RASSF1 (3F3) Antibody sc-58470 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemRASSF1 (3F3) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-58470
NCBI Gene AliasesRASSF1A, NORE2A, Rassf1A, Rassf1C, Rassf1B, REH3P21, 123F2, RDA32
Clone3F3
Quantity50 µg/500 µl
ApplicationsWB, IP, IF
Reactivitymouse, rat, human
Hostmouse
ClonalityMonoclonal
Conjugate/TagUnconjugated
FormatPurified
NCBI Full Gene NameRas association domain family member 1, Ras association (RalGDS/AF-6) domain family member 1
TargetRASSF1
Antibody TypePrimary Antibodies
IsotypeIgG1

Questions and Answers

Can this antibody be used to study the role of RASSF1A in lung cancer?

Yes, the RASSF1 (3F3) Antibody has been utilized in research demonstrating that RASSF1A plays a critical role in lung adenocarcinoma by controlling tissue stiffness and cancer stem-like cells. In a study, the antibody was employed in immunoblotting to assess RASSF1A expression, revealing its association with extracellular matrix properties and metastatic progression in lung cancer ().

Is this antibody effective for immunoprecipitation applications?

The RASSF1 (3F3) Antibody is suitable for immunoprecipitation, as indicated by its applications listed. It has been used in studies to investigate the interactions and functions of RASSF1A, particularly in the context of signaling pathways related to DNA damage response and ribosomal DNA transcription regulation ().

What species can I use this antibody on?

This antibody is reactive with multiple species, including human, mouse, and rat. This broad reactivity allows for its application in various experimental models, making it versatile for studies involving RASSF1A across different organisms.

How has this antibody been cited in scientific literature?

The RASSF1 (3F3) Antibody has been cited in 18 scientific articles, indicating its relevance and utility in various research contexts. Notably, it has been referenced in studies focusing on cancer biology, particularly in understanding the mechanisms of tumor suppression and the impact of RASSF1A on cancer stemness and metastasis (, ).

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Inhibition of colorectal cancer tumorigenesis by ursolic acid and doxorubicin is mediated by targeting the Akt signaling pathway and activating the Hippo signaling pathwayMolecular medicine reportsJanuary 1, 2023Hu D, Meng RY, Nguyen TV, Chai OH, Park BH, Lee JS, Kim SM.

(2) Folic acid depletion as well as oversupplementation helps in the progression of hepatocarcinogenesis in HepG2 cellsScientific reportsOctober 5, 2022Sharma R, Ali T, Kaur J.

(3) 53BP1-mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signalingEMBO reportsAugust 3, 2022Tsaridou S, Velimezi G, Willenbrock F, Chatzifrangkeskou M, Elsayed W, Panagopoulos A, Karamitros D, Gorgoulis V, Lygerou Z, Roukos V, et al.

(4) RASSF1A disrupts the NOTCH signaling axis via SNURF/RNF4-mediated ubiquitination of HES1EMBO reportsFebruary 3, 2022Papaspyropoulos A, Angelopoulou A, Mourkioti I, Polyzou A, Pankova D, Toskas K, Lanfredini S, Pantazaki AA, Lagopati N, Kotsinas A, et al.

(5) Tumor suppressor genes are differentially regulated with dietary folate modulations in a rat model of hepatocellular carcinomaMolecular and cellular biochemistryJanuary 1, 2021Sharma R, Ali T, Kaur J.

(6) Tricistronic expression of MOAP-1, Bax and RASSF1A in cancer cells enhances chemo-sensitization that requires BH3L domain of MOAP-1Journal of cancer research and clinical oncologyJuly 1, 2020Lee YH, Pang SW, Revai Lechtich E, Shah K, Simon SE, Ponnusamy S, Narayanan R, Poh CL, Tan KO.

(7) Molecular mechanisms underlying eicosapentaenoic acid inhibition of HDAC1 and DNMT expression and activity in carcinoma cellsBiochimica et biophysica acta. Gene regulatory mechanismsFebruary 1, 2020Ceccarelli V, Ronchetti S, Marchetti MC, Calvitti M, Riccardi C, Grignani F, Vecchini A.

(8) RASSF1A controls tissue stiffness and cancer stem-like cells in lung adenocarcinomaThe EMBO journalJuly 1, 2019Pankova D, Jiang Y, Chatzifrangkeskou M, Vendrell I, Buzzelli J, Ryan A, Brown C, O'Neill E.Scientific, dilution 1:500), Mucin 5B (sc‐20119, Santa Cruz Biotechnology, dilution 1:500), RASSF1A (sc‐58470, Santa Cruz Biotechnology, dilution 1:200), β‐catenin (Santa Cruz Biotechnology, dilution 1:500), YAP

(9) EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hypermethylation to drive B-cell proliferationPLoS pathogensJanuary 1, 2019Zhang S, Pei Y, Lang F, Sun K, Singh RK, Lamplugh ZL, Saha A, Robertson ES.

(10) Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 CellsMolecular pharmaceuticsNovember 5, 2018Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, Ying M.

(11) MST2 kinase suppresses rDNA transcription in response to DNA damage by phosphorylating nucleolar histone H2BThe EMBO journalAugust 1, 2018Pefani DE, Tognoli ML, Pirincci Ercan D, Gorgoulis V, O'Neill E.phospho‐histone H2B (Ser14) (Millipore, 07‐191), MST1 (Millipore, 07‐061), RASSF1A (3F3, Santa Cruz sc‐58470), UBF (F9, Santa Cruz, sc‐13125), SAV‐1 (Atlas, HPA001808), V5 (Cell Signalling, 13202), H2B (abcam,

(12) RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73Nature communicationsJanuary 30, 2018Papaspyropoulos A, Bradley L, Thapa A, Leung CY, Toskas K, Koennig D, Pefani DE, Raso C, Grou C, Hamilton G, et al.

(13) The RASSF1A tumor suppressor regulates XPA-mediated DNA repairMolecular and cellular biologyJanuary 1, 2015Donninger H, Clark J, Rinaldo F, Nelson N, Barnoud T, Schmidt ML, Hobbing KR, Vos MD, Sils B, Clark GJ.

(14) BRAF mutation and RASSF1A expression in thyroid carcinoma of southern ItalyJournal of cellular biochemistryMay 1, 2013Santoro A, Pannone G, Carosi MA, Francesconi A, Pescarmona E, Russo GM, Feola A, Losito S, Franco R, Nappi L, et al.

(15) Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesisCancer researchAugust 1, 2012van der Weyden L, Papaspyropoulos A, Poulogiannis G, Rust AG, Rashid M, Adams DJ, Arends MJ, O'Neill E.

(16) An apoptosis methylation prognostic signature for early lung cancer in the IFCT-0002 trialClinical cancer research : an official journal of the American Association for Cancer ResearchMay 15, 2012de Fraipont F, Levallet G, Creveuil C, Bergot E, Beau-Faller M, Mounawar M, Richard N, Antoine M, Rouquette I, Favrot MC, et al.

(17) A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcomaCancer researchMay 1, 2012Yee KS, Grochola L, Hamilton G, Grawenda A, Bond EE, Taubert H, Wurl P, Bond GL, O'Neill E.anti-Flag M2 agarose, anti-ATM (A6218) and anti-α- tubulin antibodies from Sigma; anti-RASSF1A clone 3F3 (sc-58470), anti-p53 (DO1)(sc-126), anti-p21 (sc-6246), anti Krs-1/2 (sc-6211) and anti-α-Tubulin (sc-8035) from

(18) Mutational inactivation of STAG2 causes aneuploidy in human cancerScience (New York, N.Y.)August 19, 2011Solomon DA, Kim T, Diaz-Martinez LA, Fair J, Elkahloun AG, Harris BT, Toretsky JA, Rosenberg SA, Shukla N, Ladanyi M, et al.

(19) Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and AktCancer researchFebruary 1, 2010Romano D, Matallanas D, Weitsman G, Preisinger C, Ng T, Kolch W.

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RASSF1 (3F3) Antibody

RASSF1 (3F3) Antibody from Santa Cruz Biotechnology, Inc.

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Questions and Answers

Santa Cruz Biotechnology, Inc.

Citations (19)

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RASSF1 (3F3) Antibody from Santa Cruz Biotechnology, Inc.

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