SRC-1 (128E7) Rabbit mAb 2191S from Cell Signaling Technology

Product Specs
ItemSRC-1 (128E7) Rabbit mAb
CompanyCell Signaling Technology
Price $336.00 Inquire
Catalog Number2191S
Quantity100 µl
ApplicationsW, IP, IHC-P, ChIP
ReactivityH, M, R, Mk
TargetSRC-1
HostRabbit
NCBI Gene AliasesF-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74
ClonalityMonoclonal
NCBI Full Gene Namenuclear receptor coactivator 1
Research AreaChromatin Regulation / Nuclear Function
Clone1280000000
Molecular Weight180

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) NCOA1 is a gatekeeper of the sexually dimorphic thermogenic activity of white adipose tissueNature CommunicationsJanuary 20, 2026Mounia Tannour-Louet, Didier F. Pisani, Hichem Bouguerra, Alycia Zedda, Marine Bourcier, Noura Lamghari, Nadine Gautier, Benoit Chaput, Elodie Riant, Anne Bouloumié, et al.(Millipore) according to the manufacturer’s protocol. The Ncoa1 antibody was from Cell Signaling Technology (#2191; RRID:AB_2196189; dilution 1:1000) and the Gata3 antibody from Abcam; (#ab199428; clone EPR16651; RRID:AB_2819013;

(2) Aberrantly High Expression of Steroid Receptor Coactivator-1 Drives Lung Cancer Growth and Metastasis by Enhancing Cancer StemnessBiomolecules & TherapeuticsNovember 1, 2025Jinjin Pan, Haoran Zhou, Liang Liu, Shuo Xu, Yu Hou, Ke Cheng, Yuan Li, Chenggong Zhu, Na Wu, Chunmei Bai, et al.and 1% (v/v) penicillin-streptomycin at a 37°C incubator with 5% CO2. The antibodies against SRC-1 (#2191), AKT (#9272), p-AKT (#4060), E-cadherin (#3195), vimentin (#5741), c-Myc (#5605), and Lin28A (#8706)

(3) Steroid Receptor Coactivator‐1 Drives Tumor‐Associated Macrophage Reprogramming by Mediating MMP12 Transcription in Pancreatic Cancer Perineural InvasionAdvanced ScienceSeptember 23, 2025Ke Cheng, Liang Liu, Miaomiao Gong, Yuke Ji, Chunmei Bai, Xiangqian Guo, Hui Chen, Jinjin Pan, Ying Zhang, Yuhui Yuantemperature(25 °C) for 1.5 h. Primary antibodies were diluted according to recommended ratios: SRC‐1 (CST, 2191, 1:1000), CD206 (Proteintech, 60 143, 1:5000), CD163 (WANLEI, WL03026, 1:1000), iNOS (Proteintech, 22

(4) A protective role of SRC-1 against aging associated cognitive declineAging (Albany NY)August 27, 2025Hesong Liu, Yongjie Yang, Jonathan C. Bean, Yang He, Hailan Liu, Rambabu Majji, Chen Liang, Nan Zhang, Meng Yu, Longlong Tu, et al.Briefly, brain sections were blocked (3% Normal donkey serum) for 1 h, incubated with Rabbit anti-SRC-1 (#2191, Cell Signaling Technology) on shaker at 4°C for overnight, followed by 3 washes with 1X PBS and then

(5) Human Extravillous Trophoblasts Require SRC-2 for Sustained Viability, Migration, and InvasionCellsJuly 4, 2025Vineet K. Maurya, Pooja Popli, Bryan C. Nikolai, David M. Lonard, Ramakrishna Kommagani, Bert W. O'Malley, John P. Lydon(1:2000; #610984, BD Transduction Laboratories, Inc., East Rutherford, NJ, USA), anti-SRC-1 (1:1000; #2191 Cell Signaling Technology, Inc., Danvers, MA, USA); anti-SRC-3 (1:1000, #2126 Cell Signaling Technology

(6) Machine learning–based multimodal radiomics and transcriptomics models for predicting radiotherapy sensitivity and prognosis in esophageal cancerJournal of Biological ChemistryJuly 1, 2025Chengyu Ye, Hao Zhang, Zhou Chi, Zhina Xu, Yujie Cai, Yajing Xu, Xiangmin Tongused were anti-IgG (1:100, ab172730, Abcam), anti-Ub (1:100, ab7780, Abcam), and anti-SRC (1:100, #2191, CST). The experiment was performed in triplicate. Protein stability assay To determine the stability

(7) Alleviating role of ketamine in breast cancer cell-induced osteoclastogenesis and tumor bone metastasis-induced bone cancer pain through an SRC/EGR1/CST6 axisBMC cancerDecember 18, 2024Zhang X, Zhang Y, Du W.Proteintech Group, Inc., Wuhan, Hubei, China), Vimentin (1:1,000, 5741, Cell Signaling Technology), SRC (1:1,000, 2191, Cell Signaling Technology), EGR1 (1:1,000, MA5-15008, Thermo Fisher Scientific, Rockford, IL, USA),

(8) Targeting Nuclear Receptor Coactivator SRC-1 Prevents Colorectal Cancer Immune Escape by Reducing Transcription and Protein Stability of PD-L1Advanced science (Weinheim, Baden-Wurttemberg, Germany)September 1, 2024Hong Y, Chen Q, Wang Z, Zhang Y, Li B, Guo H, Huang C, Kong X, Mo P, Xiao N, et al.(Tanon, China). The primary antibodies used in western blot were list as follows: anti‐SRC‐1 (Cat# 2191S, CST), anti‐m‐PD‐L1 (Cat# 60 475, CST), anti‐h‐PD‐L1 (Cat# 13 684, CST), anti‐β‐actin (Cat# A5441, Sigma–Aldrich),

(9) Bromodomain-containing protein 9 activates proliferation and epithelial-mesenchymal transition of colorectal cancer via the estrogen pathway in vivo and in vitroJournal of Gastrointestinal OncologyApril 29, 2023Peng Chen, Rongrong Du, Zhengyao Chang, Wenxing Gao, Wen Zhao, Guanglong DongRA, USA; #4370, 1:2,000), and anti-NCOA1 antibodies (Cell Signaling Technology, Danvers, RA, USA; #2191, 1:1,000). The secondary antibodies used were anti-mouse IgG (Promotor, Wuhan, China; 1:2,000) and anti-rabbit

(10) Phospholipase C delta 1 inhibits WNT/β‐catenin and EGFR-FAK-ERK signaling and is disrupted by promoter CpG methylation in renal cell carcinomaClinical EpigeneticsFebruary 27, 2023Jianlian Xie, Jun Zhou, Jiliang Xia, Ying Zeng, Guo Huang, Weihong Zeng, Tingyu Fan, Lili Li, Xi Zeng, Qian Tao(CST: 54,359), p-EGFR (CST: 3777), Total FAK (CST: 71,433), p-FAK (Tyr397) (CST: 8556), Total SRC (CST: 2191), p-SRC (CST: 59,548), Total β-catenin (CST: 59,548), active β-catenin (Millipore, 05,665), p-β-catenin

(11) PPARγ and C/EBPα response to acute cold stress in brown adipose tissueiScienceJanuary 20, 2023Lau KH, Waldhart AN, Dykstra H, Avequin T, Wu N.RRID:AB_675659 C/EBPα,Cell Signaling Tech.,8178; RRID:AB_11178517 C/EBPβ,Boster,M01100 NCOA1,Cell Signaling Tech.,2191; RRID:AB_2196189 H3K27Ac (ChIPseq),Cell Signaling Tech.,8173; RRID:AB_10949503 ,, "Chemicals, peptides,

(12) Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modulesThe Journal of biological chemistryNovember 1, 2022Meyer MB, Benkusky NA, Lee SM, Yoon SH, Mannstadt M, Wein MN, Pike JW.purchased from Bethyl Laboratories. CBP (D6C5; catalog no.: 7389; lot no.: 7), SRC1 (128E7; catalog no.: 2191S; lot no.: 2), and SRC3 (5E11; catalog no.: 2126S; lot no.: 4) purchased from Cell Signaling Technology.

(13) AR-regulated ZIC5 contributes to the aggressiveness of prostate cancerCell death discoverySeptember 20, 2022Tan YF, Zhang Y, Ge SY, Zhong F, Sun CY, Xia GW.performed through application of anti-Flag (#14793, CST), anti-AR (ab108341, Abcam), or anti-SRC-1 (#2191, CST), anti-SRC-2 (#96687, CST), anti-SRC-3 (#2126, CST) or anti-H3K9Ac (PA5-117092, Thermo), anti-H3K9Me2

(14) Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3Front Reprod HealthJanuary 1, 2022Maurya VK, Szwarc MM, Lonard DM, Gibbons WE, Wu SP, O''Malley BW, DeMayo FJ, Lydon JP.antibodies were used to detect SRC-1 (anti-human SRC-1 rabbit monoclonal; Cell Signaling Technology Inc., #2191) and SRC-2 (anti-human SRC-2 mouse monoclonal antibody; BD Biosciences Inc. #610984). The primary antibody

(15) An acetylation-enhanced interaction between transcription factor Sox2 and the steroid receptor coactivators facilitates Sox2 transcriptional activity and functionThe Journal of biological chemistryDecember 1, 2021Huang Y, Duan X, Wang Z, Sun Y, Guan Q, Kang L, Zhang Q, Fang L, Li J, Wong J.antibody (Abmart, 284067, mouse), anti-pan-Kac antibody (CST, 9441S, rabbit), anti-SRC-1 antibody (CST, 2191, rabbit), anti-SRC-2 antibody (CST, 96687, rabbit), anti-SRC-3 antibody (CST, 2126, rabbit), anti-p300

(16) ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In VivoMoleculesAugust 24, 2021Bisera Stepanovska Tanturovska, Aleksandra Zivkovic, Faik Imeri, Thomas Homann, Burkhard Kleuser, Holger Stark, Andrea HuwilerELISA was performed exactly as described before, but with a change in the concentration of S1P and ST-2191 [18], using Myc-tag primary (Cell Signaling, No. 2276, 1:1000) and anti-mouse HRP-linked secondary antibody

(17) The Impact of Adolescent Internet Addiction on Sexual Online Victimization: The Mediating Effects of Sexting and Body Self-EsteemInternational Journal of Environmental Research and Public HealthApril 16, 2021Alicia Tamarit, Konstanze Schoeps, Montserrat Peris-HernÃ¡ndez, Inmaculada Montoya-CastillaHelsinki: Ethical principles for medical research involving human subjects. J. Am. Med. Assoc. 2013, 310, 2191–2194. [CrossRef] [PubMed] Muthén, L.K.; Muthén, B.O. Mplus User’s Guide, 7th ed.; Muthén & Muthén: Los

(18) Living in a Hostile World: Inflammation, New Drug Development, and CoronavirusFrontiers in ImmunologyJanuary 22, 2021Geoffrey P. Dobson, Erik Biros, Hayley L. Letson, Jodie L. Morris2015:816460. doi: 10.1155/2015/816460 157. Ley K. M1 Means Kill; M2 Means Heal. J Immunol (2017) 199:2191–3. doi: 10.4049/jimmunol.1701135 158. Bahia D, Satoskar AR, Dussurget O. Editorial: Cell Signaling in

(19) Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagyNature communicationsAugust 18, 2020Yamamuro T, Kawabata T, Fukuhara A, Saita S, Nakamura S, Takeshita H, Fujiwara M, Enokidani Y, Yoshida G, Tabata K, et al.monoclonal anti-PPARγ (Santa Cruz Biotechnology, sc-7273, 1:2000), rabbit monoclonal anti-SRC-1 (CST, #2191, 1:2000), rabbit polyclonal anti-TIF2 (Bethyl Laboratories, A300-346A, 1:2000), rabbit monoclonal anti-Perilipin1

(20) Strategies and considerations of G-protein-coupled receptor photopharmacologyFrom Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled ReceptorsMay 18, 2020Alice E. Berizzi, Cyril Goudet& Feringa, B. L. (2014). Photopharmacology: beyond proof of principle. J Am Chem Soc, 136(6), 2178-2191. doi: 10.1021/ja413063e Wagner, N., Schuhmacher, M., Lohmann, A., & Nadler, A. (2019). A Coumarin Triflate

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SRC-1 (128E7) Rabbit mAb

SRC-1 (128E7) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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SRC-1 (128E7) Rabbit mAb from Cell Signaling Technology

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