Synaptophysin1 antibody 101 011 from Synaptic Systems GmbH

Product Specs
ItemSynaptophysin1 antibody
CompanySynaptic Systems GmbH
Price $440.00Supplier Page View Company Product Page
Catalog Number101 011
Formatlyophilized
IsotypeIgG1
Hostmouse
Reactivityhuman, rat, mouse, mammals
ApplicationsWB, IP, ICC, IHC, IHC-P, ELISA
TargetSynaptophysin1
Quantity50 µg
Clonalitymonoclonal
Cell Line7.2
ValidationKO, KD
Clone7.2
ImmunogenRecombinant protein corresponding to AA 1 to 307 from rat Synaptophysin1
Antibody TypePrimary antibody

Questions and Answers

What applications has the Synaptophysin1 antibody been used for in scientific research?

The Synaptophysin1 antibody has been shown to work in various applications including Western Blotting, Immunocytochemistry, Immunohistochemistry, and Immunoprecipitation, as evidenced by its use in multiple studies such as those by Banerjee et al. (2022) and Carnazza et al. (2022).

Can this antibody be used to study synaptic vesicle dynamics in neurons?

Yes, the Synaptophysin1 antibody is a well-established marker for synaptic vesicles and has been utilized in studies investigating synaptic transmission and vesicle dynamics, such as in the work by Truckenbrodt et al. (2018), which highlights the role of newly produced synaptic vesicle proteins in neurotransmitter release.

Is the Synaptophysin1 antibody effective for use in animal models, and if so, which species?

The Synaptophysin1 antibody has demonstrated reactivity with multiple species, including humans, mice, rats, and other mammals, making it suitable for use in various animal models as indicated by its broad reactivity profile.

How has the Synaptophysin1 antibody contributed to understanding neurodegenerative diseases?

The Synaptophysin1 antibody has been employed in studies examining synaptic dysfunction in neurodegenerative diseases, such as in the research by Mass et al. (2017), which explored synaptic loss and neuronal death associated with neurodegeneration, highlighting its relevance in understanding the pathophysiology of these conditions.

Synaptic Systems GmbH

Rudolf-Wissell-Str. 28

Goettingen 37079

Germany

Phone: +49-551-50556-0
+49-551-50556-384

Company Profile

Website: http://www.sysy.com/

(1) Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarksbioRxivMarch 31, 2026Audrey Coulon, Florian Rabiller, Mari Takalo, Avishek Roy, Alexandre Pelletier, Henna Martiskainen, Dolores Siedlecki-Wullich, Nina Lannette-Weimann, Nad'a Majerníková, Arthur Grenon, et al.(Synaptic Systems, 160006 and 160004), Guinea-Pig or Mouse anti-Synaptophysin (Synaptic Systems, 101004 and 101011), Mouse or Chicken or Guinea pig anti-MAP2 (Synaptic Systems, 188011, 188006 and 188004), Rabbit anti-alpha Tubulin

(2) Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across speciesNature MetabolismFebruary 11, 2026Anjali Amrapali Vishwanath, Typhaine Comyn, Rodrigo G. Mira, Claire Brossier, Carlos Pascual-Caro, Maya Faour, Kahina Boumendil, Chaitanya Chintaluri, Carla Ramon-Duaso, Ruolin Fan, et al.separation. The blots were probed with anti-Letm1 (514136, Santa Cruz Biotechnology), anti-synaptophysin 1 (101011, Synaptic Systems), anti-Total OXPHOS (110413, Abcam) and anti-PDP1 (84612-3-RR, Proteintech), and β-actin

(3) Deficient de-S-acylation in aging and CLN1 contributes to lyso-mitochondrial dysfunction, lipid dyshomeostasis, and resultant lipofuscin biogenesisResearch SquareFebruary 10, 2026Sofia Massaro Tieze, Alexander Esqueda, Rachel McAllister, Matija Lagator, Betül Yücel, Eric Sun, TuKiet T. Lam, Nicholas Lockyer, Kallol Gupta, Sreeganga S. Chandra1:1000),Novus Biologicals,H00008878-M01; RRID: AB_548364 "Mouse anti-SYPH (WB 1:10,000)",Synaptic Systems,SYS-101-011; RRID: AB_887824 Rabbit anti-SYUA (WB 1:1000),Cell Signaling,D37A6; RRID: AB_1904156 2° Goat anti-Rabbit

(4) Integrated Biofluid Proteomics Identified Dynamic Functional Biomarkers of LRRK2 -Linked Parkinson’s Disease ProgressionmedRxivJanuary 2, 2026Cong Xiao, Takahiro Shimizu, Bik Tzu Huang, Duc Tung Vu, Ericka Itang, Matthias Mann, Ozge Karayel, Zhenyu Yueanti-phosphoLRRK2 (ab203181), anti-GFAP (13–0300, Invitrogen), anti-IBA1 (019–19741, Wako), anti-synaptophysin (101011, Synaptic Systems), anti-phosphoRab10 (ab230161, abcam), anti-Rab10 (ab237703, abcam), anti-phosphoRab12

(5) Recording and modeling of pinched hysteresis loops, the fingerprint of a memristor, in neuronsSci RepOctober 24, 2025Oliver Pabst, Christin Schülke, Ilangko Balasingham, Stefan Krauss, Joel Clinton Glover, Ørjan Grøttem MartinsenMAB5326); and synaptophysin I (SYP, 1:500, mouse monoclonal, Synaptic Systems, Göttingen, Germany, Cat 101 011). After incubation with primary antibodies, cells were washed with PBS three times for 15 min per washing

(6) Condensates of synaptic vesicles and synapsin-1 mediate actin sequestering and polymerizationThe EMBO JournalAugust 14, 2025Akshita Chhabra, Christian Hoffmann, Gerard Aguilar Pérez, Aleksandr A Korobeinikov, Jakob Rentsch, Nadja Hümpfer, Linda Kokwaro, Luka Gnidovec, Arsen Petrović, Jaqulin N Wallace, et al.(Thermo Fisher, #R37602) for 30 min. Samples were stained with mouse anti-synaptophysin (Synaptic Systems 101 011, 1:50) overnight at 4 °C in 1% BSA (w/v), 0.05% Saponin (w/v), and 4% Horse serum (v/v) in PBS. Samples

(7) Disrupted Motor Neuron and Neuromuscular Junction Development in an Albino Mice Model of Infantile NystagmusInvest Ophthalmol Vis SciJuly 10, 2025Sampath Vemula, Abdikheyre Osman, Xiguang Yang, Gabriel Aronchik, Mayra Martinez Sanchez, Nafiza Meher, Mary C. Whitman841001; BioLegend, San Diego, CA, USA), and mouse anti-synaptophysin monoclonal antibody (1:1000, no. 101011; Synaptic Systems, Göttingen, Germany.21) in blocking solution at 37°C for two days. After washing,

(8) Pharmacological Inhibition of Mitochondrial Division Attenuates Simulated High-Altitude Exposure-Induced Memory Impairment in Mice: Involvement of Inhibition of Microglia-Mediated Synapse EliminationCNS Neurosci TherJune 8, 2025Panpan Chang, Mengqing Xu, Jiawei Zhu, Jiangpei Bian, Yapeng Lu, Qianqian Luo, Dan Wang, Li ZhuAnti‐LAMP1 (sc‐19992) antibody was purchased from SANTA Cruz (CA, USA). Anti‐Synaptophysin antibody (101011) was obtained from Synaptic Systems (Goettingen, Germany). Anti‐PSD‐95 (3450T) antibodies were obtained

(9) Synaptophysin accelerates synaptic vesicle fusion by expanding the membrane upon neurotransmitter loadingScience advancesApril 25, 2025Preobraschenski J, Kreutzberger AJB, Ganzella M, Münster-Wandowski A, Kreutzberger MAB, Olsthoorn LHM, Seibert S, Kiessling V, Riedel D, Witkowska A, et al.1% (w/v) Na-cholate (Sigma-Aldrich) and purified using a monoclonal synaptophysin antibody (Cl 7.2, 101011, Synaptic Systems)–coupled resin (AminoLink Resin, Thermo Fisher Scientific). The protein was flash

(10) A Screen of Plant-Based Natural Products Revealed That Quercetin Prevents Pyroglutamylated Amyloid-β (Aβ3(pE)-42) Uptake in Astrocytes As Well As Resulting Astrogliosis and Synaptic DysfunctionMolecular neurobiologyMarch 1, 2025Arndt H, Bachurski M, Yuanxiang P, Franke K, Wessjohann LA, Kreutz MR, Grochowska KM.

(11) Loss of the proton-activated chloride channel in neurons impairs AMPA receptor endocytosis and LTD via endosomal hyper-acidificationCell ReportsFebruary 25, 2025Kevin H. Chen, Junhua Yang, Bian Liu, Chaohua Jiang, Nicholas Koylass, Zhe Zhang, Shuying Sun, Richard Huganir, Zhaozhu QiuNeuroMab Facility,Cat. 75-028; RRID: AB_2292909 Mouse anti-Synaptophysin1 (7.2),Synaptic Systems,"Cat. 101011, RRID: AB_887821" Rabbit anti-Rab5 (C8B1),Cell Signaling Technology,"Cat. 3547, RRID: AB_2300649" Rabbit

(12) Expression of synaptic proteins and development of dendritic spines in fetal and postnatal neocortex of the pig, the European wild boar Sus scrofaBrain structure & functionFebruary 7, 2025Sobierajski E, Czubay K, Schmidt MR, Wiedenski S, Rettschlag S, Beemelmans C, Beemelmans C, Wahle P.124,011, RRID: AB_10804286",1:1500 p38/Synapophysin,"Mouse, WB","Synaptic Systems, Göttingen, DE, Cat# 101,011, RRID: AB_887824",1:5000 p70/Synapsin1,"Mouse, WB","Synaptic Systems, Göttingen, DE, Cat# 106,001,

(13) Microglial activation and hypothalamic structural plasticity in HFD obesity: insights from semaglutide and minocyclineJournal of Lipid ResearchFebruary 1, 2025Xi Rong, Fang Wei, Yuqi Jiang, Qintao Ma, Dongmei Wang, Jie Shenanti-CD11b (ab184308, 1:500, Abcam), mouse anti-Iba-1 (ab283319, 1:100, Abcam), mouse anti-synaptophysin1 (101011, 1:1,000, Synaptic Systems, Germany), Alexa Fluor® 488–conjugated anti-CD68 (ab201844, 1:100, Abcam),

(14) Mouse-derived Synaptosomes Trypsin Cleavage Assay to Characterize Synaptic Protein Sub-localizationBio-protocolJanuary 20, 2025Shergill JK, Tehran DA.catalog number: 105103) 35. Anti-Synaptophysin1 antibody (SYP1) (Synaptic Systems, catalog number: 101011) 36. Anti-Snap25 antibody (Synaptic Systems, catalog number: 111011) 37. IRDye 800CW goat anti-Rabbit

(15) TBC1D24 interacts with the v-ATPase and regulates intraorganellar pH in neuronsiScienceJanuary 17, 2025Pepe S, Aprile D, Castroflorio E, Marte A, Giubbolini S, Hopestone S, Parsons A, Soares T, Benfenati F, Oliver PL, et al.System,Cat#111011; RRID:AB_887794 "Mouse monoclonal anti-synaptophysin1; WB 1:1,000",Synaptic System,Cat#101011; RRID:AB_887824 "Rabbit polyclonal anti-Tbc1d24; WB 1:1,000",Novus,Cat#NBP1-82925; RRID:AB_11061868 Rabbit

(16) Altered lipid profile and reduced neuronal support in human induced pluripotent stem cell‐derived astrocytes from adrenoleukodystrophy patientsJournal of Inherited Metabolic DiseaseJanuary 1, 2025Roberto Montoro Ferrer, Yorrick R. J. Jaspers, Inge M. E. Dijkstra, Nicole Breeuwsma, Jan‐Bert van Klinken, Cato Romero, Marc Engelen, Stephan Kemp, Vivi M. Heine#82630, dilution 1:500), MAP2 (Merck, AB5543, dilution 1:2500), synaptophysin (SYN) (Synaptic Systems, #101011, dilution 1:500), ABCD1 (Abcam, ab197013, dilution 1:500). The next day, after 6× PBS washes of 5 min,

(17) Membrane mechanics dictate axonal pearls-on-a-string morphology and functionNature neuroscienceJanuary 1, 2025Griswold JM, Bonilla-Quintana M, Pepper R, Lee CT, Raychaudhuri S, Ma S, Gan Q, Syed S, Zhu C, Bell M, et al.

(18) Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibitionNeuronNovember 6, 2024Libé-Philippot B, Iwata R, Recupero AJ, Wierda K, Bernal Garcia S, Hammond L, van Benthem A, Limame R, Ditkowska M, Beckers S, et al.

(19) Structure, interaction and nervous connectivity of beta cell primary ciliaNature CommunicationsOctober 24, 2024Andreas Müller, Nikolai Klena, Song Pang, Leticia Elizabeth Galicia Garcia, Oleksandra Topcheva, Solange Aurrecoechea Duran, Davud Sulaymankhil, Monika Seliskar, Hassan Mziaut, Eyke Schöniger, et al.No. 106 009), vAChT (Synaptic Systems, Cat. No. 139 105), synaptophysin 1 (Synaptic Systems, Cat. No. 101 011). Secondary antibodies were goat-raised and conjugated with Alexa Fluor dyes. Confocal images were acquired

(20) CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neotenyCell reportsOctober 22, 2024Assendorp N, Fossati M, Libé-Philippot B, Christopoulou E, Depp M, Rapone R, Dingli F, Loew D, Vanderhaeghen P, Charrier C.

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Synaptophysin1 antibody

Synaptophysin1 antibody

Synaptophysin1 antibody

Synaptophysin1 antibody

Synaptophysin1 antibody

Synaptophysin1 antibody from Synaptic Systems GmbH

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Synaptic Systems GmbH

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Synaptophysin1 antibody from Synaptic Systems GmbH

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