The FBXW5 Polyclonal Antibody, Cy5 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to FBXW5. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The FBXW5 Polyclonal Antibody, Cy5 Conjugated has been shown to work in the following applications: Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
FBXW5 is a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW5 contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented