Phospho-IRE1 alpha (Ser724) Antibody PA1-16927 from Thermo Fisher Scientific

Product Specs
ItemPhospho-IRE1 alpha (Ser724) Antibody
CompanyThermo Fisher Scientific
Price Supplier Page
Catalog NumberPA1-16927
ClonalityPolyclonal
Conjugate/TagUnconjugated
HostRabbit
FormatPBS with 0.02% sodium azide
ApplicationsChIP Assay, ELISA, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
NCBI Full Gene Nameendoplasmic reticulum to nucleus signaling 1, endoplasmic reticulum (ER) to nucleus signalling 1
ReactivityHu, Ms, Rb, Rt, Dr, Gt, Hm, Mm, NHPr, Pg
Concentration1 mg/mL
Storage Temperature-20° C, Avoid Freeze/Thaw Cycles
PurityAntigen affinity chromatography
Storage-20°C, Avoid Freeze/Thaw Cycles
Antibody TypePrimary
ModificationsPhosphorylated: Ser724
IsotypeIgG
ImmunogenSynthetic peptide surrounding the phosphorylated serine 724 of the human IRE1 alpha protein
TargetPhospho-IRE1 alpha (Ser724)
Quantity100 µL
NCBI Gene AliasesIre1a, Ire1alpha, RGD1559716, IRE1, Ire1p, 9030414B18Rik, hIRE1p, IRE1P, IRE1a

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United States

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Fax: 800-331-2286

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Website: www.thermofisher.com

(1) Autophagy prevents ER stress-induced Tight Junction barrier disruption via claudin-2 homeostasisbioRxivJuly 20, 2026Priya Arumugam, Kushal Saha, Ashwinkumar Subramenium Subramenium Ganapathy, Alexandra Wang, Leonard Harris, Gregory Yochum, Prashant Nighotincluded anti-CLDN1, anti-CLDN3, anti-CLDN4, anti- phospho IRE1α (Invitrogen, 37–4900, 34–1700, PA5–34437, PA1–16927, respectively), anti-CLDN2 (Abcam, ab53032), anti-LC3, anti-ATG7 (Sigma Aldrich, L7543, A2856, respectively),

(2) Cell autonomous inflammation in VEXAS is mediated by cGAS-STINGbioRxivMay 29, 2026Samuel J. Magaziner, Jason C. Collins, Brecca Miller, Patrick Zheng, Amy K. Wang, Jerome Hadjadj, Juan Carlos Baladrán, Maria Sirenko, Maya English, James Bertlin, et al.3192S), phospho-PERK (Invitrogen, PA5-40294), IRE1α (Cell Signaling, 3294S), phospho-IRE1α (Invitrogen, PA1-16927), ATF6 (Cell Signaling, 65880S), PKR (Cell Signaling, 12297S), phospho-PKR (Abcam, AB32036), GCN2 (Cell Signaling

(3) Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretionCell Rep MedMay 19, 2026Alexis Onimus, Daiana Celias, Shiun Chang, Joshua Davis, Jay Mandula, Jie Li, Alycia Gardner, Kay Hänggi, Olabisi Osunmakinde, Hatem Soliman, et al.Technology,Cat# 3294RRID:AB_823545 "Anti-human/mouse/rat Phospho-IRE1 alpha (Ser724) Polyclonal Antibody, clone PA1-16927",Thermo Scientific,Cat# PA1-16927RRID:AB_2262241 Anti-mouse Phospho-STING (Ser365) (clone D1C4T) mAb,Cell

(4) Cellular retinoic acid-binding protein 1, CRABP1, in thyroid gland agingnpj AgingApril 15, 2026Fatimah Najjar, Jennifer Nhieu, Natalia Calixto Mancipe, Christy Henzler, Li-Na Weimonoclonal antibody (1:1000) or P-IRE-1α (Ser724) rabbit polyclonal antibody (1:1000, Invitrogen, Cat #PA1-16927) or IRE-1α rabbit polyclonal antibody (1:1000) or CRABP1 rabbit monoclonal antibody (1:1000) Cleaved

(5) In vivo dual RNA-Seq uncovers key effectors of epithelial barrier disruption by an extracellular pathogenNature CommunicationsFebruary 3, 2026Alexandre Giraud-Gatineau, Georges Haustant, Marc Monot, Mathieu Picardeau, Nadia BenaroudjCell Signaling), anti-pPERK (PA5-40294; ThermoFisher), anti-IRE1 (3294; Cell Signaling), anti-pIRE1 (PA1-16927; ThermoFisher) and anti-3xFLAG (87537; Cell Signaling) at a 1:1000 dilution. Membranes were washed in

(6) 1-deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathwayCell Chemical BiologyJanuary 15, 2026Yi-Ting Tsai, Nicolas-Frédéric Lipp, Olivia Seidel, Riya Varma, Aurelie Laguerre, Kristina Solorio-Kirpichyan, Adrian M. Wong, Roberto J. Brea, Grace H. McGregor, Thekla Cordes, et al.anti-β-actin,Cell Signaling Technologies,Cat# 8H10D10 rabbit anti-IRE1-phosphorylated,Invitrogen,Cat# PA1-16927 rabbit anti-AKT-phosphorylated,Invitrogen,Cat# 44-621G mouse anti-Derlin-1,Sigma-Aldrich,Cat# SAB4200148 rabbit

(7) Hemolysis-induced hepatic ferroptosis following xenotransfusion of genetically modified pig red blood cellsSci RepDecember 16, 2025Ha-Young Shin, Ju Young Lee, Young-Jin Jang, Hyung-Sun Kim, Seon Ryong Park, Goo-Hwa Kang, Joohyun Shim, Nayoung Ko, Jeong Ho Hwang(Bio-Rad, CA, USA). Primary antibodies used included BiP (3183 S, 1:1000, Cell Signaling), p-IRE1α (PA1-16927, 1:1000, Invitrogen), eIF2α (5324 S, 1:1000, Cell Signaling), p-eIF2α (3398 S, 1:1000, Cell Signaling),

(8) SCYL1 deficiency in CALFAN syndrome is associated with ER stress and cell deathDisease Models & MechanismsNovember 1, 2025John Hellicar, Tal Dattner, Tian Sun, Lily Percival, Ruby Chrisp, Andrea Pietrobattista, Tomasz Witkos, Aleksander Mironov, Lina Leghlam, Carolin Jentsch, et al.rabbit anti-IRE1α (Cell Signaling, 3294; 1:1000 for WB); rabbit anti-phosphorylated IRE1α (Invitrogen, PA1-16927, 1:1000 for WB); rabbit anti-PERK (Cell Signaling, 5683; 1:1000 for WB); rabbit anti-phosphorylated

(9) Targeting ESR1 restores SQSTM1-dependent autophagy and sensitizes ER-positive breast cancer to oxidative and radiation stressCell Death DiscovOctober 7, 2025Yi-Fang Yang, Zhao-Jing He, Han-Hsi Kuo, Yu-Yu Lin, Cheorl-Ho Kim, Huei-Yu Cai, Chi-Long Chen, Michael Hsiao, Ying-Chung Chen, Peter Mu-Hsin Chang, et al.Caspase 3/p17/p19,19677-1-AP,Proteintech,1:1000 LC3B,GTX127375,Genetex,1:1000 COX2,A2413,ABclonal,1:1000 GPX4,A1933,ABclonal,1:1000 Phospho-IRE1-α (Ser724),PA1-16927,ThermoFisher,1:1000 P62,ab207305,Abcam,1:1000 Phospho-p62 (Ser349),95697,Cell signaling,1:1000 P53,ab32389,Abcam,1:1000 P21,ab188224,Abcam,1:1000 PUMA,ab9643,Abcam,1:1000 β-actin,66009-1-Ig,Proteintech,1:5000

(10) Human immunodeficiency virus 1 glycoprotein 120 induces endoplasmic reticulum stress in neuronsCell Death DisOctober 6, 2025Christy Agbey, Lee A. Campbell, Thieu Phan, Gerard Ahern, Italo Mocchettiwith anti-GRP78/BiP antibody (1:1000, cat. no. ab21685, Abcam), anti-phospho-IRE1α (1:1000, cat. no. PA1-16927, ThermoFisher Scientific), or anti-CHOP (1:1000, cat. no. MA1-250, ThermoFisher Scientific). The following

(11) Liangfang Wenjing decoction regulates endoplasmic reticulum stress-mediated apoptosis to alleviate uterine microvascular injury in cold-stressed ratsFrontiers in PharmacologySeptember 30, 2025Tianyuan Lv, Yue Hu, Xueyan Ma, Liqun Feng, Di Wang, Xiaodan Song, Sisi Xue, Shuai Lu, Xiumei ChengXBP1s (1:1000, 40435, CST, United States), IRE1α (1:1000, 3924, CST, United States), p-IRE1α(1:1000, PA1-16927, Thermo, United States), ASK1 (1:1000, 8662, CST, United States), p-ASK1 (1:1000, MA5-36973, Thermo,

(12) Boric Acid Suppresses Cell Survival by Triggering Endoplasmic Reticulum Stress-Induced Autophagy in Cervical CancersJ Cell Mol MedJuly 19, 2025Betul Keyif, Ceyhan HaciogluSigma‐Aldrich), GRP78 (2 μg/mL, PA1‐014A, Invitrogen), p‐PERK (1:1000, PA5‐40294, Invitrogen), p‐IRE1α (1:1000, PA1‐16927, Invitrogen), CHOP (1:1000, PA5‐104528, Invitrogen), and cleaved‐caspase3 (1:1000, PA5‐114687, Invitrogen).

(13) Targeting the self-amplifying loop between ATF6 and SNAI1 to inhibit epithelial‒mesenchymal transition in fibrotic lesionsTheranosticsJuly 11, 2025Tong Wu, Yan Liu, Jiyuan Ma, Lingshan Lu, Liang Wang, Mengmei He, Zhuang Hao, Xiaomin Liu, Luning Zhang, Chao Zhao, et al.overnight. The primary antibodies used included anti-p-PERK (29546-1-AP, Proteintech, China), anti-p-IRE1α (PA1-16927, Thermo Fisher Scientific, MA, USA), anti-CHOP (#5554, Cell Signaling Technology, MA, USA), anti-GRP78

(14) Combined downregulation of TGF-β1 and GRP78 is responsible for overcoming acquired sorafenib resistance, which is initiated by rewiring the cell surface CD44-GRP78-IGF-1R signaling circuitCancer Gene TherapyJuly 9, 2025Shengji Li, Geun-Hyeok Oh, Jeong A. Hong, Soojin Choi, Minseo Kim, Hyeji Kwon, Seung-Kyun Ko, Sun Jun Park, Hee Kyung Kim, Hye Jin Choi, et al.CD44(Cat#15675-1-AP) were purchased from Proteintech (Rosemont, IL, USA). An antibody against phospho-IRE1α (Cat#PA1-16927) was purchased from Thermo Fisher Scientific (Waltham, MA, USA). An antibody against phospho-IGF1R (Tyr1161/Tyr1165/Tyr1166)

(15) N6-methyladenosine-mediated upregulation of MANF promotes ER stress resistance in renal cell carcinomaCell Death DisJuly 3, 2025Junjie Cen, Dongliang Zhao, Xin Shi, Jinlong Chen, Hang Zhou, Yanping Liang, Chengpeng Gui, Wei Chen, Junhang Luo, Xu ChenProteinTech, China), BiP (C50B12, Cell Signaling Technology), IRE1α (27528-1-AP, ProteinTech), p-IRE1α (PA1-16927, ThermoFisher) and GAPDH (D16H11, Signaling Technology). Colony-forming assay For evaluation of proliferation

(16) 1-Deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathwayBIORXIVMay 17, 2025Yi-Ting Tsai, Nicolas-Frédéric Lipp, Olivia Seidel, Riya Varma, Aurelie Laguerre, Kristina Solorio-Kirpichyan, Adrian Wong, Roberto J. Brea, Grace H. McGregor, Thekla Cordes, et al.levels were detected using the following primary antibodies: rabbit anti-IRE1-phosphorylated (Invitrogen PA1–16927, at 1:1,000), rabbit anti-AKT-phosphorylated (Invitrogen 44–621G, at 1:1,000 dilution), mouse anti-Derlin-1

(17) Narciclasine enhances cisplatin-induced apoptotic cell death by inducing unfolded protein response-mediated regulation of NOXA and MCL1Cell Mol Biol LettMay 14, 2025Ji Hae Lee, Seung Hee Seo, Jaegal Shim, Yong-Nyun Kim, Kyungsil Yoonwas from Novus Biologicals and FLAG (#F7425) was from Sigma-Aldrich. Antibody against phospho-IRE1α (PA1-16927) was from Invitrogen, and Vinculin (PM088) was from MBL. Secondary antibodies, goat anti-mouse IgG HRP

(18) Increased oxidative stress and autophagy in NGLY1 patient iPSC-derived neural stem cellsExperimental Cell ResearchMay 1, 2025Zeenat A. Shyr, Soukaina Amniouel, Kofi Owusu-Ansah, Mitali Tambe, Joshua Abbott, Matthew Might, Wei Zheng#3177S), phospho-Eifα (1:1000; CST #3398S), ERO1α (1:1000, CST#3264T), phosphor-IRE1α (1:1000; Invitrogen #PA1–16927), LC3B (1:1000; CST #3868S), p62 (1:1000, CSTD5L76), phospho-PERK (1:1000; CST #3179S), XBP1 (1:1000;

(19) The endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 3 attenuates the unfolded protein response and has pro-survival and pro-viral roles in hepatoma cells and hepatocellular carcinoma patientsJ Biomed SciJanuary 22, 2025Alina-Veronica Ghionescu, Mihaela Uta, Andrei Sorop, Catalin Lazar, Petruta R. Flintoaca-Alexandru, Gabriela Chiritoiu, Livia Sima, Stefana-Maria Petrescu, Simona Olimpia Dima, Norica Branza-Nichita(NB100-62652, Novus Biologicals, Littleton, CO, USA, 1:1000), rabbit anti-phospho-IRE1 alpha (Ser724) (PA1-16927, Invitrogen, 1:1000), rabbit anti-IRE1α (14C10, Cell Signaling Technology, Danvers, MA, USA, 1:1000),

(20) Immunopeptidome mining reveals a novel ERS-induced target in T1DCellular & molecular immunologyJune 1, 2024Wang L, Yang S, Zhu G, Li J, Meng G, Chen X, Zhang M, Wang S, Li X, Pan Y, et al.

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Phospho-IRE1 alpha (Ser724) Antibody from Thermo Fisher Scientific

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