OSR1 Antibody 3729S from Cell Signaling Technology

Product Specs
ItemOSR1 Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number3729S
Quantity100 µl
ApplicationsW
ReactivityH, Mk
TargetOSR1
Molecular Weight60
HostRabbit
NCBI Gene AliasesOSR1
NCBI Full Gene Nameoxidative stress responsive kinase 1
ClonalityPolyclonal
Research AreaCytoskeletal Signaling

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Cell Signaling Technology

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Danvers, Massachusetts 01923

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Phone: 978-867-2388
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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Central Osmolality Sensing for Arginine Vasopressin Release Is Mediated by WNK1‐OSR1/SPAK‐Kv3.1 CascadeThe FASEB JournalNovember 30, 2025Xin Jin, Jian Xie, Chia‐Wei Yeh, Yu‐Jui Li, Cheng‐Chang Lien, Chou‐Long HuangThe following primary and secondary antibodies were used: anti‐SPAK (2281, Cell Signaling); anti‐OSR (3729, Cell Signaling); GFP antibody (MA5‐15256, Invitrogen); anti‐Kv3.1 (NBP2‐12903, Novus Biologicals);

(2) Central Osmolality Sensing for Arginine Vasopressin Release Is Mediated by WNK1‐OSR1/SPAK‐Kv3.1 CascadeFASEB JNovember 17, 2025Xin Jin, Jian Xie, Chia‐Wei Yeh, Yu‐Jui Li, Cheng‐Chang Lien, Chou‐Long HuangThe following primary and secondary antibodies were used: anti‐SPAK (2281, Cell Signaling); anti‐OSR (3729, Cell Signaling); GFP antibody (MA5‐15256, Invitrogen); anti‐Kv3.1 (NBP2‐12903, Novus Biologicals);

(3) Kinase interaction analysis predicts actions of the WNK-OSR1/SPAK pathwayCommunications BiologySeptember 5, 2025Clinton A. Taylor, Ji-Ung Jung, Sachith Gallolu Kankanamalage, Justin Li, Magdalena Grzemska, Ankita B. Jaykumar, Svetlana Earnest, Steve Stippec, Purbita Saha, Eustolia Sauceda, et al.indicated elsewhere antibodies obtained from following sources: WNK1, Cobb lab Q25612; Cavin1 #69036, OSR1 #3729, and GAPDH #97166 L from Cell Signaling Technology (Beverly, MA, USA); phospho-SPAK Ser373/phospho-OSR1

(4) Expanding the druggable zinc-finger proteome defines properties of drug-induced degradationMolecular CellAugust 21, 2025Mikołaj Słabicki, Jiho Park, Radosław P. Nowak, Shourya S. Roy Burman, Jesse Pellman, Charles Zou, Hlib Razumkov, Jeannie Carreiro, Simran Rastogi, Anna Goldstein, et al.REAGENT or RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies OSR1 Rabbit,Cell Signaling,#3729S BCL6B Polyclonal Antibody,Invitrogen,#PA5-103502 Mouse beta-actin Antibody,Cell Signaling,#3700 Vinculin

(5) WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signalingbioRxivOctober 19, 2024Ankita B. Jaykumar, Derk Binns, Clinton A. Taylor, Anthony Anselmo, Shari G. Birnbaum, Kimberly M. Huber, Melanie H. Cobbanti-pOSR1/pSPAK antibody (EMD Millipore, 07–2273), anti-OSR1 polyclonal antibody (Cell Signaling, 3729S), anti-OSR1 monoclonal antibody (VWR, 10624–616), anti-WNK1 antibody (Cell Signaling, 4979S), anti-pAKT

(6) SMURF1/2 are novel regulators of WNK1 stabilitybioRxivSeptember 21, 2024Ankita B. Jaykumar, Sakina Plumber, Derk Binns, Chonlarat Wichaidit, Katherine Luby-Phelps, Melanie H. CobbV9131), anti-pOSR1 antibody (EMD Millipore, 07–2273), anti-OSR1 polyclonal antibody (Cell Signaling, 3729S), anti-OSR1 monoclonal antibody (VWR, 10624–616), anti-WNK1 antibody (Cell Signaling, 4979S), anti-

(7) SMURF1/2 Are Novel Regulators of WNK1 StabilityKinases and PhosphatasesSeptember 20, 2024Ankita B. Jaykumar, Sakina Plumber, Derk Binns, Chonlarat Wichaidit, Katherine Luby-Phelps, Melanie H. Cobb(EMD Millipore, Billerica, MA, USA; 07–2273), anti-OSR1 polyclonal antibody (Cell Signaling, Danvers, MA, USA; 3729S), anti-OSR1 monoclonal antibody (VWR, Radnor, PA, USA; 10624-616), anti-WNK1 antibody (Cell Signaling,

(8) WNK1-OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer StrategyInternational journal of molecular sciencesOctober 11, 2022Hou CY, Ma CY, Lin YJ, Huang CL, Wang HD, Yuh CH.ImageJ. The primary antibodies were anti-WNK1 (#4979, Cell signaling, Danvers, MA, USA), anti-OSR1 (#3729, Cell signaling, MA, USA), anti-PPP2AA (#2039, Cell signaling, MA, USA), and anti-β-actin (GTX109639,

(9) WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesisProceedings of the National Academy of Sciences of the United States of AmericaJuly 26, 2022Jaykumar AB, Plumber S, Barry DM, Binns D, Wichaidit C, Grzemska M, Earnest S, Goldsmith EJ, Cleaver O, Cobb MH.V9131); anti–pOSR1 antibody (EMD Millipore, 07–2273); anti–OSR1 polyclonal antibody (Cell Signaling, 3729S); anti–OSR1 monoclonal antibody (VWR, 10624–616); anti–WNK1 antibody (Cell Signaling, 4979S); anti–occludin

(10) WNK1 Enhances Migration and Invasion in Breast Cancer ModelsMolecular Cancer TherapeuticsOctober 1, 2021Ankita B. Jaykumar et al.Aldrich, B9131), anti-pOSR1 (pT325; EMD Millipore, 07–2273), anti-OSR1 (Cell Signaling Technology, 3729S), anti-WNK1 (Cell Signaling Technology, 4979S), anti-p63 (Cell Signaling Technology, 4892), anti-pan-actin

(11) Synovial Fluid of Patient With Rheumatoid Arthritis Enhanced Osmotic Sensitivity Through the Cytotoxic Edema Module in SynoviocytesFrontiers in Cell and Developmental BiologyAugust 31, 2021Min Jeong Ji, Hee Jung Ryu, Jeong Hee HongPeroxidase-conjugated β-actin antibody (A3854) was purchased from Sigma-Aldrich (St Louis, MO, United States). OSR-1 (#3729) and IL-6 (#12153) antibodies were purchased from Cell Signaling (Danvers, MA, United States). Aquaporin

(12) Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genomeCell reportsAugust 31, 2021Parrish PCR, Thomas JD, Gabel AM, Kamlapurkar S, Bradley RK, Berger AH.1:1000), MEK2 (Cell Signaling Technology #9147, 1:1000), OXSR1 (alias OSR1, Cell Signaling Technology #3729, 1:1000), STK39 (alias SPAK, Cell Signaling Technology #2281, 1:500), CDK4 (Cell Signaling Technology

(13) Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological functionCell reportsJuly 20, 2021Schiapparelli P, Pirman NL, Mohler K, Miranda-Herrera PA, Zarco N, Kilic O, Miller C, Shah SR, Rogulina S, Hungerford W, et al.corroborated by obtaining lysates and performing WB using antibodies specific for OSR1 (Cell Signaling-#3729), SPAK (Cell Signaling-#2281). Bioluminescence imaging In vivo bioluminescence images of tumor-implanted

(14) WNK1 Enhances Migration and Invasion in Breast Cancer ModelsMol Cancer TherJuly 12, 2021Ankita B. Jaykumar, Ji-Ung Jung, Pravat Kumar Parida, Tuyen T. Dang, Chonlarat Wichaidit, Ashari Rashmi Kannangara, Svetlana Earnest, Elizabeth J. Goldsmith, Gray W. Pearson, Srinivas Malladi, et al.Aldrich, B9131), anti-pOSR1 (pT325; EMD Millipore, 07–2273), anti-OSR1 (Cell Signaling Technology, 3729S), anti-WNK1 (Cell Signaling Technology, 4979S), anti-p63 (Cell Signaling Technology, 4892), anti-pan-actin

(15) Regulation of CFTR Bicarbonate Channel Activity by WNK1: Implications for Pancreatitis and CFTR-Related DisordersCellular and molecular gastroenterology and hepatologyJanuary 1, 2020Kim Y, Jun I, Shin DH, Yoon JG, Piao H, Jung J, Park HW, Cheng MH, Bahar I, Whitcomb DC, et al.and Immunoblot Analysis The antibodies against SPAK (#2281; Cell Signalling Technology, Danvers, MA), OSR1 (#3729; Cell Signalling Technology), CFTR (M3A7; Upstate Biotechnology, Waltham, MA), Flag epitope (F3165;

(16) A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic LeukemiaCancer cellNovember 13, 2017Robles-Valero J, Lorenzo-Martín LF, Menacho-Márquez M, Fernández-Pisonero I, Abad A, Camós M, Toribio ML, Espinosa L, Bigas A, Bustelo XR.

(17) Ca²⁺is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell LineThe Korean Journal of Physiology & PharmacologyApril 30, 2015Soonhong Park, Sang Kyun Ku, Hye Won Ji, Jong-Hoon Choi, Dong Min Shinpurchased from Millipore (Cat#07-2273). Rabbit polyclonal OSR1 antibody was purchased from Cell signaling (#3729). Cyclopiazonic acid was from Enzo life science (Farmingdale, NY, USA). 2-Aminoethoxydiphenyl borate

(18) MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinasesThe EMBO JournalMay 4, 2011Beatrice M Filippi, Paola de los Heros, Youcef Mehellou, Iva Navratilova, Robert Gourlay, Maria Deak, Lorna Plater, Rachel Toth, Elton Zeqiraj, Dario R Alessiantibodies were purchased from Cell Signaling: ERK1/2 (Total; cat. No. 9102), OSR1 (Total; cat. No. 3729) SPAK (Total; cat. No. 2281) and MO25a (Total; cat. No. 2716). Horseradish peroxidase (HRP)-conjugate

(19) WNK1 is required for mitosis and abscissionProceedings of the National Academy of SciencesJanuary 25, 2011Szu-wei Tu, Abhijit Bugde, Katherine Luby-Phelps, Melanie H. Cobbimmunoﬂuorescence (no. 4979; Cell Signaling) and immunoblotting [Q256 (7)], OSR1 immunoﬂuorescence (no. 3729; Cell Signaling), SPAK (no. 2281; Cell Signaling), α-tubulin (clone DM1A; Sigma Aldrich or clone YL1/2; Abcam),

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OSR1 Antibody

OSR1 Antibody from Cell Signaling Technology

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Cell Signaling Technology

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OSR1 Antibody from Cell Signaling Technology

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