LAMTOR4/C7orf59 (D6A4V) Rabbit mAb 12284S from Cell Signaling Technology

Product Specs
ItemLAMTOR4/C7orf59 (D6A4V) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number12284S
Quantity100 µl
ApplicationsW, IP, IF-IC
ReactivityH, M, R, Mk
ClonalityMonoclonal
TargetC7orf59
HostRabbit
NCBI Full Gene Namelate endosomal/lysosomal adaptor, MAPK and MTOR activator 4
NCBI Gene AliasesC7orf59
Research AreaPI3K / Akt Signaling
CloneD6A4V
Molecular Weight11

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Cell Signaling Technology

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) The lysosomal LAMTOR-Rag complex functions as a checkpoint for antiviral interferon productionThe EMBO JournalJanuary 22, 2026Zeming Feng, Lulu Wang, Shujun Chen, Sihan Cao, Miao Lei, Xiuzhen Yang, Kaixiong Ma, Shi Yu, Huina Hu, Kaixuan Zheng, et al.(IB 1:1000),Cell Signaling Technology,#8168 (D38G5) Lamtor4 (IB 1:1000),Cell Signaling Technology,#12284 (D6A4V) Lamtor5 (IB 1:1000),Cell Signaling Technology,#14633 (D4V4S) ISG15 (IB 1:1000),Cell Signaling Technology

(2) JIP4 and RILPL1 utilize opposing motor force to dynamically regulate lysosomal tubulationJournal of Cell BiologyNovember 3, 2025Luis Bonet-Ponce, Tsion Tegicho, Nuria Fernandez-Martinez, Irene A. Rozenberg, Mia Ashriem, Alexandra Beilina, Jillian H. Kluss, Yan Li, Mark R. Cooksonfor ICC), rabbit anti-LC3B (2775; 1:1,000; Cell Signaling Technology for WB), rabbit anti-LAMTOR4 (12284; 1:1,000; Cell Signaling Technologies for WB), rabbit anti-calreticulin (D3E6) (12238; 1:1,000; Cell Signaling Technologies

(3) Optogenetic and chemical genetic tools for rapid repositioning of vimentin intermediate filamentsJ Cell BiolSeptember 1, 2025Milena Pasolli, Joyce C.M. Meiring, James P. Conboy, Gijsje H. Koenderink, Anna AkhmanovaTROMA-I",AB_531826,1:12/1:100 GFP,Mouse,Sigma-Aldrich,11814460001,1:200 HA,Rat,Roche,11867423001,1:200 HA,Mouse,Covance,MMS-101R,1:200 LAMTOR4 (D6A4V),Rabbit,Cell Signaling,12284,1:200 Paxillin,Mouse,BD Biosciences,610619,1:200 Tubulin-acetylated,Mouse,Sigma-Aldrich,T7451-200UL,1:200 Tubulin-acetylated

(4) Harnessing fusion of genome-edited human stem cells to rapidly screen for novel protein functions in vivobioRxivJune 30, 2025Samantha L. Smith, Yuichiro Iwamoto, Aadhithya Manimaran, David G. Drubin(#15665),1:100,IF anti-TMEM-192,Abcam (#ab185545),1:100,IF anti-LAMTOR4,Cell Signaling Technologies (#12284),1:300,IF anti-RAGA,Cell Signaling Technologies (#4357),1:300,IF anti-mTOR,Cell Signaling Technologies

(5) Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neuronsNat CommunDecember 30, 2024Chun Hei Li, Noortje Kersten, Nazmiye Özkan, Dan T. M. Nguyen, Max Koppers, Harm Post, Maarten Altelaar, Ginny G. Fariasprimary antibodies were used in this study: rabbit anti-LAMTOR4 (Cell Signaling, clone D6A4V, Cat# 12284S, RRID: AB_2797870, 1/500), mouse anti-STX6 (BD Biosciences Cat# 610635, RRID:AB_397965, 1/100), rabbit

(6) Opposing actions of JIP4 and RILPL1 provide antagonistic motor force to dynamically regulate membrane reformation during lysosomal tubulation/sorting driven by LRRK2bioRxivAugust 28, 2024Luis Bonet-Ponce, Tsion Tegicho, Alexandra Beilina, Jillian H. Kluss, Yan Li, Mark R. Cookson(Cell Signaling Technology, 2775; 1:1000 for WB), rabbit anti-LAMTOR4 (Cell Signaling Technologies, 12284; 1:1000 for WB), rabbit anti-calreticulin (D3E6) (Cell Signaling Technologies, 12238; 1:1000 for WB),

(7) Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitmentNeurobiology of diseaseAugust 1, 2022Kluss JH, Bonet-Ponce L, Lewis PA, Cookson MR.(Cell Signaling Technology, cat #3288, 1:100 for ICC), rabbit anti-Lamtor4 (Cell Signaling Technology, cat#12284, 1:200 for ICC), rabbit anti-RAB10 (Abcam, cat #ab237703, 1:2,000 for WB), rabbit anti-RAB10 (phospho-T73)

(8) Self-assembly of pericentriolar material in interphase cells lacking centrioleseLifeJuly 5, 2022Chen F, Wu J, Iwanski MK, Jurriens D, Sandron A, Pasolli M, Puma G, Kromhout JZ, Yang C, Nijenhuis W, et al.IF Antibody,Anti-Lamtor4 (rabbit monoclonal),Cell Signaling (CST)/Bioke,"Cell Signaling Technology Cat# 12284, RRID:AB_2797870",(1:800) for IF Antibody,Anti-Tom20 (mouse monoclonal),BD Biosciences,"BD Biosciences

(9) The Ragulator complex serves as a substrate-specific mTORC1 scaffold in regulating the nuclear translocation of transcription factor EBThe Journal of biological chemistryMarch 1, 2022Kimura T, Hayama Y, Okuzaki D, Nada S, Okada M.#4060), 4E-BP1 (#9644), p-4E-BP1 (#2855), Lamtor1 (#8975), Lamtor2 (#8145), Lamtor3 (#8168), Lamtor4 (#12284), Lamtor5 (#14633), mTOR (#2983), p-mTOR (Ser2448, #5536), Raptor (#2280), RagC (#9480), Rheb (#13879),

(10) LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal functionThe EMBO journalMarch 1, 2022Sun J, Liu Y, Hao X, Lin W, Su W, Chiang E, Baudry M, Bi X.,Cell Signaling Technology,Cat#8168; RRID:AB_10949501 Rabbit monoclonal anti‐LAMTOR4,Cell Signaling Technology,Cat#12284; RRID:AB_2797870 Rabbit monoclonal anti‐LAMTOR5,Cell Signaling Technology,Cat#14633; RRID:AB_2798547 Mouse

(11) ER - lysosome contacts at a pre-axonal region regulate axonal lysosome availabilityNature communicationsJuly 23, 2021Özkan N, Koppers M, van Soest I, van Harten A, Jurriens D, Liv N, Klumperman J, Kapitein LC, Hoogenraad CC, Farías GG.primary antibodies were used in this study: rabbit anti-LAMTOR4 (Cell Signaling, clone D6A4V, Cat# 12284S, RRID: AB_2797870, 1/250), mouse anti-EEA1 (BD Biosciences, Cat# 610456, RRID: AB_397829, 1/200), mouse

(12) The Lysosomal Rag-Ragulator Complex Licenses RIPK1 and Caspase-8-mediated Pyroptosis by YersiniaScience (New York, N.Y.)June 25, 2021Zheng Z, Deng W, Bai Y, Miao R, Mei S, Zhang Z, Pan Y, Wang Y, Min R, Deng F, et al.caspase-7 (#12827), RIPK1 (#3493), Phospho-RIPK1 (#31122), RagC (#3360, #9480), Lamtor1 (#8975), Lamtor4 (#12284) and FLCN (#3697) were from Cell Signaling Technology. Monoclonal anti-FADD antibody (sc-166516) and

(13) Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cellseLifeDecember 21, 2020Peter Jan Hooikaas, Hugo GJ Damstra, Oane J Gros, Wilhelmina E van Riel, Maud Martin, Yesper TH Smits, Jorg van Loosdregt, Lukas C Kapitein, Florian Berger, Anna AkhmanovaSAB4503685). A rabbit monoclonal antibody against Lamtor4 (clone D6A4V, Cell Signaling Technology, #12284) and α-tubulin (clone EP1332Y, Abcam, ab52866). A mouse monoclonal antibody against α-tubulin (Sigma-Aldrich,

(14) Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cellsElifeDecember 21, 2020Peter Jan Hooikaas, Hugo GJ Damstra, Oane J Gros, Wilhelmina E van Riel, Maud Martin, Yesper TH Smits, Jorg van Loosdregt, Lukas C Kapitein, Florian Berger, Anna AkhmanovaSAB4503685). A rabbit monoclonal antibody against Lamtor4 (clone D6A4V, Cell Signaling Technology, #12284) and α-tubulin (clone EP1332Y, Abcam, ab52866). A mouse monoclonal antibody against α-tubulin (Sigma-Aldrich,

(15) Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signalingNature communicationsOctober 12, 2020Ketterer S, Mitschke J, Ketscher A, Schlimpert M, Reichardt W, Baeuerle N, Hess ME, Metzger P, Boerries M, Peters C, et al.p-CREB (Cell Signaling, 9198; 1:200), CREB (Cell Signaling, 9197; 1:200), LAMTOR4 (Cell Signaling, 12284; 1:1000), LC3 (Cell Signaling, 2775; 1:200), LAMP1 (Abcam, ab25245; 1:750), and mTOR (Cell Signaling,

(16) PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman SyndromeScientific reportsJune 17, 2020Sun J, Liu Y, Zhu G, Cato C, Hao X, Qian L, Lin W, Adhikari R, Luo Y, Baudry M, et al.Phosphoserine (Millipore, ab1603), HA (Sigma, H6908), EEA1 (abcam, ab2900), LAMTOR4 (Cell signaling technology, 12284), and β-actin (Sigma, A5441). All secondary antibodies for Western blots were obtained from LI-COR,

(17) Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian NeuronsCell reportsJune 16, 2020De Pace R, Britt DJ, Mercurio J, Foster AM, Djavaherian L, Hoffmann V, Abebe D, Bonifacino JS.RRID:AB_2134500 "LAMTOR4 (C7orf59) (D6A4V), rabbit, IB 1:500, IF 1:500, IHC 1:500",Cell Signaling,Cat# 12284; RRID:AB_2797870 "Synaptophysin 1 (SYP1) (D-4), mouse, IB 1:1,000",Santa Cruz,Cat# sc-17750; RRID:AB_628311 "Synaptophysin

(18) Conhecimento de enfermeiros acerca da terapia nutricionalRevista Enfermagem ContemporÃ¢neaJanuary 21, 2020Jaqueline almeida guimaraes Barbosa, Clara Marize Carlos, Raquel Fernandes Costa, Giovana Paula Rezende Siminoenteral nutrition in intensive care units: a national survey. Nurs Crit Care. 2018;23(3):152-158. doi: 10.1111/nicc.12284 16. Matsuba CST, Ciosak SI. Movimento pela segurança na terapia nutricional enteral: o que há de novo

(19) Arginase 1 Insufficiency Precipitates Amyloid-β Deposition and Hastens Behavioral Impairment in a Mouse Model of AmyloidosisFrontiers in immunologyJanuary 1, 2020Ma C, Hunt JB, Selenica MB, Sanneh A, Sandusky-Beltran LA, Watler M, Daas R, Kovalenko A, Liang H, Placides D, et al.(Cell Signaling Technologies, #8145), LAMTOR3 (Cell Signaling Technologies, #8168), LAMTOR4 (Cell Signaling Technologies, #12284), RagA (Cell Signaling Technologies, #4357), and anti-β-actin antibody (Sigma-Aldrich, #A5441). Densitometric

(20) Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3eLifeNovember 6, 2019Jia R, Bonifacino JS.Calnexin (EMD Millipore, MAB3126), GM130 (BD Biosciences, 610823), LAMTOR4 (Cell Signaling Technology, 12284), Rab5 (Cell Signaling Technology, 2143), APPL1 (Santa Cruz Biotechnology, sc-271901), EEA1 (Cell Signaling Technology

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LAMTOR4/C7orf59 (D6A4V) Rabbit mAb

LAMTOR4/C7orf59 (D6A4V) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (25)

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LAMTOR4/C7orf59 (D6A4V) Rabbit mAb from Cell Signaling Technology

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