Rad18 (D2B8) XP ® Rabbit mAb 9040S from Cell Signaling Technology

Product Specs
ItemRad18 (D2B8) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $371.00 Inquire
Catalog Number9040S
Quantity100 µl
ApplicationsW, IP, IF-IC
ReactivityH
TargetRad18
IsotypeIgG
HostRabbit
NCBI Full Gene NameRAD18 E3 ubiquitin protein ligase
NCBI Gene AliasesRNF73
CloneD2B8
Molecular Weight80, 90
ClonalityMonoclonal
Research AreaCell Cycle / Checkpoint Control

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) The E3 ligase RAD18-mediated ubiquitination of henipavirus matrix protein promotes its nuclear-cytoplasmic trafficking and viral egressEmerging Microbes & InfectionsDecember 31, 2025Dongning Jin, Linliang Zhang, Cheng Peng, Mingbin He, Weiwei Wang, Zhifei Li, Cong Liu, Jinhong Du, Jin Zhou, Lei Yin, et al.in the lifecycle of HNV. Materials and methods Antibodies Rabbit polyclonal anti-RAD18 (cat. no. 9040), rabbit polyclonal anti-Flag (cat. no. 14793), and mouse monoclonal anti-GST (cat. no. 2624) antibodies

(2) RAD18 methylation by the methyltransferase SETD6 attenuates DNA breaksSci RepAugust 27, 2025Lital Estrella Weil, Michal Feldman, Jennifer Van Duine, Ji Qiu, Joshua LaBaer, Dan LevyG041), anti-Pan-methyl (Abcam, ab23366), anti-SETD6 (Genetex, GTX629891), anti-RAD18 (Cell Signaling, #9040), anti GST (Abcam, ab9085), anti-His (Thermo Fisher scientific, rd230540a) and anti-gH2AX (Merck, 05-636-25UG,

(3) Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stressMolecular CellAugust 21, 2025Maxime Galloy, Andréanne Blondeau, Élodie Vion, Daein Kim, Collin A. Bakker, Vincent Gaggioli, Mélissa Thomas, Élise G. Lavoie, Isabelle Marois, Alberto David Delgado Monterroso, et al.anti-macroH2A1.1 (12455; Cell Signaling Technology), anti-mH2A2 (Ab242357; Abcam), anti-Rad18 (D2B8) XP (9040; Cell Signaling Technology), anti-GST (sc-459; Santa Cruz Biotechnology), anti-MBP (E8032S; New England Biolabs

(4) Tumor-associated macrophages contribute to cisplatin resistance via regulating Pol η-mediated translesion DNA synthesis in ovarian cancerCell Mol Life SciMay 29, 2025Bilash Chatterjee, Mrinmoy Sarkar, Debanjana Ghosh, Sangita Mishra, Subhankar Bose, Md. Maqsood Ahamad Khan, Senthil Kumar Ganesan, Nabanita Chatterjee, Amit Kumar SrivastavaChemiDoc imaging system (Bio-Rad, USA). The following antibodies and kits were used XPC (Abcam-ab309129), RAD18 (CST-9040T), phospho-p44/42 MAPK (CST-4370T), phospho-γH2AX (CST-9718S), polymerase eta (Abcam-ab236450), p53 (CST-2527S),

(5) Translesion-synthesis-mediated bypass of DNA lesions occurs predominantly behind replication forks restarted by PrimPolCell reportsMarch 25, 2025Dhoonmoon A, Ambrose JR, Garg S, Lascarez-Espana C, Rebok A, Spratt TE, Moldovan GL, Nicolae CM.,Cell Signaling Technology,13848; RRID:AB_2798329 PrimPol,Proteintech,29824-1-AP RAD18,Cell Signaling Technology,9040; RRID:AB_2918349 USP1,Abcam,ab264221; REV3,GeneTex,GTX100153; RRID:AB_2037856 UBC13,Santa Cruz Biotechnology,sc-376470;

(6) Combinatorial ubiquitin code degrades deubiquitylation-protected substratesNat CommunMarch 24, 2025Mai Morita, Miyu Takao, Honoka Tokuhisa, Ryotaro Chiba, Shota Tomomatsu, Yoshino Akizuki, Takuya Tomita, Akinori Endo, Yasushi Saeki, Yusuke Sato, et al.s, 1:1,000), anti-DHX32 (Proteintech, 68306-1-lg, 1:1,000), anti-Rad18 (Cell Signaling Technology, 9040 s, 1:1,000), anti–β-Actin (Santa Cruz Biotechnology, sc-47778, 1:1,000), anti-ubiquitin (P4D1, Santa Cruz Biotechnology

(7) USP7 V517F mutation as a mechanism of inhibitor resistanceNat CommunMarch 14, 2025Yu-Ling Miao, Fengying Fan, Yong-Jun Cheng, Li Jia, Shan-Shan Song, Xia-Juan Huan, Xu-Bin Bao, Jian Ding, Xuekui Yu, Jin-Xue Hepurchased from Cell Signaling Technology (Danvers, MA, USA) against the following: p21 (#2947); Rad18 (#9040); DNMT1 (#5032); UHRF1 (#12387); caspase-3 (#9662); cleaved caspase-3 (#9661); caspase-7 (#12827); cleaved

(8) CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single-stranded DNA gapsNucleic acids researchDecember 11, 2024Pale LM, Khatib JB, Nusawardhana A, Straka J, Nicolae CM, Moldovan GL.A303-434A; ZRANB3: Invitrogen PA5-65143; UBC13: Santa Cruz Biotechnology sc-376470; RAD18: Cell Signaling 9040; GAPDH: Santa Cruz Biotechnology sc-47724; Vinculin: Santa Cruz Biotechnology sc-73614. Inhibitors used

(9) Single-stranded DNA Gap Accumulation is a Functional Biomarker for USP1 Inhibitor SensitivityCancer ResOctober 15, 2024Alexandre André B A da Costa, Ozge Somuncu, Ramya Ravindranathan, Sirisha Mukkavalli, David B Martignetti, Huy Nguyen, Yuqing Jiao, Benjamin P Lamarre, Golbahar Sadatrezaei, Lisa Moreau, et al.(Rabbit polyclonal) Bethyl catalog #A301–699A; anti-RAD18 (Mouse monoclonal) Cell Signaling catalog #9040, anti-PCNA (Mouse monoclonal) Santa Cruz catalog #sc-56; anti-ubiquitinated PCNA (Rabbit monoclonal)

(10) Single-Stranded DNA Gap Accumulation Is a Functional Biomarker for USP1 Inhibitor SensitivityCancer ResearchOctober 15, 2024Alexandre A. da Costa, Ozge Somuncu, Ramya Ravindranathan, Sirisha Mukkavalli, David B. Martignetti, Huy Nguyen, Yuqing Jiao, Benjamin P. Lamarre, Golbahar Sadatrezaei, Lisa Moreau, et al.(rabbit polyclonal; Bethyl, catalog #A301-699A) anti-RAD18 (mouse monoclonal; Cell Signaling catalog #9040), anti-PCNA (mouse monoclonal; Santa Cruz, catalog #sc56), antiubiquitinated PCNA (rabbit monoclonal;

(11) A bispecific antibody targeting EGFR and AXL delays resistance to osimertinibCell Reports MedicineSeptember 17, 2024Arturo Simoni-Nieves, Moshit Lindzen, Suvendu Giri, Nitin Gupta, Rishita Chatterjee, Boobash-Raj Selvadurai, Marieke Van Daele, Danielle Love, Yuya Haga, Donatella Romaniello, et al.,Cell Signaling Technology,Cat#12231; RRID:AB_2783553 "RAD18, Rabbit monoclonal",Cell Signaling Technology,Cat#9040; RRID:AB_2756446 "Bak, Rabbit monoclonal",Cell Signaling Technology,Cat#12105; RRID:AB_2716685 "RAD51,

(12) PARP10 promotes the repair of nascent strand DNA gaps through RAD18 mediated translesion synthesisNature communicationsJuly 23, 2024Khatib JB, Dhoonmoon A, Moldovan GL, Nicolae CM.for Western blot, at 1:500 dilution, were: PARP10: Abcam ab70800; RAD18: Cell Signaling Technology 9040;USP1: Abcam ab264221; BRCA1 Santa Cruz Biotechnology sc-6954; BRCA2 Bethyl A303-434A; FEN1: Santa Cruz Biotechnology

(13) RAD18 directs DNA double-strand break repair by homologous recombination to post-replicative chromatinNucleic acids researchJuly 22, 2024Palek M, Palkova N, consortium CZECANCA, Kleiblova P, Kleibl Z, Macurek L.γH2AX (clone D7T2V, #80312, 1:300 for IF), γH2AX (clone 20E3, #9718, 1:300 for IF), RAD18 (clone D2B9, #9040, 1:400 for IF, 1:1000 for WB), PCNA ubiquityl-Lys164 (clone D5C7P, #13439, 1:100 for IF), H2A (clone

(14) USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stressNucleic acids researchMarch 21, 2024Nusawardhana A, Pale LM, Nicolae CM, Moldovan GL.GTX70212); EXO1 (Novus NBP2-16391); PRIMPOL (Proteintech 29824–1-AP); RAD18 (Cell Signaling Technology 9040); USP1 (Abcam ab264221); Ubiquityl-PCNA Lys164 (Cell Signaling Technology 13439); REV1 (Santa Cruz Biotechnology

(15) The DDUP protein encoded by the DNA damage-induced CTBP1-DT lncRNA confers cisplatin resistance in ovarian cancerCell death & diseaseAugust 26, 2023Ren L, Qing X, Wei J, Mo H, Liu Y, Zhi Y, Lu W, Zheng M, Zhang W, Chen Y, et al.Cell Signaling Technology, MA, USA), anti-PCNA (#2586, Cell Signaling Technology, MA, USA), anti-RAD18 antibody (#9040, Cell Signaling Technology, MA, USA), or anti-RAD51C antibody (PA5-77078, Invitrogen, USA). The photographs

(16) L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximabCell Reports MedicineAugust 8, 2023Ilaria Marrocco, Suvendu Giri, Arturo Simoni-Nieves, Nitin Gupta, Anna Rudnitsky, Yuya Haga, Donatella Romaniello, Arunachalam Sekar, Mirie Zerbib, Roni Oren, et al.,Cell Signaling Technology,Cat#12231; RRID:AB_2783553 "RAD18, Rabbit monoclonal",Cell Signaling Technology,Cat#9040; RRID:AB_2756446 "GAS6, Rabbit monoclonal",Cell Signaling Technology,Cat#67202; RRID:AB_2799720 "RAD51,

(17) Break-induced replication orchestrates resection-dependent template switchingNatureJuly 1, 2023Zhang T, Rawal Y, Jiang H, Kwon Y, Sung P, Greenberg RA.Cell Signaling Technology), Monoclonal ANTI-FLAG® M2 antibody (1:1000, F1804, Mouse), RAD18 (1:1000, 9040S, Cell Signaling Technology), SNM1A (1:1000, A303–747A, Bethyl Laboratories), mCherry (1:1000, ab183628,

(18) LncRNA CTBP1-DT-encoded microprotein DDUP sustains DNA damage response signalling to trigger dual DNA repair mechanismsNucleic acids researchAugust 12, 2022Yu R, Hu Y, Zhang S, Li X, Tang M, Yang M, Wu X, Li Z, Liao X, Xu Y, et al.standard protocol with the following antibodies: anti-phospho-Histone H2A.X Ser139 (#9718), anti-RAD18 (#9040), anti-PCNA (#13110), anti-ubiquityl-PCNA Lys164 (#13439), anti-DYKDDDDK Tag (#14793) were purchased

(19) Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cellsMolecular cellOctober 7, 2021Tirman S, Quinet A, Wood M, Meroni A, Cybulla E, Jackson J, Pegoraro S, Simoneau A, Zou L, Vindigni A.Thermo Fisher Scientific), Mouse anti-SMARCAL1 (1/1,000, (A-2) sc-376377, Santa Cruz), Rabbit anti-RAD18 (1/1,000, 9040S, Cell Signaling), Mouse anti-UBC13 (1/500, sc376470, Santa Cruz), Mouse anti-PCNA (1/2,000, PC10, sc-56,

(20) Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrityLife science allianceSeptember 1, 2021Mohanty BK, Karam JA, Howley BV, Dalton AC, Grelet S, Dincman T, Streitfeld WS, Yoon JH, Balakrishnan L, Chazin WJ, et al.SCBT), RPA32 (rat, 2208S; Cell signaling), Rad6 (R6A/R6B, rabbit, 4944S; Cell signaling), Rad18 (rabbit, 9040S; Cell signaling), and Fen1 (rabbit; SCBT). Plasmids containing hnRNP E1 and its three KH domains namely

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Rad18 (D2B8) XP ® Rabbit mAb

Rad18 (D2B8) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Rad18 (D2B8) XP ® Rabbit mAb from Cell Signaling Technology

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