Coagulation Factor III/Tissue Factor Antibody NBP2-15139 from Novus Biologicals, a Bio-Techne Brand

Product Specs
ItemCoagulation Factor III/Tissue Factor Antibody
CompanyNovus Biologicals, a Bio-Techne Brand
Price $469.00Supplier Page View Company Product Page
Catalog NumberNBP2-15139
Quantity0.1 ml
ApplicationsImmunohistochemistry,Western Blot,Immunohistochemistry-Paraffin
Conjugate/TagUnconjugated
FormatPBS, 1% BSA, 20% Glycerol
ReactivityHuman,Mouse
TargetCoagulation Factor III/Tissue Factor
HostRabbit
ImmunogenRecombinant protein encompassing a sequence within the center region of human Coagulation factor III/Tissue Factor. The exact sequence is proprietary
NCBI Full Gene Namecoagulation factor III, tissue factor
NCBI Gene AliasesTF, TFA, CD142
ClonalityPolyclonal
PurityAntigen Affinity-purified
IsotypeIgG
Molecular Weight33 kDa
Research AreaCancer
Antibody TypePrimary Antibodies
StorageAliquot and store at -20C or -80C. Avoid freeze-thaw cycles

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Sizes Available: 0.1 ml

Questions and Answers

Can this antibody be used to study tissue factor expression in macrophages?

Yes, the Coagulation Factor III/Tissue Factor Antibody has been utilized in research to investigate tissue factor expression in macrophages, particularly in the context of inflammation and coagulation. For instance, it was used in a study that demonstrated the role of type I interferon signaling in the release of tissue factor from macrophages, linking innate immunity to coagulation processes ().

What applications has this antibody been shown to work in?

The Coagulation Factor III/Tissue Factor Antibody has been shown to work in Western blotting and immunohistochemistry applications. It has been specifically cited in a study where it was used for immunohistochemical analysis of lung tissue sections to assess tissue factor expression ().

Is this antibody reactive with human and mouse tissues?

Yes, this antibody is reactive with both human and mouse tissues, making it suitable for comparative studies in these species. Its reactivity has been confirmed in various applications, including those involving macrophages from both species ().

What is the significance of using this antibody in cancer research?

The Coagulation Factor III/Tissue Factor Antibody is relevant in cancer research due to the role of tissue factor in coagulation and inflammation, which are critical in cancer progression and metastasis. Studies have indicated that tissue factor can influence thrombin generation and inflammatory responses, which are important factors in cancer biology ().

Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I InterferonNature communicationsJune 14, 2023Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, Brien ECO, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, et al.Willebrand factor (VWF; cat. no.: A 0082; Dako), or a rabbit anti-Tissue Factor antibody (Novus Bio; NBP2-15139). Afterwards, the lung tissue sections were extensively washed with TBS and incubated with a secondary

(2) Evaluation of different commercial antibodies for their ability to detect human and mouse tissue factor by western blottingResearch and practice in thrombosis and haemostasisAugust 1, 2020Rosell A, Moser B, Hisada Y, Chinthapatla R, Lian G, Yang Y, Flick MJ, Mackman N.Inh",Y‐Human Human,Rabbit,Polyclonal,Coagulation Factor III/Tissue Factor Antibody,Novus Biologicals,NBP2‐15139,42928,0.64 mg/mL,"IHC, WB",Y‐Human Human,Rabbit,Polyclonal,Tissue Factor/CD142 Antibody,Cell Signaling,47769,1,0.055

(3) A unique protein kinase C-dependent pathway for tissue factor downregulation in pericytesJournal of thrombosis and haemostasis : JTHApril 1, 2019Sommerville LJ, Gorman KL, Snyder SA, Monroe DM, Hoffman M.from InvivoGen. Go 6983 (#2285) and GF 109203X (#0741) were from Tocris. Rabbit anti-TF antibody (#NBP2–15139) was from Novus Biologicals. Mouse anti-TF antibody (#H00002152-B01P) was from Abnova. Mouse anti-actin

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