LKB1 (27D10) Rabbit mAb 3050S from Cell Signaling Technology

Product Specs
ItemLKB1 (27D10) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number3050S
Quantity100 µl
ApplicationsW, IP
ReactivityH, Mk
TargetLKB1
HostRabbit
NCBI Gene AliasesLKB1, PJS, hLKB1
ClonalityMonoclonal
NCBI Full Gene Nameserine/threonine kinase 11
Research AreaMetabolism
IsotypeIgG
Clone27D10
Molecular Weight54

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Cell-specific delivery of GJB2 restores auditory function in mouse models of DFNB1 deafness and mediates appropriate expression in NHP cochleaNat CommunDecember 16, 2025Maryna V. Ivanchenko, Kevin T. A. Booth, K. Domenica Karavitaki, Larisa M. Antonellis, M. Aurel Nagy, Cole W. Peters, Spencer Price, Yaqiao Li, Anton Lytvyn, Andrew Ward, et al.OCT compound and stored at −80 °C prior to sectioning. Cryosections were generated using a Leica CM 3050 S cryostat at 20 μm step size. For immunofluorescence labeling, the following primary antibodies and

(2) Uncovering the role of c-Fos in the bidirectional relationship between depression/anxiety behaviors and α-synuclein propagation in Parkinson’s diseaseNeurotherapeuticsNovember 26, 2025Soo-Jeong Kim, Jae-Bong Kim, Seonghui Ham, Sang Myun Parkparaformaldehyde overnight, cryoprotected in 30 % sucrose, and coronally sectioned at 35 μm (Leica CM-3050). Sections (≥3/mouse) were permeabilized in 1 % Triton X-100/5 % BSA (PBS) for 60 min, then incubated

(3) High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapyCell Reports MedicineSeptember 16, 2025Xiangyu Sun, Xiaoting Cai, Shangbiao Li, Ruozheng Pi, Zeqin Guo, Jiayu Jiang, Pinhao Wang, Jingrong Xiong, Zhuangzhuang Liu, Zixuan Rong, et al.provided. Method details Antibodies and reagents The antibodies used were as below: anti-LKB1 (27D10) (CST, #3050), anti-DFNA5/GSDME (Abcam, #ab215191), anti-Caspase-3 (Proteintech, #19677-1-AP), anti-GSDMD (Abcam,

(4) High PER1 expression is associated with STK11 mutation and clinical biomarkers of immunotherapy resistance in lung adenocarcinomaJournal of cancer research and clinical oncologyJuly 26, 2025Parker RE, McSwain L, Zhou W, Marcus AI, Fu H, Ramalingam SS, Zhang S, Gilbert-Ross M.indicated dilutions: PER1 (1:1000, Boster Bio, A00876, RRID:AB_3086701), LKB1 (1:1000, Cell Signaling, #3050, RRID:AB_823559), JAG1 (1:1000, Cell Signaling, #70,109, RRID:AB_2799774), pAMPK-T172 (1:1000, Cell Signaling

(5) Energy stress-induced PKCζ S-glutathionylation is essential for LKB1 cytoplasmic translocation and AMPK activationLife MetabolismJuly 16, 2025Junjie Fei, Shuhan Yu, Mingzhe Xu, Yang Liu, Guoqiang Wang, Xueqing Li, Xinyue Yu, Yifan Zhang, Wenhua Zhang, Yang Wang, et al.purchased from Santa Cruz (USA). Antibodies for pAMPK (#2535, 1:1000), pACC (#3661,1:1000), LKB1 (#3050, 1:1000), pLKB1 (#3482, 1:1000), HA (#3724, 1:1000), and Flag (#117935, 1:1000) were purchased from

(6) Hepatic glycogen directly regulates gluconeogenesis through an AMPK/CRTC2 axis in miceJ Clin InvestJune 2, 2025Bichen Zhang, Morgan M. Johnson, Timothy Yuan, Tammy-Nhu Nguyen, Junichi Okada, Fajun Yang, Alus M. Xiaoli, Liana H. Melikian, Songran Xu, Benyamin Dadpey, et al.3661), ACC (3676), phospho-CREB (Ser133; 9198), CREB (9197), PKA substrate (9621), GS (3886), LKB1 (3050), phospho-CaMKII (Thr286; 12716), CaMKII (3362), β-tubulin (2128), and histone H3 (9715) antibodies

(7) AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathwayCell BiosciMay 22, 2025Aru Su, Linghui Pan, Qian Zhou, Qin Zhu, Ruihua Li, Mingming Liu, Ruifan Wu, Lina Wang, Songbo Wang, Qingyan Jiang, et al.microtome (Leica SM2010 R, Germany), while ganglia were sectioned into 15-µm slices using a cryostat (Leica 3050 S, Germany). The sections were washed three times in PBS with 1% Triton X-100 (0.1% PBST, pH 7.4). Primary

(8) LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancersNat CommunMay 2, 2025Chendi Li, Mohammed Usman Syed, Anahita Nimbalkar, Yi Shen, Melissa D. Vieira, Cameron Fraser, Zintis Inde, Xingping Qin, Jian Ouyang, Johannes Kreuzer, et al.8120) followed by primary antibody diluted 1:200 in TBS-T (pJNK CST 4668S, pAMPK CST 2535S, LKB1 CST 3050S) overnight at 4 °C. Following primary antibody incubation, slides were washed with TBS-T and incubated

(9) Liver TET1 promotes metabolic dysfunction-associated steatotic liver diseaseEMBO Molecular MedicineMarch 31, 2025Hongze Chen, Muhammad Azhar Nisar, Joud Mulla, Xinjian Li, Kevin Cao, Shaolei Lu, Katsuya Nagaoka, Shang Wu, Peng-Sheng Ting, Tung-Sung Tseng, et al.,ABclonal Technology,A6830 CD36 antibody (1:500),Proteintech,32181-1-AP LKB1 antibody (1:1000),Cell Signaling Technology®,3050S pLKB1 antibody (1:1000),Cell Signaling Technology®,3482S 5-methylcytosine antibody (1:1000),Active Motif

(10) Isoquercitrin Attenuates Oxidative Liver Damage Through AMPK-YAP Signaling: An Integrative In Silico, In Vitro, and In Vivo StudyInt J Mol SciMarch 18, 2025So-Hyun Kwon, Won-Yung Lee, Young Woo Kim, Kwang Suk Ko, Seon Been Bak, Sun-Dong Park(PARP, #9542), anti-procaspase 3, anti-phospho liver kinase B1 (p-LKB1, #3482), liver kinase B1 (LKB1, #3050), and Bcl-xL were purchased from Cell Signaling Technology (Beverly, MA, USA), and anti-mouse and anti-rabbit

(11) TGF-β1-mediated intercellular signaling fuels cooperative cellular invasionCell reportsFebruary 25, 2025Khatib TO, Pedro BA, Bombin S, Matsuk VY, Robinson IE, Webster SF, Marcus LJ, Summerbell ER, Tharp GK, Knippler CM, et al.antibody,GeneTex,Cat#GTX101147; RRID: AB_1950502 LKB1 (27D10) Rabbit mAb,Cell Signaling Technology,Cat#3050; RRID: AB_823559 Phospho-AMPKa (Thr 172) (40H9) Rabbit mAb,Cell Signaling Technology,Cat#2535; RRID:

(12) STK11 genetic alterations in metastatic EGFR mutant lung cancerSci RepFebruary 17, 2025Dandan Yin, Xiyi Lu, Xiao Liang, Yiting Lu, Lei Xiong, Pingping Wu, Tingting Wang, Jinfei Chenprotein. ShRNA lentiviruses were purchased from GeneChem. The STK11 antibody was acquired from CST (Cat#: #3050). p-S6 antibody and ACTIN antibody were acquired from Proteintech (29223-1-AP and 66009-1-Ig). Cell

(13) A CRISPR-edited isoform of the AMPK kinase LKB1 improves the response to cisplatin in A549 lung cancer cellsJournal of Biological ChemistryFebruary 13, 2025Matheus Brandemarte Severino, Ana Paula Morelli, Isadora Carolina Betim Pavan, Mariana Camargo Silva Mancini, Mariana Marcela Góis, Rafael Junqueira Borges, Renata Rosseto Braga, Luiz Guilherme Salvino da Silva, Nathalia Quintero-Ruiz, Maíra Maftoum Costa, et al.cultures were screened by Western blotting for the LKB1 expression using an LKB1 antibody (Cell signaling #3050). To evaluate the INDELs generated by the CRISPR/Cas9 system, the targeted genomic region for LKB1 was

(14) FBXL19 Targeted STK11 Degradation Enhances Cigarette Smoke-Induced Airway Epithelial Cell CytotoxicityCOPD: Journal of Chronic Obstructive Pulmonary DiseaseDecember 31, 2024Xiuying Li, Sowmya P. Lakshmi, Kiyoshi Uemasu, Zachary Lane, Rajan T. Reddy, Divay Chandra, Chunbin Zou, Yu Jiang, Toru NyunoyaCO2 incubator at 37°C. V5 antibody (#PA1–993) was purchased from Invitrogen (St. Louis, MO). STK11 (#3050) antibody was purchased from Cell Signaling (Danvers, MA). Anti-ubiquitin (#sc-166553) antibody was

(15) LKB1 and STRADα Promote Epithelial Ovarian Cancer Spheroid Cell InvasionCancers (Basel)November 5, 2024Charles B. Trelford, Adrian Buensuceso, Emily Tomas, Yudith Ramos Valdes, Owen Hovey, Shawn Shun-Cheng Li, Trevor G. ShepherdReagents Primary antibodies were used against fibronectin (Abcam, Cambridge, UK, ab2413), LKB1 (CST, 3050), STRADα (Abcam, ab192879), vinculin (Sigma, V9264), and actin (Sigma, Markham, ON, Canada, A2066).

(16) Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancereLifeAugust 30, 2024Phaedra C Ghazi, Kayla T O'Toole, Sanjana Srinivas Boggaram, Michael T Scherzer, Mark R Silvis, Yun Zhang, Madhumita Bogdan, Bryan D Smith, Guillermina Lozano, Daniel L Flynn, et al.,Cell Signaling Technology,Cat# 13031,IHC (1:250) Antibody,Anti-LKB1 (rabbit monoclonal),Cell Signaling Technology,Cat# 3050,WB (1:1000) Antibody,Anti-NKX2.1 (rabbit monoclonal),Abcam,Cat# ab76013,IHC (1:2000) Antibody,Anti-p44/p42

(17) Methyl Cinnamate (MC) Alleviates Free Fatty Acids (FFAs) Induced Lipid Accumulation Through the AMPK Pathway in HepG2 CellsDiabetes Metab Syndr ObesMarch 7, 2024Yingda Fu, Guangbing Li, Zichen Feng, Jun Liu, Xiaoyu Wang, Tao Wang, Jun LiuAntibodies against β-actin were obtained from Proteintech (Wuhan, China). Antibodies against LKB1 (#3050) (A2122) and PPARγ were purchased from CST (Danvers, USA). Antibodies against CAMKK2 were purchased

(18) Discoveries of GPR39 as an evolutionarily conserved receptor for bile acids and of its involvement in biliary acute pancreatitisScience AdvancesFebruary 2, 2024Zhentao Zi, Yi Raodehydrated by 30% sucrose. Then, cryosections (40 μm) were cut using a freezing microtome (Leica CM 3050). For detecting the expression of HA-tagged GPR39 in pancreas slides, rabbit anti-HA antibody (1:500

(19) Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6PCell researchDecember 1, 2023Ai YL, Wang WJ, Liu FJ, Fang W, Chen HZ, Wu LZ, Hong X, Zhu Y, Zhang CX, Liu LY, et al.anti-phospho-ACC (Cat# 3661S), anti-cleaved caspase-3 (Cat# 9661S), anti-PARP (Cat# 9532) and anti-LKB1 (Cat# 3050S) antibodies were purchased from Cell Signaling Technology. Anti-GSDMC (Cat# A14550), anti-PMI (Cat#

(20) Honokiol acts as an AMPK complex agonist therapeutic in non-alcoholic fatty liver disease and metabolic syndromeChinese medicineMarch 17, 2023Tian R, Yang J, Wang X, Liu S, Dong R, Wang Z, Yang Z, Zhang Y, Cai Z, Yang H, et al.(#2983), p-mTOR (#2971), CaMKK2 (#16,810), p-CaMKK2 (#12818), TAK1 (#4505), p-TAK1 (#4508), LKB1 (#3050), and p-LKB1 (#3055) were procured from Cell Signaling Technology (Danvers, MA). Primary antibodies

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LKB1 (27D10) Rabbit mAb

LKB1 (27D10) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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LKB1 (27D10) Rabbit mAb from Cell Signaling Technology

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