FNDC5 Polyclonal Antibody bs-8486R from Bioss Inc.

Product Specs
ItemFNDC5 Polyclonal Antibody
CompanyBioss Inc.
Price $375.00Supplier Page View Company Product Page
Catalog Numberbs-8486R
Quantity100ul, 20uL
ApplicationsWB, ELISA, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC), IF(IHC-F), WB
Concentration1ug/ul
Conjugate/TagUnconjugated
Format0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol
ReactivityHuman, Mouse, Rat, Mouse
ClonalityPolyclonal
TargetFNDC5
IsotypeIgG
Molecular Weight22kDa
HostRabbit
Antibody TypePrimary Antibody
ImmunogenKLH conjugated peptide, human FNDC5 Irisin
NCBI Gene Aliasesirisin, FRCP2
NCBI Full Gene Namefibronectin type III domain containing 5

Questions and Answers

Can this antibody be used for studying the role of FNDC5 in lung inflammation?

Yes, the FNDC5 Polyclonal Antibody has been utilized in research examining the role of irisin in acute lung injury. In a study, it was shown that exogenous irisin reduced inflammatory cell infiltration and pro-inflammatory factor secretion in a mouse model of lipopolysaccharide-induced acute lung injury, indicating its potential in studying lung inflammation mechanisms ().

Is this antibody effective for immunohistochemistry in pancreatic tissues?

The FNDC5 Polyclonal Antibody has been successfully used in immunohistochemistry to stain pancreatic sections from human donors and animal models. It was shown to identify FNDC5 expression in both α- and β-cells of the islets of Langerhans, which is crucial for understanding its role in pancreatic physiology ().

How has this antibody been applied in studies related to exercise and cognitive function?

This antibody has been employed in research investigating the effects of exercise on FNDC5 levels and cognitive function in models of Parkinson's disease. The study demonstrated that treadmill exercise increased FNDC5 levels, which in turn promoted synaptic plasticity and improved cognitive outcomes, highlighting the antibody's utility in neurobiology research ().

What is the significance of FNDC5 in skeletal muscle dysfunction studies?

The FNDC5 Polyclonal Antibody has been used to explore the expression of FNDC5 in models of chronic obstructive pulmonary disease, where it was found that FNDC5 levels were decreased in skeletal muscle dysfunction. This suggests that FNDC5 may play a role in the pathogenesis of muscle comorbidities associated with respiratory diseases ().

Bioss Inc.

300 Tradecenter Drive

Suite 4610

Woburn, MA 01801

United States

Phone: 800.501.7654 (Toll free)
Phone: +1.781.569.5821 (International)

Email: info@biossusa.com
orders@biossusa.com
support@biossusa.com
sales@biossusa.com

Company Profile

Website: www.biossusa.com

(1) Targeting the PINK1/Parkin-FNDC5 pathway: a novel mechanism of icariin in regulating muscle-bone metabolic coupling in osteosarcopeniaJ Transl MedMarch 17, 2026Mengyan Zhao, Fei Yuan, Chaoyang Liu, Tao GuoBS-23687R), LC3 (1:500, Solarbio, K008014P), p62 (1:1000, Bioss, BS-55207R), FNDC5 (1:1000, Bioss, BS-8486R), Runx2 (1:1000, BS-1134R), OCN (1:500, BS-4917R), Actin (1:20,000, Bioss, BS-10966R) as the internal

(2) Irisin activates the AMPK-Beclin1 signaling pathway to regulate pulmonary autophagy induced by CSE + LPSSci RepDecember 21, 2025Zelin Chen, Siyu Wu, Zina Bai, Tongxinwei Sun, Cuiqing Ma, Yahong Chen, Ping Jiang, Aihong MengPM036), P62(1:1000, PM045) and Beclin1(1:1000, PD017) were obtained from MBL(Beijing China); FNDC5(1:200, bs-8486R) was obtained from Bioss (Beijing China); Lipofectamine 2000 was purchased from Thermo Fisher Scientific

(3) Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophagesInternational journal of molecular medicineApril 1, 2023Han Z, Ma J, Han Y, Yuan G, Jiao R, Meng A.pH 9.0) at 98°C for 15 min. Subsequently, the sections were stained with anti-FNDC5 (1:100; cat. no. BS-8486R, BIOSS) primary antibody at 4°C overnight. Subsequently, at room temperature, the sections were incubated

(4) Irisin-A Pancreatic Islet HormoneBiomedicinesJanuary 25, 2022Norman D, Drott CJ, Carlsson PO, Espes D.followed by overnight incubation at 4 °C with primary antibodies for FNDC5 (Rabbit polyclonal antibody bs-8486R, Bioss, Woburn, MA, USA) and insulin (Cat No. 20-IP30, Fitzgerald, Acton, MA, USA) or glucagon (Biotin

(5) Dysregulated myokines and signaling pathways in skeletal muscle dysfunction in a cigarette smoke-induced model of chronic obstructive pulmonary diseaseFrontiers in physiologyJanuary 1, 2022Zhang L, Li C, Xiong J, Chang C, Sun Y.Germany) in TBST, and 5% goat serum in TBST. The primary antibodies, including anti-FNDC5 antibody (bs-8486R, Bioss, Beijing, China) (1:1,000), anti-GDF8/myostatin antibody (ab203076, Abcam, Cambridge, United

(6) The effect of antecedent-conditioning high-intensity interval training on BDNF regulation through PGC-1α pathway following cerebral ischemiaBrain researchFebruary 15, 2020Abbasian S, Asghar Ravasi A.

(7) Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 AdipocytesPloS oneJanuary 1, 2016Gao S, Li F, Li H, Huang Y, Liu Y, Chen Y.(catalog number: ab92501), ATGL (catalog number: ab109251), Abcam, England; FNDC5 (catalog number: bs-8486R), BIOSS, Beijing, China) overnight at 4°C at 1:5000 dilution. Anti-β-actin antibody (catalog number:

(8) New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitroCellular signallingSeptember 1, 2015Park MJ, Kim DI, Choi JH, Heo YR, Park SH.

(9) Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson's DiseaseInternational journal of molecular sciencesJanuary 1, 0001"Tang C, Liu M, Zhou Z, Li H, Yang C, Yang L, Xiang J."ab52636, Abcam, Shanghai, China), BDNF (1:200, ANT-010, Alomone Labs, Jerusalem, Israel), FNDC5 (1:1000, bs-8486R, Bioss, Beijing, China), integrin αV (1:200, sc-9969, Santa Cruz, Dallas, TX, USA), integrin β5 (1:200,

Be the First to Write a Review!

FNDC5 Polyclonal Antibody

FNDC5 Polyclonal Antibody from Bioss Inc.

Description

Questions and Answers

Bioss Inc.

Citations (9)

Reviews

FNDC5 Polyclonal Antibody from Bioss Inc.

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map