RGC32/C13orf15 Rabbit Polyclonal Antibody orb2372 from Biorbyt

Product Specs
ItemRGC32/C13orf15 Rabbit Polyclonal Antibody
CompanyBiorbyt
Price $250.00Supplier Page
Catalog Numberorb2372
Quantity50 ul, 100 ul, 200 ul
ApplicationsFC, IF, IHC-Fr, IHC-P
Conjugate/TagUnconjugated
TargetRGCC
ReactivityHuman, Mouse, Rat
ClonalityPolyclonal
FormatLiquid
ImmunogenKLH conjugated synthetic peptide derived from human RGC32 (65-137/137aa)
Molecular Weight15 kDa
IsotypeIgG
HostRabbit
Concentration1mg/ml
NCBI Full Gene Nameregulator of cell cycle
NCBI Gene AliasesC13orf15, RGC-32, RGC32, bA157L14.2
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Research AreaEpigenetics and Nuclear Signaling, p53 Signaling Pathway

Specifications/Features

Application Dilutions: IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=1ug/test

Questions and Answers

How has the RGC32 antibody been utilized in cancer research?

The RGC32 antibody has been shown to play a significant role in cancer research, particularly in studies related to colon cancer. For instance, it was used to investigate the expression of RGC-32 in tumor-associated macrophages, revealing that increased RGC-32 expression correlates with cancer progression. The antibody facilitated the examination of macrophage migration and its impact on tumor cell behavior, as detailed in the study by Zhao et al. (2019).

What specific applications can I use the RGC32 antibody for in my experiments?

The RGC32 antibody is suitable for various applications, including ELISA, flow cytometry, immunofluorescence, and both frozen and paraffin-embedded tissue immunohistochemistry. This versatility allows researchers to explore RGC-32's role in different experimental contexts, such as studying its effects on macrophage polarization and tumor progression.

Can the RGC32 antibody help in understanding the tumor microenvironment?

Yes, the RGC32 antibody can provide insights into the tumor microenvironment, particularly regarding the interaction between tumor-associated macrophages and cancer cells. Research has indicated that RGC-32 expression in macrophages is influenced by factors such as TGF-β1 secreted by colon cancer cells, which can alter macrophage behavior and contribute to tumor progression.

What species does the RGC32 antibody react with, and is it effective for human studies?

The RGC32 antibody is reactive with multiple species, including humans, mice, and rats. This broad reactivity makes it a valuable tool for studies involving human tissues, as well as comparative studies in animal models, enhancing its applicability in translational research.

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(1) Response gene to complement 32 promotes tumorigenesis by mediating DNA damage repair and inhibits CD8+ T cells infiltration in diffuse large B-cell lymphomaFront ImmunolJuly 16, 2025Xiyuan Zhang, Tiange Lu, Chunlei Shi, Mengfei Ding, Ling Wang, Xinting Hu, Xin Wanggroups based on composite score thresholds. The antibody panel comprised anti-RGC32 antibody (Biorbyt, orb2372, 1:200), human anti-CD8a antibody (ABclonal, A0663, 1:200), mouse anti-CD8a antibody (Servicebio, GB114196,

(2) Response gene to complement 32 expression in macrophages augments paracrine stimulation-mediated colon cancer progressionCell death & diseaseOctober 10, 2019Zhao P, Wang B, Zhang Z, Zhang W, Liu Y.R&D Systems (AF4198 and MAB20401). Rabbit polyclonal anti-RGC-32 antibody was purchased from Biorbyt (orb2372). Anti-smad2 and anti-p-smad2 were purchased from Cell Signaling Technology (5339 and 18338). TGF-β1

(3) RGC-32 regulates reactive astrocytosis and extracellular matrix deposition in experimental autoimmune encephalomyelitisImmunologic researchAugust 1, 2018Tatomir A, Tegla CA, Martin A, Boodhoo D, Nguyen V, Sugarman AJ, Mekala A, Anselmo F, Talpos-Caia A, Cudrici C, et al.

(4) RGC-32 is expressed in the human atherosclerotic arterial wall: Role in C5b-9-induced cell proliferation and migrationExperimental and molecular pathologyOctober 1, 2016Vlaicu SI, Tatomir A, Boodhoo D, Ito T, Fosbrink M, Cudrici C, Mekala AP, Ciriello J, Crişan D, Boţan E, et al.

(5) Quantitative and qualitative determinations of the combined effect of tetracycline and oleandomycin. I. In vitro effectThe Japanese journal of antibioticsMay 1, 1976Tone J, Niki K, Maeda H, Ihara I, Kawakami M.

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