Progesterone Receptor A/B (D8Q2J) XP ® Rabbit mAb 8757S from Cell Signaling Technology

Product Specs
ItemProgesterone Receptor A/B (D8Q2J) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $371.00 Inquire
Catalog Number8757S
Quantity100 µl
ApplicationsW, IP, IHC-P, IF-IC, FC-FP, ChIP, ChIP-seq, C&R
ReactivityH
ClonalityMonoclonal
TargetProgesterone receptor
HostRabbit
NCBI Full Gene Nameprogesterone receptor
NCBI Gene AliasesNR3C3, PR
Research AreaNuclear Receptor Signaling
CloneD8Q2J
Molecular Weight90 (PR-A), 118 (PR-B)

Questions and Answers

What applications has the Progesterone Receptor A/B antibody been shown to be effective in?

The Progesterone Receptor A/B antibody has been utilized in various applications, including immunohistochemistry and Western blotting, as evidenced by its citation in numerous scientific articles.

Can this antibody be used to study the role of progesterone receptors in breast cancer?

Yes, the Progesterone Receptor A/B antibody has been referenced in studies investigating the crosstalk between estrogen and progesterone receptors in breast cancer, particularly in the context of endocrine therapy resistance, highlighting its relevance in cancer research.

Is there any evidence supporting the use of this antibody in research related to uterine development?

The antibody has been cited in research that explores the epigenetic regulation of uterine stromal development, indicating its potential utility in studies focused on reproductive biology and uterine health.

How does the antibody contribute to understanding the mechanisms of progesterone action in cellular contexts?

The Progesterone Receptor A/B antibody has been employed to elucidate the mechanisms by which progesterone influences gene expression and cellular responses, particularly in studies examining the modulation of innate immune responses and cell differentiation processes.

Cell Signaling Technology

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) The Selective Estrogen Receptor Degrader ZN-c5 Has Broad Anti-Tumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer ModelsMolecular Cancer TherapeuticsApril 2, 2026Jianhui Ma, Sayee Hegde, Masha Sergeeva, Binita Chakraborty, Suzanne E. Wardell, Donald P. McDonnell, Peter Q. Huang, Kevin D. Bunker, Fernando Doñate, Mark R. Lackner, et al.Antibodies for ERα were purchased from Abcam (ab16660, RRID: AB_443420). Progesterone receptor (PR; #8757, RRID: AB_2797144) and GAPDH (#2118, RRID: AB_561053) were purchased from Cell Signaling Technology,

(2) Human receptive endometrial assembloid for deciphering the implantation windoweLifeApril 1, 2026Yu Zhang, Rusong Zhao, Chaoyan Yang, Jinzhu Song, Peishu Liu, Yan Li, Boyang Liu, Tao Li, Changjian Yin, Minghui Lu, et al.SRRID:AB_2341188,IF (1:400) Antibody,Progesterone Receptor A/B (D8Q2J) XP (Rabbit monoclonal),Cell Signaling,Cat#: 8757 SRRID:AB_2797144,IF (1:800) Antibody,FoxO1 (D7C1H) (Mouse monoclonal),Cell Signaling,Cat#:14952 S RRID:AB_2722487,IF

(3) Single cell RNA-sequencing reveals that testosterone reduces estrogen signaling in the healthy human mammary glandJournal of Mammary Gland Biology and NeoplasiaMarch 25, 2026Kiet T. Phong, Siyou Song, Esther A. Kim, Daniel N. Conrad, Zev J. Gartnerand reagents used are as follow: ERα (1:500; Abcam ab16660), PRa/b (1:100; Cell Signaling Technology 8757 S), Cytokeratin 19 (1:200; BioLegend 628502), Alexa Fluor™ 555 Tyramide SuperBoost™ Kit (Invitrogen

(4) Mechanistic dissection of GRHL2 and PR transcriptional co-regulation in breast cellsPLoS GenetMarch 17, 2026Marleen T. Aarts, Anna Nordin, Claudio Cantù, Antonius L. van Boxtel, Renée van Amerongensupplemented with 2 mM EDTA, and then transferred to PCR tubes. Antibodies (anti-PR (1:100, Cell Signaling, #8757S), anti-GRHL2 (1:100, Sigma-Aldrich, #HPA004820), or rabbit IgG isotype control (1:100, Invitrogen, #100500C))

(5) Multi-Omics Data Reveal Estrogen-Driven Dysregulation and Stromal-Epithelial Signaling Alterations in Endometrial PolypsFASEB JMarch 15, 2026Tingwei Chen, Bo Zhang, Zhengli Zhou, Naixue Yang, Ting Liu, Huimei Zhang, Yu Yin, Xiaomei Wu, Xiaozhuo Li, Tao Yu, et al.1:600, R&D system, AF7649‐SP; Progesterone Receptor A/B antibody, 1:500, Cell Signaling Technology, 8757S; Cytokeratin 7 antibody (ck7), 1:500, abcam, ab181598; CK7, 1:500, invitrogen, MA1‐06316). The following

(6) HIF2α-induced lysyl oxidase safeguards successful pregnancy by remodelling collagens at the feto-maternal interfaceCell Death DisMarch 9, 2026Shizu Aikawa, Ryoko Shimizu-Hirota, Akihiko Sakashita, Xueting He, Daiki Hiratsuka, Chihiro Ishizawa, Rei Iida, Yamato Fukui, Takehiro Hiraoka, Mitsunori Matsuo, et al.antibodies were used: Ki67 (Thermo Fisher Scientific, SP6, 1:300), Pgr (Cell Signaling Technology, 8757, 1:300), Esr1 (Abcam, ab32063, 1:300), E-Cadherin (Cell Signaling Technology, 3195, 1:300), CK8 (DSHB,

(7) Role of DCAF8 in Mammary Ductal Elongation and Branching MorphogenesisJournal of Mammary Gland Biology and NeoplasiaMarch 6, 2026Qianying Han, Miaomiao Ban, Ting Zhang, Tianyun Yu, Xingyue Yan, Yumeng Hu, Pengfei Wu, Yanfang Ma, Luzheng Xu, Yanrong Su, et al.Sigma-Aldrich, 1:8000 dilution), anti-ERα (#8644S, Cell Signaling Technology, 1:1000 dilution), anti-PR (#8757S, Cell Signaling Technology, 1:1000 dilution). For Imunochemistry and/or Immunofluorescence staining,

(8) Patient-derived epithelial cell organoids mimic the phenotypic complexity of endometriosis subtypesHuman ReproductionFebruary 1, 2026K Gunther, D Liu, M Cortesi, E Powell, E Nesbitt-Hawes, J A Abbott, C E Ford(1:100, GeneTex GTX29269, USA), progesterone receptor (PR) (1:1000, Cell Signalling Technology No. 8757, USA), and Ki67 (1:3000, Cell Signalling Technology, No. 9449, USA). IF was conducted with rabbit CD10

(9) Single cell RNA-sequencing reveals an association between testosterone treatment and reduced hormone signaling in the human mammary glandbioRxivJanuary 5, 2026Kiet T. Phong, Siyou Song, Esther Kim, Danny Conrad, Zev Gartnerand reagents used are as follow: ERα (1:500; Abcam ab16660), PRa/b (1:100; Cell Signaling Technology 8757S), Cytokeratin 19 (1:200; BioLegend 628502), Alexa Fluor™ 555 Tyramide SuperBoost™ Kit (Invitrogen B40923),

(10) A tumor-targeted heptamethine cyanine dye induces suppression of progesterone receptor activity to treat hormone receptor-positive breast cancerTheranosticsJanuary 1, 2026Yoonbin Park, Sang-Hyo Kim, Moon Suk Kim, Hoon HyunCell Signaling, Beverly, MA, USA), CHOP (Cat# 2895, Cell Signaling), Progesterone Receptor A/B (Cat# 8757, Cell Signaling), β-catenin (Cat# 9562, Cell Signaling), Calreticulin (Cat# 12238, Cell Signaling),

(11) Transcriptional coregulator ZMIZ1 modulates estrogen responses that are essential for healthy endometrial functionJournal of Clinical InvestigationDecember 1, 2025Sylvia C. Hewitt, Frank Orellana, Ryan M. Marquardt, MyeongJin Yi, Cynthia J. Willson, Mark Y. Chiang, Yong Song, Goutham Venkata Naga Davuluri, Christopher Day, Ramakrishna Kommagani, et al.(50 mM Tris 138 mM NaCl with 0.1% Tween 20; Sigma). Antibodies to PGR (Cell Signaling Technologies 8757 1:1000), ESR1 (Millipore 06-935 1:5000), ZMIZ1 (Cell Signaling Technologies 89500 1:1000), or GAPDH

(12) Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial CancerAdvanced ScienceNovember 21, 2025Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang(CST, #9154), p‐ERK (CST, #3179), FOXM1 (Proteintech, 13147‐1‐AP), FGF19 (abcam, ab320829), PGR (CST, #8757), FGF1 (Proteintech, 17400‐1‐AP), FGF9 (Proteintech, 26554‐1‐AP), FGF13 (abcam, ab186300), and GAPDH

(13) Discovery of a novel small molecule degrader of wild type and mutant estrogen receptors using DNA encoded librariesnpj Breast CancerNovember 12, 2025Anil Kumar Devakrishnan, Chandrashekhar Madasu, Yong Wang, Ramkumar Modukuri, Kurt M. Bohren, Kevin R. MacKenzie, Damian W. Young, Suzanne A. W. Fuqua, Martin M. Matzuk, Murugesan Palaniappan3742), anti-TFF1 (CST, Cat. # 15571S), anti-cleaved PARP (CST, Cat. # 5625S), anti-PR A/B (CST, Cat. # 8757S), anti-c-MYC (CST, Cat. # 5605S), anti-GREB1 (Sigma, Cat. # MABS62), anti-CDK2 (CST, Cat. # 2546T) anti-β-actin

(14) Maf1 cooperates with progesterone receptor to repress RNA polymerase III transcription of select tRNAsNucleic Acids ResearchNovember 8, 2025Jessica Finlay-Schultz, Kiran Vinod Paul, Benjamin Erickson, Lynsey M Fettig, Benjamin S Hastings, Deborah L Johnson, David L Bentley, Peter Kabos, Carol A Sartoriuswas collected for nuclear fraction. Antibodies for immunoblots were PR (Cell Signaling Technology, 8757; Dako, 1294), POLR3A (Cell Signaling Technology 12825; Bio-Rad Laboratories MCA6411GA), Maf1 (Invitrogen

(15) The Novel Immunocompetent Eµ-SOX11CCND1 Mouse Model Phenotypically and Molecularly Resembles Human Mantle Cell LymphomaClinical Cancer ResearchNovember 3, 2025Hedieh Jafari, Fiona Brown-Burke, Betsy Pray, Shelby Sloan, JoBeth Helmig-Mason, Ian Hout, Sydney Leon, Mackenzie Long, Wing Keung Chan, Walter Hanel, et al.protein detection: BTK (Cell Signaling technology #56044S), P-BTK (Y223) (cell signaling technology #8757S), AKT (cell signaling technologies #2920S), P-AKT (S373) (cell signaling technologies #4060S), MTAP

(16) Neurofibromin Encoded by the Neurofibromatosis Type 1 (NF1) Gene Promotes the Membrane Translocation of SPRED2, Thereby Inhibiting the ERK Pathway in Breast Cancer CellsInt J Mol SciOctober 16, 2025Nang Thee Su Pwint, Chunning Li, Tong Gao, Yuze Wang, Masayoshi Fujisawa, Toshiaki Ohara, Masakiyo Sakaguchi, Teizo Yoshimura, Akihiro Matsukawa(D6R2W),Cell Signaling Technology (13258) 1 Progesterone Receptor A/B (D8Q2J),Cell Signaling Technology (8757) 1 HER2/ErbB2 (29D8),Cell Signaling Technology (2165) 1 Mouse IgG Isotype control,Cell Signaling Technology

(17) HDAC7 influences ER-⍺ transcription via NCoR-HDAC3 dissociationBiochimica et Biophysica Acta (BBA) - Proteins and ProteomicsSeptember 1, 2025Ishadi K. M. Kodikara, Valentine O. Nwanelo, Angela K. Belanger, Mary Kay H. PflumHA (Invitrogen, Cat. No. 26183), AR (Cell signaling, Cat. No. 5153T), PR (Cell signaling, Cat. No. 8757T), GR (Cell signaling, Cat. No. 12041T), RXR (Cell signaling, Cat. No. 5388S), ER-α (Cell signaling,

(18) WT1 directs normal progesterone receptor-chromatin binding essential for uterine receptivity at peri-implantationProc Natl Acad Sci U S AJuly 15, 2025Zhangli Ni, Chuanhui Guo, Xiaojing Liu, Gaizhen Li, Yedong Tang, Han Cai, Weiyu Huang, Fei Gao, Zhaowei Tu, Chao Wang, et al.were used for immunofluorescence. Primary antibodies against WT1 (Abcam, Ab89901, 1:200), PR (CST, 8757, 1:200), ERα (Sigma, 06-935, 1:200), Ki67 (Abcam, Ab15580, 1:100), BrdU (Abcam, Ab6326, 1:200), HAND2

(19) The roles of AKT isoforms in decidualization and embryo implantation using a Progesterone Receptor-Cre mouse model†Biology of ReproductionJune 15, 2025Pascal Adam, François Fabi, Sophie Parent, Léa-Isabelle Renaud, Monique Cadrin, Eric Asselinantibodies used from Cell Signaling Technology: IGFBP1 (#31025, 1:200), Progesterone Receptor A/B (#8757, 1:150), PTGS2 (COX2) (#12282, 1:300), AKT (#4691, 1:150), pAKT substrate (#9614, 1:500), FOXO1 (#2880,

(20) ST6GALNAC1-mediated sialylation in uterine endometrial epithelium facilitates the epithelium-embryo attachmentJournal of Advanced ResearchJune 1, 2025Xinyue Dong, Hao Wang, Jinxuan Cai, Yichun Wang, Dezhi Chai, Zichen Sun, Jie Chen, Mengxia Li, Tianxia Xiao, Chunhua Shan, et al.(Proteintech, 30000–0-AP, 1:100), and Progesterone Receptor A/B Antibody (Cell Signaling Technology, 8757 T, 1:100) at 4 °C overnight with rotation. After washing, DNA was extracted and purified. The purified

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Progesterone Receptor A/B (D8Q2J) XP ® Rabbit mAb

Progesterone Receptor A/B (D8Q2J) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Progesterone Receptor A/B (D8Q2J) XP ® Rabbit mAb from Cell Signaling Technology

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