ITCH (D8Q6D) Rabbit mAb 12117S from Cell Signaling Technology

Product Specs
ItemITCH (D8Q6D) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number12117S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R
ClonalityMonoclonal
TargetITCH
HostRabbit
NCBI Full Gene Nameitchy E3 ubiquitin protein ligase
NCBI Gene AliasesADMFD, AIF4, AIP4, NAPP1
Research AreaUbiquitin and Ubiquitin-like proteins
CloneD8Q6D
Molecular Weight105

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Cell Signaling Technology

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Danvers, Massachusetts 01923

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Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Targeting of Itch by Clomipramine or Gene Therapy improves cognitive defects related to Alzheimer's DiseaseiScienceApril 17, 2026Monika Chauhan, Komal Singh, Pushkar Sharma1:500 for WB, 1:50 for IHC), cleaved caspase 3 (CST, cat. no. 966l; 1:1000 for WB), Itch (CST, cat. no. 12117; 1:1000 for WB), TAp73 (Novus, cat. no. NBP2-24737, 1:1000 for WB, 1:50 for IP), myc-tag (9B11) (CST,

(2) TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescenceThe EMBO JournalOctober 20, 2025Jennifer Kahlhofer, Nikolas Marchet, Kristian Zubak, Brigitta Seifert, Madlen Hotze, Anna-Sophia Egger-Hörschinger, Lucija Kucej, Claudia Manzl, Yannick Weyer, Sabine Weys, et al.,Cell Signaling,"#70140S, RRID:AB_3662810" WWP2,Cell Signaling,"#41182S, RRID:AB_3662809" ITCH,Cell Signaling,"#12117S, RRID:AB_2797822" GFP,Roche Life Science,"(Roche Cat# 11814460001, RRID:AB_390913)" Ubiquitin (P4D1),Santa Cruz

(3) Oxidative stress triggers Itch-mediated TXNIP degradation and NF-κB activation promoting chronic obstructive pulmonary diseaseRespir ResOctober 17, 2025Pei-Yun Lin, Kang-Yun Lee, Shu-Chuan Ho, Hsiao-Chi Chuang, Bing-Hua Su, Ying-Jung Wu, Po-Chun Tseng, Tsung-Ting Tsai, Chiou-Feng Lin, Rahmat Dani Satria, et al.(#9252), phospho-p38 (Thr180/Tyr182) (# 9211), p38 (#9212), phospho-NF-κB (#3033), NF-κB (#4764), Itch (#12117), iNOS (#13120), COX-2 (#12282S) and the secondary antibodies HRP-conjugated goat anti-mouse (#7076S)

(4) GATAD2B O-GlcNAcylation Regulates Breast Cancer Stem-like Potential and Drug ResistanceCellsMarch 8, 2025Giang Le Minh, Jessica Merzy, Emily M. Esquea, Nusaiba N. Ahmed, Riley G. Young, Ryan J. Sharp, Tejsi T. Dhameliya, Bernice Agana, Mi-Hye Lee, Jennifer R. Bethard, et al.(Cell-Signaling, cat #57156), anti-RBBP4 (Cell-Signaling, cat #9067), anti-ITCH (Cell-Signaling, cat #12117). 2.8. Mass Spectrometry Analysis Effect of Thiamet G on protein expression. MDA-MB-231 cells were

(5) NEDD4 family ubiquitin ligase AIP4 interacts with Alix to enable HBV naked capsid egress in an Alix ubiquitination-independent mannerPLOS PathogensSeptember 11, 2024Sheng Shen, Dawei Cai, Hongyan Liang, Ge Zeng, Wendong Liu, Ran Yan, Xiaoyang Yu, Hu Zhang, Shi Liu, Wanying Li, et al.Western Breeze blocking buffer (Life Technologies) and probed with antibodies against HBc [115], AIP4 (12117, Cell Signaling Technology (CST)), Alix (92880, CST), ubiquitin (sc-166553, Santa Cruz), HA-tag (3724,

(6) SOX2 Promotes Invasion in Human Bladder Cancers through MMP2 Upregulation and FOXO1 DownregulationInternational journal of molecular sciencesOctober 19, 2022Xie Q, Hua X, Huang C, Liao X, Tian Z, Xu J, Zhao Y, Jiang G, Huang H, Huang C.specifically against SOX2(23064S), FOXO1(2880S), GFP(2956S), Src(2109S), HSP70(4872S), SKP1(2156S), ITCH(12117S), Flag(2368S), p-c-Jun Ser63(2361S), p-c-Jun Ser73(3270S), c-Jun (9165S), and CREB(9197S) were purchased

(7) H5N1 infection impairs the alveolar epithelial barrier through intercellular junction proteins via Itch-mediated proteasomal degradationCommunications biologyMarch 1, 2022Ruan T, Sun Y, Zhang J, Sun J, Liu W, Prinz RA, Peng D, Liu X, Xu X.Santa Cruz Biotechnologies, Inc. (San Diego, CA, USA). Antibodies against Gli1 (#2643), Snail (#3895), Itch (#12117), TAK1 (#5206), phospho-TAK1S412 (#9339), p38 (#4685), phospho-p38 (#4060), JNK (#9252), phospho-JNK

(8) The deubiquitinase Usp27x as a novel regulator of cFLIP(L) protein expression and sensitizer to death-receptor-induced apoptosisApoptosis : an international journal on programmed cell deathFebruary 1, 2022Dold MN, Ng X, Alber C, Gentle IE, Häcker G, Weber A.(#2933), caspase-8 (#9746), CHIP (#2080), cIAP1 (#7065), cIAP2 (#3130), c-Jun (#9165), GFP (#2956), Itch (#12117), phospho IkBα (#9246), phospho JNK (#4668), phospho Akt (Ser473, #4058), phospho Akt (Thr308, #2965),

(9) CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1TheranosticsJanuary 1, 2022Lu Y, Mu Y, Chen J, Guan X, Guo L, Wu C.(1:1000, Mouse monoclonal, Santa Cruz, sc-101199), AIP-4 (1:1000, Rabbit polyclonal, Cell Signaling, 12117S), Phospho-YAP (Ser127) (1:1000, Rabbit polyclonal, Cell Signaling, 4911S), LATS1 (1:1000, Rabbit polyclonal,

(10) Proteome-wide mapping of short-lived proteins in human cellsMolecular cellNovember 18, 2021Li J, Cai Z, Vaites LP, Shen N, Mitchell DC, Huttlin EL, Paulo JA, Harry BL, Gygi SP.(#13329), anti-CDC23 (#15100), anti-CDC16 (#9499), anti-CDC20 (#14866), anti-ANAPC11 (#14090), anti-ITCH (#12117), anti-PJA2 (#40180), anti-LRSAM1 (#28405) and anti-RCHY1 (#5754) were from Cell Signaling Technology.

(11) Sushi domain-containing protein 4 controls synaptic plasticity and motor learningeLifeMarch 4, 2021Inés González-Calvo et al.Germany, Cat#11867423001), rabbit monoclonal anti-ITCH (1:1000; Cell Signaling Technology, MA, Cat#12117), rabbit polyclonal anti-NEDD4 (1:10,000; Millipore, Cat#07–049), guinea pig polyclonal anti-VGLUT1

(12) ITCH regulates oxidative stress induced by high glucose through thioredoxin interacting protein in cultured human lens epithelial cellsMolecular medicine reportsNovember 1, 2020Jiang L, Zhou W, Lu B, Yan Q.1:5,000; Abcam), Txnip (cat. no. 14715s; 1:1,000; Cell Signaling Technology, Inc.), ITCH (cat. no. 12117s; 1:1,000; Cell Signaling Technology, Inc.), GAPDH (cat. no. 10494-1-AP; 1:5,000; ProteinTech Group, Inc

(13) Isorhapontigenin (ISO) inhibits stem cell-like properties and invasion of bladder cancer cell by attenuating CD44 expressionCellular and molecular life sciences : CMLSJanuary 1, 2020Luo Y, Tian Z, Hua X, Huang M, Xu J, Li J, Huang H, Cohen M, Huang C.human CD44 (#5640S), Oct4 (#2840S), Sox2 (#23064S), Nanog (#4903P), Skpl (#2156), Skp2 (#4358), ITCH (#12117S), USP4 (#2651S), LC3A, LC3B (#4445S, autophagy kit), p62 (#88588), ELK1 (#9182), GAPDH (#5174), GFP

(14) E3 Ligase ITCH Interacts with the Z Matrix Protein of Lassa and Mopeia Viruses and Is Required for the Release of Infectious ParticlesVirusesDecember 31, 2019Nicolas Baillet, Sophie Krieger, Xavier Carnec, Mathieu Mateo, Alexandra Journeaux, Othmann Merabet, Valérie Caro, Frédéric Tangy, Pierre-Olivier Vidalain, Sylvain Baizeanti-Ubiquitin (1:1000) from R&D systems (Noyal Chatillon Sur Seiche, France) and anti-ITCH (1:500; 12117) from Cell Signaling Technology (Beverly, MA, USA). The secondary antibodies used for western blotting

(15) Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP DestabilizationCellSeptember 20, 2018Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, et al.1:1,000), HK2 (Cell Signaling 2867, 1:1,000), HMMR/CD168 (Abcam ab108339, 1:1,000), ITCH (Cell Signaling 12117, 1:1,000), p-ITCH Thr222 (EMD Millipore AB10050, 1:500), LDHA (Cell Signaling 3582, 1:1,000), LDHB (Abcam

(16) Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZThe Journal of cell biologyApril 2, 2018Guo L, Cai T, Chen K, Wang R, Wang J, Cui C, Yuan J, Zhang K, Liu Z, Deng Y, et al.Cell Signaling), mouse anti-RhoA (sc-418; Santa Cruz), rabbit anti-ALP (GTX62596; Genetex), or rabbit anti-AIP4 (12117S; Cell Signaling) antibodies. After washing and incubation with appropriate HRP-conjugated secondary

(17) ARMMs as a versatile platform for intracellular delivery of macromoleculesNature communicationsMarch 6, 2018Wang Q, Yu J, Kadungure T, Beyene J, Zhang H, Lu Q.FLAG antibody (Sigma M2, F1804, 1:2000), rabbit monoclonal HA-Tag antibody (Cell Signaling, 3724S, 12117S, 1:2000), and rabbit monoclonal Flotillin antibody (Cell Signaling, 18634S, 1:2000). Uncropped scans

(18) Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progressionThe Journal of clinical investigationDecember 1, 2017Guo L, Zhang P, Chen Z, Xia H, Li S, Zhang Y, Kobberup S, Zou W, Lin JD.4691), phospho-JNK1/2 (T183/Y185) (catalog 4668), total JNK1/2 (catalog 9252), total Itch (catalog 12117), phospho-MLKL (S345) (catalog 62233), and phospho-MLKL (S358) (catalog 91689) were from Cell Signaling Technology

(19) Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signalingNature communicationsSeptember 27, 2017Wang Q, Lu Q.1:1000 dilution) and rabbit monoclonal NOTCH2 and ITCH antibodies (Cell Signaling, catalogue #4530S, 12117S, both at 1:2000 dilution). Second antibodies were anti-rabbit IgG HRP-linked antibody (Cell Signaling,

(20) DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT ProteinsPloS oneJanuary 1, 2017Nguyen HT, Kugler JM, Cohen SM.DUB3-mediated regulation of YAP. Materials and Methods Antibodies Antibodies to NEDD4 (Cat #2740), ITCH (#12117), SMURF1 (#2174), phosphor-YAP (S127, #4911), YAP (#4912), YAP/TAZ (#8418), phospho-LATS1 (T1079,#8654),

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ITCH (D8Q6D) Rabbit mAb

ITCH (D8Q6D) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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ITCH (D8Q6D) Rabbit mAb from Cell Signaling Technology

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