SorCS2 Antibody AF4237 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemSorCS2 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $489.00Supplier Page View Company Product Page
Catalog NumberAF4237
NCBI Gene AliasesmKIAA1329
ApplicationsImmunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Frozen,Immunocytochemistry
TargetSorCS2
HostSheep
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
Quantity100 ug (also 25 ug)
ReactivityMouse,Transgenic Mouse
IsotypeIgG
Conjugate/TagUnconjugated
NCBI Full Gene Namesortilin related VPS10 domain containing receptor 2, sortilin-related VPS10 domain containing receptor 2
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse SorCS2, Ala118-Gly1078, Accession # Q9EPR5
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse SorCS2 in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant human (rh) SorCS2 and less than 5% cross-reactivity with rhSorCS1 and recombinant mouse SorCS1 is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cellsiScienceJanuary 19, 2024Kalnytska O, Qvist P, Kunz S, Conrad T, Willnow TE, Schmidt V.REAGENT or RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, SORCS2,R&D systems,Cat# AF4237; RRID: AB_2192264 SORCS2,in-house,N/A Insulin,Agilent,Cat# IR002; RRID: AB_2800361 Insulin,ProteinTech,Cat#

(2) Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic FactorBiologyOctober 23, 2023Ayon-Olivas M, Wolf D, Andreska T, Granado N, Lüningschrör P, Ip CW, Moratalla R, Sendtner M.1D4B-S; RRID: AB_528127), and sheep anti-mouse SORCS-2 (1:500; R&D systems, Minneapolis, MN, USA, #AF4237). After washing three times with 1XPBS for 10 min, primary antibodies were detected with the following

(3) Alternative splicing regulates adaptor protein binding, trafficking, and activity of the Vps10p domain receptor SorCS2 in neuronal developmentThe Journal of biological chemistrySeptember 1, 2023Skeldal S, Voss LF, Lende J, Pedersen SB, Mølgaard S, Kaas M, Demange P, Bentsen AH, Fuglsang M, Sander MR, et al.from BD transduction Laboratories. Anti-GST (27457701V) was from GE Healthcare, anti-mouse SorCS2 (AF4237) from R&D Systems, and anti-KLC1 (ab174273) from Abcam. Anti-extracellular SorCS2 F7100 antibody is

(4) ProBDNF signaling is involved in periodontitis-induced depression-like behavior in mouse hippocampusInternational immunopharmacologyMarch 1, 2023Li Y, Guan X, He Y, Jia X, Pan L, Wang Y, Han Y, Zhao R, Yang J, Hou T.

(5) SorCS2 is required for social memory and trafficking of the NMDA receptorMolecular psychiatryMarch 1, 2021Yang J, Ma Q, Dincheva I, Giza J, Jing D, Marinic T, Milner TA, Rajadhyaksha A, Lee FS, Hempstead BL.

(6) SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced PathologyCell reportsMarch 5, 2019Malik AR, Szydlowska K, Nizinska K, Asaro A, van Vliet EA, Popp O, Dittmar G, Fritsche-Guenther R, Kirwan JA, Nykjaer A, et al.(Cell Signaling, #9367, 1:100), anti-Rab11 (Cell Signaling, #5589, 1:100), anti-SorCS2 (R&D Systems, AF4237, 1:100), anti-GSH:NEM (Millipore, MAB3194, 1:100). Primary antibodies were visualized using Alexa Fluor

(7) The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and BehaviorNeuronJuly 11, 2018Giza JI, Kim J, Meyer HC, Anastasia A, Dincheva I, Zheng CI, Lopez K, Bains H, Yang J, Bracken C, et al.or RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies sheep anti-SorCS2,R&D Systems,"Cat# AF4237, RRID: AB_2192264" rabbit anti-p75 9992,New York University,"Cat# MC0002, RRID: AB_2335792" goat anti-Trio,Santa Cruz

(8) Prions amplify through degradation of the VPS10P sorting receptor sortilinPLoS pathogensJune 1, 2017Uchiyama K, Tomita M, Yano M, Chida J, Hara H, Das NR, Nykjaer A, Sakaguchi S.anti-SorLA Abs (AF5699, R&D systems), goat anti-SorCS1 Abs (AF3457, R&D systems), sheep anti-SorCS2 Abs (AF4237, R&D systems), rat anti-SorCS3 Abs (MAB3067, R&D systems), rat anti-LAMP1 Ab (ab25245, Abcam, UK), rabbit

(9) SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's diseaseJCI insightMay 4, 2017Ma Q, Yang J, Milner TA, Vonsattel JG, Palko ME, Tessarollo L, Hempstead BL.hours at 4°C. The following primary antibodies were used: sheep anti-SorCS2 (1:1,000, R&D Systems, AF4237), mouse anti–Darpp-32 (gift from Hugh C. Hemmings, Weill Cornell Medicine, New York, NY, USA), mouse

(10) Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner earPLoS geneticsMarch 1, 2017Forge A, Taylor RR, Dawson SJ, Lovett M, Jagger DJ.Denmark); sheep polyclonal anti-SorCS2-ED (extracellular domain) (1:50; R&D Systems, Abingdon, UK; AF4237); rabbit polyclonal anti-Vangl2 (1:500; gift from Mireille Montcouquiol, INSERM, Bordeaux, France). FM1-43

(11) Spatiotemporal patterns of sortilin and SorCS2 localization during organ developmentBMC cell biologyMarch 10, 2016Boggild S, Molgaard S, Glerup S, Nyengaard JR.Primary antibodies used were goat α-sortilin (R&D systems, AF2934,1:100), sheep α-SorCS2 (R&D systems, AF4237, 1:50), rabbit α-TTF-1 (Santa Cruz, H-190,1:250), rabbit α-calretinin (Milipore, ab5054, 1:250), rabbit

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SorCS2 Antibody

SorCS2 Antibody

SorCS2 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (11)

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SorCS2 Antibody from R&D Systems, a Bio-Techne Brand

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