Substance P (SP-DE4-21) Antibody sc-58591 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemSubstance P (SP-DE4-21) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-58591
NCBI Gene AliasesNkna, NPK, 4930528L02Rik, SP, NKNA, NK1, NK2, PPT-A, PPTA, TAC2, Hs.2563, NK-1
Antibody TypePrimary Antibodies
Quantity50 µg/500 µl
CloneSP-DE4-21
ApplicationsIF, IHC(P)
Reactivitymouse, rat, human
FormatPurified
Conjugate/TagUnconjugated
ClonalityMonoclonal
Hostmouse
NCBI Full Gene Nametachykinin 1, tachykinin precursor 1
TargetSubstance P
IsotypeIgG1

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Efficacy of Rosmarinus officinalis nanoemulsion as an anti-inflammatory and antinociceptive agent by targeting the interleukin-1β, substance P, and neurokinin-1 receptor pathways in experimental pulpitisOpen Vet JMarch 31, 2026Yuli Nugraeni, Agustine Hanafi Putri, Abdur Razaq Kamaruzzaman, Regina Putri Virigirinia, Rahmavidyanti Priyanto, Wibi Riyawanmonoclonal, catalog no. sc-32294, Santa Cruz Biotechnology), Substance P (mouse monoclonal, catalog no. sc-58591, Santa Cruz Biotechnology), or NK1-R (mouse monoclonal, catalog no. sc-365091, Santa Cruz Biotechnology)

(2) The Anti-Angiogenic Effect of Microbotox on Rosacea Is Due to the Suppressed Secretion of VEGF by Mast Cells Resulting From Internalization of the MRGPRX2 ReceptorAnnals of DermatologyJune 11, 2025Jing Wan, Yue Le, Meng-Meng Geng, Bing-Qi Dong, Zhi-Kai Liao, Lin-Xia Liu, Tie-Chi Leiantibody (Cat#: A19101) was purchased from ABclonal (Wuhan, China), the anti-substance P antibody (Cat#: sc-58591) was purchased from Santa Cruz (Dallas, TX, USA), the anti-VEGF-A polyclonal antibody (Cat#: 19003)

(3) Effect of bioactive glasses used as dentin desensitizers on the dentin-pulp complex in ratsDental materials journalNovember 30, 2022Dalmolin AC, Acevedo LFA, Campos LA, Dechandt ICJ, Serbena FC, Zanotto ED, Pochapski MT, Arrais CAG, Campagnoli EB, Santos FAD.

(4) Inhibitory effects of vibegron, a β(3)-adrenoceptor agonist, on the myogenic contractile and mechanosensitive afferent activities in an obstructed rat bladderEuropean journal of pharmacologyOctober 15, 2022Aizawa N, Fujita T.

(5) Estrogen receptor β/substance P signaling in spinal cord mediates antinociceptive effect in a mouse model of discogenic low back painFrontiers in cellular neuroscienceJanuary 1, 2022Song XX, Jin LY, Li Q, Li XF, Luo Y.(Vector, S-1000). They were incubated overnight with a mouse anti-substance P antibody (Santa Cruz, sc-58591, 1:100 dilution). Then at room temperature, slides were incubated with Alexa Fluor§ 594 Goat anti-rabbit

(6) Cross-Talk of Toll-Like Receptor 5 and Mu-Opioid Receptor Attenuates Chronic Constriction Injury-Induced Mechanical Hyperalgesia through a Protein Kinase C Alpha-Dependent SignalingInternational journal of molecular sciencesFebruary 14, 2021Chang C, Liu HK, Yeh CB, Yang ML, Liao WC, Liu CH, Tseng TJ.polyclonal MOR (1:200, RA10104, Neuromics, Edina, MN, USA) were mixed with mouse monoclonal SP (1:100, sc-58591, Santa Cruz Biotechnology; Santa Cruz, CA, USA), mouse monoclonal CGRP (1:100, sc-57053,Santa Cruz Biotechnology;

(7) Evaluation of innervation in cleft affected oral mucosaPapers on AnthropologyJuly 14, 2020Olga Rimdenoka, Māra Pilmane9.5 (Lot number 439273A, obtained from rabbit, dilution 1:100, Invitrogen, USA), substance P (code sc-58591, obtained from mouse, dilution 1:100, Santa Cruz, USA), VIP (code sc-20727, obtained from rabbit, dilution 1:100,

(8) Isolation and Culture of Primary Neurons and Glia from Adult Rat Urinary BladderJournal of visualized experiments : JoVEMay 23, 2020Wang R, Huang ZT, Ren WK, Zhang J, Zhang Y, Tan B, Huang P, Cao HY.

(9) Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in MiceMolecules and cellsApril 30, 2020Lee Y, Han NE, Kim W, Kim JG, Lee IB, Choi SJ, Chun H, Seo M, Lee CJ, Koh HY, et al.USA), choline acetyltransferase (ChAT) (1:1,200, AB144P; Millipore, USA), Substance P (SP) (1:100, SC-58591; Santa Cruz Biotechnology), or D2R (1:100, AB5084P; Millipore); Synaptophysin (SYP) (1:100, SC-17750;

(10) The Anti-Inflammatory and Antioxidative Effects of Ningmitai Capsule in the Experimental Autoimmune Prostatitis Rat ModelEvidence-based complementary and alternative medicine : eCAMJanuary 1, 2020Chen H, Xie Y, Deng C, Zhang C, Lv L, Yao J, Sun X, Deng C, Liu G.Santa Clara, CA, USA) for 30 min, after which they were incubated with the antibodies of SP, SP-DE4-21 (sc58591; dilution 1 : 100; Santa Cruz Biotechnology). Evidence-Based Complementary and Alternative Medicine 2.7.

(11) Contribution of GABAergic modulation in DRGs to electroacupuncture analgesia in incisional neck pain ratsJournal of pain researchJanuary 1, 2019Qiao LN, Yang YS, Liu JL, Zhu J, Tan LH, Shi YN, Zhu B, Rong PJ.serum for 30 minutes and incubated with GABAAα2R (AGA-002; Alomone Labs, Jerusalem, Israel) and SP (sc58591; Santa Cruz Biotechnology Inc., Dallas, TX, USA), or GABABR1 (ab90883; Abcam, Cambridge, MA, USA) and

(12) Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized ratsPhysiological reportsJune 1, 2018Shanks J, Xia Z, Lisco SJ, Rozanski GJ, Schultz HD, Zucker IH, Wang HJ.dilution, NB100‐1617, Novus Biologicals, Littleton, CO, USA) and/or mouse anti‐SP antibody (1:200 dilution, sc‐58591, Santa Cruz, Inc, Dallas, TX USA) overnight at 4°C. Sections were then washed with PBS and incubated

(13) Occurrence of substance P and neurokinin receptors during the early phase of spinal fusionMolecular medicine reportsMay 1, 2018Wu S, Xu X, Zhang Y, Liu P, Sun K, Xu T, Shi J.incubated with a rabbit anti‑rat polyclonal primary antibody (1:1,000; Substance P antibody: Cat. no. sc‑58591; Santa Cruz Biotechnology, Inc., Dallas, TX, USA; NK‑1R antibody: Cat. no. sc‑365091; Santa Cruz; Biotechnology, Inc.;

(14) Calcitriol regulates immune genes CD14 and CD180 to modulate LPS responses in human trophoblastsReproduction (Cambridge, England)December 1, 2017Longtine MS, Cvitic S, Colvin BN, Chen B, Desoye G, Nelson DM.used included goat antiactin (SC-1616, 1:3000, Santa Cruz Biotechnology), mouse monoclonal anti-CD14 (SC-58591, 1:1000, SCBT), and rabbit monoclonal anti-CD180 (AB18495, 1:1000, Abcam). HRPconjugated secondary antibodies

(15) Expression of angiotensinogen and receptors for angiotensin and prorenin in the rat and monkey striatal neurons and glial cellsBrain structure & functionAugust 1, 2017Garrido-Gil P, Rodriguez-Perez AI, Fernandez-Rodriguez P, Lanciego JL, Labandeira-Garcia JL.

(16) Effect of Electroacupuncture on Thermal Pain Threshold and Expression of Calcitonin-Gene Related Peptide, Substance P and γ-Aminobutyric Acid in the Cervical Dorsal Root Ganglion of Rats with Incisional Neck PainAcupuncture in MedicineAugust 1, 2017Li-na Qiao, Jun-ling Liu, Lian-hong Tan, Hai-long Yang, Xu Zhai, Yong-sheng YangCambridge, UK) plus either glutamic acid decarboxylase 67 (GAD67, a marker for GABA; ab104561, Abcam), SP (sc58591, Santa Cruz, Dallas, TX, USA) or CGRP (ab181887, Abcam) at 4°C overnight. Sections were washed three

(17) Altered neurotransmitter expression profile in the ganglionic bowel in Hirschsprung's diseaseJournal of pediatric surgeryMay 1, 2016Coyle D, O'Donnell AM, Gillick J, Puri P.

(18) H2O2 generated by NADPH oxidase 4 contributes to transient receptor potential vanilloid 1 channel-mediated mechanosensation in the rat kidneyAmerican journal of physiology. Renal physiologyAugust 15, 2015Lin CS, Lee SH, Huang HS, Chen YS, Ma MC.

(19) Menurunkan Biomarker Migren Secara Cepat dengan Terapi “Assisted Drainage” (Studi Eksperimental pada Hewan coba)Majalah Kedokteran Gigi IndonesiaJune 1, 2015Haryono UtomoMonoklonal antibodi yang digunakan; Substans P (Santa Cruz Biotechnology, Inc., Amerika; nomor catalog SP: sc-58591); LTC4 jaringan (US-Biological, Amerika; nomor katalog L-2047) dan TNF-α (Santa Cruz Biotechnology, Inc.,

(20) Mast cell number, substance P and vasoactive intestinal peptide in irritable bowel syndrome with diarrheaScandinavian journal of gastroenterologyJanuary 1, 2014Sohn W, Lee OY, Lee SP, Lee KN, Jun DW, Lee HL, Yoon BC, Choi HS, Sim J, Jang KS.

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Substance P (SP-DE4-21) Antibody

Substance P (SP-DE4-21) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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Substance P (SP-DE4-21) Antibody from Santa Cruz Biotechnology, Inc.

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