RIP2 (D10B11) Rabbit mAb 4142S from Cell Signaling Technology

Product Specs
ItemRIP2 (D10B11) Rabbit mAb
CompanyCell Signaling Technology
Price $399.00 Inquire
Catalog Number4142S
Quantity100 µl
ApplicationsW
ReactivityH, M, R, Mk
ClonalityMonoclonal
TargetRIP2
HostRabbit
NCBI Full Gene Namereceptor interacting serine/threonine kinase 2
NCBI Gene AliasesCARD3, CARDIAK, CCK, GIG30, RICK, RIP2
Research AreaImmunology and Inflammation
IsotypeIgG
CloneD10B11
Molecular Weight62

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Shenqi compound enhances pancreatic β-cell secretion by promoting the maturation and transport of insulin secretory vesicles through the NOD1/RIP2 signaling pathwayFrontiers in NutritionJanuary 26, 2026Nairong Yao, Yiqian Xing, Ruobing Tang, Chunguang Xie, Qiyue Yang, Ya Liu, Xiyu Zhang(1:1000, Cell Signaling Technology, USA, 3545S), anti-RIP2 (1:1000, Cell Signaling Technology, USA, 4142S), anti-β-actin (1:5000, Affinity, USA, AF7018)] at 4 °C, probed with secondary antibodies HRP-linked

(2) Inhibitors supercharge kinase turnover through native proteolytic circuitsNatureJanuary 22, 2026Natalie S. Scholes, Martino Bertoni, Arnau Comajuncosa-Creus, Katharina Kladnik, Xuefei Guo, Fabian Frommelt, Matthias Hinterndorfer, Hlib Razumkov, Polina Prokofeva, Martin P. Schwalm, et al.Cell Signaling Technology, 2796), BLK (1:1,000; Cell Signaling Technology, 3262), RIPK2 (1:1,000; Cell Signaling Technology, 4142S), phosphorylated LYN (Tyr507) (1:1,000; Cell Signaling Technology, 2731), FIP200 (1:1,000; Cell Signaling Technology

(3) XIAP down-regulation inhibits RIPK2 ubiquitination-mediated insulin resistanceEndocr ConnectDecember 16, 2025Chunnan Zhao, Zezhi Zhang, Ran Li, Xueli GengName,Catalog,Molecular weight,Dilution,Manufacturer RIPK2,4142,60 kDa,"1/1,000","CST, USA" XIAP,ab229050,55 kDa,"1/1,000","Abcam, UK" p-ERK1/2,4370,"41, 43 kDa","1/2,000","CST,

(4) Avenanthramide-C Mitigates High-Fat Diet-Accelerated Alzheimer’s Pathologies via NOD1-Driven Neuroinflammation in 5×FAD MiceNutrientsAugust 19, 2025Ming Wang, Baoyuan Jin, Jia Xu, Chuang WangCell Signaling), IL-10 (#12163, D13A11, Cell Signaling), NOD1 (#3545, polyclonal antibody, Cell Signaling), RIP2 (#4142, D10B11, Cell Signaling), p-p65 (Ser536) (#3033, 93H1, Cell Signaling), NF-κB (p65) (#8242, D14E12,

(5) RIP2/NF-κB/PD-L1 signaling pathway is involved in temozolomide resistance by inducing autophagy in glioblastoma cellsTranslational OncologyAugust 1, 2025Xiaomeng Liu, Xiaosong Liu, Lei Zhao, Jianliang Wu, Xiaoliang Wang, Yuhua Huh, the membranes were incubated overnight at 4 °C with the following primary antibodies: anti-RIP2 (4142S), anti-α-Tubulin (2144S), anti-NF-κB p65 (8242S), anti-p-NF-κB p65 (3033S), anti-IκBα (4812S), anti-

(6) CARTp/GPR160 mediates behavioral hypersensitivities in mice through NOD2PainApril 1, 2025Rachel M. Schafer, Luigino A. Giancotti, John C. Chrivia, Ying Li, Fatma Mufti, Thomas A. Kufer, Jinsong Zhang, Timothy M. Doyle, Daniela SalveminiNOD2 antibody has been previously validated elsewhere [90]. The RIPK2 monoclonal antibody (D10B11; 4142; anti-rabbit) was purchased from Cell Signaling Technology, Danvers, MA USA. The allograft inflammatory

(7) Nucleotide-binding oligomerization domain 1 (NOD1) regulates microglial activation in pseudorabies virus infectionVeterinary ResearchDecember 18, 2024Xiuxiu Sun, Xinxin Jin, Zhengdan Lin, Xi Liu, Junjie Yang, Li Li, Helong Feng, Wanpo Zhang, Changqin Gu, Xueying Hu, et al.and reagents Anti-GFAP (80788), anti-MHCI (79769), anti-MHCII (86285), anti-NOD1 (3545), anti-RIPK2 (4142), anti-IκBα (4812), anti-NF-κB (8242), anti-p-NF-κB (3033), anti-JNK (9252), anti-p-JNK (4668), anti-P38

(8) Receptor interacting serine/threonine kinase 2 promotes rheumatoid arthritis progression and partially regulates nuclear factor kappa B pathwayCytojournalNovember 27, 2024Yanzheng Wang, Meiyu Xu, Xinxin Liu, Deheng Liusectioned with a thickness of 3–4 μm. IHC experiments were analyzed by RIPK2 polyclonal antibody (1:1000, 4142, CST, Boston, USA) at 4°C overnight. Subsequently, secondary antibodies (A-11011, 1:1000, Invitrogen,

(9) RIPK2 Is Crucial for the Microglial Inflammatory Response to Bacterial Muramyl Dipeptide but Not to LipopolysaccharideInternational Journal of Molecular SciencesNovember 1, 2024Changjun Yang, Maria Carolina Machado da Silva, John Aaron Howell, Jonathan Larochelle, Lei Liu, Rachel E. Gunraj, Antônio Carlos Pinheiro de Oliveira, Eduardo Candelario-Jalilmembranes were incubated at 4 °C overnight with primary antibodies rabbit anti-RIPK2 (1:1000; Cat. No. 4142; Cell Signaling Technology, Danvers, MA, USA), rabbit anti-iNOS (1:1000; Cat. No. ab15323; Abcam, Cambridge,

(10) Deubiquitination of RIPK2 by OTUB2 augments NOD2 signalling and protective effects in intestinal inflammationClinical and translational medicineOctober 1, 2024Du X, Xu J, Mei F, Shen J, Zhou B, Zhu Z, Li Z, Su X, Li J, Schlüter D, et al.sc‐56168, Santa Cruz Biotechnology), p‐RIPK2 (Cat#: 14397, Cell Signaling Technology), RIPK2 (Cat#: 4142S, Cell Signaling Technology), XIAP (CAT#: 10037‐1‐Ig, Proteintech), p‐p65 (Cat#: 3033S, Cell Signaling Technology

(11) A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell deathImmunityJuly 9, 2024Mannion J, Gifford V, Bellenie B, Fernando W, Ramos Garcia L, Wilson R, John SW, Udainiya S, Patin EC, Tiu C, et al.,Cell Signaling Technology,Cat#3493 α-human RIPK1 N-terminal,Cell Signaling Technology,Cat#73271 α-mouse RIPK2,Cell Signaling Technology,Cat#4142S α-mouse RIPK2,Cell Signaling Technology,Cat#4928 α-mouse RIPK3,Cell Signaling Technology,Cat#15828 α-human

(12) Expression of Truncated Products at the 5′-Terminal Region of RIPK2 and Evolutive Aspects that Support Their Biological ImportanceGenome Biology and EvolutionJuly 3, 2024Ulises M M Villagra, Bianca R da Cunha, Giovana M Polachini, Tiago Henrique, Ana Carolina Buzzo Stefanini, Tialfi Bergamin de Castro, Carlos H T P da Silva, Olavo A Feitosa, Erica E Fukuyama, Rossana V M López, et al.corresponding to the C-terminal domain, diluted 1:100 to 1:200); (d) a rabbit monoclonal antibody (D10B11) (#4142, Cell Signaling Technology/CST, immunogenic peptide near the C-terminal domain, diluted 1:10000. The

(13) Pharmacological inhibition of receptor-interacting protein kinase 2 (RIPK2) elicits neuroprotective effects following experimental ischemic strokeExperimental neurologyJuly 1, 2024Larochelle J, Howell JA, Yang C, Liu L, Gunraj RE, Stansbury SM, de Oliveira ACP, Baksh S, Candelario-Jalil E.Membranes were blocked with 5% milk and were incubated overnight at 4°C with rabbit anti-RIPK2 (1:1000; Cat#4142S, Cell Signaling Technology, Danvers. MA or 1:500: Cat#GTX28428, GeneTex, Irvine, CA), rabbit antibody

(14) Wybutosine hypomodification of tRNAphe activates HERVK and impairs neuronal differentiationiScienceMay 17, 2024Sun C, Guo R, Ye X, Tang S, Chen M, Zhou P, Yang M, Liao C, Li H, Lin B, et al.,Novus Biologicals,Cat#nbp-2-20321 Anti-TYW1,customized,N/A Anti-GAPDH,Boster,Cat#BM1623; RRID:AB_2885058 Anti-ACTB,Beyotime,Cat#AF0003; RRID:AB_2893353 Anti-KAP1,CST,Cat#4142s; RRID: AB_2209886 HRP Conjugated Anti-Mouse,Beyotime,Cat#A0216; RRID:AB_2860575 HRP Conjugated Anti-Rabbit,Beyotime,Cat#A0208;

(15) Identifying functional dysregulation of NOD2 variant Q902K in patients with Yao syndromeArthritis Research & TherapyFebruary 23, 2024Jingyuan Zhang, Yi Luo, Bingxuan Wu, Xin Huang, Mengzhu Zhao, Na Wu, Junke Miao, Ji Li, Lei Zhu, Di Wu, et al.follows: NOD2 antibody (Abcam ab31488, Santa Cruz sc-56168), RIP2 rabbit mAb (Cell Signaling Technology,4142), phospho-RIP2 rabbit mAb (Cell Signaling Technology,14397), NF-κB p65 mouse mAb (Cell Signaling Technology,6956),

(16) Receptor-interacting protein kinase 2 (RIPK2) profoundly contributes to post-stroke neuroinflammation and behavioral deficits with microglia as unique perpetratorsJournal of neuroinflammationSeptember 30, 2023Larochelle J, Tishko RJ, Yang C, Ge Y, Phan LT, Gunraj RE, Stansbury SM, Liu L, Mohamadzadeh M, Khoshbouei H, et al.were blocked with 5% milk and were incubated overnight at 4 °C with rabbit anti-RIPK2 (1:1000; Cat#4142S, Cell Signaling Technology, Danvers. MA, USA), rat anti-β-Actin (1:5000; Cat#664802, BioLegend; San

(17) XIAP promotes the expansion and limits the contraction of CD8 T cell response through cell extrinsic and intrinsic mechanisms respectivelyPLoS pathogensJune 1, 2023Thakker P, Ariana A, Hajjar S, Cai D, Rijal D, Sad S.P65 (Cell signaling, 3033), rabbit anti JNK (Cell signaling, 9252), anti-mouse RipK2 (Cell signaling, 4142S), anti-mouse NOD2 (Novus Biologicals, NB100-524SS), rabbit anti-mouse phospho (T183/Y185) JNK (Cell signaling

(18) Mechanism of RIP2 enhancing stemness of glioma cells induces temozolomide resistanceCNS Neuroscience & TherapeuticsDecember 1, 2022Xiao‐liang Wang, Bao‐hua Jiao, Jian‐liang Wu, Jian‐kai Yang, Yu‐hua Hu, Kai Cuimembranes were blocked with 5% BSA (Beyotime) for 4 h and incubated with primary antibodies anti‐RIP2 (4142S, 1:1000), anti‐NF‐κB p65 (8242S, 1:2000), anti‐p‐NF‐κB p65 (3033S, 1:8000), anti‐IκBα (4812S, 1:1000),

(19) Phosphorylation of muramyl peptides by NAGK is required for NOD2 activationNatureSeptember 1, 2022Stafford CA, Gassauer AM, de Oliveira Mann CC, Tanzer MC, Fessler E, Wefers B, Nagl D, Kuut G, Sulek K, Vasilopoulou C, et al.antibodies were used for probing: rabbit anti-NAGK (1:1,000, ab203900, Abcam), rabbit anti-RIPK2 (1:1,000, 4142, Cell Signaling Technology), mouse anti-β-actin horseradish peroxidase (HRP) (1:1,000, sc-47778, Santa Cruz Biotechnology

(20) Ubiquitination of SARS-CoV-2 NSP6 and ORF7a Facilitates NF-κB ActivationmBioAugust 30, 2022Nishitsuji H, Iwahori S, Ohmori M, Shimotohno K, Murata T.[CST], Danvers, MA, USA), anti-TRAF6 (1:1,000; catalog no. 8028; CST), anti-RIP2 (1:1,000; catalog no. 4142; CST), anti-TAK1 (1:1,000; catalog no. 5206; CST), anti-IKKγ (1:1,000; catalog no. 2685; CST), anti-HA

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RIP2 (D10B11) Rabbit mAb

RIP2 (D10B11) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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RIP2 (D10B11) Rabbit mAb from Cell Signaling Technology

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