Bioss Inc.'s CTDSPL Polyclonal Antibody, PE-Cy5.5 Conjugated is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The CTDSPL Polyclonal Antibody, PE-Cy5.5 Conjugated was generated using CTDSPL as the antigen and it reacts with Homo Sapiens, Human, Mouse, and Rat.
Description
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation