FoxO3a (75D8) Rabbit mAb 2497S from Cell Signaling Technology

Product Specs
ItemFoxO3a (75D8) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2497S
Quantity100 µl
ApplicationsW, IP, IF-IC
ReactivityH, M, R, Mk
TargetFoxO3a
HostRabbit
NCBI Gene AliasesAF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
ClonalityMonoclonal
NCBI Full Gene Nameforkhead box O3
Research AreaPI3K / Akt Signaling
IsotypeIgG
Clone75D8
Molecular Weight82 to 97

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Autophagy-Lysosomal Axis Stimulation by Beta-Hydroxybutyrate in AstrocytesMol NeurobiolApril 21, 2026Perla Coronado-Monroy, Teresa Montiel, Lizbeth García-Velázquez, Margarita Zahar-Pérez, Lourdes Massieu1:1000 (Cell signaling, 9475T); FOXO1, 1:1000 (Cell signaling, 2880S); FOXO3a, 1:1000 (Cell signaling, 2497S) and Actin, 1:10,000 (Merck Millipore, MAB1501). Detection of primary antibodies was performed using

(2) An Integrative Proteotranscriptomics Approach Reveals New ADAM9 Substrates and Downstream PathwaysMolecular & Cellular ProteomicsApril 1, 2026Congyu Lu, Xiaolu Xu, Neha Sindhu, Jessica Rainey, Yuhan Zhang, Shawn W. Polson, Jing Qiu, Shuo Weireceptor subunit beta (IL10RB) (R&D Systems, MAB874, 5 μg/ml), rabbit anti–Forkhead Box O3 (FOXO3) (CST, 2497, 1:1000 dilution for Western blotting, and 1:100 dilution for immunocytochemistry [ICC]), rabbit anti–immunoglobulin

(3) High-fat diet and obesity each increase tumor cell proliferation and muscle wasting in experimental cancer cachexiaAmerican Journal of Physiology-Cell PhysiologyApril 1, 2026Brittany R. Counts, Andrea Bonetto, Ho Lam Chan, Ernie D. Au, Yanlin Jiang, Marion E. Couch, Denis C. Guttridge, Michael C. Ostrowski, Leonidas G. Koniaris, Teresa A. ZimmerspSTAT3-Y705 (9145), STAT3 (9132), p-AKT-S473 (4060), AKT (4685), p-Foxo3a-S381/321 (9465), Foxo3a (2497), and GAPDH (2118) from Cell Signaling Technology (Beverly, MA); and IL-6 (MABF41) from EMD Millipore

(4) Veronicastrum sibiricum (L.) Pennell extract alleviates inflammation‑induced muscle atrophy through NLRP3 inflammasome regulation and mitochondrial function restorationMolecular Medicine ReportsMarch 26, 2026Eunhye Lee, Minjeong Kwon, Ju-Ock NamInc.","1:1,000" p-Akt,Rabbit monoclonal,9271,"Cell Signaling Technology, Inc.","1:1,000" Foxo3a,Rabbit monoclonal,2497,"Cell Signaling Technology, Inc.","1:1,000" p-Foxo3a,Rabbit monoclonal,5538,"Cell Signaling Technology,

(5) Canonical BAF chromatin remodeling complex specifies stem cell fate via cell-type-specific co-factor recruitmentNature CommunicationsMarch 3, 2026Mingyi Zhang, Jifan Feng, Tingwei Guo, Lin Meng, Fei Pei, Lu Gao, Yuchen Yang, Thach-Vu Ho, Yang Chai(Cell Signaling Technology, 96585), DLX5 (Abcam, ab109737), and FOXO3A (Cell Signaling Technology, 2497), followed by detection using the Azure 300 imaging system (Azure Biosystems). siRNA treatment of primary

(6) Protective effects of 3-(4-hydroxy-3-methoxyphenyl) propionic acid against dexamethasone-induced muscle atrophy: modulation of associated genes and oxidative stress in female miceBiochemistry and Biophysics ReportsMarch 1, 2026Anayt Ulla, Honomi Ogura, Md Mizanur Rahman, Saya Nakamura, Yuka Ichiba, Haruka Tsuda, Takayuki Uchida, Hiroyuki Kayaki, Yosuke Nishitani, Susumu Yoshino, et al.(ab77577) (Abcam, Cambridge, UK); Cbl-b (1:200) (9498S), IRS-1 (1:100) (3407S), total FoxO3a (1:100) (2497S), phosphorylated FoxO3a (1:100) (9466S), total Akt (1:100) (9272) and phosphorylated-AktThr308 (1:1000)

(7) Eight-week dietary methionine restriction does not impair resistance exercise-induced mTORC1 signalling activation in ratsBiochemistry and Biophysics ReportsMarch 1, 2026Naoki Fukao, Mito Watanabe, Ryo Takagi, Koki Okumura, Naomi Yoshii, Koma Kawabata, Satoshi Fujita(#12753, CST), LC3B (#2775, CST), p62 (#PM045, Medical & Biological Laboratory, Nagoya, Japan), FoxO3a (#2497, CST), Phospho-FoxO3a Ser253 (#13129, CST), Fbx32 (#168372 Abcam, Cambridge, UK), MuRF-1 (#sc-398608,

(8) Erk3 deletion drives oxidative adaptations in skeletal muscleMolecular MetabolismFebruary 24, 2026Angel Loza-Valdes, Carlos Acosta-Gallo, Toufic Kassouf, Andrei Belykh, Małgorzata Stelmach, Dominika Malińska, Katia El Ghoz, Rabih El-Merahbi, Filip Dziaczkowski, Katarzyna Kolczyńska-Matysiak, et al.α-FOXO1 (Cell Signaling, 2880S), α-p-FOXO1 (Thr24) (Cell Signaling, 94645), α-FOXO3a (Cell Signaling, 2497s), α-p-FOXO3a (Ser413) (Cell Signaling, 8174S), α-GAPDH (Sigma, G9545), α-MYHC (Bio-Techne, MAB4470),

(9) Metformin Suppresses Glioblastoma Tumor Growth and Progression Through the AMPK/FoxO3a/Survivin AxisCellsFebruary 6, 2026Fabiola Cavaliere, Michele Pellegrino, Alessandro Cormace, Sofia Spadafora, Mariarosa Fava, Seung Ho Yang, Jung Eun Lee, Marta Claudia Nocito, Rosa Sirianni, Ivan Casaburi, et al.5832S), p-AMPK (T172) (D4D6D; 50081S), AKT (11E7; 4685S), p-AKT (S473) (D9E; 4060S), FoxO3a (75D8; 2497S), and p-FoxO3a (all from Cell Signaling Technology Europe, ZA Leiden, The Netherlands); Cyclin D1 (A-12;

(10) A simple, efficient, and scalable method to generate oocyte-like cells in vitroLife Science AllianceFebruary 1, 2026Ami Banno, Kana Mizuno, Mizuki Sakamoto, Sota Komatsubara, Kenjiro Shirane, Katsuhiko Hayashi, Nobuhiko Hamazaki, Koshi Imami, Shigenobu Yonemura, Takashi Ishiuchianti-UHRF1 (sc-373750, 1:200; Santa Cruz Biotechnology), anti-MVH (ab27591, 1:200; Abcam), anti-FOXO3 (#2497, 1:400; CST), anti-DNMT1 (ab188453, 1:200; Abcam), anti-ZP2 (IE-3, 1:200), and anti-ZP3 (IE-10, 1:200)

(11) FoxO3a‐Mediated Modulation of PD‐L1 Expression and Inhibition by Dihydroartemisinin in Triple‐Negative Breast CancerJournal of Cellular and Molecular MedicineJanuary 11, 2026Xingan Xing, Zhiwei Zhou, Mohd Farhan, Xia Zhao, Shuai Li, Bingxi Lei, Jiankang Fang, Wenshu Zhou, Wenhua Zhengpreviously described [20]. Antibodies used included T‐FoxO3a (Cell Signalling Technology, Danvers, MA, USA, 2497), p644‐FoxO3a (Signalway antibody, College Park, MD, USA, 12978), PD‐L1 (Abcam, Cambridge, UK, 238697),

(12) Toxoplasma gondii infection inhibits invasion and migration of human extravillous trophoblasts through dysregulation of FOXO1- and FOXO3a-dependent and -independent mechanismsFront Cell Infect MicrobiolDecember 10, 2025Aurore Lebourg, Louis-Philippe Leroux, Visnu Chaparro, Sophie Chagneau, Cathy Vaillancourt, Maritza Jaramilloh at RT with the following primary antibodies diluted in PBS with 1% BSA: anti-FOXO3a (clone 75D8, #2497), anti-FOXO1 (clone C29H4, #2880), and anti-phospho-SMAD2 (S465/S467) (clone E8F3R, #18338) were obtained

(13) Targeting CHD1L suppresses prostate cancer progression via the FOXO3-PUMA axisJournal of Translational MedicineDecember 4, 2025Pusheng Hui, Yanru Lai, Haiqi Fan, Qinrong Yan, Yue Yang, Zhe Chen, Yu Hou, Youlin Kuanganti-BAX (1:1000; #2772; CST), rabbit anti-BCL-2 (1:1000; #3498; CST), rabbit anti-FOXO3 (1:1000; #2497; CST), rabbit anti-PUMA (1:1000; #98672; CST), rabbit anti-Tubulin (1:2000; #AF001; Beyotime). Secondary

(14) Selective AMPKβ1 activation induces fetal hemoglobin in human erythroid cells and sickle cell mice via the noncanonical NRF2 pathwayScience AdvancesNovember 21, 2025Yannis Hara, Viktor T. Lemgart, Samuel Lessard, Courtney J. Mercadante, Jean-Antoine Ribeil, Alexandra Hicks, Pauline Rimmele, David R. Lightanti–phospho-ULK1-Ser555 (Cell Signaling Technology, #5869), anti-FOXO3 (Cell Signaling Technology, #2497), anti–phospho-FOXO3-Ser413 (Cell Signaling Technology, #8174), anti-SQSTM1 (Cell Signaling Technology,

(15) Stigmasterol Protects Against Dexamethasone-Induced Muscle Atrophy by Modulating the FoxO3–MuRF1/MAFbx Signaling Pathway in C2C12 Myotubes and Mouse Skeletal MuscleBiomoleculesNovember 5, 2025Young-Sool Hah, Seung-Jun Lee, Yeung-Ho Ji, Jeongyun Hwang, Han-Gil Kim, Young-Tae Ju, Jun-Il Yoo, Seung-Jin KwagUSA), AMPK (5831S, Cell Signaling Technology), phospho-FoxO3 (9466S, Cell Signaling Technology), FoxO3 (2497S, Cell Signaling Technology), MuRF1 (sc-398608, Santa Cruz Biotechnology, Dallas, TX, USA), MAFbx (sc-166806,

(16) Activation of a FOXO3-induced cell cycle arrest regulates ferroptosisCell Death DiscovOctober 16, 2025Huanjie Huang, Matthias van Sligtenhorst, Alida M. M. Smits, Can Gulersonmez, Edwin Stigter, Tobias B. Dansen, Boudewijn M. T. Burgeringresource,Source,Identifier Antibodies,Antibodies,Antibodies Vinculin,Sigma-Aldrich,V9131 FOXO3,Cell Signaling Technology,2497 P27,BD Biosciences,610241 SOD2,Enzo Life Sciences,ADI-SOD-110 BCL6,Abcam,Ab183308 ACSL4,Thermo Fisher,PA5-27137 TFR1,Thermo Fisher

(17) SKP2 regulates TERT independently of RUNX1/ETO in AML subtypes lacking the t(8,21) translocation via CDKN1B and RB phosphorylation statesSci RepOctober 6, 2025Adam Azlan, Yaashini Rajasegaran, Aliaa Arina Rosli, Mohamed Saleem, Narazah Mohd Yusoff, Mot Yee Yik, Emmanuel Jairaj Mosespolyclonal, Cell Signaling Technology, Cat# 2552), FOXO3a (Rabbit polyclonal, Cell Signaling Technology, Cat# 2497), TERT (Rabbit Polyclonal, Merck milipore ABE2075). All detection Antibodies were diluted to a factor

(18) Divergent roles of PKM2 in regulating PD-L1 and PD-L2 expression and their implications in human and mouse cancer modelsActa Biochimica et Biophysica SinicaOctober 1, 2025Shuo He, Shujuan Luo, Bangwu Cai, Jiao Chen, Yao Zhang, Feng Zhao, Qing Liu, Tao Liu, Wei Wang, Tianyuan Peng, et al.Motif, Carlsbad, USA). Chromatin derived from AKR cells was immunoprecipitated with a GATA3 antibody (2497, 1:100; Cell Signaling Technology, Danvers, USA). Chromatin samples without antibody pull-down were

(19) Integration of focal adhesion morphogenesis and polarity by DOCK5 promotes YAP/TAZ-driven drug resistance in TNBC†Molecular OmicsSeptember 22, 2025Patricia Pascual-Vargas, Mar Arias-Garcia, Theodoros I. Roumeliotis, Jyoti S. Choudhary, Chris Bakal(mouse),"BD Transduction Laboratories, cat#610153",,1 : 1000 FOXO3A,Anti-FOXO3A (75D8) (rabbit),"CST, cat#2497S",,1 : 200 DOCK5,Anti-DOCK5 (rabbit),"Frank et al., 2017.",1 : 500, PHH3,Anti-P-Histone H3 (S10) (mouse),"CST,

(20) Anti-Atrophic Effects of Dichotomine B from Stellaria dichotoma During Starvation-Induced Skeletal Muscle AtrophyMoleculesSeptember 22, 2025Jae-Yong Kim, Uttapol Permpoon, Ju-hee Lee, Ji Hoon Kim, Hye Mi Kim, Je-Seung Jeon, Tae-gyu Nam, Chul Young Kimsc-376157, Santa Cruz Biotechnology, Dallas, TX, USA), a rabbit anti-FoxO3a monoclonal antibody (clone 75D8, 2497, Cell Signaling Technology, Danvers, MA, USA), a mouse anti-MAFbx (Atrogin-1) monoclonal antibody (clone

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FoxO3a (75D8) Rabbit mAb

FoxO3a (75D8) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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FoxO3a (75D8) Rabbit mAb from Cell Signaling Technology

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