MAPKAPK-2 (D1E11) Rabbit mAb 12155S from Cell Signaling Technology

Product Specs
ItemMAPKAPK-2 (D1E11) Rabbit mAb
CompanyCell Signaling Technology
Price $399.00 Inquire
Catalog Number12155S
Quantity100 µl
ApplicationsW, W-S, IP
ReactivityH, M, R, Mk, B, Pg
ClonalityMonoclonal
TargetMAPKAPK-2
HostRabbit
NCBI Full Gene NameMAPK activated protein kinase 2
NCBI Gene AliasesMAPKAP-K2, MK-2, MK2
Research AreaMAP Kinase Signaling
IsotypeIgG
CloneD1E11
Molecular Weight47, 49 (Phosphorylated)

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) MK2/p38/p53 Suppress Basal IL-1β and Non-Canonical NF-κB Signaling in MacrophagesInt J Mol SciApril 2, 2026Sarah M. Herr, Diana Stalkopf, Sofie Padaszus, Lukas A. Herbst, Anneke Dörrie, Rainer Niedenthal, Natalia Ronkina, Tatiana Yakovleva, Alexey Kotlyarov, Matthias GaestelIsoform 2 (MAB3278 R&D systems, Bio-Techne GmbH, Wiesbaden-Nordenstadt, Germany), MAPKAPK-2 (D1E11) (12155, CST, Cambridge, UK), MAPKAPK-3 (3043, CST, Cambridge, UK), caspase-3 (H-277) (sc-7148, SCBT, Dallas,

(2) High-throughput assay for measuring target occupancy of covalent compounds: a case study with MK2RSC Chemical BiologyMarch 11, 2026Julian L. Wong, Mari Manuia, Sandra Gao, Natacha Stoehr, Theresa Boersig, Krystine Vuong, Tao Jiang, Jian Cao, Yong Jia, C. C. King, et al.2B5 (H00007867-M02) was purchased from Abnova (Taipei City, Taipei, Taiwan). Anti-MK2 clone D1E11 (#12155) and anti-MK3 clone D54E4 (#7421) were purchased from Cell Signaling Technology (Danvers, MA, U.S.A.)

(3) MUC1-C dependency in drug resistant HR+/HER2- breast cancer identifies a new target for antibody-drug conjugate treatmentNPJ Breast CancerApril 26, 2025Ayako Nakashoji, Atrayee Bhattacharya, Hiroki Ozawa, Naoki Haratake, Keisuke Shigeta, Atsushi Fushimi, Nami Yamashita, Akira Matsui, Shoko Kure, Tomoe Kameyama, et al.anti-SRC-3 (2126S, 1:1000, CST), anti-pSRC3(S857) (PA5-106189, Thermo Fischer Scientific), anti-MK2 (12155S, 1:1000, CST), anti-MED1 (51613S, 1:1000, CST), anti-pMED1(T1457) (ab60950, 1:500, abcam), anti-CDK7

(4) Protocol for optimizing culture conditions for ex vivo activation during CRISPR-Cas9 gene editing in human hematopoietic stem and progenitor cellsSTAR ProtocMarch 31, 2025Lucrezia Della Volpe, Roberta Vacca, Raffaella Di MiccoRRID: AB_490936 "Rabbit anti-human MAPKAPK-2 (clone D1E11) (1:1,000)",Cell Signaling Technology,Cat#12155; RRID: AB_2797831 Rabbit anti-human histone H3 (1:500),Abcam,Cat#ab1791; RRID: AB_302613 "Goat anti-rabbit

(5) Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s diseaseNeuronJanuary 22, 2025Pourya Naderi Naderi Yeganeh, Sang Su Kwak, Mehdi Jorfi, Katjuša Koler, Thejesh Kalatturu, Djuna von Maydell, Zhiqing Liu, Kevin Guo, Younjung Choi, Joseph Park, et al.,Cell Signaling Technologies,Cat. # 3316; RRID:AB_2141311 Anti-MAPKAPK-2,Cell Signaling Technologies,Cat. # 12155; RRID:AB_2797831 Anti-phospho-HSP27 (S82),Cell Signaling Technologies,Cat. # 9709; RRID:AB_11217429 Anti-HSP27,Cell Signaling Technologies

(6) Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastomaCell Death DisJanuary 14, 2025Soo Yeon Kim, Miaolu Tang, Stephen Y. Chih, Jessica Sallavanti, Yan Gao, Zhiqiang Qiu, Hong-Gang Wang, Wei Li(Cell Signaling Technology, 8690), p-MK2 (T334) (Cell Signaling Technology, 3007), MK2 (Cell Signaling Technology, 12155), p-ERK (Cell Signaling Technology, 4370), p-AKT(S473) (Cell Signaling Technology, 4060), anti-rabbit

(7) Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27Current BiologyDecember 16, 2024Elizabeth R. Gallagher, Peace T. Oloko, Tessa C. Fitch, Elizabeth M. Browne, Lynn A. Spruce, Erika L.F. Holzbauranti-pT334 MK2 (Cell Signaling, 3007, Lot: 12, WB: 1:1000); rabbit monoclonal anti-MK2 (Cell Signaling, 12155, Lot: 4, WB: 1: 1000); rabbit monoclonal anti-MK3 (Cell Signaling, 7421, Lot: 1, WB: 1:1000); mouse

(8) Long non-coding RNA MAGEA4-AS1 binding to p53 enhances MK2 signaling pathway and promotes the proliferation and metastasis of oral squamous cell carcinomaFunctional & Integrative GenomicsOctober 1, 2024Xiaoxiao Wei, Zhangfu Li, Heng Zheng, Xiaolian Li, Yuntao Lin, Hongyu Yang, Yuehong Shenblocked with 5% skimmed milk and exposed to primary antibodies (anti-MAPKAPK2, 1:1000, Catalog Number: 12155, CST, Danvers, USA; anti-P53, 1:500, Catalog Number: 2527, CST; anti-vimentin 1:1000, Catalog Number:

(9) Dexamethasone acetate loaded poly(ε-caprolactone) nanofibers for rat corneal chemical burn treatmentScientific reportsSeptember 18, 2024Kim DR, Park SK, Kim EJ, Kim DK, Yoon YC, Myung D, Lee HJ, Na KS.(sc-130348, Santa cruz, USA; 1:200 dilution), TGF-β2 (PA5-86215, invitrogen, USA; 1:500 dilution), MK2 (#12155S, Cell Signaling, USA; 1:1000 dilution ), and Anti-β-Actin (A5441, Sigma, USA; 1:5000 dilution) as a

(10) In vitro hair growth-promoting effects of araliadiol via the p38/PPAR-γ signaling pathway in human hair follicle stem cells and dermal papilla cellsFrontiers in pharmacologyJanuary 1, 2024Park S, Park HW, Seo DB, Yoo DS, Bae S.Tech,4782 phospho-PKA,Rabbit,Polyclonal,Cell Signaling Tech,4781 MAPKAPK2,Rabbit,Monoclonal,Cell Signaling Tech,12155 phospho-MAPKAPK2,Rabbit,Monoclonal,Cell Signaling Tech,3007 α-Tubulin,Mouse,Monoclonal,Cell Signaling

(11) Mechanism of TNFα-induced downregulation of salt-inducible kinase 2 in adipocytesScientific reportsJune 29, 2023Vaváková M, Hofwimmer K, Laurencikiene J, Göransson O.p-IκBα (CST, #9246), anti-p38 (CST, #9212), anti-T180/Y182 p-p38 (CST, #9211), anti-MAPKAPK-2 (CST, #12155), anti-T334 p-MAPKAPK-2 (CST, #3007), anti-PKB (CST, #9272) and anti-S473 p-PKB (Thermo Fisher, #44621G). RNA

(12) Kaposi’s sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodiesPLOS PathogensJanuary 12, 2023Carolyn-Ann Robinson, Gillian K. Singh, Mariel Kleer, Thalia Katsademas, Elizabeth L. Castle, Bre Q. Boudreau, Jennifer A. Corcoran14793,Immunoblot,1:1000 FLAG,Mouse,CST 8146,Immunoprecipitation,1:100 GFP,Rabbit,CST 2956,Immunoblot,1:1000 MK2,Rabbit,CST 12155S,Immunoblot,1:1000 Total hsp27,Mouse,CST 2401S,Immunoblot,1:1000 Phospho-hsp27 (Ser82),Rabbit,CST 2401S,Immunoblot,1:1000 ORF57,Mouse,Santa Cruz

(13) PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancerFront Endocrinol (Lausanne)October 18, 2022Jeanesse Scerri, Christian Scerri, Felix SchÃ¤fer-Ruoff, Simon Fink, Markus Templin, Godfrey Grechreceptor beta, CD221)",Cell Signaling,3018,Rb mAb,308,153,166,1.02,0.12 MEK/ERK,MAPKAPK-2,Cell Signaling,12155,Rb mAb,392,556,453,-0.50,-0.29 MEK/ERK,MEK 1,Cell Signaling,9124,Rb pAb,1128,610,644,0.89,0.08 MEK/ERK,MEK1

(14) Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degenerationNature communicationsSeptember 21, 2022Jiang Y, Alam JJ, Gomperts SN, Maruff P, Lemstra AW, Germann UA, Stavrides PH, Darji S, Malampati S, Peddy J, et al.1:1000), bCTF (M3.2, 1:250)18, BACE1 (Rockland; 200-401-984; 1:500), MAPKAPK-2 (MK2; Cell Signaling; 12155; 1:500), phospho-MK2 (Cell Signaling; 3007; 1:500), p38 MAPK (p38α; Cell Signaling; 9218; 1:500), phosphor-p38

(15) Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase A(2)Frontiers in cell and developmental biologyJanuary 1, 2022Mangini M, D'Angelo R, Vinciguerra C, Payré C, Lambeau G, Balestrieri B, Charles JF, Mariggiò S.anti-p38 MAPK (cod. 9212), anti-phospho MAPKAPK-2 (T334; 27B7, cod. 3007), anti-MAPKAPK-2 (D1E11, cod. 12155), all used at dilution 1:1,000 were from Cell Signaling Technology (Danvers, MA, United States). The

(16) Mechanism of activation of porcine dendritic cells by an α-D-glucan nanoparticle adjuvant and a nanoparticle/poly(I:C) combination adjuvantFrontiers in immunologyJanuary 1, 2022Hernandez-Franco JF, Xie S, Thimmapuram J, Ragland D, HogenEsch H.at room temperature. Blots were then washed twice with TBS-Tween20, and probed with anti-MAPKAPK-2 (#12155; Cell Signaling, Danvers, MA), anti-phospho-MAPKAPK-2 (#3007; Cell Signaling) and anti-GAPDH (sc-47724;

(17) Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammationiScienceDecember 17, 2021Suarez-Lopez L, Shui B, Brubaker DK, Hill M, Bergendorf A, Changelian PS, Laguna A, Starchenko A, Lauffenburger DA, Haigis KM.immunoblotting. Primaries antibodies were used as follows: anti-phospho-MK2 (CST 3041, 1:2000), anti-MK2 (CST 12155, 1:2000), anti-phospho-Hsp27 (CST 9709, 1:2000) anti-Hsp27 (CST 2442, 1:2000) anti-GAPDH (CST 8174 1:2000).

(18) The MK2/Hsp27 axis is a major survival mechanism for pancreatic ductal adenocarcinoma under genotoxic stressSci Transl MedDecember 1, 2021Patrick M. Grierson et al.#8690), p-p38 MAPK T180/Y182 (Cell Signaling Technology #9215), MK2 total Cell Signaling Technology #12155), p-MK2 T334 (Cell Signaling Technology #3041), Hsp27 total (Cell Signaling Technology #2042), p-Hsp27

(19) E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancerCell death and differentiationMay 1, 2021Morgan EL, Scarth JA, Patterson MR, Wasson CW, Hemingway GC, Barba-Moreno D, Macdonald A.(Thr202/Tyr204) (43705, CST), ERK1/2 (137F5; 4695, CST), Phospho-MAPKAP2 (Thr334) (3007, CST), MAPKAP2 (12155, CST), Phospho-c-Jun (Ser73) (D47G9; 3270, CST), c-Jun (60A8; 9165, CST), JunD (D17G2; 5000, CST), EGFR

(20) MYD88 signals induce tumour-initiating cell generation through the NF-κB-HIF-1α activation cascadeScientific reportsFebruary 17, 2021Tanimura A, Nakazato A, Tanaka N.Cell Signaling Technology, Inc.), phosphor-MAPKAP2 (#3316; Cell Signaling Technology, Inc.), and MAPKAP2 (#12155; Cell Signaling Technology, Inc.). Immunofluorescence staining MEFs were seeded on glass coverslips,

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MAPKAPK-2 (D1E11) Rabbit mAb

MAPKAPK-2 (D1E11) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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MAPKAPK-2 (D1E11) Rabbit mAb from Cell Signaling Technology

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