Fig 2: C/EBPβ orchestrates recruitment of components of the RNA Pol III transcriptional complex: (A) UCSC Genome Browser view showing ChIP-seq data for C/EBP-β in the indicated cancer cell lines on miR-138 locus. Signal intensity (y-axis) is a representation of enrichment for transcription factor binding based on the number of overlapping ChIP DNA fragments at each nucleotide position. (B) UCSC Genome Browser view showing ChIP-seq data for C/EBP-β in the indicated cancer cell lines on miR-886 locus. (C) UCSC Genome Browser view showing ChIP-seq data for C/EBP-β in the indicated cancer cell lines on tRNA-GLU locus. (D) Bar graph depicting a concomitant down-regulation of miR-138 expression upon knockdown of C/EBPβ (n = 5). (E) Bar graph depicting a concomitant down-regulation of miR-886 expression upon knockdown of C/EBPβ (n = 3). (F) Bar graph depicting a concomitant down-regulation of tRNA-GLU expression upon knockdown of C/EBPβ (n = 3). (G) ChIP analysis indicates a significant decrease in PolR3D, BRF1 and TFIIIC occupancy on miR-138 locus upon C/EBPβ knockdown. (H) ChIP analysis indicates a significant decrease in PolR3D, BRF1 and TFIIIC occupancy on miR-886 locus upon C/EBPβ knockdown (n = 2). (I) ChIP analysis indicates a significant decrease in PolR3D, BRF1 and TFIIIC occupancy on tRNA-GLU locus upon C/EBPβ knockdown. Error bars represent the standard deviation. (Student's t-test; *[P < 0.05], **[P < 0.001])