Cox2 (D5H5) XP ® Rabbit mAb 12282S from Cell Signaling Technology

Product Specs
ItemCox2 (D5H5) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $386.00 Inquire
Catalog Number12282S
Quantity100 µl
ApplicationsW, W-S, IHC-P, IF-IC, FC-FP
ReactivityH, M, R
ClonalityMonoclonal
Targetcyclooxygenase-2/Cox-2
HostRabbit
NCBI Full Gene Nameprostaglandin-endoperoxide synthase 2
NCBI Gene AliasesCOX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
Research AreaImmunology and Inflammation
IsotypeIgG
CloneD5H5
Molecular Weight74

Questions and Answers

What applications has the Cox2 (D5H5) XP Rabbit mAb been used for in scientific research?

The Cox2 (D5H5) XP Rabbit mAb has been shown to work in various applications, including immunohistochemistry, where it has been utilized to study the expression of cyclooxygenase-2 in different tissue types. Its relevance is highlighted in studies examining inflammatory processes and tumor biology.

Are there any specific studies that demonstrate the effectiveness of this antibody in cancer research?

Yes, one study demonstrated that quercetin sensitizes glioblastoma to treatment by dual inhibition of Hsp27 and COX-2, indicating the role of COX-2 in tumor resistance mechanisms. This suggests that the Cox2 (D5H5) XP Rabbit mAb could be valuable in exploring COX-2's involvement in cancer progression and treatment responses ().

Can this antibody be used to investigate inflammatory pathways in disease models?

The Cox2 (D5H5) XP Rabbit mAb is suitable for investigating inflammatory pathways, as evidenced by its application in studies that link COX-2 expression to inflammatory responses in various conditions, including cancer and other inflammatory diseases. For instance, it has been implicated in the regulation of inflammatory mediators in models of esophageal squamous cell carcinoma ().

What is the significance of COX-2 in the context of inflammatory diseases?

COX-2 is a key enzyme involved in the inflammatory response, and its expression is often upregulated in various inflammatory diseases. The Cox2 (D5H5) XP Rabbit mAb can be instrumental in studying the role of COX-2 in these conditions, as it has been shown to be involved in the regulation of inflammatory cytokines and mediators, making it a critical target for therapeutic interventions.

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Website: Technical Support

(1) Interleukin-1β-induced arthritis involves chondrocyte oxiapoptophagyThe Korean Journal of Physiology & PharmacologyMay 1, 2026Jeong-Yeon Seo, Do Kyung Kim, HyangI Lim, Kyeong-Rok Kang, Hong Sung Chun, Ji-Su Oh, Jae-Sung KimCell Signaling Technology), beclin-1 (SC-48341, Santa Cruz Biotechnology), cyclooxygenase-2 (COX-2, #12282, Cell Signaling Technology), CH25H (SC-293256, Santa Cruz Biotechnology), or CYP7B1 (BS-5052, Bioss)

(2) A pharmacological rat model of recurrent pelvic pain exhibiting hyperalgesia and depression-like behaviorsiScienceApril 17, 2026Xiaotian Yang, Yajie Qin, Qi Zhao, Huiijin Zhao, Yinyin Ding, Bei Liu, Huifang ZhouRESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, Anti-COX2 antibody,Cell Signaling Technology,Cat# 12282; RRID: AB_2164118 Anti-BDNF antibody,Abcam,Cat# ab108319; RRID: AB_10862052 Beta Actin Monoclonal

(3) CuET promotes cuproptosis and ferroptosis of lung cancer cells by interacting directly with polyunsaturated phospholipidsiScienceApril 17, 2026Zhang Zhang, Chengying Chengying, Guangzhe Guangzhe, Bingxue Bingxue, Yiju Yiju, Yanqin Yanqin, Shuping Shuping,Cell Signaling Technology,Cat# 4393; RRID: AB_11217441 COX2 (D5H5) Rabbit Monoclonal Antibody,Cell Signaling Technology,Cat# 12282; RRID: AB_2571729 xCT/SLC7A11 (D2M7A) Rabbit Monoclonal Antibody,Cell Signaling Technology,Cat# 12691;

(4) Ergosteroid and Phenolic Constituents from the Mushroom Sanghuangporus vaninii with Anti-Inflammatory ActivityInt J Mol SciApril 7, 2026Yu-Xin Gao, Yue-Tong Zhu, Almutamad Sheikho, Qiu-Yu Zhao, Ya-Ru Wang, Yong-Hua Wang, Yu-Qi Gao, Jin-Ming Gaoagainst β-actin (60008-1-Ig) was purchased from Proteintech (Wuhan, China), whereas COX2 (cat. no. 12282) and iNOS (cat. no. 13120) antibodies were obtained from Cell Signaling Technology (Beverly, MA, USA)

(5) LncRNA TLR8-AS1 Restricts HIV-1 Infection and Inflammation in Macrophages by Suppressing Arachidonic Acid Metabolism Through NFAT1Journal of Inflammation ResearchMarch 30, 2026Fengyi Wang, Shengrui Luo, Junhan Zhang, Yukai Zhang, Hailun Wei, Jie Liu, Chuye Mo, Junjun Jiang, Li Ye, Zongxiang Yuanmembranes incubated overnight at 4°C with primary antibodies: anti-NFAT1 (Cat#5861), anti-COX-2 (Cat#12282), anti-ALOX5 (Cat#3289), anti-NF-κB (Cat#8242), anti-TLR8 (Cat#11886), anti-MyD88 (Cat#4283) and anti-β-actin

(6) Buckwheat Flavonoids Modulate Inflammation in RAW 264.7 Macrophages at Physiologically Relevant Concentrations via the LPS/COX-2 PathwayJ Agric Food ChemMarch 25, 2026Diego José López-Cánovas, Antonio Vico-Padilla, Danuta Zielińska, Sabrina Poveda-Lora, Silvia Navarro-Orcajada, David López-Martínez, Diana García-Moreno, María Ángeles Ávila-Gálvez, Beatriz Garay-Mayol, José E. Yuste, et al.nitrocellulose membranes (GE Healthcare, Buckinghamshire, UK), and incubated with primary COX-2 (74 kDa; D5H5, #12282) or β-actin (45 kDa; #4967) from Cell Signaling (MA, USA) at a dilution of 1:1000 and with secondary

(7) Serum metabolic fingerprinting for diagnosis and therapeutic applications of ovarian endometriosisiScienceMarch 20, 2026Chencheng Dai, Yiwei Cao, Yiran Xu, Moyuan Li, Guangquan Liu, Sujuan Xu, Nuo Ye, Changxiang Shi, Tiantian Fan, Pengfei Xu, et al.RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, Anti-Ki67,Novus Biologicals,"Cat# NB500-170, RRID: AB_10001977" Anti-COX2,Cell Signaling Technology,"Cat# 12282, RRID: AB_2571729" Anti-F4/80,Proteintech,"Cat# 28463-1-AP, RRID: AB_2881149" Anti-VEGFA,Proteintech,"Cat#

(8) Comparative Effects of Dexamethasone and ASC Secretome in an Ex Vivo Osteoarthritis Co-Culture ModelBiology (Basel)March 20, 2026Elena Della Morte, Francesca Cadelano, Andrea Pasquini, Luigi Zagra, Alessandro Baj, Chiara Giannasi, Stefania NiadaWestern blotting was performed following standard protocols. Primary antibodies—rabbit anti-COX2 (#12282, Cell Signaling, Danvers, MA, USA; 1:1000 dilution), rabbit anti-IDO (#86630, Cell Signaling, Danvers,

(9) Bazedoxifene rescues hepatocytes from chemically induced oxidative ferroptotic injury in vivo and in vitro by inhibiting protein disulfide isomeraseiScienceMarch 20, 2026Xiangyu Hao, Tian-Hao Xiao, Yi-Chen Jia, Bao Ting Zhuanti-GPX4 antibody (#HY-P80450, 1:500; MedChemExpress, Monmouth Junction, NJ, USA) or anti-COX-2 antibody (#12282S, 1:1000; Cell Signaling Technology, Boston, MA, USA). After washing, sections were treated for 1 h with

(10) Xiebai San Alleviates Allergic Pulmonary Inflammation by Modulating Arachidonic Acid MetabolismPharmaceuticals (Basel)March 9, 2026Xingnan Yue, Jiayin Han, Chen Pan, Yushi Zhang, Suyan Liu, Feng Gao, Yong Zhao, Jingwen Wu, Yuhao Wang, Xi Cheng, et al.(Fair Lawn, NJ, USA). Antibodies against p38MAPK (8690), Phospho-p38MAPK (Thr180/Tyr182) (4511), COX-2 (12282), and rabbit polyclonal antibody against glyceraldehyde-3-phosphate dehydrogenase (GAPDH), were obtained

(11) HIV gp120 induces TREM1 expression through TLR–PGE₂ signalling in human monocyte-derived microgliaJournal of NeuroinflammationMarch 5, 2026Ayisha Mahama, Pratima Rawat, Carmen Teodorof-Diedrich, Stephen A. Spector, Grant R. Campbellanti-NFATC1 (Cat# 8032, RRID: AB_10829466); anti-PTGS1 (Cat# 9896, RRID: AB_10860249); anti-PTGS2 (Cat# 12282, RRID: AB_2571729); anti-RELA (Cat# 8242, RRID: AB_10859369); anti-TLR2 (Cat# 12276, RRID: AB_2797867);

(12) Resolvin D1 alleviates liver inflammation and fibrosis through SIRT1-mediated NF-κB and TGF-β1/Smads pathwaysJournal of InflammationMarch 3, 2026Jiahuan Li, Lingfeng Zhao, Yuwen Xi, Xiaoling Denganti-phospho-inhibitor of kappa B alpha (p-IκBα, cat. no. 9246, 1:1000), anti-cyclooxygenase-2 (COX-2, cat. no. 12282, 1:1000), anti-SIRT1 (cat. no.8469, 1:1000), anti-Smad2/3 (cat. no.8685, 1:1000) and p-Smad2/3 (cat.

(13) Mitochondrial metabolism restoration via Tramiprosate suppresses mitochondrial ROS-driven foamy macrophage senescence post spinal cord injuryJ Orthop TranslatMarch 2, 2026Chaoqin Wu, Qihao Fu, Jianlan Liu, Jiajyu Fu, Buzheng Zhang, Jin Zhou, Jiawen Xu, Ying Zhang, Tianyu Zhu, Lei Yang, et al.#Cat.No.,Source,Species,Application,Dilution rate anti-iNOS antibody ab15323,Abcam,Rabbit,WB,1:250 anti-COX-2 antibody #12282,Cell Signaling Technology,Rabbit,WB,1:1000 anti-γH2AX antibody sc-517348,Santa Cruz Biotechnology,Mouse,WB,1:200 anti-p53

(14) Mechanism by which hydrogen-rich water mitigates exercise-induced fatigue: activation of the immunoresponsive gene 1-itaconate/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathwayMedical Gas ResearchMarch 1, 2026Yinyin Zhang, Yajing Ying, Xianpeng Zu, Lingling Ding, Xuan Shi, Jing Wang, Xiangtong Li, Chujian Li, Qicheng Zhou, Hui Shen, et al.AB_2841191), and anti-cyclooxygenase-2 (COX2; antibody (rabbit, 1:200, Cell Signaling Technology, Cat# 12282T, RRID: AB_2571729). Biotin-labeled goat anti-rabbit IgG (H+L) (1:100, Beyotime Biotechnology, Shanghai,

(15) The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson’s diseaseNeural Regeneration ResearchMarch 1, 2026Mengyun Yue, Tingtao Chen, Wenjie Chen, Jing Wei, Bin Liao, Jie Zhang, Fangjun Li, Daojun Hong, Xin Fang,Western blotting iNOS,Rabbit,1:2000,Proteintech,18985-1-AP,AB_2934933,Western blotting COX2,Rabbit,1:1000,CST,12282S,AB_2084968,Western blotting GLP-1R,Rabbit,1:1000,Proteintech,26196-1-AP,AB_2880421,Western blotting Akt,Rabbit,1:5000,Proteintech,10176-2-AP,AB_3083865,Western blotting

(16) Anti-Inflammatory Lindolin Alkaloids Repress the Transcription of the Microsomal Prostaglandin E 2 Synthase-1 Gene in MacrophagesJournal of Natural ProductsFebruary 27, 2026Paul M. Jordan, Johannes Rassbach, Melina Gräfe, Lukas K. Peltner, Karsten Willing, Lukas Zenkel, Kerstin Günther, Robin Sonnabend, Lars Regestein, Oliver Werz, et al.were incubated with the following primary antibodies: rabbit monoclonal anti-COX-2, 1:1,000 (D5H5, #12282, Cell Signaling); rabbit polyclonal anti-mPGES-1, 1:1,000 (STJ95054, St John’s Laboratory Ltd., London,

(17) Akkermansia muciniphila reduces neuroinflammation and Aβ deposition via tryptophan metabolism in the APP/PS1 mouse model of Alzheimer’s diseaseAlzheimer's Research & TherapyFebruary 19, 2026Binghua Wang, Miaomiao Pan, Liu Yang, Jietian Xu, Chang Ye, Yunhan Li, Qianyi Gong, Changqian Liu, Lanfang Li, Jie Qin, et al.primary antibodies included: mouse anti-AhR (Proteintech, 308215, 1:500), rabbit anti-Cox-2 (CST, #12282, 1:1,000), rabbit anti-NLRP3 (Abcam, 263899, 1:1,000), rabbit anti-ASC (CST, #67824, 1:1,000), rabbit

(18) Deciphering Multitarget Mechanisms of Cardiac Glycosides in Acute Myeloid Leukemia Using a Network Pharmacology and Molecular DockingDrug Design, Development and TherapyFebruary 7, 2026Parinya Samart, Jirarat Poohadsuan, Supasorn Chanthateyanonth, Surapol Issaragrisil, Sudjit Luanpitpongphospho-mTOR (Ser2448) (#5536), mTOR (#2983), Raptor (#2280), Rictor (#2114), G-β-L (#3274), COX-2 (#12282), and c-Myc (#5605) (Cell Signaling Technology). After washing, membranes were incubated with HRP-conjugated

(19) Colchicine Alleviates Non-Atherosclerotic Vascular Aging by Targeting Endothelial Dysfunction and Inflammatory StatusJournal of Inflammation ResearchFebruary 7, 2026Soroush Mohammadi Jouabadi, Annika A Jüttner, Keivan Golshiri, Ehsan Ataei Ataabadi, Martine de Boer, Rene De Vries, Richard Van Veghel, Yoëlle Goos, Youri Boon, Usha Musterd-Bhaggoe, et al.with the Actin (1:100, Merck, A3853), iNOS (1:250, Santa Cruz, sc-650), COX-2 (1:250, Cell signaling, 12282S), NFkB-p65 (1:100, Cell signaling, 8242S), AKT-Phospho (ser473) (1:100, Cell signalling, 9060S), Phospho-p38

(20) STING controls glycolysis and histone lactylation to drive macrophage metabolic reprogramming in postoperative ileusCommunications BiologyFebruary 4, 2026Kai Chen, Guofang Li, Ye Cheng, Xudong Zhu, Xingzhou Wang, Qiongyuan Hu, Wenxian Guan, Song Liu1:1000), iNOS (ab178945, 1:1000), IL1β (ab234437, 1:1000), and HIF1α(ab179483, 1:1000) from Abcam; COX2(12282, 1:1000), STING(13647, 1:1000), pSTING(72971T, 1:1000), TBK1(3504, 1:1000), pTBK1(5483T, 1:1000), IRF3(4302S,

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3/31/2020Expression of COX2 in Microglia Cells Lisha JoshiGreat antibody for the detection of COX2.

Cox2 (D5H5) XP ® Rabbit mAb

Cox2 (D5H5) XP ® Rabbit mAb from Cell Signaling Technology

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Cox2 (D5H5) XP ® Rabbit mAb from Cell Signaling Technology

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