Biorbyt's PIAS1 (C) Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Precipitation, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, and Western Blot. The PIAS1 (C) Antibody, Rabbit Polyclonal was generated using PIAS1 as the antigen and it reacts with Homo Sapiens, Human, and Mouse.
Description
Rabbit polyclonal to PIAS1.E3 SUMO-protein ligase PIAS1 is a member of the mammalian PIAS (protein inhibitor of activatedSTAT-1 (signal transducer and activator of transcription-1)) family, which contains a putative zincbindingmotif and a highly acidic region. PIAS1 functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMOtetheringfactor. PIAS1 plays a crucial role as a transcriptional coregulation in various cellularpathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.In vitro, PIAS1 binds A/T-rich DNA. The effects of the transcriptional coregulation, transactivation orsilencing, may vary depending upon the biological context