The MITF Polyclonal Antibody, PE-Cy5.5 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to melanocyte inducing transcription factor, and MITF. This antibody recognizes Homo Sapiens, Human, and Mouse antigen. The MITF Polyclonal Antibody, PE-Cy5.5 Conjugated has been shown to work in the following applications: Western Blot.
Description
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium