TLR4 Antibody (MTS510) NB100-56560 from Novus Biologicals, a Bio-Techne Brand

Product Specs
ItemTLR4 Antibody (MTS510)
CompanyNovus Biologicals, a Bio-Techne Brand
Price $249.00Supplier Page View Company Product Page
Catalog NumberNB100-56560
ImmunogenThis TLR4 Antibody (MTS510) was developed by immunizing rats with the Ba/F3 cell line expressing mouse TLR4 and MD-2 (Akashi et al, 2000)
NCBI Gene AliasesTLR-4, TOLL, CD284, ARMD10
Concentration0.5 mg/ml
Conjugate/TagUnconjugated
TargetTLR4
Quantity0.1 mg (also 0.025 mg)
HostRat
ReactivityFlow,Human,Mouse
CloneMTS510
FormatPBS, 0.05% BSA
IsotypeIgG2a Kappa
ClonalityMonoclonal
ApplicationsFlow Cytometry,Immunoprecipitation,Flow (Cell Surface),Immunocytochemistry/ Immunofluorescence
NCBI Full Gene Nametoll like receptor 4
PurityProtein G purified
Research AreaAdaptive Immunity, Autophagy, Cytokine Research, Immunology, Inflammation, Innate Immunity, Neurodegeneration, Signal Transduction, Virology Bacteria and Parasites
Antibody TypePrimary Antibodies
Molecular Weight95.7 kDa
StorageStore at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: This antibody preferentially recognizes TLR4-MD-2 complex than of TLR4 alone.

Sizes Available: 0.1 mg (also 0.025 mg)

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Questions and Answers

Can this TLR4 antibody be used for flow cytometry applications?

Yes, the TLR4 Antibody (MTS510) has been shown to work in flow cytometry applications, allowing for the analysis of TLR4 expression on the surface of cells.

What species does this antibody react with, and is it suitable for human studies?

This antibody is reactive with both mouse and human species, making it suitable for studies involving human samples as well as mouse models.

How does this antibody perform in immunocytochemistry?

The TLR4 Antibody (MTS510) has been utilized in immunocytochemistry, providing reliable detection of TLR4 in cultured cells, which is essential for studying cellular responses to pathogens.

Is there any specific advantage of using this antibody over others targeting TLR4?

This antibody preferentially recognizes the TLR4-MD-2 complex rather than TLR4 alone, which may provide more specific insights into the signaling pathways activated by this receptor in immune responses.

Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

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(2) The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signalingThe Journal of biological chemistryJanuary 1, 0001"Tsai CC, Lin CR, Tsai HY, Chen CJ, Li WT, Yu HM, Ke YY, Hsieh WY, Chang CY, Wu YT, et al."

(3) hsp70 and a novel axis of type I interferon-dependent antiviral immunity in the measles virus-infected brainJournal of virologyJanuary 1, 0001"Kim MY, Shu Y, Carsillo T, Zhang J, Yu L, Peterson C, Longhi S, Girod S, Niewiesk S, Oglesbee M."

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(6) Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cellsInternational immunologyJanuary 1, 0001"Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M."

(7) The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophagesThe Journal of clinical investigationJanuary 1, 0001"Schaefer L, Babelova A, Kiss E, Hausser HJ, Baliova M, Krzyzankova M, Marsche G, Young MF, Mihalik D, Götte M, et al."

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(10) "TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker""Journal of immunology (Baltimore, Md. : 1950)"January 1, 0001"Jung DY, Lee H, Jung BY, Ock J, Lee MS, Lee WH, Suk K."

(11) Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection"Journal of immunology (Baltimore, Md. : 1950)"January 1, 0001"Macedo GC, Magnani DM, Carvalho NB, Bruna-Romero O, Gazzinelli RT, Oliveira SC."

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(13) TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophagesFrontiers in immunologyJanuary 1, 0001"Mahish C, De S, Chatterjee S, Ghosh S, Keshry SS, Mukherjee T, Khamaru S, Tung KS, Subudhi BB, Chattopadhyay S, et al."

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