ADAM17 Antibody PA5-27395 from Thermo Fisher Scientific

Product Specs
ItemADAM17 Antibody
CompanyThermo Fisher Scientific
Price Supplier Page
Catalog NumberPA5-27395
Quantity100 µL
ApplicationsImmunohistochemistry (Paraffin), Western Blot
Conjugate/TagUnconjugated
FormatPBS with 20% glycerol and 0.025% Proclin 300; pH 7
ReactivityHuman, Mouse, Rat
ClonalityPolyclonal
TargetADAM17
IsotypeIgG
HostRabbit
NCBI Full Gene NameADAM metallopeptidase domain 17, a disintegrin and metallopeptidase domain 17
NCBI Gene AliasesNISBD, CSVP, Tace, NISBD1, ADAM18, TACE, CD156b, CD156B
Concentration1.21 mg/mL
ImmunogenRecombinant protein encompassing a sequence within the Intracellular domain of human ADAM17. The exact sequence is proprietary
Storage Temperature-20° C, Avoid Freeze/Thaw Cycles
PurityAntigen affinity chromatography
Antibody TypePrimary
StorageStore at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles

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Waltham, MA 02451

United States

Phone: 800-678-5599
Fax: 800-331-2286

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Website: www.thermofisher.com

(1) Alzheimer's disease-related mutations in APP influence colorectal tumor formation in a sex-dependent manneriScienceJuly 17, 2026Takako Ishida-Takaku, Mona Sohrabi, Heidi L. Pecoraro, Colin K. Combswere incubated with primary antibody: APP (1:500, ab32136, Abcam, Cambridge, MA, USA), TACE (1:1000, PA5-27395, Invitrogen, ThermoFisher Scientific, Waltham, MA, USA), PS1 (1:500, PA5-119872, Invitrogen, ThermoFisher

(2) Fat mass and obesity-mediated N 6 -methyladenosine modification modulates neuroinflammatory responses after traumatic brain injuryNeural regeneration researchFebruary 1, 2026Chen X, Lai J, Wu Z, Chen J, Yang B, Chen C, Ding C.(1:500, Abcam, Cat# ab94482, RRID: AB_10860661), rabbit polyclonal anti-ADAM17 (1:1000, Invitrogen, Cat# PA5-27395, RRID: AB_2544871) for 12 hours at 4°C, followed by incubation with goat anti-rabbit IgG H&L (1:2000,

(3) Alzheimer’s Disease-Related Mutations in APP Influence Colorectal Tumor Formation in a Sex-Dependent MannerbioRxivJanuary 16, 2026Takako Ishida-Takaku, Mona Sohrabi, Heidi L. Pecoraro, Colin K. Combswere incubated with primary antibody: APP (1:500, ab32136, Abcam, Cambridge, MA, USA), TACE (1:1000, PA5–27395, Invitrogen, ThermoFisher Scientific, Waltham, MA, USA), PS1 (1:500, PA5–119872, Invitrogen, ThermoFisher

(4) RAB25 modulates pit cell commitment by coordinating transforming growth factor-alpha secretion from gastric epithelial cellsCell death & diseaseDecember 9, 2025Jeong H, Lee Y, Uhm C, Hwang SY, Hur S, Noh M, Coffey RJ, Goldenring JR, Nam KT.(R&D Systems, Minneapolis, MN, USA, #AF2519), anti-HMGB2 (Abcam, #ab124670), anti-ADAM17 (Invitrogen, #PA5-27395). Bioinformatics of human samples For scRNA-seq analysis for inflamed normal samples obtained from

(5) Prolyl hydroxylase inhibitor desidustat improves stroke outcomes via enhancing efferocytosis in mice with chronic kidney diseaseExperimental NeurologyApril 1, 2025Harpreet Kaur, Nilesh Pandey, Lakshmi Chandaluri, Nirvana Shaaban, Alexa Martinez, Evan Kidder, Vishal J. Pate.l, Samadhan G. Kshirsagar, Dhananjay Kumar, Louise Frausto, et al.stained with anti-p-NFkB p65 (ab16502, 2μg/ml), MerTK (Thermo#14-5751-82, 5μg/ml), ADAM17 (Thermo# PA5–27395, 1:200) antibodies at 4°C overnight. Next day, sections were washed with 1X PBST thrice and incubated

(6) Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophagesNature communicationsFebruary 1, 2024Sun R, Lei C, Xu Z, Gu X, Huang L, Chen L, Tan Y, Peng M, Yaddanapudi K, Siskind L, et al.

(7) The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytesNature communicationsFebruary 25, 2022Xu M, Tan J, Dong W, Zou B, Teng X, Zhu L, Ge C, Dai X, Kuang Q, Zhong S, et al.anti-p-IKKβ (#PA5-36653, dilution 1:1000), anti-Trim31 (#PA5-40961, dilution 1:1000), anti-ADAM17 (#PA5-27395, dilution 1:1000) and anti-p-IRS-1(Ser307) (#PA1-1054, dilution 1:1000) were obtained from Thermo Fisher Scientific

(8) Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19International journal of molecular sciencesSeptember 9, 2021Rezq S, Huffman AM, Basnet J, Yanes Cardozo LL, Romero DG.(1:500; ThermoFisher Scientific MA5–23891, Waltham, MA, USA), ADAM17 (1:500; ThermoFisher Scientific PA5-27395, Waltham, MA, USA) or GAPDH (1:3,000,000; Cell Signaling Technology 5174, Danvers, MA, USA). The membranes

(9) Iron-Overload triggers ADAM-17 mediated inflammation in Severe Alcoholic HepatitisScientific reportsJuly 6, 2018Maras JS, Das S, Sharma S, Sukriti S, Kumar J, Vyas AK, Kumar D, Bhat A, Yadav G, Choudhary MC, et al.

(10) Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH developmentImmunityJanuary 1, 0001"Wang X, He Q, Zhou C, Xu Y, Liu D, Fujiwara N, Kubota N, Click A, Henderson P, Vancil J, et al."

(11) Elevated PDGF-BB from Bone Impairs Hippocampal Vasculature by Inducing PDGFRβ Shedding from Pericytes"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"January 1, 0001"Liu G, Wang J, Wei Z, Fang CL, Shen K, Qian C, Qi C, Li T, Gao P, Wong PC, et al."Abcam), MMP1 (1:1000, PA5‐27210, Invitrogen), ADAM10 (1:5000, ab124695, Abcam), and ADAM17 (1:500, PA5‐27395, Invitrogen). Immunocytochemistry Primary human brain pericytes were treated with rh‐PDGFBB for 1

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ADAM17 Antibody

ADAM17 Antibody from Thermo Fisher Scientific

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ADAM17 Antibody from Thermo Fisher Scientific

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