LRIG1 Antibody AF3688 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemLRIG1 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $519.00Supplier Page View Company Product Page
Catalog NumberAF3688
NCBI Gene AliasesLIG-1, LIG1, Img, D6Bwg0781e
ApplicationsFlow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunofluorescence,Immunocytochemistry,CyTOF-ready
Conjugate/TagUnconjugated
IsotypeIgG
ReactivityMouse,Transgenic Mouse
HostGoat
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
Quantity100 ug (also 25 ug)
TargetLRIG1
NCBI Full Gene Nameleucine-rich repeats and immunoglobulin-like domains 1, leucine rich repeats and immunoglobulin like domains 1
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse LRIG1, Ala37-Thr794, Accession # P70193
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse LRIG1 in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant human (rh) LRIG1 is observed and less than 5% cross-reactivity with rhLRIG3 is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signalingThe EMBO JournalMarch 18, 2026Heming Cao, Xiawei Huang, Xiaobing Jiang, Jingrong Deng, Jiahui Wang, Chengfang Wu, Minhuang Hu, Bei Zeng, Zhihao Hu, Huimin Pan, et al.anti-HA (GNI #GNI4110-HA-B, 1:250), rabbit anti-DCP-1 (CST #9578S, 1:100), anti-mLRIG1 (R&D Systems #AF3688, 10 µg/mL). For immunohistochemistry (IHC): Rabbit anti-YAP (Abclonal #A19134, 1:100), rabbit anti-phospho-SPAK

(2) Lgr5+ Stem Cells Maintain Apex Position in Cell Hierarchy of the Intestinal Epithelium During Homeostasis and InjurybioRxivJanuary 16, 2026Julian Chua, Lucy Driver, Masahiro Narimatsu, Mardi Fink, Lixia Luo, Jordan Tran, Arshdeep Kaur, Rida Habib, Jatin Roper, David G. Kirsch, et al.(Cell Signaling Technology, Cat# 39141S), goat anti-Sca1Ly6 (R&D Systems, Cat# AF1226-SP), goat anti-Lrig1 (R&D Systems, Cat# AF3688), rabbit anti-Fzd5 (Abcam, Cat#ab75234) and rabbit polyclonal anti-lysozyme (Dako, Cat# EC32117). After

(3) Ferroptosis in Meibomian Gland Progenitor Cells Contributes to Pathogenesis of Meibomian Gland DysfunctionInvestigative Ophthalmology & Visual ScienceJanuary 7, 2026Yuli Guo, Sai Luo, Wansui Li, Xuechun Wang, Wenxin Sun, Wei Zha, Rongrong Zhang, Dandong Liu, Mingyan Wei, Houjian Zhang, et al.(AS053) secondary antibody was purchased from ABclonal Technology (Wuhan, China). Goat anti-Lrig1 (AF3688) antibody was purchased from R&D Systems. Rabbit anti-Keratin 14 (K14, ab181595), anti-peroxisome proliferator

(4) Establishment of Mouse Meibomian Gland Organoids for In Vitro Modeling of Meibomian Gland DysfunctionInvestigative Ophthalmology & Visual ScienceJanuary 6, 2026Jingyu Qu, Lingling Yang, Xiaolei Wang, Leilei Zhao, Zongyi Li, Xiangzheng Zhang, Yujing Lin, Qunqin Guo, Hongran Zhao, Yanlin Zhong, et al.Santa Cruz Biotechnology, Dallas, TX, USA), leucine-rich repeats and Ig-like domains-1 (LRIG1, 1:100, AF3688; R&D Systems, Minneapolis, MN, USA), PPARγ (1:100, ab209350; Abcam), or acyl-CoA wax-alcohol acyltransferase

(5) TGFα is required for hair follicle function during aging and its loss leads to progressive alopeciaJournal of Investigative DermatologyNovember 26, 2025Jackelyn R. Raymundo, Jasson Makkar, Michael G. Fasci, Ryan R. Driskell, Alexander G. MarnerosCell Signaling Technology, cat# 82630S, RRID:AB_2665492), goat anti-Lrig1 (1:100, R&D systems, cat#AF3688, RRID:AB_2138836), rabbit anti-phospho-histone H2X.A (Ser139) (20E3) (1:300, Cell Signaling Technology,

(6) Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regenerationCellDecember 26, 2024Ying Lyu, Soo Jin Kim, Ericka S. Humphrey, Richa Nayak, Yinglu Guan, Qingnan Liang, Kun Hee Kim, Yukun Tan, Jinzhuang Dou, Huandong Sun, et al.rabbit monoclonal",Cell Signaling Technology 9664,Clone: 5A1E "Anti-LRIG1, goat polyclonal",R&D Systems AF3688,RRID: AB_2138836 "Anti-LEF1, rabbit monoclonal",Cell Signaling Technology 2230,Cone: C12A5 "Anti-SOX9,

(7) Urban Particulate Matter Triggers Meibomian Gland DysfunctionInvestigative ophthalmology & visual scienceFebruary 1, 2024Tu M, Liu R, Xue J, Xiao B, Li J, Liang L.anti-Ki67 (1:150, MA5-14520; Invitrogen), rabbit anti-P63 (1:100, ab124762; Abcam), goat anti-Lrig1 (1:100, AF3688; R&D Systems, Minneapolis, MN, USA), rabbit anti-NLRP3 (1:100, NBP2-12446; R&D Systems), rabbit anti-cleaved

(8) Control of murine brown adipocyte development by GATA6Developmental CellNovember 1, 2023Seoyoung Jun, Anthony R. Angueira, Ethan C. Fein, Josephine M. E. Tan, Angela H. Weller, Lan Cheng, Kirill Batmanov, Jeff Ishibashi, Alexander P. Sakers, Rachel R. Stine, et al.AF6677",RRID:AB_10890570 Anti-PDGFRɑ-PECy7,"Biolegend, 135912",RRID:AB_2715974 Goat anti-LRIG1,"R and D Systems, AF3688",RRID:AB_2138836 Donkey anti-goat Alexa 488,"Invitrogen, A11055",RRID:AB_2534102 Anti-human/mouse

(9) Myc-dependent dedifferentiation of Gata6(+) epidermal cells resembles reversal of terminal differentiationNature cell biologyOctober 1, 2023Bernabé-Rubio M, Ali S, Bhosale PG, Goss G, Mobasseri SA, Tapia-Rojo R, Zhu T, Hiratsuka T, Battilocchi M, Tomás IM, et al.14-0495-81); Myc (1:100, Abcam ab32072); Ki67 (1:50, Novus Biologicals NB600-1252); Lrig1 (1:200, R&D Systems AF3688); Involucrin (1:500, ERLI-3 clone, in-house); CD45 (1:200, 30-F11 clone, eBioscience 14-0451-82); pMLC

(10) Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sortingCell reportsMarch 15, 2022Lewis AE, Kuwahara A, Franzosi J, Bush JO.

(11) Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse developmentCell reportsFebruary 22, 2022Xie Y, Kuan AT, Wang W, Herbert ZT, Mosto O, Olukoya O, Adam M, Vu S, Kim M, Tran D, et al.RRID:AB_2298772 Mouse monoclonal anti-VGluT2,Millipore,MAB5504; RRID:AB_10677395 Goat monoclonal anti-Lrig1,Novus Bio,AF3688; RRID:AB_2138836 Goat monoclonal anti-Il33,Novus Bio,AF3626; RRID:AB_884269 Goat monoclonal anti-Sparc,R&D Systems

(12) Differential toxicity to murine small and large intestinal epithelium induced by oncology drugsCommunications biologyJanuary 27, 2022Bieber JM, Sanman LE, Sun X, Hammerlindl H, Bao F, Roth MA, Koleske ML, Huang L, Aweeka F, Wu LF, et al.

(13) Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin developmentDevelopmental biologyOctober 1, 2021Thulabandu V, Nehila T, Ferguson JW, Atit RP.anti-Dlk1,R&D Systems,Cat: AF1144 RRID:AB_2230586,IF (1:50) Antibody,goat anti-Lrig1,R&D Systems,Cat: AF3688 RRID:AB_2138836,IF (1:100) Antibody,rabbit anti-TCF4,Cell Signaling,Cat: 2569 RRID:AB_2199816,IHC (1:100) Antibody,rabbit

(14) Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelializationCell stem cellSeptember 2, 2021Huang S, Kuri P, Aubert Y, Brewster M, Li N, Farrelly O, Rice G, Bae H, Prouty S, Dentchev T, et al.R&D Systems), anti-KLF4 (1:50, AF3158, R&D Systems), anti-KLF5 (1:50, AF3758, R&D Systems), anti-LRIG1 (1:50, AF3688, R&D Systems) and anti-BrdU (1:100, B-35128, Invitrogen). The following secondary antibodies were used:

(15) Cutaneous Effects of In Utero and Lactational Exposure of C57BL/6J Mice to 2,3,7,8-Tetrachlorodibenzo-p-dioxinToxicsAugust 20, 2021Bhuju J, Olesen KM, Muenyi CS, Patel TS, Read RW, Thompson L, Skalli O, Zheng Q, Grice EA, Sutter CH, et al.Santa Cruz Biotechnology, Dallas, TX, USA), CYP1B1 [1:250 (IF), 1:500 (IHC), Walker et al., 1998], LRIG1 (1:25, AF3688, R&D Systems, Minneapolis, MN, USA) and LGR6 (1:100, sc-393010, Santa Cruz Biotechnology). Prior to

(16) LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the NeocortexCell reportsOctober 13, 2020Jeong D, Lozano Casasbuenas D, Gengatharan A, Edwards K, Saghatelyan A, Kaplan DR, Miller FD, Yuzwa SA.

(17) Delineating the early transcriptional specification of the mammalian trachea and esophaguseLifeJune 9, 2020Kuwahara A, Lewis AE, Coombes C, Leung FS, Percharde M, Bush JO.polyclonal) NovusBio Cat: NBP188644 1:200 for IF Antibody a-LRIG1 (Goat polyclonal) R&D Systems Cat#: AF3688 1:250 for IF Antibody a-SMA (Rabbit polyclonal) Abcam AB5694 1:300 for IF Antibody a-SMA-cy3 (mouse

(18) A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in miceNature communicationsMarch 18, 2020Piedrafita G, Kostiou V, Wabik A, Colom B, Fernandez-Antoran D, Herms A, Murai K, Hall BA, Jones PH.overnight with primary antibody at 4 °C. Primary antibodies used were Lrig1 antibody (R&D Systems, Cat. AF3688), ITGA6 antibody (clone GoH3, Biolegend, Cat. B204094), Alexa Fluor® 647 anti-CD45 (clone 30-F11, Biolegend,

(19) The aging skin microenvironment dictates stem cell behaviorProceedings of the National Academy of Sciences of the United States of AmericaMarch 10, 2020Ge Y, Miao Y, Gur-Cohen S, Gomez N, Yang H, Nikolova M, Polak L, Hu Y, Verma A, Elemento O, et al.

(20) Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the SkinDevelopmental cellNovember 4, 2019Veniaminova NA, Grachtchouk M, Doane OJ, Peterson JK, Quigley DA, Lull MV, Pyrozhenko DV, Nair RR, Patrick MT, Balmain A, et al.

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Mouse LRIG1 Antibody

LRIG1 Antibody

LRIG1 Antibody

LRIG1 Antibody

LRIG1 Antibody

LRIG1 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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LRIG1 Antibody from R&D Systems, a Bio-Techne Brand

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