NeuN Antibody 266 004 from Synaptic Systems GmbH

Product Specs
ItemNeuN Antibody
CompanySynaptic Systems GmbH
Price $405.00Supplier Page View Company Product Page
Catalog Number266 004
Quantity100 µl
ApplicationsICC, IHC, IHC-P, IHC-Fr
Formatlyophilized
Reactivityrat, mouse, human
TargetNeuN
HostGuinea pig
Clonalitypolyclonal
ImmunogenRecombinant protein corresponding to AA 1 to 97 from mouse NeuN
Antibody TypePrimary antibody

Questions and Answers

What species does this NeuN antibody work with, and how has it been utilized in research?

The NeuN antibody is reactive with mouse, human, and rat species. It has been utilized in various studies, including immunocytochemistry and immunohistochemistry, to identify neuronal populations and assess neuronal health in models of neurological disorders, such as autism spectrum disorder and Huntington's disease, as demonstrated in research articles like and .

Can this antibody be used for specific applications in tissue analysis, and what are some examples from the literature?

Yes, the NeuN antibody has been shown to be effective for applications such as immunocytochemistry and immunohistochemistry. For instance, it was used at a dilution of 1:500 in studies examining neuronal populations in mouse models, as reported in and .

How does the NeuN antibody contribute to understanding neuronal function in disease models?

The NeuN antibody is crucial for identifying and quantifying neuronal populations in various disease models. For example, it has been employed to assess neuronal integrity and changes in expression in models of Huntington's disease, as seen in . This helps elucidate the cellular mechanisms underlying neurodegenerative conditions.

What is the significance of using the NeuN antibody in the context of neuronal research?

The NeuN antibody is significant because it labels a neuron-specific nuclear protein, allowing researchers to distinguish neurons from other cell types in the central nervous system. Its application in studies, such as those investigating the effects of genetic mutations on neuronal excitability, highlights its importance in understanding neuronal function and pathology, as illustrated in .

Synaptic Systems GmbH

Rudolf-Wissell-Str. 28

Goettingen 37079

Germany

Phone: +49-551-50556-0
+49-551-50556-384

Company Profile

Website: http://www.sysy.com/

(1) Remodeling synaptic connections via engineered neuron-astrocyte interactionsNat CommunApril 15, 2026Shin Heun Kim, Woojin Won, Gyu Hyun Kim, Yeon Hee Kook, Seungkyu Son, Songhee Choi, Dong Yeop Kang, Mingu Gordon Park, Young-Jin Choi, Seong Su Won, et al.(Synaptic systems, 131 003, 1:500), anti-Gephyrin (Abcam, Ab32206, 1:500). anti-NeuN (Synaptic systems, 266 004, 1:1000), anti-FLAG Tag (Invitrogen, 740001, 1:1000), anti-GluA1 (EMD Millipore, AB1504, 1:500), anti-Synaptopodin

(2) α4 Integrin blockade impairs CD8+ T cell neuroimmune surveillance following SIV infectionJournal of Clinical InvestigationApril 15, 2026Pabitra B. Pal, Sonny R. Elizaldi, Giovanne B. Diniz, Ravi Prakash Rai, Yashavanth Shaan Lakshmanappa, Anil Verma, Daniel Rossmiller, Jesse Kaufman, Rahul Srivastava, Sean Ott, et al.1 μg/section), HLA-DR (Invitrogen, 14-9956-82, mouse, 2.5 μg/section), and NeuN (Synaptic Systems, 266004, guinea pig, 1 μL/section). Secondary antibodies included Alexa Fluor 488 anti-rabbit, 555 anti-mouse,

(3) ACSS2 mediates prenatal alcohol exposure-related morphological and behavioral phenotypesNeurobiology of DiseaseApril 1, 2026Kala M. Dodson, Erica M. Periandri, Anjali Yadav, Mariana Lopes, Amelia J. Barfield, Anjola Ola, Francisca N. de Luna Vitorino, Cory Cearlock, Benjamin A. Garcia, Cheryl A. Hill, et al.Tween20–1xPBS. Blocking solution was removed and sections stained with 1:500 NeuN (Synaptic Systems, Cat. No. 266004) in 10 mM glycine in 0.5% Tween20–1xPBS solution shaking overnight at 4 °C. Washing and blocking were

(4) Bidirectional Roles of TRPV1 in a Latent Sensitization Model of Myofascial Low Back PainEur J PainMarch 26, 2026Vivian Blechschmidt, Bastian Schlickenrieder, Jonathan R. Husk, Ulrich Hoheisel, Handan Mörz, Rolf-Detlef Treede, Wolfgang Greffrath(rabbit, 1:500; Cat. No. ACC‐030, Alomone Labs, Jerusalem, Israel) and NeuN (guinea pig, 1:1000; Cat. No. 266004, Synaptic Systems, Göttingen, Germany) primary antibodies were used to determine TRPV1 expression. The

(5) Neuroinflammatory stress preferentially impacts synaptic MAPK signaling and mitochondria in excitatory neuronsMolecular Neurodegeneration AdvancesMarch 24, 2026Claudia Espinosa-Garcia, Upasna Srivastava, Prateek Kumar, Dilpreet Kour, Sneha Malepati, Brendan R. Tobin, Hailian Xiao, Sydney Sunna, Christine A. Bowen, Lihong Cheng, et al.,287 004,RRID:AB_2620025,"1:1,000",IF GFAP,Invitrogen,13–0300,RRID:AB_2532994,"1:1,000","WB, IF" NeuN,Synaptic Systems,266 004,RRID:AB_2619988,"1:2,000",IF MBP,Abcam,ab7349,RRID:AB_305869,"1:1,000",WB B. Secondary antibodies,,,,, Streptavidin-

(6) Protocol for mouse vascular dementia model and evaluation of progressive tissue damage in subcortical white matter and adjacent cortexSTAR ProtocMarch 20, 2026Min Tian, Irene L. Llorente, S. Thomas Carmichaeldilution",Chemicon,Cat#MAB377; RRID: AB_2298772 "Guinea pig Polyclonal anti-NeuN, 1:500 dilution",Synaptic Systems GmbH,Cat#266004; RRID: AB_2619988 "Mouse monoclonal anti-NF160, 1:500 dilution",Abcam,Cat#Ab7794-1001; RRID: AB_306083 "Rabbit

(7) Neuron-specific expression of murine thyroid hormone transporters Mct8 and Oatp1c1 is dispensable for hippocampus-dependent neuronal functionsFront Endocrinol (Lausanne)March 17, 2026Andrea Alcaide-Martin, Rim Jaber, Anita Boelen, Heike Heuer, Steffen MayerlSwant), mouse anti-NeuN (1:500, MAB377, Sigma-Aldrich), guinea pig anti-neuronal nuclei (NeuN, 1:1000, 266004, Synaptic Systems), guinea pig anti-doublecortin (1:500, AB2253, Millipore). qPCR For qPCR studies,

(8) Neuron-specific expression of murine thyroid hormone transporters Mct8 and Oatp1c1 is dispensable for hippocampus-dependent neuronal functionsFront Endocrinol (Lausanne)March 17, 2026Andrea Alcaide-Martin, Rim Jaber, Anita Boelen, Heike Heuer, Steffen MayerlSwant), mouse anti-NeuN (1:500, MAB377, Sigma-Aldrich), guinea pig anti-neuronal nuclei (NeuN, 1:1000, 266004, Synaptic Systems), guinea pig anti-doublecortin (1:500, AB2253, Millipore). qPCR For qPCR studies,

(9) Central nervous system-penetrant anti-C1q therapy reduces neuroinflammation and preserves neurological function in a model of progressive multiple sclerosisBrain Behav ImmunMarch 3, 2026Michael Linzey, Steven C. Pike, Nour-Maria Bouzid, Aine Scholand, Cinthia Gonzalez Cruz, Andrew Philips, Laura DeCristofano, Hiep Tran, Francesca Gillianti-IBA1 (1:500, Fujifilm Wako Pure Chemical Co. #019-19741), anti-NeuN (1:500, Synaptic Systems #266-004), anti-MBP (1:1000, Neuromics #ch22112), anti-GFAP (1:500, Abcam #Ab4674), anti-APP (1:1000, Abcam #Ab32136),

(10) Ageing promotes microglial accumulation of slow-degrading synaptic proteinsNatureFebruary 26, 2026Ian H. Guldner, Viktoria P. Wagner, Patricia Moran-Losada, Sophia M. Shi, Sophia W. Golub, Johannes F. Hevler, Kelly Chen, Barbara T. Meese, Ali Ghoochani, Ernst Pulido, et al.1:400; rabbit anti-IBA1 (Fujifilm Wako, 019-19741) at 1:2,000; guinea pig anti-NeuN (Synaptic Systems, 266 004) at 1:1,000; rabbit anti-SATB2 (Synaptic Systems, 327 003) at 1:500; guinea pig anti-parvalbumin (Synaptic Systems

(11) Functional border-associated macrophages limit Alzheimer's Disease progressionbioRxivFebruary 3, 2026Drew Adler, Natália Pinheiro-Rosa, Alon Millet, Zoran Z Gajic, Evan Cheng, Begoña Gamallo-Lana, Yosuke Morizawa, Eric Klann, Wen-Biao Gan, Adam C Mar, et al.(1:150, AF3628, R& D systems), Rabbit anti-IBA1 (1:1000, 019–19741, Wako), Guinea Pig anti-NeuN (1:1000, 266 004, Synaptic systems), Rat anti-CD206 (1:500, MCA2235, Bio-Rad), Rat anti LAMP1 (1:250, 1D4B, DSHB), Rabbit anti-Laminin

(12) Super-resolved, three-dimensional spatial transcriptomics reveals cell-type and brain-region-specific modulation of key epitranscriptomic switches following adolescent alcohol exposurebioRxivJanuary 28, 2026Jamuna Tandukar, Anam Islam, Emir Malovic, Bisma Afzal, Huaibo Zhang, Subhash C. Pandey, Ruixuan Gao(1:200 dilution with the blocking buffer) overnight at RT. Primary antibodies against NeuN [guinea pig, 266004, Synaptic Systems (SYSY)], GFAP (guinea pig, 173308, SYSY), or IBA1 (chicken, 234009, SYSY) were used

(13) Scalable and multiplexed recorders of gene regulation dynamics across weeksNatureJanuary 26, 2026Lirong Zheng, Dongqing Shi, Yixiao Yan, Bingxin Zhou, Jormay Lim, Yongjie Hou, Bobae An, Jason K. Adhinarta, Michael Lin, BumJin Ko, et al.Cell Signaling Technology, 1:50 for brain slices), anti-γH2AX (05-636, Sigma), anti-synaptophysin (S5768, Sigma), anti-NeuN (266004, Synaptic Systems, 1:1,000 for brain slices), anti-Iba1 (019-19741, Wako Chemicals), anti-Ki67 (ab279653,

(14) Mislocalization of KCNQ2 Channels as a Pathogenic Mechanism in KCNQ2 Developmental and Epileptic EncephalopathyJ NeurosciJanuary 21, 2026Kristen Springer, Heun Soh, Raquel Paz Paz Zavala, Nissi Varghese, Cathleen Lutz, Aamir R. Zuberi, Alexander C. Jackson, Anastasios V. Tzingounisα-AnkG (Synaptic Systems Cat# 386 005, RRID:AB_2737033), and guinea pig α-NeuN (Synaptic Systems Cat# 266 004, RRID:AB_2619988). Following three washes in PBS, slices were incubated for 2 hr at room temperature

(15) Haptoglobin and Hemopexin Redirect Heme-Driven Oxidative Stress and Neurotoxicity in Organotypic Brain SlicesACS Chemical NeuroscienceJanuary 7, 2026Anna-Lea T. Stalder, Raphael M. Buzzi, Florence Vallelian, Dominik J. Schaerimmunostaining. Primary antibodies (72 h, 4 °C, in PB: PBS 1:1): guinea-pig anti-NeuN 1:1000 (Synaptic Systems 266 004), rabbit anticleaved Caspase-3 1:300 (Cell Signaling Technology #9661), rat anti-GFAP 1:300 (Thermo Fisher

(16) Synchrotron‐generated microbeams as a radiosurgical alternative for drug‐resistant epilepsies: Proof of concept in a mouse model of mesiotemporal lobe epilepsyEpilepsiaDecember 23, 2025Loan Samalens, Camille Beets, Clothilde Courivaud, Sarvenaz Keshmiri, Jean‐François Adam, Paolo Pellicioli, Emmanuel Luc Barbier, Raphaël Serduc, Antoine DepaulisPrimary antibody,Secondary antibody "Guinea Pig monoclonal anti‐NeuN (Synaptic System, ref.: 266004) Dilution: 1/1000","Goat anti‐Guinea Pig AlexaFluor 488 (Life Technologies, ref.: A11073) Dilution:

(17) Inhibition of N6-Methyladenosine Accumulation by Targeting METTL3 Mitigates Tau Pathology and Cognitive Decline in Alzheimer’s DiseaseResearch SquareDecember 19, 2025Lulu Jiang, Allison Tucker, Camron Sepehri, Dev Patel, Qingbo Wang, Shuo Yuan, Eliana Sherman, Yicheng Chen, Joey Beh, Addysen Downey, et al.(Thermo Fisher Scientific, Cat# 13–0300, RRID: AB_2532994); guinea pig polyclonal anti-NeuN antibody (Synaptic Systems, Cat# 266 004, RRID: AB_2619988). STM2457 treatment via osmotic pump delivery STM2457 (MedChem Express, Cat#HY-134836),

(18) Regulation of glypican 6-mediated Wnt activation maintains TDP-43 nuclear localization in neuronsScientific ReportsDecember 11, 2025Nan Zhang, Shanthini Sockanathananti-Tubulin,BioRad,"12,004,166",Immunoblotting: 1:5000 MYC,Cell Signaling Technologies,2278,IHC: 1:250 NeuN,Synaptic Systems,266 004,IHC: 1:1000 non-phospho-β-catenin,Cell Signaling Technologies,8814,Immunoblotting: 1:1000 Nup98,Abcam,ab50610,IHC:

(19) Early life stress alters microglia in ventral hippocampus and dorsal CA2 associated with anxiety-like behavior in adolescent male ratsExp Brain ResDecember 8, 2025Kezzia Jones, Lindsay Teliska, Martine M. Mirrione, Adrienne J. Betzusing rabbit Iba1 at 1:1000 (Wako, Cat. 019–19741) and guinea pig NeuN at 1:500 (Synaptic Systems, Cat. 266004). Brain tissues were stained in series, with Iba1 primary first, followed by NeuN, to eliminate cross-reactivity

(20) Neonatal sevoflurane exposures inhibits DHHC5-mediated palmitoylation of TfR1 in oligodendrocytes, leading to hypomyelination and neurological impairmentsJournal of advanced researchDecember 1, 2025Liu H, Su B, Zhang Z, Jia S, Wang J, Zhou F, Liu Y, Cao Q, Tang J, Ou Z, et al.Glutathione Peroxidase 4(GPX4, 1:100, Abcam, #ab125066), neuronal nuclei (NeuN, 1:200, Synaptic Systems, #266004), PDGFRα (1:100, Abcam, #ab203491), CC1 (Calbiochem, #OP80), and GFP (1:100, Abcam, #ab92456) were added

Be the First to Write a Review!

NeuN Antibody

NeuN Antibody

NeuN Antibody

NeuN Antibody

NeuN Antibody from Synaptic Systems GmbH

Description

Questions and Answers

Synaptic Systems GmbH

Citations (230)

Reviews

NeuN Antibody from Synaptic Systems GmbH

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map