Fig 1: The FOXM1-MYB-MuvB complex (MMB) was found to be necessary for Wee1-like protein kinase (WEE1) inhibitor sensitivity. (A,B) The mRNA and protein expression levels of FOXM1 were measured after overexpressing FOXM1 through reverse transcription quantitative polymerase chain reaction (RT-qPCR) and western blotting. (C,D) The mRNA and protein expression levels of FOXM1 were measured after inhibiting FOXM1 through RT-qPCR and western blotting. (E,F) Cell survival was measured after AZD-1775 (WEE1 inhibitor) treatment and FOXM1 overexpression (or inhibition) through Cell Counting Kit-8 (CCK-8) assay. (G) The mRNA expression of LIN54 was detected after silencing LIN54, as determined through RT-qPCR. (H) The protein expression of LIN54 was detected after silencing LIN54 was examined through western blot. (I)The protein expressions of FOXM1 and LIN54 were measured through western blot. (J) Cell survival was evaluated after overexpressing FOXM1 and silencing MMB through a CCK-8 assay. **, P<0.01; ***, P<0.001; ##, P<0.01 vs. pcDNA3.1-FOXM1+si-NC.