G6PD (D5D2) Rabbit mAb 12263S from Cell Signaling Technology

Product Specs
ItemG6PD (D5D2) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number12263S
Quantity100 µl
ApplicationsW
ReactivityH, M, R, Hm, Mk
ClonalityMonoclonal
TargetG6PD
HostRabbit
NCBI Full Gene Nameglucose-6-phosphate dehydrogenase
NCBI Gene AliasesG6PD1
Research AreaMetabolism
IsotypeIgG
CloneD5D2
Molecular Weight58

Questions and Answers

Can this antibody be used to study G6PD in mouse models?

Yes, the G6PD (D5D2) Rabbit mAb has been shown to recognize endogenous levels of total G6PD protein in mouse tissues, making it suitable for studies involving mouse models.

Is there any evidence supporting the use of this antibody in cancer research?

Yes, the G6PD antibody has been utilized in studies examining metabolic reprogramming in cancer cells. For instance, it has been referenced in research highlighting the role of G6PD in maintaining NADPH levels, which is crucial for the metabolic fitness of T cells in the tumor microenvironment ().

How has this antibody been applied in studies related to metabolic pathways?

The G6PD antibody has been employed in various studies to investigate its role in the pentose phosphate pathway and its implications in metabolic diseases and cancer. For example, it has been used to analyze G6PD's involvement in glucose metabolism and redox balance in different cellular contexts, including its interaction with signaling pathways in immune cells (; ).

What species can this antibody react with in experimental settings?

The G6PD (D5D2) Rabbit mAb is reactive with several species, including humans, mice, rats, non-human primates, and hamsters, making it versatile for comparative studies across different biological models.

Cell Signaling Technology

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Phone: 978-867-2388
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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) AMPK Suppresses Multiple Forms of Cell Death Including Disulfidptosis in Tumor-Associated Macrophages During Tumor ProgressionInt J Mol SciJuly 9, 2026Ruixuan Wang, Huan Wang, Dianyuan Zhao, Wenting Yang, Di Liu, Li TangMA, USA), GLUT1 (1:1000; Cat#12939, Cell Signaling Technology, Danvers, MA, USA), G6PD (1:1000, Cat#12263, Cell Signaling Technology, Danvers, MA, USA). 4.11. Measurement of Lipid Peroxidation Measurements

(2) IL21—STAT3 controls the pentose phosphate pathway to support metabolic reprogramming and tumor progression in chronic lymphocytic leukemiaHemaSphereJanuary 27, 2026Rosita Del Prete, Vjola Tusha, Helga Simon‐Molas, Virginia Anna Gazziero, Federica Nardi, Roberta Drago, Gaia Bartolini, Danilo Licastro, Margherita Malchiodi, Cristina Mariottini, et al.mouse CLL cell lysates: rabbit anti‐β‐actin antibody (4967; Cell Signaling), rabbit anti‐G6PD antibody (12263; Cell Signaling), rabbit anti‐TKT antibody (64414; Cell Signaling), rabbit anti‐STAT3 antibody (06‐596;

(3) Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupusCell ReportsDecember 23, 2025Seung Chul Choi, Yong Ge, Ahmed Elshikha, Yuk Pheel Park, Cenxiao Fang, Milind V. Joshi, Maria Montes Montes de Oca Arena, Lauren Padilla, Yanan Zhu, William L. Clapp, et al.RRID:AB_2338469 Anti-mouse FOXP3-FITC,Thermo Fisher,Cat#11-5773-82; RRID:AB_465243 Anti-mouse G6PD,Cell Signaling,Cat#12263; RRID:AB_2797861 Anti-mouse GL7-eFluor 450,Thermo Fisher,Cat#48-5902-82; RRID:AB_10870775 Anti-mouse

(4) Elevating cytosolic NADPH metabolism in endothelial cells ameliorates vascular agingNature CommunicationsNovember 3, 2025Dan Wu, Bo Tan, Zijie Cheng, Haoqi Li, Huimin Li, Yun Yin, Fenfen Ma, Tao Chen, Xin Dong, Wang Wang, et al.Cell Signaling Technology, Cat. No. 2118S), anti-G6PD (1:2000, Cell Signaling Technology, Cat. No. 12263), anti-PGD (1:2000, Proteintech, Cat. No. 14718-1-AP), anti-IDH1 (1:2000, Proteintech, Cat. No. 12331-1-AP),

(5) Oxidized phosphatidylcholines activate NOX1-mediated oxidative stress response and shift glucose metabolism in cardiac cellsAmerican Journal of Physiology-Cell PhysiologyOctober 1, 2025Anna A. Licznerska, Caitlin M. Pavelec, Priyanka Rawat, Scott Yeudall, Clint M. Upchurch, Hannah L. Luviano, Kyla N. Mucciarone, Norbert Leitingerthis study were: rabbit anti-Heme Oxygenase 1 (Abcam #ab13243), rabbit anti-G6PD (Cell Signaling, #12263), rabbit anti-G6PD (Bethyl Laboratories #A300–404A), rabbit anti-vinculin (Cell Signaling 13901s), rabbit

(6) Endogenous histidine peptides are physiological antioxidants that prevent oligodendrocyte cell death and myelin loss in vivoGliaJanuary 1, 2025Sajrawi C, Odeh M, Tiwari AK, Agranovich B, Abramovich I, Zubedat S, Saar G, Shaulov L, Avital A, Reznik D, et al.rabbit polyclonal",Sigma-Aldrich,G9545s "Anti-G6PD, rabbit monoclonal",Cell Signaling Technology,#12263 "Anti-PGD, mouse monoclonal",Santa Cruz biotechnology,sc-398977 "Anti-Transketolase, rabbit monoclonal",Cell Signaling Technology

(7) Metabolomics Reveals the Mechanism by Which Sodium Butyrate Promotes the Liver Pentose Phosphate Pathway and Fatty Acid Synthesis in Lactating GoatsAnimals (Basel)November 13, 2024Lin Li, Xi Chen, Shuping Yan, Yuanshu Zhangdehydrogenase (rb-anti-6PGDH, #13389, CST), and anti-glucose 6-phosphate dehydrogenase (rb-anti-G6PDH, #12263, CST). First, the blots were treated with a primary antibody against GAPDH (A531, Bioworld, Nanjing,

(8) A novel effect of sulforaphane on promoting mouse granulosa cells proliferation via the NRF2–TKT pathwayJournal of Advanced ResearchSeptember 27, 2024Xuan Zhang, Dingding Zhang, Aoyun Fan, Xinyi Zhou, Caixia Yang, Jiaqi Zhou, Ming Shen, Honglin Liu, Kang Zou, Jingli TaoCell Signaling Technology), CDK2 (2546, Cell Signaling Technology), cyclin E1 (A14225, Abclonal), G6PD (12263, Cell Signaling Technology), TKT (11039–1-AP, Proteintech), NRF2 (12721, Cell Signaling Technology),

(9) RYR2 deficient human model identifies calcium handling and metabolic dysfunction impacting pharmacological responsesFrontiers in cardiovascular medicineJanuary 1, 2024Starnes L, Hall A, Etal D, Cavallo AL, Grabowski P, Gallon J, Kha M, Hicks R, Pointon A.protein expression following the protocol described earlier [primary antibodies used were G6PD (D5D2) #12263, 1:1,000, Cell Signaling Technology, CSRP3 ab173301 1:1,000, Abcam]. Calcium handling Cardiomyocytes

(10) Cyclin D1 extensively reprograms metabolism to support biosynthetic pathways in hepatocytesThe Journal of biological chemistryDecember 1, 2023Wu H, Kren BT, Lane AN, Cassel TA, Higashi RM, Fan TWM, Scaria GS, Shekels LL, Klein MA, Albrecht JH.14). Additional antibodies for Western blot included the following: CAD (93925), ph-CAD (67235), G6PD (12263), GAPDH (5174), ph-RB (35908), ph-S6 (2211), ph-S6K1 (9205), and ph-mTOR (5536) from Cell Signaling Technology

(11) Exosomal Long Non-Coding Ribonucleic Acid Ribonuclease Component of Mitochondrial Ribonucleic Acid Processing Endoribonuclease Is Defined as a Potential Non-Invasive Diagnostic Biomarker for Bladder Cancer and Facilitates Tumorigenesis via the miR-206/G6PD AxisCancers (Basel)November 6, 2023Yuting Gao, Xuan Wang, Huarong Luo, Chen Chen, Jing Li, Ruixin Sun, Dong Li, Zujun SunMA, USA), TSG101 (1:1000, Ab83; Abcam, Cambridge, UK), MG130 (1:1000, 12480S; CSTUSA); G6PD (1:1000, 12263S; CST, USA) and β-Actin (1:1000, 4967S; CST, USA) overnight at 4 °C. The membranes were then incubated

(12) MAVS integrates glucose metabolism and RIG-I-like receptor signalingNature communicationsSeptember 2, 2023He QQ, Huang Y, Nie L, Ren S, Xu G, Deng F, Cheng Z, Zuo Q, Zhang L, Cai H, et al.anti-GFPT2 (6917) and anti-GAPDH (97166), anti-β-tubulin (86298), anti-ubiquitin (3936), anti-G6PD (12263) were purchased from Cell Signaling Technology (Beverly, MA, USA). Anti-β-actin (ab179467), anti-Myc

(13) The Metabolic Changes between Monolayer (2D) and Three-Dimensional (3D) Culture Conditions in Human Mesenchymal Stem/Stromal Cells Derived from Adipose TissueCellsJanuary 1, 2023Rybkowska P, Radoszkiewicz K, Kawalec M, Dymkowska D, Zabłocka B, Zabłocki K, Sarnowska A.phosphofructokinase-2 (PFK-2) (1:250, #13123, Cell Signaling) and glucose-6-phosphate dehydrogenase (G6PDH) (1:250, #12263, Cell Signaling). Spheroids and monolayer ASCs and DFATs were lysed in RIPA Lysis and Extraction Buffer

(14) Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cellsJCI insightSeptember 8, 2022Zhao T, Liu S, Ding X, Johnson EM, Hanna NH, Singh K, Sen CK, Wan J, Du H, Yan C.and non-fluorescence-conjugated antibodies against metabolic molecules including G6PD (D5D2, catalog 12263S), LDH (C28H7, catalog 3558S), PDH (catalog 2784S), and GLUD (D9F7P, catalog 12793S) (Cell Signaling Technology

(15) Nitrostilbenes: Synthesis and Biological Evaluation as Potential Anti-Influenza Virus AgentsPharmaceuticals (Basel, Switzerland)August 26, 2022De Angelis M, De Filippis B, Balaha M, Giampietro L, Miteva MT, De Chiara G, Palamara AT, Nencioni L, Mollica A.AB1074 Merck Millipore, Darmstadt, Germany), anti-Nrf2 (#12721 Cell Signaling) or with anti G6PD (#12263 Cell Signaling) overnight at 4 °C. After three washes with T-TBS, the membranes were incubated with

(16) Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in miceCell death & diseaseMarch 29, 2022Zhang Y, Chen Y, Zhang Z, Tao X, Xu S, Zhang X, Zurashvili T, Lu Z, Bayascas JR, Jin L, et al.anti-Ehhadh (Santa Cruz, sc-393123), TOP3B (Santa Cruz, sc-137238), anti-FH (4567, CST), anti-G6PD (12263, CST), anti-HK2 (2867, CST), anti-Flag (CST, 8146), and anti-Myc (CST, 2278). Statistics Data are

(17) Mutant p53(K120R) expression enables a partial capacity to modulate metabolismFrontiers in geneticsJanuary 1, 2022Monti P, Ravera S, Speciale A, Velkova I, Foggetti G, Degan P, Fronza G, Menichini P.anti-BAX (clone N-20, sc-493 Santa Cruz), anti-TIGAR (clone E-2, sc-166290 Santa Cruz), anti-G6PD (D5D2, #12263 Cell Signaling Technology), anti-GCLM (ab154017, Abcam), anti-GCLC (clone EP13475, ab190685 Abcam),

(18) Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix compositionNature metabolismJanuary 1, 2022Facchinello N, Astone M, Audano M, Oberkersch RE, Spizzotin M, Calura E, Marques M, Crisan M, Mitro N, Santoro MM.(1:1000, #C4710, Sigma), RRM2 E7Y9J XP (1:1000, #65939, Cell Signaling Technology), G6PD (1:1000, #12263, Cell Signaling Technology), PGD (1:1000, #PA5-21376, Thermo Fisher Scientific), PGD (1:1000, #ab129199,

(19) The Energy Status of Astrocytes Is the Achilles’ Heel of eIF2B-LeukodystrophyCellsJuly 22, 2021Melisa Herrero, Maron Daw, Andrea Atzmon, Orna Elroy-Steinmouse anti p-S6K, rabbit anti t-S6K, rabbit anti G6PD (#2535, #2793, #11818, #3676, #9206, #2708, #12263, respectively, Cell Signaling, Danvers, MA, USA), mouse anti mt-COI, mouse anti SDHB, rabbit anti-acetylated

(20) Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancerMed (N Y)July 5, 2021Jonathan M. Ghergurovich et al.,Cell Signaling Technology,3810 Enolase-2,Cell Signaling Technology,8171 G6PD,Cell Signaling Technology,12263 GAPDH,Cell Signaling Technology,5174 GLUT-4,Bioss,bs-03848 Hexokinase 1,Cell Signaling Technology,2024 Hexokinase2,Cell Signaling Technology

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G6PD (D5D2) Rabbit mAb

G6PD (D5D2) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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G6PD (D5D2) Rabbit mAb from Cell Signaling Technology

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