p16 INK4A (JC8) Antibody sc-56330 from Santa Cruz Biotechnology, Inc.

Product Specs
Itemp16 INK4A (JC8) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-56330
Quantity200 µg/ml
ApplicationsWB, IP, IF, IHC(P), ELISA
Conjugate/TagUnconjugated
FormatPurified
Reactivityhuman
Targetp16 INK4A
CloneJC8
Hostmouse
Antibody TypePrimary Antibodies
NCBI Full Gene Namecyclin dependent kinase inhibitor 2A
NCBI Gene AliasesP16INK4A, P16, CDKN2, MTS1, INK4, MTS-1, P16-INK4A, MLM, P14, CMM2, ARF, P19, P16INK4, P14ARF, TP16, INK4A, P19ARF, CDK4I
ClonalityMonoclonal
IsotypeIgG2a

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Impairment of Macrophage Functions by the Senescence-Associated Secretory Phenotype of Vascular Smooth Muscle Cells-Brief ReportArterioscler Thromb Vasc BiolApril 2, 2026Dimitrios Tsitsipatis, Tatiana Rodriguez Rivera, Mary Kaileh, Ada N. Okereke, Aditi Gupta, Amit Singh, Sean M. Raph, Charnae' Henry-Smith, Allison B. Hermanovernight at 4 °C. Primary antibodies that recognized p16 (CDKN2A [cyclin-dependent kinase inhibitor 2A], sc-56330; Santa Cruz Biotechnology), GDF15 (growth differentiation factor 15; sc-377195; Santa Cruz Biotechnology),

(2) In Vitro Model Characterizing Carcinogenic Progression of HPV-Positive Oropharyngeal CancerCancers (Basel)February 19, 2026Jesus Avila Tejeda, Sreejata Chatterjee, Craig Meyers(1:1000 dilution; catalog number MA5-14428; Invitrogen), p16INK4A (1:1000 dilution; catalog number sc-56330; Santa Cruz Biotechnology), COX5b (C-5) (1:1000 dilution; catalog number sc-374416; Santa Cruz Biotechnology),

(3) Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistanceNature AgingJanuary 29, 2026Masahiro Wakita, Koyu Ito, Kaho Fujii, Dai Sakamoto, Takumi Mikawa, Sho Sugawara, Xiangyu Zhou, Jeong Hoon Park, Hideka Miyagawa, Daisuke Motooka, et al.dilution; A5316, Sigma-Aldrich), lamin B1 (1:1,000 dilution; ab16048, Abcam), p16 (1:1,000 dilution; sc-56330, Santa Cruz), p21 (1:1,000 dilution; 2947, Cell Signaling Technology), XRCC4 (1:1,000 dilution; sc-271087,

(4) SAMP-Score: a morphology-based machine learning classification method for screening pro-senescence compounds in p16 positive cancer cellsAging (Albany NY)November 30, 2025Ryan Wallis, Bethany K. Hughes, Madeleine Moore, Emily A. O’Sullivan, Luke C. McIlvenna, Luke Gammon, Anthony Hope, Fiona Bellany, Parul Dixit, Claire Mackenzie, et al.Immunoblotting/immunofluorescence was performed as previously described using antibodies against p16 (Santa Cruz, sc-56330; 1:100 or Protein Tech 10883-1-AP; 1:1,000), p21 (Cell Signalling, 12D1; 1:2,000), p53 (Cell Signalling,

(5) High expression of CDKN2A in oral squamous cell carcinoma is associated with distant metastasis: Cell‑free DNA as a new prognostic featureMolecular and Clinical OncologyOctober 17, 2025Natsuki Eboshida, Atsuko Hamada, Asami Tanigawa, Mirai Higaki, Fumitaka Obayashi, Nanako Ito, Sachiko Yamasaki, Ryouji Tani, Tomoaki Shintani, Koichi Koizumi, et al.incubated overnight at 4˚C with a 1:100 dilution of mouse monoclonal anti-CDKN2SA/p16INK4A antibody (sc-56330, Santa Cruz Biotechnology, TX, USA) or a 1:100 dilution of mouse monoclonal anti-p53 antibody (DO-1,

(6) The antitumor effect of tlr4 inhibition in head and neck cancer cell linesSci RepAugust 28, 2025Natália Meneses Araújo, Giovanna Barbosa Chanes, Kayo Alexandre Souza da Cruz, Ileana Gabriela Sanchez de Rubio, Luisa Lina Villa, Rodrigo Esaki Tamura, Mirian Galliote Moralewere used: anti-TLR4 (1:100) (ab13556) (RRID: AB_300457) (Abcam, Cambridge, UK), anti-p16 (1:1000) (sc-56330) (RRID: AB_785018) (Santa Cruz Biotechnology, Texas, USA), and anti-alpha/beta-tubulin (1:5000) (2148

(7) Argan Callus Extract Restores Skin Cells via AMPK-Dependent Regulation of Energy Metabolism, Autophagy, and Inflammatory PathwaysAntioxidants (Basel)June 28, 2025Ramona Hartinger, Felix Quirin Fenzl, Vanessa Martina Nalewaja, Karima Djabaliproteins, including p62 (SQSTM1, 66184-1-Ig, Proteintech, Manchester, UK, 1:1000), p16 (INK4A, JC8, sc-56330, Santa Cruz, Dallas, TX, USA, 1:1000), p21 (Wafa1/Cip1, DCS60, Cell Signaling, Leiden, The Netherlands,

(8) ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylationNature communicationsFebruary 28, 2025Yang L, You J, Yang X, Jiao R, Xu J, Zhang Y, Mi W, Zhu L, Ye Y, Ren R, et al.(Abcam, cat. no. ab125068; 1:10,000 for western blots), anti-p16 (Santa Cruz Biotechnology, cat. no. sc-56330; 1:1000 for western blots), anti-RAS (Becton Dickinson, cat. no. 610001; 1:1000 for western blots),

(9) Senescence of endothelial cells increases susceptibility to Kaposi's sarcoma-associated herpesvirus infection via CD109-mediated viral entryJournal of Clinical InvestigationDecember 12, 2024Myung-Ju Lee, Jun-Hee Yeon, Jisu Lee, Yun Hee Kang, Beom Seok Park, Joo Hee Park, Sung-Ho Yun, Dagmar Wirth, Seung-Min Yoo, Changhoon Park, et al.as described previously (63). The primary antibodies were mouse-derived anti-p16 (1:1,000 dilution; sc-56330, JC8; Santa Cruz), anti-p21 (1:1,000 dilution; sc-6246, F-5; Santa Cruz), anti-HHV-8 K8.1A/B (1:1,000

(10) p63 affects distinct metabolic pathways during keratinocyte senescence, evaluated by metabolomic profile and gene expression analysisCell Death & DiseaseNovember 14, 2024Maria Cristina Piro, Rosalba Pecorari, Artem Smirnov, Angela Cappello, Erica Foffi, Anna Maria Lena, Yufang Shi, Gerry Melino, Eleonora Candiprimary antibodies were used: anti-p63 (Cell Signaling, D9L7L); anti-p16 (Santa Cruz Biotechnology (JC8): sc-56330), anti-p53 (Santa Cruz Biotechnology (DO-1): sc-126), anti-β-actin (Sigma, AC-15: A5441) and anti-GAPDH

(11) Enhancing Cellular Homeostasis: Targeted Botanical Compounds Boost Cellular Health Functions in Normal and Premature Aging FibroblastsBiomoleculesOctober 16, 2024Ramona Hartinger, Khushboo Singh, Jesse Leverett, Karima DjabaliSignaling, 1:1000), p62 (SQSTM1, 66184-1-Ig, Proteintech, Manchester, UK, 1:1000), p16 (INK4A, JC8, sc-56330, Santa Cruz, 1:1000), p21 (Wafa1/Cip 1, DCS60, Cell Signaling, 1:1000), LC3B (LC3A/B, D3U4C, 12741,

(12) Sodium valproate affects the expression of p16(INK4a) and p21(WAFI/Cip1) cyclin‑dependent kinase inhibitors in HeLa cellsOncology lettersSeptember 1, 2024Rocha MA, Cardoso AL, Martins C, Mello MLS.at 25°C. The cells were then incubated overnight with mouse anti-p16INK4a (1:100 dilution; cat. no. sc-56330), mouse anti-p21WAFI/Cip1 (1:100 dilution; cat. no. sc-6246) (both from Santa Cruz Biotechnology, Inc.)

(13) Voluntary Wheel Running Reduces Cardiometabolic Risks in Female Offspring Exposed to Lifelong High-Fat, High-Sucrose DietMedicine & Science in Sports & ExerciseAugust 1, 2024KASSANDRA GONZALEZ, ANDREA CHIÑAS MERLIN, ERIN ROYE, BEOMSOO JU, YOUNGIL LEE, ADAM J. CHICCO, EUNHEE CHUNGovernight at 4 °C with designated primary antibodies: p53 (sc-393031), p21CIP1 (sc-817) and p16INK4a (sc-56330), nitrotyrosine (sc-32757), MAO-A (sc-271123), CD36 (sc-7309), DGAT1 (sc-271934), p-IRb (sc-81500),

(14) Overcoming Clinical Resistance to EZH2 Inhibition Using Rational Epigenetic Combination TherapyCancer DiscoveryJune 3, 2024Yaniv Kazansky, Daniel Cameron, Helen S. Mueller, Phillip Demarest, Nadia Zaffaroni, Noemi Arrighetti, Valentina Zuco, Yasumichi Kuwahara, Romel Somwar, Marc Ladanyi, et al.anti p21 (0.8ug/ml, Cell Signaling Technology, 2947), and mouse anti-p16 antibody (0.2ug/ml,Santa Cruz,sc56330) were incubated for 4h at room temperature. Samples were then incubated with either OmniMap anti-rabbit

(15) Integrated aerobic exercise with LDE-docetaxel treatment: a novel approach to combat prostate cancer progressionScientific ReportsApril 26, 2024Allice Santos Cruz Veras, Victor Rogério Garcia Batista, Rafael Ribeiro Correia, Maria Eduarda de Almeida Tavares, Rafael Jesus Gonçalves Rubira, Elaine Rufo Tavares, Inês Cristina Giometti, Raul Cavalcante Maranhão, Giovana Rampazzo TeixeiraSanta Cruz Biotechnology® primary antibodies of BAX 1:1000 (B-9, sc-7480), BCL-2 1:1000 (C-2, sc-7382), P-16 1:1000 (JC8, sc-56330), P-21 1:1000 (187, sc-817), P-27 1:1000 (F8, sc-1641), P-53 1:1000 (DO-1, sc-126). Then, the samples

(16) Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson's disease through Mfn2-cGAS signalingJournal of neuroinflammationApril 2, 2024Wang M, Tian T, Zhou H, Jiang SY, Jiao YY, Zhu Z, Xia J, Ma JH, Du RH.dilution, Abcam), anti-lamin B1 (Abcam, ab16048, 1:400 dilution), anti-p16 (Santa Cruz Biotechnology, sc-56330, 1:200 dilution) or anti-cGAS (31659S, 1:400 dilution, Cell Signaling Technology, USA) overnight at

(17) An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosisThe Journal of clinical investigationMarch 7, 2024Lee JY, Reyes NS, Ravishankar S, Zhou M, Krasilnikov M, Ringler C, Pohan G, Wilson C, Ang KK, Wolters PJ, et al.used for human lung slide staining were ACTA2 (1:200, Abcam, ab5694), p16INK4a (1:200, Santa Cruz, sc-56330), and CTHRC1 (1:200, Abcam, ab85739). Collagen staining was performed using Trichrome stain kit according

(18) Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expressionPharm BiolDecember 1, 2023Ji-Hong Y, Yu M, Ling-Hong Y, Jing-Jing G, Ling-Li X, Lv W, Yong-Mei J.Sirt3 (1:1000; cat. no. sc-365175; Santa Cruz Biotechnology, Inc., Dallas, TX), p16 (1:1000, cat. no. sc-56330; Santa Cruz Biotechnology, Inc., Dallas, TX), Smad4 (1:1000; cat. no. sc-7966; Santa Cruz Biotechnology, Inc

(19) DYRK1B inhibition exerts senolytic effects on endothelial cells and rescues endothelial dysfunctionsMechanisms of ageing and developmentJuly 1, 2023Pramotton FM, Abukar A, Hudson C, Dunbar J, Potterton A, Tonnicchia S, Taddei A, Mazza E, Giampietro C.

(20) Induction of Senescence by Loss of Gata4 in Cardiac FibroblastsCellsJune 17, 2023Zhang Z, Shayani G, Xu Y, Kim A, Hong Y, Feng H, Zhu H.(Thermofisher, Waltham, MA, USA, cat# PA1-102, 1:200 dilution), anti-p16 (Santa Cruz, Dallas, TX, USA, cat# sc56330, 1:200 dilution), or indicated combinations of the primary antibodies for 1 h at room temperature. After

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p16 INK4A (JC8) Antibody

p16 INK4A (JC8) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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p16 INK4A (JC8) Antibody from Santa Cruz Biotechnology, Inc.

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