Upf1 (D15G6) Rabbit mAb 12040S from Cell Signaling Technology

Product Specs
ItemUpf1 (D15G6) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number12040S
Quantity100 µl
ApplicationsW, IP, IF-IC, eCLIP
ReactivityH, M, R, Mk
ClonalityMonoclonal
TargetUPF1
HostRabbit
NCBI Full Gene NameUPF1 RNA helicase and ATPase
NCBI Gene AliasesHUPF1, NORF1, RENT1, UTF, pNORF1, smg-2
Research AreaTranslational Control
IsotypeIgG
CloneD15G6
Molecular Weight140

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Cell Signaling Technology

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Phone: 978-867-2388
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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Zika and dengue viruses differentially modulate host mRNA processing factors defining its virulenceNAR Molecular MedicineSeptember 8, 2025Aaron Scholl, Binsheng Gong, Bingjie Li, Tahira Fatima, Nikki Tirrell, Spyros Karaiskos, Maria Rios, Joshua Xu, Sandip DeNovus Biologicals), Rb anti-GAPDH [Cat# 5174S, Cell Signaling Technology (CST)], Rb anti-UPF1 (Cat# 12040, CST) Rb anti-UPF2 (Cat# 11875, CST), Rb anti-ZIKV NS5 (Cat# GTX133312, GeneTex), Rb anti-ZIKV envelope

(2) Centrosome‑, mitotic spindle‑ and cytokinetic bridge‑specific compartmentalization of AGO2 protein in human liver cells undergoing mitosis: Non‑canonical, RNAi‑dependent, control of local homeostasisMolecular medicine reportsSeptember 1, 2025Theotoki EI, Kakoulidis P, Nikolakopoulos KS, Vlachou EN, Tsitsilonis OE, Voutsinas GE, Anastasiadou E, Stravopodis DJ.RNA-binding protein; cat. no. ab180947; Abcam) (1:100), anti-UPF1 (up-frameshift protein 1) (cat. no. 12040, Cell Signalling Technology, Inc.; 1:100), anti-centrin-2 (cat. no. 2091, Cell Signalling Technology,

(3) Plasticity of the mammalian integrated stress responseNatureMay 1, 2025Chen CW, Papadopoli D, Szkop KJ, Guan BJ, Alzahrani M, Wu J, Jobava R, Asraf MM, Krokowski D, Vourekas A, et al.(1:1,000, Cell Signaling Technology number 6924); anti-UPF1 (1:1,000, Cell Signaling Technology number 12040); anti-S6 ribosomal protein (1:1,000, Cell Signaling Technology number 2217); anti-phospho-S6 ribosomal protein (Ser240/244

(4) A Novel Mouse Model Unveils Protein Deficiency in Truncated CDKL5 MutationsNeuroscience BulletinMarch 5, 2025Xue Feng, Zi-Ai Zhu, Hong-Tao Wang, Hui-Wen Zhou, Ji-Wei Liu, Ya Shen, Yu-Xian Zhang, Zhi-Qi XiongMerck Millipore); EB2 (ab45767, Abcam, Cambridge, UK); EB2 pS222 (00117739, Covalab, Grenoble, France); UPF1 (#12040, Cell Signaling Technology, MA, USA). Real-Time PCR Total mRNA was extracted from mouse brain tissue

(5) SNORD80-guided 2’-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responsesProceedings of the National Academy of SciencesFebruary 18, 2025Liang Xu, Xiao Hong Zhao, Yuan Yuan Zhang, Meng Yao Zhang, Long Yue Zhang, Kai Hong Ye, Liu Teng, Man Man Han, Yi Meng Yue, Jiezhen Yang, et al.(mAb) (#2639), rabbit anti-acetyl-lysine (Ace-K) polyclonal Ab (#9441), and rabbit anti-UPF1 mAb (#12040) were purchased from Cell Signaling Technology. The mouse anti-b-actin mAb was from Santa Cruz Biotechnology

(6) DDX50 cooperates with STAU1 to effect stabilization of pro-differentiation RNAsCell ReportsJanuary 28, 2025Weili Miao, Douglas F. Porter, Zurab Siprashvili, Ian D. Ferguson, Luca Ducoli, Duy T. Nguyen, Lisa A. Ko, Vanessa Lopez-Pajares, Suhas Srinivasan, Audrey W. Hong, et al.(CST, #13202), Ms-anti-V5 (Abcam, ab27671), anti-STAU1 (ProteinTech, 14225-1-AP), anti-UPF1 (CST, #12040), anti-Actin (Sigma, A2228), anti-KRT1 (Covance, PRB-149P), anti-KRT10 (Neomarkers, MS611P), anti-Filaggrin

(7) UPF1 Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating SMURF2-Mediated Ubiquitination Degradation of FOXA2Korean Circulation JournalJanuary 1, 2025Aixin Li, Peng Li, Chunling Mu, Dong Li, Keyan Chen, Zhaoguang Liangblockade with 5% bovine serum albumin, membranes were incubated with antibodies overnight at 4˚C: UPF1 (#12040, Cell Signaling Technology, CST, Danvers, MA, USA), FOXA2 (#8186T, 1:1,000, CST), PAR4 (#2328, 1:1,000,

(8) Eukaryotic initiation factor 4B is a multi-functional RNA binding protein that regulates histone mRNAsNucleic acids researchOctober 28, 2024Quintas A, Harvey RF, Horvilleur E, Garland GD, Schmidt T, Kalmar L, Dezi V, Marini A, Fulton AM, Pöyry TAA, et al.no. 07-471), GAPDH (CST, no. 2118), DDX3 (Abcam, no. 37160), FMR1 (CST, no. 4317S), UPF1 (CST, no. 12040), pUPF1 (CST, no. 84283), Cyclin A2 (CST, no. 4656), Cyclin B1 (CST, no. 4138), Cyclin E2 (CST, no.

(9) Role of UPF1 in lncRNA-HEIH regulation for hepatocellular carcinoma therapyExperimental & molecular medicineFebruary 1, 2024Cha H, Kim M, Ahn N, Jeong SD, Ignatova E, Chi SW, Kim HH, Hwang J.membranes. WB was performed using antibodies specific to the following proteins: UPF1 (Cell Signaling, #12040 S), calnexin (Cell Signaling, #2679), β-actin (Sigma, #A2228), FLAG (Sigma, #F3165), GST (GE Healthcare,

(10) Nucleolar dynamics are determined by the ordered assembly of the ribosomebioRxivOctober 1, 2023Jessica Sheu-Gruttadauria, Xiaowei Yan, Nico Stuurman, Stephen N. Floor, Ronald D. Vale(Rabbit),Proteintech,Cat 3 17504-1-AP, Antibody,UPF1 (D15G6) Rabbit mAb,Cell Signaling Technology,Cat # 12040, Antibody,SKIV2L2 polyclonal antibody (Rabbit),Novus Biologicals,Cat # NB100-1574, Antibody,DDX54 polyclonal antibody

(11) Nuclear accumulation of host transcripts during Zika Virus InfectionPLoS pathogensJanuary 1, 2023Leon KE, Khalid MM, Flynn RA, Fontaine KA, Nguyen TT, Kumar GR, Simoneau CR, Tomar S, Jimenez-Morales D, Dunlap M, et al.antibodies used were anti-UPF1 (Bethyl laboratories, Montgomery, TX, A300-38A, CST, Newburyport, MA, 12040S and Abcam, Cambridge, UK, ab109363), anti-FREM2 (Invitrogen, Carlsbad, CA, PA5-20982), anti-FLAG (Abcam,

(12) Elucidation of TRIM25 ubiquitination targets involved in diverse cellular and antiviral processesPLoS pathogensSeptember 1, 2022Yang E, Huang S, Jami-Alahmadi Y, McInerney GM, Wohlschlegel JA, Li MMH.polyclonal",Proteintech,14960-1-AP,"WB (1:2,000)" Antibody,"anti-UPF1, rabbit monoclonal",Cell Signaling Technology,12040,"WB (1:1,000)" Antibody,"anti-V5, mouse monoclonal",Invitrogen,MA5-1523,"WB (1:5,000)" Antibody,donkey

(13) Rta is the principal activator of Epstein-Barr virus epithelial lytic transcriptionPLoS pathogensSeptember 1, 2022Ali A, Ohashi M, Casco A, Djavadian R, Eichelberg M, Kenney SC, Johannsen E.MAPK Cell Signaling Technologies catalog #4511T, 1:1000 anti-UPF1 Cell Signaling Technologies catalog #12040S, 1:1000 anti-STREP abcam catalog #76950, and 1:10000 anti-YTHDF2 Proteinteck catalog #24744-1-AP), diluted

(14) Proximity-based labeling reveals DNA damage-induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactomeThe Journal of biological chemistryAugust 1, 2022Johnson MA, Nuckols TA, Merino P, Bagchi P, Nandy S, Root J, Taylor G, Seyfried NT, Kukar T.P36935). The following primary antibodies were used: UPF1 (Cell Signaling Technologies; catalog no.: 12040S; 1:2000 dilution), MOV10 (Proteintech; catalog no.: 10370-1-AP; 1:1000 dilution), eIF2α (Cell Signaling Technologies

(15) Modular scaffolding by lncRNA HOXA10-AS promotes oral cancer progressionCell Death & DiseaseJuly 20, 2022Yi-Tung Chen, Chia-Hua Kan, Hsuan Liu, Yu-Hao Liu, Chih-Ching Wu, Yu-Ping Kuo, Ian Yi-Feng Chang, Kai-Ping Chang, Jau-Song Yu, Bertrand Chin-Ming Tanused antibodies were listed as follows: control rabbit IgG (P120-101, Bethyl), UPF1 antibody (mAb #12040, Cell Signaling Technology), and Anti-Argonaute-2 antibody (ab32381, Abcam). Nuclear and cytoplasmic

(16) Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapyNature communicationsMay 27, 2022Kim YJ, Nomakuchi T, Papaleonidopoulou F, Yang L, Zhang Q, Krainer AR.(Supplementary Fig. 11A). UPF1 was detected with rabbit antibody D15G6 (Cell Signaling Technology #12040S). Na/K-ATPase, detected with a mouse monoclonal antibody (Santa Cruz, sc-48345), and Tubulin, detected

(17) PRMT5 regulates ATF4 transcript splicing and oxidative stress responseRedox biologyMay 1, 2022Szewczyk MM, Luciani GM, Vu V, Murison A, Dilworth D, Barghout SH, Lupien M, Arrowsmith CH, Minden MD, Barsyte-Lovejoy D.Antibodies Anti-Rme2s (#13222), ATF4 (#1185), XBP1 (#12782), IREa (3294), EIF2A (#9722), pEIF2A (#3398), UPF1 (#12040), phospho p90RSK, pAKT. P44/42 MAPK, pS6 (#7100), NRF2 (#12721), HA (#3724) were purchased from Cell Signaling Technologies

(18) Functional interactomes of the Ebola virus polymerase identified by proximity proteomics in the context of viral replicationCell ReportsMarch 22, 2022Jingru Fang, Colette Pietzsch, George Tsaprailis, Gogce Crynen, Kelvin Frank Cho, Alice Y. Ting, Alexander Bukreyev, Juan Carlos de la Torre, Erica Ollmann Saphireanti-GSPT1/eRF3",Abcam,Cat#ab49878; RRID:AB_2115507 "Rabbit, anti-UPF1 (D15G6) (monoclonal)",Cell signaling technology,Cat#12040 Streptavidin-AlexaFluor488,Thermofisher/Invitrogen,Cat#s11223 "Goat, anti-mouse-HRP",Thermofisher/Invitrogen,Cat#31437;

(19) NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translationGenes & developmentMarch 1, 2022Huth M, Santini L, Galimberti E, Ramesmayer J, Titz-Teixeira F, Sehlke R, Oberhuemer M, Stummer S, Herzog V, Garmhausen M, et al.1:1000 for anti-p-UPF1 (rabbit; Millipore 07-1016), 1:1000 for anti-UPF1 (D15G6; rabbit; Cell Signaling 12040S), 1:1000 for anti-Flag M2 (mouse; Sigma-Aldrich F1804), 1:1000 for anti-c-MYC (D84C12; rabbit; Cell Signaling

(20) C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repressionNature communicationsJuly 3, 2020Sun Y, Eshov A, Zhou J, Isiktas AU, Guo JU.PBST, the membrane was incubated with primary antibodies (rabbit anti-UPF1, Cell Signaling Technology #12040; mouse anti-G3BP1, Millipore #05–1938; mouse anti-puromycin clone 12D10, Millipore #MABE343; rabbit

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Upf1 (D15G6) Rabbit mAb

Upf1 (D15G6) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Upf1 (D15G6) Rabbit mAb from Cell Signaling Technology

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