Cdc45 (D7G6) Rabbit mAb 11881S from Cell Signaling Technology

Product Specs
ItemCdc45 (D7G6) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number11881S
Quantity100 µl
ApplicationsW, IP, IF-IC
ReactivityH, M, R, Mk
ClonalityMonoclonal
TargetCDC45L
HostRabbit
NCBI Full Gene Namecell division cycle 45
NCBI Gene AliasesCDC45L, CDC45L2, MGORS7, PORC-PI-1
Research AreaCell Cycle / Checkpoint Control
IsotypeIgG
CloneD7G6
Molecular Weight65

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) MCM5 UFMylation regulates replication origin firing and fork progressionThe EMBO JournalSeptember 12, 2025Zheng Li, Xingxuan Wu, Liu Liu, Shaohong Rao, Yanting Liao, Mengting Liu, Bin Peng, Qiongdan Zhang, Yisui Xia, Yuanliang Zhai, et al.#A8592 Rabbit anti-PCNA,Abcam,Cat #ab92552 Rabbit anti-H3,Abcam,Cat # ab1791 Rabbit anti-CDC45,CST,Cat #11881S Rabbit anti-CDC45,Proteintech,Cat #15678-1-AP Rabbit anti-UBA5,Bethyl,Cat #A304-115A Rabbit anti-UFM1,Abcam,Cat

(2) The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplicationNature CommunicationsSeptember 8, 2025Kyohei Matsuhashi, Kei K. Ito, Kaho Nagai, Akira Sanada, Koki Watanabe, Kasuga Takumi, Atsushi Toyoda, Masamitsu Fukuyama, Shohei Yamamoto, Takumi Chinen, et al.(Cell Signaling Technology, 53061, WB 1:100), p97 (VCP; GeneTex, GTX101089, IF 1:1000), Cdc45 (Cell Signaling Technology, 11881, IF 1:200, WB 1:500), LRR1 (Atlas antibodies, HPA069364, IF 1:200, WB 1:1000) and MCM3 (Cell Signaling Technology

(3) USP37 prevents unscheduled replisome unloading through MCM complex deubiquitinationNat CommunMay 16, 2025Derek L. Bolhuis, Dalia Fleifel, Thomas Bonacci, Xianxi Wang, Brandon L. Mouery, Jeanette Gowen Cook, Nicholas G. Brown, Michael J. Emanueleantibody (1:190, BD biosciences, cat. #610700) or CDC45 antibody (1:50, Cell Signaling Technology, cat. #11881) or γH2AX antibody (1:200, Cell Signaling Technology, cat. #9718S) or PCNA antibody (1:50, Santa Cruz,

(4) Replication-dependent histone labeling dissects the physical properties of euchromatin/heterochromatin in living human cellsSci AdvMarch 28, 2025Katsuhiko Minami, Kako Nakazato, Satoru Ide, Kazunari Kaizu, Koichi Higashi, Sachiko Tamura, Atsushi Toyoda, Koichi Takahashi, Ken Kurokawa, Kazuhiro Maeshima(1:1000; CEC-006; Cosmo Bio), mouse anti-HaloTag (1:1000; G9281, Promega), or rabbit anti-CDC45 (1:1000; 11881S, Cell Signaling Technology), followed by the appropriate secondary antibody: anti-rabbit immunoglobulin

(5) USP37 prevents unscheduled replisome unloading through MCM complex deubiquitinationbioRxiv : the preprint server for biologySeptember 3, 2024Bolhuis DL, Fleifel D, Bonacci T, Wang X, Mouery BL, Cook JG, Brown NG, Emanuele MJ.antibody (1:190, BD biosciences, cat. #610700) or CDC45 antibody (1:50, Cell Signaling Technology, cat. #11881) diluted in 1% BSA-PBS + 0.1% NP-40 for 1 hour at 37°C in the dark. Cells were washed in 1% BSA-PBS

(6) mTORC2-driven chromatin cGAS mediates chemoresistance through epigenetic reprogramming in colorectal cancerNature cell biologySeptember 1, 2024Lv G, Wang Q, Lin L, Ye Q, Li X, Zhou Q, Kong X, Deng H, You F, Chen H, et al.D9C4, 1:1,000 dilution), anti-BAF200 (CST, no. 82342, D8D8U, 1:1,000 dilution), anti-CDC45 (CST, no. 11881, D7G6, 1:1,000 dilution), anti-p70 S6K (CST, no. 9202, 1:1,000 dilution), anti-pThr389-p70 S6K (CST,

(7) The Novel ATR Inhibitor Tuvusertib (M1774) Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer DrugsMolecular Cancer TherapeuticsJuly 2, 2024Ukhyun Jo, Yasuhiro Arakawa, Astrid Zimmermann, Daiki Taniyama, Makito Mizunuma, Lisa M. Jenkins, Tapan K. Maity, Suresh Kumar, Frank T. Zenke, Naoko Takebe, et al.Santa Cruz Biotechnology), phospho-Histone H3 (S10) (06–570, Upstate Biotechnology), TIMELESS (ab72458, Abcam), CDC45 (#11881, Cell Signaling Technology), TIPIN (ab229329, Abcam), PCNA (sc-56, Santa Cruz Biotechnology), Lamin

(8) Replication Stress in Activated Human NK Cells Induces Sensitivity to ApoptosisThe Journal of ImmunologyJuly 1, 2024Nicole C. Guilz, Yong-Oon Ahn, Hijab Fatima, Luis Alberto Alberto Pedroza, Seungmae Seo, Rajesh Kumar Soni, Ning Wang, Dieter Egli, Emily M Maceprimary antibodies ([anti-Sld5 (Abcam, catalogue no. ab101346), anti-Cdc45 (Cell Signaling, catalogue no. 11881), actin (Sigma, catalogue no. A5441)] then secondary Abs to mouse or rabbit (Licor, catalogue no. 926-68070

(9) Induction of the human CDC45 gene promoter activity by natural compound trans‑resveratrolMolecular Medicine ReportsApril 4, 2024Jun Arakawa, Hikaru Kondoh, Tokiyoshi Matsushita, Yoko Ogino, Masashi Asai, Sei-Ichi Tanuma, Fumiaki UchiumiBrand), at 4°C for 15 h. Western blot analysis was carried out with antibodies against CDC45 (cat. no. 11881, Cell Signaling, Danvers, MA) (1:1,000), and β-actin (cat. no. A5441; MilliporeSigma) (1:1,000) at 20°C

(10) The structural mechanism of dimeric DONSON in replicative helicase activationMolecular CellNovember 16, 2023Milos A. Cvetkovic, Paolo Passaretti, Agata Butryn, Alicja Reynolds-Winczura, Georgia Kingsley, Aggeliki Skagia, Cyntia Fernandez-Cuesta, Divyasree Poovathumkadavil, Roger George, Anoop S. Chauhan, et al.(Gambus lab; 1:500), MCM2 (BD Transduction labs, 610700; 1:2000), CDC45 (Cell Signaling Technology, 11881; 1:500), PCNA (Santa Cruz Biotechnology, sc-56; 1:1000), GFP (Abcam, ab6556; 1:2000) and TOPBP1 (Fortis

(11) RNAPII-dependent ATM signaling at collisions with replication forksNature communicationsAugust 24, 2023Einig E, Jin C, Andrioletti V, Macek B, Popov N.(flow cytometry)" BrdU [BU1/75 (ICR1)],ab6326,Abcam,Species independent,"ICC/IF, Flow Cyt (Intra), IHC-P" CDC45,11881S,Cell Signaling,H M R Mk,"WB, IP, IF" CHK2,2662T,Cell Signaling,H M R Mk,"WB, IP" H2AX (938CT5.1.1),sc-517336,Santa Cruz

(12) ORC1 binds to cis-transcribed RNAs for efficient activation of replication originsNature CommunicationsJuly 24, 2023Aina Maria Mas, Enrique Goñi, Igor Ruiz de los Mozos, Aida Arcas, Luisa Statello, Jovanna González, Lorea Blázquez, Wei Ting Chelsea Lee, Dipika Gupta, Álvaro Sejas, et al.cellular fractions, was performed as previously described in ref. 55, with anti-CDC45 (Cell Signalling 11881) and anti-PCNA (sc-56) antibodies. After immunofluorescence staining with secondary antibodies, coverslips

(13) Replication-associated formation and repair of human topoisomerase IIIα cleavage complexesNature communicationsApril 6, 2023Saha LK, Saha S, Yang X, Huang SN, Sun Y, Jo U, Pommier Y.Cell Signaling Technology, Cat# 13110, Clone D3H8P); anti-CDC45 (dilution 1:100, Cell Signaling Technology, Cat# 11881 ); anti-H3 (dilution 1:1000, Cell Signaling Technology, Cat# 9715); anti-EGFP (dilution 1:500, Clontech,

(14) CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesisMolecular cellJanuary 5, 2023Ratnayeke N, Baris Y, Chung M, Yeeles JTP, Meyer T.RRID:AB_1549585), mouse anti-GFP (1:500, Abcam Cat# ab1218, RRID:AB_298911), rabbit anti-CDC45 (1:100, CST Cat# 11881, RRID:AB_2715569), rabbit anti-POLA2 (1:100, Atlas Antibodies Cat# HPA037570, RRID:AB_10672280), rabbit

(15) Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomesNature communicationsOctober 14, 2022Polasek-Sedlackova H, Miller TCR, Krejci J, Rask MB, Lukas J.used as follows: AND-1 (rabbit, Abcam, ab224221, 1:1,000), CDC45 (rabbit, Cell Signaling Technology, 11881S, clone D7G6, 1:1,000), CLASPIN (mouse, Santa Cruz, sc-376773, clone B-6, 1:1,000), GFP (rabbit, Chromotek,

(16) The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transitionMolecular cellSeptember 15, 2022Zonderland G, Vanzo R, Gadi SA, Martín-Doncel E, Coscia F, Mund A, Lerdrup M, Benada J, Boos D, Toledo L.antibodies,Primary antibodies,Primary antibodies ,, BrdU,GE-Helthacare,Cat# RPN20AB CDC45,Cell Signaling,Cat# 11881S CDK1/2-pY15,Cell Signaling,Cat# 9111S CDK1,BD Biosciences,Cat# 610037 CDK2,Santa Cruz,Cat# sc-6248 CHK1,Cell Signaling

(17) Essential role of CK2α for the interaction and stability of replication fork factors during DNA synthesis and activation of the S-phase checkpointCellular and molecular life sciences : CMLSJune 4, 2022Guerra B, Doktor TK, Frederiksen SB, Somyajit K, Andresen BS.Cell Signaling Technology), rabbit monoclonal anti-NF-κB (8242, Cell Signaling Technology), rabbit monoclonal anti-CDC45 (11881, Cell Signaling Technology), rabbit monoclonal anti-phospho-histone H2A.X S139 (9718, Cell Signaling Technology

(18) SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewalDevelopmental cellMarch 14, 2022Yu T, Cazares O, Tang AD, Kim HY, Wald T, Verma A, Liu Q, Barcellos-Hoff MH, Floor SN, Jung HS, et al.,Cell Signaling Technology,"Cat# 39141, RRID:AB_2650511" Rabbit Anti-Cdc45 (D7G6) antibody,Cell Signaling Technology,"Cat# 11881, RRID:AB_2715569" Mouse Anti-P21 antibody,BD Biosciences,"Cat# 556431, RRID:AB_396415" Mouse Anti-Incenp

(19) LRR1-mediated replisome disassembly promotes DNA replication by recycling replisome componentsThe Journal of cell biologyAugust 2, 2021Fan Y, Köberlin MS, Ratnayeke N, Liu C, Deshpande M, Gerhardt J, Meyer T.antibodies used for immunofluorescence in this study were rabbit anti-CDC45 (Cell Signaling Technology; 11881; 1:200; requires methanol treatment), mouse anti-PCNA (Santa Cruz Biotechnology; sc-56; 1:500; requires

(20) MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivityCell reportsMarch 2, 2021Branigan TB, Kozono D, Schade AE, Deraska P, Rivas HG, Sambel L, Reavis HD, Shapiro GI, D'Andrea AD, DeCaprio JA.AB_2062659 MYBL2,Millipore,Cat# MABE866 pT487 MYBL2,Abcam,Cat# Ab76009; RRID: AB_1309969 CDC45,Cell Signaling Technologies,Cat# 11881S; RRID: AB_2715569 CDK1,Santa Cruz Biotechnology,Cat# sc-54; RRID: AB_627224 pT161 CDK1,Cell Signaling Technologies

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Cdc45 (D7G6) Rabbit mAb

Cdc45 (D7G6) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Cdc45 (D7G6) Rabbit mAb from Cell Signaling Technology

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