SRC-3 (5E11) Rabbit mAb 2126S from Cell Signaling Technology

Product Specs
ItemSRC-3 (5E11) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2126S
Quantity100 µl
ApplicationsW, IP, ChIP, ChIP-seq
ReactivityH, M, R, Mk
TargetSRC-3
HostRabbit
NCBI Gene AliasesACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP
ClonalityMonoclonal
NCBI Full Gene Namenuclear receptor coactivator 3
Research AreaChromatin Regulation / Nuclear Function
IsotypeIgG
Clone500000000000
Molecular Weight160

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Cell Signaling Technology

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Danvers, Massachusetts 01923

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Phone: 877-616-CELL
Phone: 978-867-2388
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Website: http://www.cellsignal.com/

Website: Technical Support

(1) An AIB1 isoform rewires glucocorticoid receptor signaling to promote TNBC progressioniScienceFebruary 20, 2026Amber J. Kiliti, Ghada M. Sharif, Megan E. McNamara, Raneen Rahhal, Susan Prewitt, Marcel O. Schmidt, Ci Wu, Junfeng Ma, Eric Glasgow, Anton Wellstein, et al.room temperature followed by incubation with AIB1/SRC-3 primary antibody (Cell Signaling Technology, 2126) in 2% milk PBST for 1 hour at room temperature. The membrane was then washed 3X with PBST and incubated

(2) PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal regionJournal of Biomedical ScienceSeptember 11, 2025Masaki Takahashi, Takeshi Kondo, Shogo Kimura, Akira Nakazono, Shusei Yoshida, Takeshi Wada, Masashi Watanabe, Shigetsugu HatakeyamaCat# AM4300, RRID:AB_2536381, 1:100,000 dilution), anti-NCOA3/SRC3 (Cell Signaling Technology Cat# 2126, RRID:AB_823642, 1:2000 dilution), anti-CDKN1A/p21 (Cell Signaling Technology Cat# 2947, RRID:AB_823586,

(3) PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblastsNucleic Acids ResJuly 24, 2025Qingqing Guo, Joonhyuk Choi, Muyoung Lee, Jonghwan KimSignaling Technology, 3085S, 10 μl), EP300 (Abcam, ab10485, 10 μl), NCOA3 (Cell Signaling Technology, 2126S, 10 μl), MED1 (Novus Biologicals, NB100-2574, 10 μl), MED12 (Bethyl Laboratories, A300-774A, 10 μl),

(4) Human Extravillous Trophoblasts Require SRC-2 for Sustained Viability, Migration, and InvasionCellsJuly 4, 2025Vineet K. Maurya, Pooja Popli, Bryan C. Nikolai, David M. Lonard, Ramakrishna Kommagani, Bert W. O'Malley, John P. Lydon(#A300-345A; 1:500 dilution, Bethyl Laboratories, Montgomery, TX, USA); a rabbit monoclonal anti-human SRC-3 (#2126; 1:200 dilution Cell Signaling Technologies, Inc. Danvers, MA, USA), and a rabbit polyclonal anti-human

(5) MUC1-C dependency in drug resistant HR+/HER2- breast cancer identifies a new target for antibody-drug conjugate treatmentNPJ Breast CancerApril 26, 2025Ayako Nakashoji, Atrayee Bhattacharya, Hiroki Ozawa, Naoki Haratake, Keisuke Shigeta, Atsushi Fushimi, Nami Yamashita, Akira Matsui, Shoko Kure, Tomoe Kameyama, et al.1:1000, Cell Signaling Technology), anti-β-actin (A5441, 1:10,000 dilution, Sigma-Aldrich), anti-SRC-3 (2126S, 1:1000, CST), anti-pSRC3(S857) (PA5-106189, Thermo Fischer Scientific), anti-MK2 (12155S, 1:1000, CST),

(6) Mechanism Study of Bufalin Reversal of Drug Resistance by Inhibiting Hypoxic Colon Cancer Cell-Induced Polarization of M2 MacrophagesIntegr Cancer TherMarch 12, 2025Haijing Wang, Linlin Jia, Hongjie Yu, Hui Tang, Huabowen Chi, Wei Zhang, Jinbao Chendetection system (Bio-Rad). The primary antibodies required for the experiments were specific for SRC-3 (2126T), HIF-1α (48085T), and β-actin (4967S) and bought from Cell Signaling. Flow Cytometry Analysis After

(7) TAS3681, an androgen receptor antagonist, prevents drug resistance driven by aberrant androgen receptor signaling in prostate cancerMolecular OncologyAugust 1, 2024Shohei Yoshida, Daisuke Kajiwara, Masanao Seki, Manabu Tayama, Yuki Tanaka, Hiroya Mizutani, Ryoto Fujita, Keisuke Yamamura, Shigeo Okajima, Masanori Asai, et al.Catalog #2275‐PC‐100; Trevigen, Gaithersburg, MD, USA), HDAC1 (Catalog #2062), β‐tubulin (Catalog #2126), and cleaved‐poly (ADP‐ribose) polymerase (cPARP; Catalog #5625; Cell Signaling Technology). 2.7 Real‐time

(8) Antimicrobial Resistance Profiles of Pseudomonas aeruginosa in the Arabian Gulf Region Over a 12-Year Period (2010–2021)Journal of Epidemiology and Global HealthJune 10, 2024A. Alatoom, M. Alattas, B. Alraddadi, C. Ayoub Moubareck, A. Hassanien, W. Jamal, A. Kurdi, N. Mohamed, A. Senok, A. M. Somily, et al.CST: 5808) [2016–2021]; and Southeast Asia (Malaysia, Philippines, Singapore, Thailand and Vietnam), 2126 (CZA and CST: 2027) [2016–2021]). AMK, amikacin; CZA, ceftazidime-avibactam; CST, colistin; DTR, difficult-to-treat

(9) Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modulesThe Journal of biological chemistryNovember 1, 2022Meyer MB, Benkusky NA, Lee SM, Yoon SH, Mannstadt M, Wein MN, Pike JW.no.: 7389; lot no.: 7), SRC1 (128E7; catalog no.: 2191S; lot no.: 2), and SRC3 (5E11; catalog no.: 2126S; lot no.: 4) purchased from Cell Signaling Technology. RNA pol II (8WG16) purchased from Covance. Traditional

(10) Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironmentBreast cancer research : BCROctober 31, 2022Han SJ, Sung N, Wang J, O'Malley BW, Lonard DM.performing Western blotting with an SRC-3 antibody (rabbit, Cell Signaling Technology, catalog number: 2126; 1:1,000 dilution), and the results were compared to parental luciferase-labeled E0771 cells. Orthotopic

(11) AR-regulated ZIC5 contributes to the aggressiveness of prostate cancerCell death discoverySeptember 20, 2022Tan YF, Zhang Y, Ge SY, Zhong F, Sun CY, Xia GW.CST), anti-AR (ab108341, Abcam), or anti-SRC-1 (#2191, CST), anti-SRC-2 (#96687, CST), anti-SRC-3 (#2126, CST) or anti-H3K9Ac (PA5-117092, Thermo), anti-H3K9Me2 (PA5-120810, Thermo) antibodies, incubated overnight

(12) Defining the mammalian coactivation of hepatic 12-h clock and lipid metabolismCell ReportsMarch 8, 2022Huan Meng, Naomi M. Gonzales, Sung Yun Jung, Yue Lu, Nagireddy Putluri, Bokai Zhu, Clifford C. Dacso, David M. Lonard, Bert W. O’Malleyusage. 200 μg of NE was used for per IP followed by Immunoblotting. 5 μg of anti-SRC-3 (Rabbit mAb #2126, 5E11, Cell signaling) or control IgG were coupled to 1.5 mg of magnetic Dynabeads (Life Technologies)

(13) Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3Front Reprod HealthJanuary 1, 2022Maurya VK, Szwarc MM, Lonard DM, Gibbons WE, Wu SP, O''Malley BW, DeMayo FJ, Lydon JP.primary rabbit monoclonal antibody against human SRC-3 [Cell Signaling Technology Inc., Danvers, MA (#2126); diluted 1 : 400] followed by incubation with a horseradish peroxidase (HRP)-conjugated goat anti-rabbit

(14) A set of accessible enhancers enables the initial response of breast cancer cells to physiological progestin concentrationsNucleic Acids ResearchDecember 16, 2021Roser Zaurin et al.described (12) using anti-PR (H190 SC-7208, Santa Cruz), anti-ERK2(D12) (05-157, Merck), anti-SRC3-(5E11) (#2126, Cell Signaling), anti-p300, clone NM11 (#61401, Active Motif), anti-RNApol II (#2629, Cell Signaling),

(15) Transcriptional regulation and ubiquitination-dependent regulation of HnRNPK oncogenic function in prostate tumorigenesisCancer cell internationalDecember 2, 2021Wu HL, Li SM, Huang YC, Xia QD, Zhou P, Li XM, Yu X, Wang SG, Ye ZQ, Hu J.anti-CDK6 (ab124821) antibody and anti-Bax (ab32503) antibody were purchased from Abcam. Anti-SRC3 (2126), polyclonal anti-Myc-Tag antibody (2278) and monoclonal anti-Myc-Tag (2276) antibodies were purchased

(16) Targeting NSD2-mediated SRC-3 liquid–liquid phase separation sensitizes bortezomib treatment in multiple myelomaNature CommunicationsDecember 1, 2021Jing Liu et al.permeabilized and blocked. After incubation with anti-SRC-3 antibody (1:500) (Cell Signaling Technology, #2126, Danvers, MA, USA) and anti-NSD2 antibody (1:250) (Abcam, ab75359, Cambridge, UK) overnight at 4 °C,

(17) An acetylation-enhanced interaction between transcription factor Sox2 and the steroid receptor coactivators facilitates Sox2 transcriptional activity and functionThe Journal of biological chemistryDecember 1, 2021Huang Y, Duan X, Wang Z, Sun Y, Guan Q, Kang L, Zhang Q, Fang L, Li J, Wong J.anti-SRC-1 antibody (CST, 2191, rabbit), anti-SRC-2 antibody (CST, 96687, rabbit), anti-SRC-3 antibody (CST, 2126, rabbit), anti-p300 antibody (CST, 54062, rabbit), anti-GAPDH antibody (Abcam, M20006L, mouse), and

(18) Genetic fusions favor tumorigenesis through degron loss in oncogenesNature communicationsNovember 18, 2021Liu J, Tokheim C, Lee JD, Gan W, North BJ, Liu XS, Pandolfi PP, Wei W.TRCN0000145024). Antibodies The anti-ABL1 (2862, 1:1000), anti-p27 (3686, 1:1000), anti-DEK (13962, 1:1000), anti-SRC3 (2126, 1:1000), anti-CUL3 (2759, 1:1000), anti-GST (2625, 1:2000), anti-β-TRCP (4394, 1:1000), anti-p-ERK(9101,

(19) A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial InfarctionCellsOctober 23, 2021Maric D, Paterek A, Delaunay M, López IP, Arambasic M, Diviani D.rabbit polyclonal anti-Src3 (Cell Signaling Technologies, Danvers MA, USA, 1:1000 dilution, catalog n°2126), mouse monoclonal anti-actin (Sigma, 1:1000 dilution, catalog n°A3853), rabbit polyclonal anti-phospho estrogen receptor α, (Ser305

(20) An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast CancerCancer ResearchAugust 15, 2021Ghada M. Sharif et al.Denville, NJ). Pre-cleared lysates were mixed with protein A magnetic beads bound to AIB1 (Cell signaling, #2126, RRID:AB_823642), H3K4me1 (Active motif, #39297, RRID:AB_2615075) or H3K27ac (Active motif, #39135,

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SRC-3 (5E11) Rabbit mAb

SRC-3 (5E11) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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SRC-3 (5E11) Rabbit mAb from Cell Signaling Technology

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