Mast Cell Chymase (CC1) Antibody sc-59586 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemMast Cell Chymase (CC1) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-59586
Antibody TypePrimary Antibodies
NCBI Gene AliasesMMCP-5, chymase, Mcp5, CYH, Mcpt5, Mcp-5, MCT1
CloneCC1
Quantity200 µg/ml
Reactivitymouse, rat, human
ApplicationsWB, IP, IF, IHC(P)
FormatPurified
ClonalityMonoclonal
Hostmouse
Conjugate/TagUnconjugated
NCBI Full Gene Namechymase 1, mast cell, chymase 1
Targetskin chymase
IsotypeIgG1

Questions and Answers

Can this antibody be used to study mast cell activation in inflammatory conditions?

Yes, the Mast Cell Chymase (CC1) Antibody has been utilized in studies examining mast cell activation in various inflammatory conditions. For instance, in a study on acute lung injury, the antibody was employed to assess the expression of chymase in lung tissue, demonstrating its role in mast cell activation and inflammation (Interdonato et al., 2022).

Is this antibody effective for immunohistochemical analysis in animal models?

The Mast Cell Chymase (CC1) Antibody has been shown to work effectively in immunohistochemical analyses. It was used in a study investigating endometriosis, where it helped identify chymase expression in endometriotic lesions, indicating its utility in histological evaluations (Arangia et al., 2023).

What species can this antibody react with, and is it suitable for cross-species studies?

This antibody is reactive with mouse, human, and rat tissues, making it suitable for cross-species studies. Its reactivity across these species allows researchers to investigate mast cell functions and related pathways in various biological contexts.

Has this antibody been cited in any significant research studies?

Yes, the Mast Cell Chymase (CC1) Antibody has been cited in at least 12 scientific articles, indicating its relevance and application in various research studies focused on mast cell biology and related inflammatory processes.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Novel Findings on CCR1 Receptor in CNS Disorders: A Pathogenic Marker Useful in Controlling Neuroimmune and Neuroinflammatory Mechanisms in Parkinson's DiseaseInternational journal of molecular sciencesApril 14, 2024Repici A, Capra AP, Hasan A, Bulzomì M, Campolo M, Paterniti I, Esposito E, Ardizzone A.USA), IBA-1 (1:100; sc-32725 Santa Cruz Biotechnology, Santa Cruz, CA, USA), Mast Cell Chymase (1:100; sc-59586 Santa Cruz Biotechnology, Santa Cruz, CA, USA), Mast Cell Tryptase (1:100; sc-59587 Santa Cruz Biotechnology,

(2) Fisetin, a Natural Polyphenol, Ameliorates Endometriosis Modulating Mast Cells Derived NLRP-3 Inflammasome Pathway and Oxidative StressInternational journal of molecular sciencesMarch 7, 2023Arangia A, Marino Y, Fusco R, Siracusa R, Cordaro M, D'Amico R, Macrì F, Raffone E, Impellizzeri D, Cuzzocrea S, et al.(Santa Cruz Biotechnology SCB,1:100 Biogenerica srl CT, Italy) and TGF-β (SCB, sc-130348 1:100) anti-chymase (1:100, SCB #sc59586 Biogenerica srl CT, Italy), and anti-tryptase (1:100, SCB, #sc59587 Biogenerica srl CT, Italy), anti-poly

(3) Aerosol-Administered Adelmidrol Attenuates Lung Inflammation in a Murine Model of Acute Lung InjuryBiomoleculesSeptember 16, 2022Interdonato L, D'amico R, Cordaro M, Siracusa R, Fusco R, Peritore AF, Gugliandolo E, Crupi R, Coaccioli S, Genovese T, et al.[47,48,49]. Primary antibodies anti-MC chymase (1:100, Santa Cruz Biotechnology (SCB) Heidelberg, Germany, #sc59586) and anti-MC tryptase (1:100, SCB, #sc59587) were incubated overnight on the lung tissue sections. Images

(4) ChipCytometry for multiplexed detection of protein and mRNA markers on human FFPE tissue samplesSTAR protocolsJune 17, 2022Jarosch S, Köhlen J, Wagner S, D'Ippolito E, Busch DH.

(5) Flagellin maintains eosinophils in the intestineCytokineFebruary 1, 2022Lv X, Chang Q, Wang Q, Jin QR, Liu HZ, Yang SB, Yang PC, Yang G.

(6) Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular CoagulationInternational journal of molecular sciencesOctober 21, 2021D'Amico R, Monaco F, Siracusa R, Cordaro M, Fusco R, Peritore AF, Gugliandolo E, Crupi R, Cuzzocrea S, Di Paola R, et al.

(7) Regulation of osteoclastogenesis by mast cell in rheumatoid arthritisArthritis research & therapyApril 21, 2021Kim KW, Kim BM, Won JY, Min HK, Lee KA, Lee SH, Kim HR.

(8) Flagellin Alleviates Airway Allergic Response by Stabilizing Eosinophils through Modulating Oxidative StressJournal of innate immunityJanuary 1, 2021Luo XQ, Liu J, Mo LH, Yang G, Ma F, Ning Y, Yang PC, Liu DB.

(9) Rh-relaxin-2 attenuates degranulation of mast cells by inhibiting NF-κB through PI3K-AKT/TNFAIP3 pathway in an experimental germinal matrix hemorrhage rat modelJournal of neuroinflammationAugust 28, 2020Li P, Zhao G, Chen F, Ding Y, Wang T, Liu S, Lu W, Xu W, Flores J, Ocak U, et al.Biorbyt, orb157275), mouse anti-tryptase (1:200, Abcam, ab2378), mouse anti-chymase (1:200, Santa Cruz, sc-59586), and rabbit anti-TNFAIP3 (1:100, Lifespan, LS-C352948) followed by incubation with appropriate fluorescence-conjugated

(10) CAGE-miR-140-5p-Wnt1 Axis Regulates Autophagic Flux, Tumorigenic Potential of Mouse Colon Cancer Cells and Cellular Interactions Mediated by ExosomesFrontiers in oncologyJanuary 1, 2019Yeon M, Lee S, Lee JE, Jung HS, Kim Y, Jeoung D.(Santa Cruz, sc-25575, 1:500), tryptase (Santa Cruz, sc-59587,1:100), chymase (Santa Cruz, sc-25575, sc-59586, 1:200), Wnt1 (Abcam, ab-15251, 1:500), β-catenin (Santa Cruz, sc-59737, 1:100), cyclin D1(Santa Cruz,

(11) Total and antigen- (fungi, mites and staphylococcal enterotoxins) specific IgEs in nasal polyps is related to local eosinophilic inflammationInternational archives of allergy and immunologyJanuary 1, 2013Matsuwaki Y, Uno K, Okushi T, Otori N, Moriyama H.

(12) Absence of TLR4 reduces neurovascular unit and secondary inflammatory process after traumatic brain injury in micePloS oneJanuary 1, 2013Ahmad A, Crupi R, Campolo M, Genovese T, Esposito E, Cuzzocrea S.

(13) Administration of palmitoylethanolamide (PEA) protects the neurovascular unit and reduces secondary injury after traumatic brain injury in miceBrain, behavior, and immunityNovember 1, 2012Ahmad A, Crupi R, Impellizzeri D, Campolo M, Marino A, Esposito E, Cuzzocrea S.

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Mast Cell Chymase (CC1) Antibody

Mast Cell Chymase (CC1) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

Citations (13)

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Mast Cell Chymase (CC1) Antibody from Santa Cruz Biotechnology, Inc.

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