PTCH1 (C53A3) Rabbit mAb 2468S from Cell Signaling Technology

Product Specs
ItemPTCH1 (C53A3) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2468S
Quantity100 µl
ApplicationsW, IP
ReactivityH
TargetPTCH1
HostRabbit
NCBI Gene AliasesBCNS, BCNS1, NBCCS, PTC, PTC1, PTCH
ClonalityMonoclonal
NCBI Full Gene Namepatched 1
Research AreaDevelopmental Biology
IsotypeIgG
CloneC53A3
Molecular Weight180-210

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) TRV130 inhibits colon cancer progression via suppressing the Hedgehog signaling pathway: in vitro and in vivo evidenceHereditasJanuary 19, 2026Yuanzhao Zhuang, Changcheng Jiang, Yuqing Guo, Jiaxiao Sunwith anti-GLI1 (Proteintech, Cat. no. 66905-1-Ig) and anti-PTCH1 (Cell Signaling Technology, Cat. no. 2468S) overnight at 4℃, followed by HRP-conjugated secondary antibodies (Proteintech, Cat. no. SA00001-2/RGAM001)

(2) Exome Sequencing Reveals the Genetic Architecture of Non‐syndromic Orofacial Clefts and Identifies BOC as a Novel Causal GeneAdvanced ScienceAugust 1, 2025Qing He, Min Yu, Yuhua Jiao, Yizhu Xu, Xuqin Liang, Wenbin Huang, Linping Xu, Yuxia Hou, Zhanping Ren, Beile Lyu, et al.Immunofluorescence (IF) were performed as described previously.[ 30 ] The antibodies used were PTCH1 (CST, #2468S), HA (Proteintech, # 51064‐2‐AP), FLAG (Origene, #TA180144) and β‐actin (Origene, #TA811000). Pull‐Down

(3) YY1-induced transcription of AKR1C3 activates the Hedgehog signalling pathway to enhance lenalidomide resistance and glycolytic activity in multiple myeloma cellsClin Exp MedMarch 29, 2025Yang Chen, Aijia Zhang, Yuan Wang, Daoda Qi, Chengyi Peng, Zihao Liang, Jingjing Guo, Yan GuTarget,Catalogue,Company AKR1C3,"PA5-28,065",Thermofisher HK2,#2867,CST GLUT1,"#MA5-31,960",Thermofisher LDHA,"#PA5-27,406",Thermofisher GLI1,#2553,CST PTCH1,#2468,CST HIP1,#8226,CST YY1,ab109237,abcam ACTB,#MA1-140,Thermofisher gamma-H2AX,A700-053,Thermofisher CEBPA,ab317442,abcam PKM2,#4053,CST ATF4,Ab85049,abcam Antibodies

(4) Molecular characteristics and cancer immunity of LRP1B and its relationship with the Hedgehog signaling pathway in colorectal cancerFrontiers in ImmunologyMarch 18, 2025Yuan Liu, Yang Zhong, Yaodong Sang, Siqiang Zhu, Kang Xu, Xingyu Zhu, Xiaoling Cui, Xinyu Liu, Xiaohan Wang, Hao Chen, et al.2207T, Cell Signaling Technology, Shengxia Road, Pudong New Area, Shanghai, China), PTCH1 (1:1,000, 2468T, Cell Signaling Technology, USA), PTCH2 (1:1,000, 2470T, Cell Signaling Technology, USA), SMO (1:1,000,

(5) COLEC10: A potential tumor suppressor and prognostic biomarker in hepatocellular carcinoma through modulation of EMT and PI3K-AKT pathwaysOpen Life SciFebruary 26, 2025Rui-Sheng Ke, Yun Dai, Yan-ling Tu, Zhao-Hui Liu, Kun-Zhai Huang, Fu-Xing ZhangN-cadherin (#13116T), E-cadherin (#14472S), Vimentin (#5741T), GLI1 (#3538T), SHH (#2207T), PTCH1 (#2468T), SMO (#92981S), phospho-AKT (#2920S), PI3K (#4257), AKT (#4060T), and phospho-PI3K (#4228T) from Cell Signaling Technology

(6) GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathwayJ Exp Clin Cancer ResJanuary 24, 2025Chao Tang, Lin Li, Chongying Zhu, Qiang Xu, Zihao An, Shouying Xu, Chao Lin1:2000) and normal mouse IgG (sc-2025) were from Santa Cruz Biotechnology (Santa Cruz, CA, USA). PTCH1 (#2468, 1:1000) antibody, and normal rabbit IgG (#2729) were purchased from Cell Signaling Technology (Danvers,

(7) Multiplatform molecular profiling uncovers two subgroups of malignant peripheral nerve sheath tumors with distinct therapeutic vulnerabilitiesNature communicationsMay 10, 2023Suppiah S, Mansouri S, Mamatjan Y, Liu JC, Bhunia MM, Patil V, Rath P, Mehani B, Heir P, Bunda S, et al.antibodies against B-Actin (Cell Signaling Technologies #8457S, 1:10), PTCH1 (Cell Signaling Technologies #2468, 1:10), GLI1 (Cell Signaling Technologies #3538, 1:10). Anchorage independent growth assay 6-well

(8) Hedgehog costimulation during ischemia-reperfusion injury potentiates cytokine and homing responses of CD4(+) T cellsFrontiers in immunologyJanuary 1, 2023Wang S, Song G, Barkestani MN, Tobiasova Z, Wang Q, Jiang Q, Lopez R, Adelekan-Kamara Y, Fan M, Pober JS, et al.(Biolegend, No. 257208), CXCR5 Pacific Blue (Biolegend, No. 356918), and Ptch1 (Cell Signal, clone C53A3, No. 2468T, Cell Signaling Technology, Danvers, MA, USA). For intracellular staining, T cells were fixed and permeabilized

(9) Low-intensity pulsed ultrasound-generated singlet oxygen induces telomere damage leading to glioma stem cell awakening from quiescenceiScienceJanuary 21, 2022Song S, Ma D, Xu L, Wang Q, Liu L, Tong X, Yan H.GLI1 (V812) antibody,Cell Signaling Technology,#2534 RRID: AB_2294745 PTCH1 (C53A3) rabbit mAb,Cell Signaling Technology,#2468 RRID: AB_2300741 Wnt3a (C64F2) rabbit mAb,Cell Signaling Technology,#2721 RRID: AB_2215411 Wnt5a/b

(10) ALKAL1 gene silencing prevents colorectal cancer progression via suppressing Sonic Hedgehog (SHH) signaling pathwayJournal of CancerJanuary 1, 2021Chen S, Wang B, Fu X, Liang Y, Chai X, Ye Z, Li R, He Y, Kong G, Lian J, et al.1:1000), MMP3 (CST, 143513s, 1:1000), MMP9 (CST, 13667s, 1:1000), GLI1 (CST, 3538s, 1:1000), PTCH (CST, 2468s, 1:1000) and p84 (Abcam, ab102684, 1:1000). Secondary antibodies conjugated to HRP were used prior to

(11) RUNX1 regulates the proliferation and chemoresistance of colorectal cancer through the Hedgehog signaling pathwayJournal of CancerJanuary 1, 2021Li Q, Lai Q, He C, Zhang H, Pan X, Li H, Yan Q, Fang Y, Liu S, Li A.blotted according to standard methods using antibodies to the following: RUNX1 (#4336, CST), PTCH1 (#2468, CST), PTCH2 (#2470, CST), GLI1 (#3538, CST), Shh (#2207, CST), ABCG2 (#42078, CST) and GAPDH (60004-1-Ig,

(12) SHARPIN regulates cell proliferation of cutaneous basal cell carcinoma via inactivation of the transcriptional factors GLI2 and c‑JUNMolecular Medicine ReportsFebruary 7, 2020Yao Yang, Yan‑Hua Liang, Yan Zheng, Ling‑Jie Tang, Si‑Tong Zhou, Jing‑Na ZhuCell Signaling Technology, Inc.), GLI2 (1:200; cat. no. sc‑28674; Santa Cruz Biotechnology, Inc.), PTCH1 (1:1,000; cat. no. 2468; Cell Signaling Technology, Inc.), PTCH2 (1:1,000; cat. no. 2470; Cell Signaling Technology, Inc.) and

(13) CDCA2 acts as an oncogene and induces proliferation of clear cell renal cell carcinoma cellsOncology LettersJanuary 21, 2020Fang Li, Huahua Zhang, Qian Li, Fei Wu, Yu Wang, Zhenzhen Wang, Xiaofei Wang, Chen HuangCell Signaling Technology, Inc.) overnight at 4˚C. Following the primary incubation, membranes were 2468 ONCOLOGY LETTERS 19: 2466-2474, 2020 Figure 1. CDCA2 is upregulated in ccRCC and is associated with

(14) The Screening Methods for Locomotive Syndrome in the Elderly; An Integrative ReviewJournal of GerontologyAugust 1, 2019nasim Sadeghi Mahali, Mohamad Ali Hoseini, Kian Norouzi, Nursing Department of University of Social Welfare and Rehabilitation Sciences, Tehran, Iran, Nursing Department of University of Social Welfare and Rehabilitation Sciences, Tehran, Iran, Nursing Department of University of Social Welfare and Rehabilitation Sciences, Tehran, Iran‪-‬‬ ‫ابزار سازی‬ ‫به دو روش انجام شد‪:‬‬ ‫گذشته نگر‬ ‫آینده نگر‬ ‫‪CST .‬‬ ‫‪TUG .‬‬ ‫‪67‬‬ ‫‪2468‬‬ ‫زنان و مردان ‪ 40‬سال‬ ‫به باال‬ ‫مقادیر متوسط برای قدرت چنگ‬ ‫(دست غیر غالب)‪ ،‬توده عضالنی ران‪،‬‬ ‫زمان

(15) Evaluation of the Hydroâ€”Mechanical Efficiency of External Gear PumpsEnergiesJune 26, 2019Zardin, Natali, Borghi[cSt] N and K[ mm 2 ], called load intensity, is: 1000Tth /2 K= . (21) br2p Energies 2019, 12, 2468 10 of 19 From the previous equations, the contribution of loss due to the meshing process, can be

(16) HER2-mediated GLI2 stabilization promotes anoikis resistance and metastasis of breast cancer cellsCancer LettersFebruary 1, 2019Parul Gupta, Nehal Gupta, Neel M. Fofaria, Alok Ranjan, Sanjay K. Srivastava(Cell Signaling #2585, rabbit mAb), PTCH2 (Cell Signaling #2470, rabbit mAb), PTCH1 (Cell Signaling #2468, rabbit mAb), SHH (Cell Signaling #2207, rabbit mAb), SUFU (Cell Signaling #2520, rabbit mAb), C-caspase 3

(17) Non-canonical activation of hedgehog in prostate cancer cells mediated by the interaction of transcriptionally active androgen receptor proteins with Gli3OncogeneApril 1, 2018Li N, Truong S, Nouri M, Moore J, Al Nakouzi N, Lubik AA, Buttyan R.antibody (sc-7305) was from Santa Cruz Biotech. (Santa Cruz, CA); rabbit anti-human Gli1 (2553), Ptch1 (2468), PSA (5877), β-TrCP (4394), and GAPDH (5174) antibodies were from Cell Signaling (Danvers, MA); rabbit

(18) PDGF controls contact inhibition of locomotion by regulating N-cadherin during neural crest migrationJournal of Cell ScienceJuly 15, 2017Isabel Bahm, Elias H. Barriga, Antonina Frolov, Eric Theveneau, Paul Frankel, Roberto MayorUO126 (in vivo 100 μM, in vitro 25 μM, 9903, Cell Signaling Technology). Development (2017) 144, 2456-2468 doi:10.1242/dev.147926 oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice.

(19) mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCTMolecular CellJuly 6, 2017Yuchao Gu et al.

(20) Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathwayOncotargetFebruary 14, 2017Subramani R, Gonzalez E, Nandy SB, Arumugam A, Camacho F, Medel J, Alabi D, Lakshmanaswamy R.pPTEN (9549), pmTOR (2974), mTOR (4517), p-p70s6kinase (9206), p70s6kinase (9202), Shh (2207), PTCH1 (2468), PTCH2 (2470), SUFU (2520) and Gli1(3538) were procured from Cell Signaling Technology, Boston, MA,

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PTCH1 (C53A3) Rabbit mAb

PTCH1 (C53A3) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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PTCH1 (C53A3) Rabbit mAb from Cell Signaling Technology

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