibrillarin (C13C3) Rabbit mAb 2639S from Cell Signaling Technology

Product Specs
ItemFibrillarin (C13C3) Rabbit mAb
CompanyCell Signaling Technology
Price $336.00 Inquire
Catalog Number2639S
Quantity100 µl
ApplicationsW, IF-F, IF-IC
ReactivityH, M, R, Mk
TargetFibrillarin
HostRabbit
NCBI Gene AliasesFIB, FLRN, Nop1, RNU3IP1
ClonalityMonoclonal
NCBI Full Gene Namefibrillarin
Research AreaCytoskeletal Signaling
CloneC13C3
Molecular Weight37

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5′-cap trimethylationGenes & DevelopmentApril 1, 2026Aniruddha Samajdar, Roberta Amato, Seongmoon Jo, Ethan Cordes, Albert Tai, Grazia Daniela Raffa, Luis F.Z. BatistaStellaris probes and a rabbit monoclonal antifibrillarin antibody (1:100; Cell Signaling Technology 2639T). Subsequently, cells were washed three times for 5 min each at room temperature with wash buffer, incubated

(2) Biosensor-Guided Discovery of Peptide Inhibitors Targeting the Ribosomal Protein uS5-PDCD2 Chaperone InteractionJournal of Biological ChemistryMarch 31, 2026Zabih Mir Mir Hassani, Frédérique Goulet, Duc Tai Nguyen, Anne-Marie Landry-Voyer, Lauren Kwiatek, Shany Gaudet, Pierre-Luc Boudreault, Taha Azad, François BachandGFP fluorescence. DAPI (Sigma, #D9542) and antibody staining against Fibrillarin (Cell Signalling, #2639) were used to stain nucleus and nucleolus, respectively. Flag-PDCD2 was stained using anti-Flag (Sigma,

(3) The EHMT2-MBLAC2 axis suppresses ribosomal DNA transcription in response to nucleolar DNA damageCell Death & DiseaseMarch 18, 2026Chenyue Wang, Qiutian Lu, Lianbao Cao, Simeng Zeng, Zihan Gao, Yinglong Yang, Xiaowen Liu, Shanshan Gao, Chao Dongimmunofluorescence (IF) staining: anti-γH2AX (EMD Millipore, #JBW301); Anti-53BP1 (Novusbio, #NB100-304); Fibrillarin(CST, 2639T); anti-Ki-67 (Abcam, #ab15580); anti-C23 (Nucleolin; CST, #14574); anti-UBF (F-9) (Santa Cruz, #sc-13125);

(4) HDAC5 -encoded Microprotein NISM Mediates Nucleolar Formation and Ribosomal RNA SynthesisbioRxivFebruary 25, 2026Kevin Cao, Dat Ha, Jesse Hulahan, Lilianna Houston, Gregory Tong, Jiayi Weng, Natasha Huey, Hannah E. DeMerit, Pedro Ortega, Rémi Buisson, et al.(Santa Cruz Biotechnology, sc-48385) diluted 1:200 and FBL rabbit monoclonal antibody (Cell Signaling Technology, 2639) diluted 1:400 in blocking buffer for nucleolar morphology experiments. For p53 experiments, p53 mouse

(5) Loss of p53 Provokes NF-κB-Dependent Disruption of Nucleolar Cap and Nucleoplasmic Redistribution of Fibrillarin During Nucleolar StressBiomoleculesFebruary 13, 2026Takeru Torii, Mako Sumida, Atsushi Kobayashi, Toshiyuki Goto, Ryosuke Suzuki, Shin Kuwamoto, Wataru Nakajima, Wataru Sugimoto, Kohei Takeuchi, Yuma Tanaya, et al.Absolute Antibody, Redcar, UK, ab206498, Cambridge, MA, USA) bound to BG4, anti-fibrillarin (C13C3: #2639, Cell Signaling Technology, Danvers, MA, USA), anti-B23 (0412: sc-47725, Santa Cruz Biotechnology, Dallas,

(6) Molecular interactome of HNRNPU reveals regulatory networks in neuronal differentiation and DNA methylationNucleic Acids ResFebruary 12, 2026Marika Oksanen, Francesca Mastropasqua, Krystyna Mazan-Mamczarz, Jennifer L Martindale, Xuan Ye, Abishek Arora, Nirad Banskota, Myriam Gorospe, Kristiina Tammimies67195-1-Ig, 1:1000), DDX17 (Novus Bio, NB200-352, 1:500), and Fibrillarin (Cell Signaling Technology, 2639, 1:500)] were diluted in blocking buffer and incubated overnight at +4°C. After washing with 1× DPBS,

(7) Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor GrowthMolecular Cancer TherapeuticsFebruary 4, 2026Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez, Andrew Massey, Vivek K. Kashyap, Neeraj Chauhan, Emmanuel Anning, Manish K. Tripathi, Dae J. Kim, et al.(Cat. No. 2524), PARP (Cat. No. 9542), nucleolin (NCL; Cat. No. 14574S), fibrillarin (FBL; Cat No. 2639S), and Ki-67 (Cat. No. 9449) were procured from Cell Signaling Technology. Another p53 primary antibody

(8) TGFβ pathway represses hepatic ribosome biogenesis and protein synthesis by regulating p70S6K–S6RP proteinsCellular & Molecular Biology LettersJanuary 16, 2026Athanasios Stavropoulos, Vassiliki Stamatopoulou, Eleftherios Pavlos, Maria Manioudaki, Stratigoula Sakellariou, Constantinos Stathopoulos, Maria Xilouriincubated overnight at 4 °C with the following primary antibodies: rabbit anti-Fibrillarin (Cell Signaling, 2639), rabbit anti-Nucleolin (Santa Cruz sc-13057), rabbit anti-Collagen1 (Abcam ab34710), mouse anti-Ribosomal

(9) HAND2 invades nucleolar condensates to pioneer lineage-specific cardiac pacemaker gene programsNat CommunOctober 10, 2025Kartik Kulkarni, Gabriella Quinn, Jared Dela Rosa, Sean Goetsch, Vrushali Pandit, Lin Wang, Akane Sakaguchi, Sushama Sivakumar, Nikhil V. Munshi(BioRad), probed with mouse anti-myc (SantaCruz 9E10), or rabbit anti-GFP (Invitrogen), fibrillarin (CST 2639), H3K9me3 (CST 13969), RNA pol II CTD phosphor-Ser5 (Active Motif 91119), and detected with HRP-conjugated

(10) RECQ5 mediates pre-rRNA processing in nucleolusNucleic acids researchAugust 11, 2025Ma Y, Yu X.5847S; Abcam, Rabbit, ab224135), anti-Nucleolin (Invitrogen, Mouse, ZN004), anti-FBL (CST, Rabbit, 2639S; Abcam, Rabbit, ab5821), anti-NOP56 (AiFang biological, Rabbit, AF07227; Invitrogen, Mouse, MA5-24641),

(11) Proteome solubility is differentially reshaped by thermal stress and regulators of ubiquitinationJournal of Biological ChemistryJuly 24, 2025Liam C. Hunt, Anna Stephan, Suresh Poudel, Kaiwen Yu, Kanisha Kavdia, Vishwajeeth R. Pagala, Wei Wang, Yingxue Fu, Yong-Dong Wang, Xusheng Wang, et al.(Cell Signaling #13452), anti-histone H3 (Cell Signaling #4499), anti-fibrillarin (Cell Signaling #2639), anti-α-tubulin (Cell Signaling #2125), and anti-CHEK1 (R&D Systems #AF1630). qRT-PCR Total RNA was

(12) Nuclear SUMOylation and Proteotoxic Stress Responses to Metals with Different Ligand PreferencesChemical Research in ToxicologyMay 19, 2025Giorgiana Madalina Ursu, Casey Krawic, Anatoly Zhitkovich(BD Biosciences, 610958), Pro564-hydroxylated HIF1α (Cell Signaling, 3434), fibrillarin (Cell Signaling, 2639), L7A (Cell Signaling, 2415), γ-tubulin (Sigma, T6557). Horseradish peroxidase-conjugated secondary

(13) SNORD80-guided 2’-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responsesProceedings of the National Academy of SciencesFebruary 18, 2025Liang Xu, Xiao Hong Zhao, Yuan Yuan Zhang, Meng Yao Zhang, Long Yue Zhang, Kai Hong Ye, Liu Teng, Man Man Han, Yi Meng Yue, Jiezhen Yang, et al.written informed consent. Antibodies (Abs) and Reagents. The rabbit anti-FBL monoclonal Ab (mAb) (#2639), rabbit anti-acetyl-lysine (Ace-K) polyclonal Ab (#9441), and rabbit anti-UPF1 mAb (#12040) were purchased

(14) USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expressionCell Commun SignalJanuary 30, 2025Shaoxuan Cheng, Zhiyuan Qiu, Ziyi Zhang, Yuxuan Li, Yue Zhu, Yuxin Zhou, Yinghui Yang, Yaowen Zhang, Dian Yang, Yingqiu Zhang, et al.antibody (santa cruz biotechnology, sc-374443), rabbit anti-FBL antibody (Cell Signaling Technology, 2639 S), and mouse anti-NPM1 antibody (Invitrogen, 32-5200) were used. For Western blot and immunohistochemistry

(15) Bioinformatic Analysis of Actin-Binding Proteins in the Nucleolus During Heat ShockGenes (Basel)December 9, 2024Shinya Taniguchi, Takeru Torii, Toshiyuki Goto, Kohei Takeuchi, Rine Katsumi, Mako Sumida, Sunmin Lee, Wataru Sugimoto, Masaya Gessho, Katsuhiko Itoh, et al.(D3F9: #5175; Cell Signaling Technology, Danvers, MA, USA), anti-fibrillarin rabbit monoclonal (C13C3: #2639; Cell Signaling Technology), and anti-NPM1 mouse monoclonal (0412: sc-47725; Santa Cruz Biotechnology,

(16) Monoubiquitinated H2B, a Main Chromatin Target of Formaldehyde, Is Important for S‐Phase Checkpoint Signaling and Genome StabilityMolecular CarcinogenesisDecember 1, 2024Sasmita Mishra, Casey Krawic, Michal W. Luczak, Anatoly Zhitkovich4335-MC-100), LMP7 (Cell Signaling, 13635), lamin B1 (Cell Signaling, 12586), fibrillarin (Cell Signaling, 2639), L7A (Cell Signaling, 2415) and γ-tubulin (Sigma, T6557). Horseradish peroxidase-conjugated goat anti-mouse IgG

(17) Super-resolution imaging reveals nucleolar encapsulation by single-stranded DNAJournal of Cell ScienceOctober 15, 2024Koichiro Maki, Jumpei Fukute, Taiji Adachinucleophosmin 1 (NPM1) (1:500 dilution; FC-61991, Thermo Fisher Scientific), fibrillarin (1:500 dilution; #2639, Cell Signaling Technology), RNA polymerase I (RPA194) (1:500 dilution; SC-48385, Santa Cruz Biotechnology)

(18) Honey Targets Ribosome Biogenesis Components to Suppress the Growth of Human Pancreatic Cancer CellsCancersOctober 9, 2024Bangash AA, Alvi SS, Bangash MA, Ahsan H, Khan S, Shareef R, Villanueva G, Bansal D, Ahmad M, Kim DJ, et al.c-Myc (Santacruz; #Sc-40; 1:000), RPL29 (Abcam; #ab88514; 1:000), NCL (CST; #14574S; 1:000), FBL (CST; #2639S; 1:000), NPM (Thermo Fisher; #PA5-12447; 1:000), p53 (DO-1) (Santacruz; #Sc-126; 2:000), Bcl-2 (Santacruz;

(19) Sensitive Detection of Histones and γ-H2AX by Immunoblotting: Problems and SolutionsChemical research in toxicologySeptember 16, 2024Krawic C, Luczak MW, Zhitkovich A.MABE285), TRX1 (Cell Signaling, 2429), ubiquitin (Cell Signaling, 58395), fibrillarin (Cell Signaling, 2639), GAPDH (Cell Signaling, 3683), L7A (Cell Signaling, 2415), β-actin (Cell Signaling, 4967), PCNA (Santa Cruz

(20) Impaired phase separation and nucleolar functions in hiPSC models of SNORD118-related ribosomopathiesiScienceAugust 16, 2024Wei Zhang, Minjie Zhang, Li Ma, Supawadee Jariyasakulroj, Qing Chang, Ziying Lin, Zhipeng Lu, Jian-Fu Chen,Thermo Fisher Scientific,Cat# PA5-28922; RRID: AB_2546398 Rabbit-anti FBL,Cell Signaling Technology,Cat# 2639; RRID: AB_2278087 Rabbit-anti β-Actin,Cell Signaling Technology,Cat# 4970; RRID: AB_2223172 Goat Anti-Rabbit-HRP

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Fibrillarin (C13C3) Rabbit mAb

Fibrillarin (C13C3) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Fibrillarin (C13C3) Rabbit mAb from Cell Signaling Technology

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